Oakley, Fiona

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 819

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

Mann, J., Chu, D. C. K., Maxwell, A., Oakley, F., Zhu, N., Tsukamoto, H., & Mann, D. A. (2010) · Gastroenterology

Liver physiology and pathologyEpigenetics and DNA Methylation

Cited by 397

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis

Selvaraj, E. A., Mózes, F. E., Jayaswal, A. N. A., Zafarmand, M. H., Vali, Y., Lee, J. A., Levick, C. K., Young, L. A. J., Palaniyappan, N., Liu, C.-H., et al. (2021) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentUltrasound Imaging and Elastography

Cited by 376

Multigenerational epigenetic adaptation of the hepatic wound-healing response

Zeybel, M., Hardy, T., Wong, Y. K., Mathers, J. C., Fox, C. R., Gackowska, A., Oakley, F., Burt, A. D., Wilson, C. L., Anstee, Q. M., et al. (2012) · Nature Medicine

Liver physiology and pathologyEpigenetics and DNA Methylation

Cited by 279

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

Ebrahimkhani, M. R., Oakley, F., Murphy, L. B., Mann, J., Moles, A., Perugorria, M. J., Ellis, E., Lakey, A. F., Burt, A. D., Douglass, A., et al. (2011) · Nature Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 221

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Mózes, F. E., Lee, J. A., Vali, Y., Alzoubi, O., Staufer, K., Trauner, M., Paternostro, R., Stauber, R. E., Holleboom, A. G., van Dijk, A.-M., et al. (2023) · The Lancet Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver Disease and Transplantation

Cited by 214

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Lagnado, A., Leslie, J., Ruchaud‐Sparagano, M., Victorelli, S., Hirsova, P., Ogrodnik, M., Collins, A. L., Vizioli, M. G., Habiballa, L., Saretzki, G., et al. (2021) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 211

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma

Wilson, C. L., Jurk, D., Fullard, N., Banks, P., Page, A., Luli, S., Elsharkawy, A. M., Gieling, R. G., Chakraborty, J. B., Fox, C., et al. (2015) · Nature Communications

Immune cells in cancerHepatocellular Carcinoma Treatment and Prognosis

Cited by 171

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., et al. (2014) · Journal of Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 169

The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes

Elsharkawy, A. M., Oakley, F., Lin, F., Packham, G., Mann, D. A., & Mann, J. (2010) · Journal of Hepatology

NF-κB Signaling PathwaysLiver physiology and pathology

Cited by 160

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

Perugorria, M. J., Esparza-Baquer, A., Oakley, F., Labiano, I., Korosec, A., Jais, A., Mann, J., Tiniakos, D., Santos-Laso, A., Arbelaiz, A., et al. (2019) · Gut

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 144

Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury

Oakley, F., Mann, J., Nailard, S., Smart, D. E., Mungalsingh, N., Constandinou, C., Ali, S., Wilson, S. J., Millward-Sadler, H., Iredale, J. P., et al. (2005) · The American Journal of Pathology

Liver physiology and pathologyNF-κB Signaling Pathways

Cited by 123

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices

Paish, H. L., Reed, L. H., Brown, H., Bryan, M. C., Govaere, O., Leslie, J., Barksby, B. S., Garcia Macia, M., Watson, A., Xu, X., et al. (2019) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 106

Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice

Correia‐Melo, C., Birch, J., Fielder, E., Rahmatika, D., Taylor, J., Chapman, J., Lagnado, A., Carroll, B. M., Miwa, S., Richardson, G., et al. (2019) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 77

Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice

Fielder, E., Tweedy, C., Wilson, C., Oakley, F., LeBeau, F. E. N., Passos, J. F., Mann, D. A., von Zglinicki, T., & Jurk, D. (2020) · Aging Cell

Neuroinflammation and Neurodegeneration MechanismsAntioxidants, Aging, Portulaca oleracea

Cited by 71

Hepatic Nuclear Factor κB Regulates Neutrophil Recruitment to the Injured Brain

Campbell, S. J., Anthony, D. C., Oakley, F., Carlsen, H., Elsharkawy, A. M., Blomhoff, R., & Mann, D. A. (2008) · Journal of Neuropathology & Experimental Neurology

NF-κB Signaling PathwaysTraumatic Brain Injury and Neurovascular Disturbances

Cited by 67

Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis

Vacca, M., Leslie, J., Virtue, S., Lam, B. Y. H., Govaere, O., Tiniakos, D., Snow, S., Davies, S., Petkevicius, K., Tong, Z., et al. (2020) · Nature Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 60

Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

Azzu, V., Vacca, M., Kamzolas, I., Hall, Z., Leslie, J., Carobbio, S., Virtue, S., Davies, S. E., Lukasik, A., Dale, M., et al. (2021) · Molecular Metabolism

Liver Disease Diagnosis and TreatmentCancer, Lipids, and Metabolism

Cited by 52

Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3

Wilson, C. L., Mann, J., Walsh, M., Perrugoria, M. J., Oakley, F., Wright, M. C., Brignole, C., Di Paolo, D., Perri, P., Ponzoni, M., et al. (2014) · PLoS ONE

Immune Response and InflammationLiver physiology and pathology

Cited by 31

Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct-Ligated Mice

Gee, L. M. V., Barron-Millar, B., Leslie, J., Richardson, C., Zaki, M. Y. W., Luli, S., Burgoyne, R. A., Cameron, R. I. T., Smith, G. R., Brain, J. G., et al. (2023) · The American Journal of Pathology

Liver Diseases and ImmunityDrug Transport and Resistance Mechanisms

Cited by 18