Kayed, Rakez

Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies

Gaikwad, S., Senapati, S., Haque, M. A., & Kayed, R. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 117

Tau oligomers derived from traumatic brain injury cause cognitive impairment and accelerate onset of pathology in htau mice

Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E., & Kayed, R. (2016) · Journal of Neurotrauma

Alzheimer's disease research and treatmentsTraumatic Brain Injury Research

Cited by 94

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E., & Kayed, R. (2018) · Biological Psychiatry

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 84

Tau Oligomers as Potential Targets for Immunotherapy for Alzheimers Disease and Tauopathies

A. Lasagna-Reeves, C., L. Castillo-Carranza, D., R. Jackson, G., & Kayed, R. (2011) · Current Alzheimer Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 80

Tau oligomers in cerebrospinal fluid in Alzheimer's disease

Sengupta, U., Portelius, E., Hansson, O., Farmer, K., Castillo‐Carranza, D., Woltjer, R., Zetterberg, H., Galasko, D., Blennow, K., & Kayed, R. (2017) · Annals of Clinical and Translational Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 77

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

Kim, Y., Choi, H., Lee, W., Park, H., Kam, T.-I., Hong, S.-H., Nah, J., Jung, S., Shin, B., Lee, H., et al. (2016) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 71

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

Deger, J. M., Gerson, J. E., & Kayed, R. (2015) · Aging Cell

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

Cited by 69

Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease

Puangmalai, N., Sengupta, U., Bhatt, N., Gaikwad, S., Montalbano, M., Bhuyan, A., Garcia, S., McAllen, S., Sonawane, M., Jerez, C., et al. (2022) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

Cited by 68

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., et al. (2017) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 61

The Role of Glial Cell Senescence in Alzheimer's Disease

Alshaebi, F., Sciortino, A., & Kayed, R. (2025) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 60

Neurotoxic tau oligomers after single versus repetitive mild traumatic brain injury

Bittar, A., Bhatt, N., Hasan, T. F., Montalbano, M., Puangmalai, N., McAllen, S., Ellsworth, A., Carretero Murillo, M., Taglialatela, G., Lucke-Wold, B., et al. (2019) · Brain Communications

Alzheimer's disease research and treatmentsTraumatic Brain Injury Research

Cited by 60

Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers

Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., et al. (2020) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 56

Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies

Bittar, A., Sengupta, U., & Kayed, R. (2018) · npj Vaccines

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 50

Aβ/tau oligomer interplay at human synapses supports shifting therapeutic targets for Alzheimer’s disease

Marcatti, M., Fracassi, A., Montalbano, M., Natarajan, C., Krishnan, B., Kayed, R., & Taglialatela, G. (2022) · Cellular and Molecular Life Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 38

Tau Oligomers in Sera of Patients with Alzheimer’s Disease and Aged Controls

Kolarova, M., Sengupta, U., Bartos, A., Ricny, J., & Kayed, R. (2017) · Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 27

Amyloid-β oligomers increase the binding and internalization of tau oligomers in human synapses

Kadamangudi, S., Marcatti, M., Zhang, W.-R., Fracassi, A., Kayed, R., Limon, A., & Taglialatela, G. (2024) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 25

ApoE4‐Driven Accumulation of Intraneuronal Oligomerized A β 42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E., & Michaelson, D. M. (2011) · International Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 23

Retraction Note: A specific amyloid-β protein assembly in the brain impairs memory

Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2024) · Nature

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 18

Passive Immunotherapy Targeting Tau Oligomeric Strains Reverses Tauopathy Phenotypes in Aged Human-Tau Mice in a Mouse Model-Specific Manner

Bittar, A., Al-Lahham, R., Bhatt, N., Moore, K., Montalbano, M., Jerez, C., Fung, L., McAllen, S., Ellsworth, A., & Kayed, R. (2022) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 18