Asokan, Aravind

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

Nelson, C. E., Hakim, C. H., Ousterout, D. G., Thakore, P. I., Moreb, E. A., Rivera, R. M. C., Madhavan, S., Pan, X., Ran, F. A., Yan, W. X., et al. (2016) · Science

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 1,144

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Mestre, H., Hablitz, L. M., Xavier, A. L., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Castellanos Rivera, R. M., Simon, M. J., et al. (2018) · eLife

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 738

Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles

Li, W., Asokan, A., Wu, Z., Van Dyke, T., DiPrimio, N., Johnson, J. S., Govindaswamy, L., Agbandje-McKenna, M., Leichtle, S., Eugene Redmond Jr, D., et al. (2008) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 261

Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia

Li, C., Narkbunnam, N., Samulski, R. J., Asokan, A., Hu, G., Jacobson, L. J., Manco-Johnson, M. J., Monahan, P. E., & The Joint Outcome Study Investigators (2012) · Gene Therapy

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 225

Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion

Tse, L. V., Klinc, K. A., Madigan, V. J., Castellanos Rivera, R. M., Wells, L. F., Havlik, L. P., Smith, J. K., Agbandje-McKenna, M., & Asokan, A. (2017) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 210

Adeno-Associated Virus Type 2 Contains an Integrin α5β1 Binding Domain Essential for Viral Cell Entry

Asokan, A., Hamra, J. B., Govindasamy, L., Agbandje-McKenna, M., & Samulski, R. J. (2006) · Journal of Virology

Virus-based gene therapy researchCell Adhesion Molecules Research

Cited by 183

Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry

Pierson, E. E., Keifer, D. Z., Asokan, A., & Jarrold, M. F. (2016) · Analytical Chemistry

Mass Spectrometry Techniques and ApplicationsVirus-based gene therapy research

Cited by 152

Biophysical and Ultrastructural Characterization of Adeno-Associated Virus Capsid Uncoating and Genome Release

Horowitz, E. D., Rahman, K. S., Bower, B. D., Dismuke, D. J., Falvo, M. R., Griffith, J. D., Harvey, S. C., & Asokan, A. (2013) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 139

Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme

Elmore, Z. C., Oh, D. K., Simon, K. E., Fanous, M. M., & Asokan, A. (2020) · JCI Insight

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 137

Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity

Guo, J., Otis, J. M., Higginbotham, H., Monckton, C., Cheng, J., Asokan, A., Mykytyn, K., Caspary, T., Stuber, G. D., & Anton, E. S. (2017) · Developmental Cell

Genetic and Kidney Cyst DiseasesNeurogenesis and neuroplasticity mechanisms

Cited by 136

Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles

Li, C., Diprimio, N., Bowles, D. E., Hirsch, M. L., Monahan, P. E., Asokan, A., Rabinowitz, J., Agbandje-McKenna, M., & Samulski, R. J. (2012) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 96

Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing

Gonzalez, T. J., Simon, K. E., Blondel, L. O., Fanous, M. M., Roger, A. L., Maysonet, M. S., Devlin, G. W., Smith, T. J., Oh, D. K., Havlik, L. P., et al. (2022) · Nature Communications

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 85

Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier

Albright, B. H., Storey, C. M., Murlidharan, G., Castellanos Rivera, R. M., Berry, G. E., Madigan, V. J., & Asokan, A. (2018) · Molecular Therapy

Virus-based gene therapy researchBarrier Structure and Function Studies

Cited by 82

Cellular immune response to cryptic epitopes during therapeutic gene transfer

Li, C., Goudy, K., Hirsch, M., Asokan, A., Fan, Y., Alexander, J., Sun, J., Monahan, P., Seiber, D., Sidney, J., et al. (2009) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 79

rAAV-compatible MiniPromoters for restricted expression in the brain and eye

de Leeuw, C. N., Korecki, A. J., Berry, G. E., Hickmott, J. W., Lam, S. L., Lengyell, T. C., Bonaguro, R. J., Borretta, L. J., Chopra, V., Chou, A. Y., et al. (2016) · Molecular Brain

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 76

Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain

Murlidharan, G., Crowther, A., Reardon, R. A., Song, J., & Asokan, A. (2016) · JCI Insight

Virus-based gene therapy researchCerebrospinal fluid and hydrocephalus

Cited by 72

Strategies to circumvent humoral immunity to adeno-associated viral vectors

Tse, L. V., Moller-Tank, S., & Asokan, A. (2015) · Expert Opinion on Biological Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 61

Production of recombinant adeno-associated viral vectors for in vitro and in vivo use

Choi, V. W., Asokan, A., Haberman, R. A., & Samulski, R. J. (2007) · Current Protocols in Molecular Biology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 52

Development of patient-specific AAV vectors after neutralizing antibody selection for enhanced muscle gene transfer

Li, C., Wu, S., Albright, B., Hirsch, M., Li, W., Tseng, Y.-S., Agbandje-McKenna, M., McPhee, S., Asokan, A., & Samulski, R. J. (2016) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 48

Cytotoxic-t-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo

Li, C., Hirsch, M., DiPrimio, N., Asokan, A., Goudy, K., Tisch, R., & Samulski, R. J. (2009) · Journal of Virology

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 42

Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion

Castle, M. J., Cheng, Y., Asokan, A., & Tuszynski, M. H. (2018) · Science Advances

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 41

Glycated AAV vectors: chemical redirection of viral tissue tropism

Horowitz, E. D., Weinberg, M. S., & Asokan, A. (2011) · Bioconjugate Chemistry

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 40

Preclinical Toxicity Evaluation of AAV for Pain: Evidence from Human AAV Studies and from the Pharmacology of Analgesic Drugs

Pleticha, J., Heilmann, L. F., Evans, C. H., Asokan, A., Samulski, R. J., & Beutler, A. S. (2014) · Molecular Pain

Virus-based gene therapy researchPain Mechanisms and Treatments

Cited by 21