van Boxtel, Ruben

Sequential cancer mutations in cultured human intestinal stem cells

Drost, J., van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R. M., Offerhaus, G. J., Begthel, H., et al. (2015) · Nature

Cancer Cells and MetastasisGenetic factors in colorectal cancer

Cited by 1,067

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

Blokzijl, F., Janssen, R., van Boxtel, R., & Cuppen, E. (2018) · Genome Medicine

Cancer Genomics and DiagnosticsGenomics and Phylogenetic Studies

Cited by 660

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., et al. (2017) · Science

Cancer Genomics and DiagnosticsDNA Repair Mechanisms

Cited by 461

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

Driehuis, E., Kolders, S., Spelier, S., Lõhmussaar, K., Willems, S. M., Devriese, L. A., de Bree, R., de Ruiter, E. J., Korving, J., Begthel, H., et al. (2019) · Cancer Discovery

Cancer Cells and MetastasisHead and Neck Cancer Studies

Cited by 408

The mutational landscape of human somatic and germline cells

Moore, L., Cagan, A., Coorens, T. H. H., Neville, M. D. C., Sanghvi, R., Sanders, M. A., Oliver, T. R. W., Leongamornlert, D., Ellis, P., Noorani, A., et al. (2021) · Nature

Cancer Genomics and DiagnosticsDNA Repair Mechanisms

Cited by 379

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Geurts, M. H., de Poel, E., Amatngalim, G. D., Oka, R., Meijers, F. M., Kruisselbrink, E., van Mourik, P., Berkers, G., de Winter-de Groot, K. M., Michel, S., et al. (2020) · Cell Stem Cell

CRISPR and Genetic EngineeringCystic Fibrosis Research Advances

Cited by 222

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

Artegiani, B., van Voorthuijsen, L., Lindeboom, R. G. H., Seinstra, D., Heo, I., Tapia, P., López-Iglesias, C., Postrach, D., Dayton, T., Oka, R., et al. (2019) · Cell Stem Cell

Cholangiocarcinoma and Gallbladder Cancer StudiesChromatin Remodeling and Cancer

Cited by 218

Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer

Lõhmussaar, K., Oka, R., Espejo Valle-Inclan, J., Smits, M. H. H., Wardak, H., Korving, J., Begthel, H., Proost, N., van de Ven, M., Kranenburg, O. W., et al. (2021) · Cell Stem Cell

Cervical Cancer and HPV ResearchCancer Cells and Metastasis

Cited by 211

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

Geurts, M. H., de Poel, E., Pleguezuelos-Manzano, C., Oka, R., Carrillo, L., Andersson-Rolf, A., Boretto, M., Brunsveld, J. E., van Boxtel, R., Beekman, J. M., et al. (2021) · Life Science Alliance

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 151

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Villiger, L., Rothgangl, T., Witzigmann, D., Oka, R., Lin, P. J. C., Qi, W., Janjuha, S., Berk, C., Ringnalda, F., Beattie, M. B., et al. (2021) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 105

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

Jager, M., Blokzijl, F., Sasselli, V., Boymans, S., Janssen, R., Besselink, N., Clevers, H., van Boxtel, R., & Cuppen, E. (2018) · Nature Protocols

Cancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics

Cited by 66