α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M.-Y. (2012) · Science · doi:10.1126/science.1227157 · Cited by 2,563 · see citing works

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

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Prion-like spreading of pathological α-synuclein in brain

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Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry

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Proteopathic tau seeding predicts tauopathy in vivo

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Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

Guo, J. L., Covell, D. J., Daniels, J. P., Iba, M., Stieber, A., Zhang, B., Riddle, D. M., Kwong, L. K., Xu, Y., Trojanowski, J. Q., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.057 · Cited by 680 · see citing works

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

Iba, M., Guo, J. L., McBride, J. D., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2642-12.2013 · Cited by 664 · see citing works

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R., & Kayed, R. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-39 · Cited by 633 · see citing works

The Formation of Highly Soluble Oligomers of α-Synuclein Is Regulated by Fatty Acids and Enhanced in Parkinson's Disease

Sharon, R., Bar-Joseph, I., Frosch, M. P., Walsh, D. M., Hamilton, J. A., & Selkoe, D. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00024-2 · Cited by 562 · see citing works

Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65722-7 · Cited by 533 · see citing works

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

Lasagna‐Reeves, C. A., Castillo‐Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R., & Kayed, R. (2012) · The FASEB Journal · doi:10.1096/fj.11-199851 · Cited by 527 · see citing works

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R., & Kayed, R. (2012) · Scientific Reports · doi:10.1038/srep00700 · Cited by 502 · see citing works

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

Ishizawa, T., Mattila, P. M., Davies, P., Wang, D., & Dickson, D. W. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.389 · Cited by 391 · see citing works

Prefibrillar Amyloid Protein Aggregates Share Common Features of Cytotoxicity

Bucciantini, M., Calloni, G., Chiti, F., Formigli, L., Nosi, D., Dobson, C. M., & Stefani, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400348200 · Cited by 369 · see citing works

Preparation and Characterization of Neurotoxic Tau Oligomers

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Jackson, G. R., & Kayed, R. (2010) · Biochemistry · doi:10.1021/bi1016233 · Cited by 359 · see citing works

Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease

Patterson, K. R., Remmers, C. L., Fu, Y., Brooker, S. M., Kanaan, N. M., Vana, L., Ward, S., Reyes, J. F., Philibert, K., Glucksman, M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237974 · Cited by 354 · see citing works

Seeded Aggregation and Toxicity of α-Synuclein and Tau

Nonaka, T., Watanabe, S., Iwatsubo, T., & Hasegawa, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.148460 · Cited by 330 · see citing works

Structural Organization of α-Synuclein Fibrils Studied by Site-directed Spin Labeling

Der-Sarkissian, A., Jao, C. C., Chen, J., & Langen, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305266200 · Cited by 328 · see citing works

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

Shafiei, S. S., Guerrero-Muñoz, M. J., & Castillo-Carranza, D. L. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00083 · Cited by 314 · see citing works

Seeding induced by α‐synuclein oligomers provides evidence for spreading of α‐synuclein pathology

Danzer, K. M., Krebs, S. K., Wolff, M., Birk, G., & Hengerer, B. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06324.x · Cited by 303 · see citing works

Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease

Maeda, S., Sahara, N., Saito, Y., Murayama, S., Ikai, A., & Takashima, A. (2006) · Neuroscience Research · doi:10.1016/j.neures.2005.11.009 · Cited by 301 · see citing works

Template-assisted filament growth by parallel stacking of tau

Margittai, M., & Langen, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401911101 · Cited by 276 · see citing works

Detection of elevated levels of soluble -synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies

Paleologou, K. E., Kragh, C. L., Mann, D. M. A., Salem, S. A., Al‐Shami, R., Allsop, D., Hassan, A. H. M., Jensen, P. H., & El‐Agnaf, O. M. A. (2008) · Brain · doi:10.1093/brain/awn349 · Cited by 225 · see citing works

Tau-dependent microtubule disassembly initiated by prefibrillar β-amyloid

King, M. E., Kan, H.-M., Baas, P. W., Erişir, A., Glabe, C. G., & Bloom, G. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605187 · Cited by 215 · see citing works

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

Fang, Y.-S., Tsai, K., Chang, Y.-J., Kao, P. F., Woods, R., Kuo, P. H., Wu, C., Liao, J., Chou, S.-C., Lin, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms5824 · Cited by 211 · see citing works

Induction of Intracellular Tau Aggregation Is Promoted by α-Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

Waxman, E. A., & Giasson, B. I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0297-11.2011 · Cited by 193 · see citing works

Confluence of α-Synuclein, Tau, and β-Amyloid Pathologies in Dementia With Lewy Bodies

Colom‐Cadena, M., Gelpí, E., Charif, S., Belbin, O., Blesa, R., Martı́, M. J., Clarimón, J., & Lleó, A. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000018 · Cited by 184 · see citing works

Pathological Interface Between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

Sengupta, U., Guerrero‐Munoz, M. J., Castillo‐Carranza, D. L., Lasagna‐Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R., & Kayed, R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.019 · Cited by 181 · see citing works

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy

Badiola, N., de Oliveira, R. M., Herrera, F., Guardia‐Laguarta, C., Gonçalves, S. A., Pera, M., Suárez‐Calvet, M., Clarimón, J., Outeiro, T. F., & Lleó, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026609 · Cited by 150 · see citing works

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

Prots, I., Veber, V., Brey, S., Campioni, S., Buder, K., Riek, R., Böhm, K. J., & Winner, B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.451815 · Cited by 140 · see citing works

Tau and α-Synuclein Pathology in Amygdala of Parkinsonism-Dementia Complex Patients of Guam

Forman, M. S., Schmidt, M. L., Kasturi, S. S., Perl, D. P., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61119-4 · Cited by 127 · see citing works

Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson’s disease

Haggerty, T., Credle, J. J., Rodriguez, O. C., Wills, J., Oaks, A. W., Masliah, E., & Sidhu, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07660.x · Cited by 126 · see citing works

Lewy Bodies in the Amygdala

Popescu, A., Lippa, C. F., Lee, V. M. ‐., & Trojanowski, J. Q. (2004) · Archives of Neurology · doi:10.1001/archneur.61.12.1915 · Cited by 117 · see citing works

Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins

Guerrero‐Munoz, M. J., Castillo‐Carranza, D. L., & Kayed, R. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.023 · Cited by 103 · see citing works

Characterization of tau oligomeric seeds in progressive supranuclear palsy

Gerson, J. E., Sengupta, U., Lasagna‐Reeves, C. A., Guerrero‐Munoz, M. J., Troncoso, J. C., & Kayed, R. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-73 · Cited by 95 · see citing works

Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies

Obi, K., Akiyama, H., Kondo, H., Shimomura, Y., Hasegawa, M., Iwatsubo, T., Mizuno, Y., & Mochizuki, H. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.11.019 · Cited by 91 · see citing works

Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer’s disease

Chu, J., Lauretti, E., & Praticò, D. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.214 · Cited by 90 · see citing works

Conformational Features of Tau Fibrils from Alzheimer’s Disease Brain Are Faithfully Propagated by Unmodified Recombinant Protein

Morozova, O. A., March, Z. M., Robinson, A. S., & Colby, D. W. (2013) · Biochemistry · doi:10.1021/bi400866w · Cited by 87 · see citing works

C-terminal α-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders

Takeda, A., Hashimoto, M., Mallory, M., Sundsumo, M., Hansen, L., & Masliah, E. (2000) · Acta Neuropathologica · doi:10.1007/pl00007441 · Cited by 83 · see citing works

Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease

Roy, B., & Jackson, G. R. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu011 · Cited by 75 · see citing works

NACP/α-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies

Arima, K., Mizutani, T., Alim, A., Tonozuka-Uehara, H., Izumiyama, Y., Hirai, S., & Uéda, K. (2000) · Acta Neuropathologica · doi:10.1007/s004010050002 · Cited by 71 · see citing works

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

Guerrero‐Munoz, M. J., Castillo‐Carranza, D. L., Krishnamurthy, S., Paulucci-Holthauzen, A. A., Sengupta, U., Lasagna‐Reeves, C. A., Ahmad, Y., Jackson, G. R., & Kayed, R. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.008 · Cited by 67 · see citing works

Detection of Lewy Bodies in Trisomy 21 (Down's Syndrome)

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MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies

Colom‐Cadena, M., Gelpí, E., Martı́, M. J., Charif, S., Dols‐Icardo, O., Blesa, R., Clarimón, J., & Lleó, A. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.015 · Cited by 53 · see citing works

Untitled work

Price (1999) · doi:10.1002/1531-8249(199903)45:3

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Nguyen, P. H., Ramamoorthy, A., Sahoo, B. R., Zheng, J., Faller, P., Straub, J. E., Domı́nguez, L., Shea, J., Dokholyan, N. V., Simone, A. D., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01122 · Cited by 676 · see citing works

Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases

Sengupta, U., & Kayed, R. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102270 · Cited by 303 · see citing works

The Role of α-Synuclein Oligomers in Parkinson’s Disease

Du, X.-Y., Xie, X.-X., & Liu, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228645 · Cited by 242 · see citing works

Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

Limorenko, G., & Lashuel, H. A. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00127b · Cited by 162 · see citing works

Passive immunotherapies targeting Aβ and tau in Alzheimer's disease

Plotkin, S. S., & Cashman, N. R. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105010 · Cited by 156 · see citing works

Tau accelerates α-synuclein aggregation and spreading in Parkinson’s disease

Pan, L., Li, C., Meng, L., Tian, Y., He, M., Yuan, X., Zhang, G., Zhang, Z., Xiong, J., Chen, G., et al. (2022) · Brain · doi:10.1093/brain/awac171 · Cited by 154 · see citing works

Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology

Ivanova, M. I., Lin, Y., Lee, Y., Zheng, J., & Ramamoorthy, A. (2020) · Biophysical Chemistry · doi:10.1016/j.bpc.2020.106507 · Cited by 155 · see citing works

An outline for the pharmacological effect of icariin in the nervous system

Jin, J., Wang, H., Hua, X., Chen, D., Huang, C., & Chen, Z. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.10.006 · Cited by 137 · see citing works

Fundamentals of cross-seeding of amyloid proteins: an introduction

Ren, B., Zhang, Y., Zhang, M., Liu, Y., Zhang, D., Gong, X., Feng, Z., Tang, J., Chang, Y., & Zheng, J. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01871a · Cited by 135 · see citing works

P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. N., & Kayed, R. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01012-6 · Cited by 126 · see citing works

Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies

Gaikwad, S., Senapati, S., Haque, M. A., & Kayed, R. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13490 · Cited by 117 · see citing works

Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition

Subedi, S., Sasidharan, S., Nag, N., Saudagar, P., & Tripathi, T. (2022) · Molecules · doi:10.3390/molecules27061776 · Cited by 114 · see citing works

α-Synuclein modulates tau spreading in mouse brains

Bassil, F., Meymand, E. S., Brown, H. J., Xu, H. W., Cox, T. O., Pattabhiraman, S., Maghames, C. M., Wu, Q., Zhang, B., Trojanowski, J. Q., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192193 · Cited by 111 · see citing works

TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

Montalbano, M., McAllen, S., Cascio, F. L., Sengupta, U., García, S., Bhatt, N. N., Ellsworth, A., Heidelman, E. A., Johnson, O. D., Doskocil, S. D., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105130 · Cited by 107 · see citing works

Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies

Zhang, X., Wang, J., Zhang, Z., & Ye, K. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00429-6 · Cited by 106 · see citing works

Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets

Kwon, S., Iba, M., Kim, C., & Masliah, E. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00853-2 · Cited by 92 · see citing works

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Singh, B., Covelo, A., Martell-Martinez, H. A., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J. P., Teravskis, P. J., Gallardo, C., Savonenko, A. V., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02032-w · Cited by 84 · see citing works

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

Cascio, F. L., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Piccionello, A. P., & Kayed, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-55419-w · Cited by 71 · see citing works

Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk

Kayed, R., Dettmer, U., & Lesné, S. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-201965 · Cited by 62 · see citing works

Modulating disease-relevant tau oligomeric strains by small molecules

Cascio, F. L., García, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P., & Kayed, R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014630 · Cited by 51 · see citing works

Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates

Zhu, W., Zhang, W., Chen, J., Tong, Y., Xu, F., & Pang, J. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01719 · Cited by 51 · see citing works

Diverse Misfolded Conformational Strains and Cross-seeding of Misfolded Proteins Implicated in Neurodegenerative Diseases

Lim, K. H. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00158 · Cited by 46 · see citing works

Update on the association between alpha‐synuclein and tau with mitochondrial dysfunction: Implications for Parkinson's disease

Feng, S., Wang, Z., Yuan, Y., Sun, H., Chen, N., & Zhang, Y. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14699 · Cited by 47 · see citing works

The prion-like transmission of tau oligomers via exosomes

Jackson, N. A., Guerrero‐Munoz, M. J., & Castillo‐Carranza, D. L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.974414 · Cited by 44 · see citing works

Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological Approaches

Hill, E., Wall, M. J., Moffat, K. G., & Karikari, T. K. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00155 · Cited by 42 · see citing works

Advances in Proteasome Enhancement by Small Molecules

George, D. E., & Tepe, J. J. (2021) · Biomolecules · doi:10.3390/biom11121789 · Cited by 40 · see citing works

Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein

Sengupta, U., Puangmalai, N., Bhatt, N. N., García, S., Zhao, Y., & Kayed, R. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01913-6 · Cited by 38 · see citing works

Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias

Wren, M. C., Lashley, T., Årstad, E., & Sander, K. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0535-z · Cited by 37 · see citing works

In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor

Bodily, T. A., Ramanathan, A., Wei, S., Karkisaval, A. G., Bhatt, N. N., Jerez, C., Haque, M. A., Ramil, A., Heda, P., Wang, Y., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311565120 · Cited by 37 · see citing works

What is strain in neurodegenerative diseases?

Tian, Y., Meng, L., & Zhang, Z. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03298-9 · Cited by 37 · see citing works

The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease

Caligiore, D., Giocondo, F., & Silvetti, M. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.09.007 · Cited by 36 · see citing works

Structurally Distinct α‐Synuclein Fibrils Induce Robust Parkinsonian Pathology

Hayakawa, H., Nakatani, R., Ikenaka, K., Aguirre, C., Choong, C., Tsuda, H., Nagano, S., Koike, M., Ikeuchi, T., Hasegawa, M., et al. (2019) · Movement Disorders · doi:10.1002/mds.27887 · Cited by 36 · see citing works

Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities

Cascio, F. L., Park, S., Sengupta, U., Puangmalai, N., Bhatt, N. N., Shchankin, N., Jerez, C., Moreno, N., Bittar, A., Xavier, R., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07499-w · Cited by 35 · see citing works

Tau induces formation of α-synuclein filaments with distinct molecular conformations

Hojjatian, A., Dasari, A. K. R., Sengupta, U., Taylor, D. W., Daneshparvar, N., Yeganeh, F. A., Dillard, L. B., Michael, B. C., Griffin, R. G., Borgnia, M. J., et al. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.091 · Cited by 40 · see citing works

Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration

Li, W., & Li, J. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00407-y · Cited by 35 · see citing works

“Prion-like” seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders

Zampar, S., Gregorio, S. E. D., Grimmer, G., Watts, J. C., & Ingelsson, M. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1436262 · Cited by 34 · see citing works

A Comprehensive Review of Alzheimer’s Association with Related Proteins: Pathological Role and Therapeutic Significance

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Pharmacological Modulators of Tau Aggregation and Spreading

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Additional file 1 of P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

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Additional file 2 of P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

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Additional file 4 of P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

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Additional file 3 of P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

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Lifestyles of a Toxic Twosome: A Novel Tau Strain Induced by α-Synuclein Oligomers

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