Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion
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An inverted position after intrathecal AAV9 infusion markedly enhances gene delivery to the brain.
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Michael and colleagues adopted the Trendelenburg position (lying head approximately 25° below the feet) after intrathecal infusion of AAV9, resulting in a marked improvement of cortical distribution with 15-fold increase in neuron transduction.
“Interestingly, Michael and colleagues adopted Trendelenburg position that lying head approximately 25° below the feet after intrathecal infusion of AAV9, resulting a marked improvement of cortical distribution with 15-fold increase in neuron transduction [92].”
From Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedside (2024) · cites this paper as [92]
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Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works
Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy
Mendell, J. R., Al-Zaidy, S., Shell, R., Arnold, W. D., Rodino-Klapac, L. R., Prior, T. W., Lowes, L., Alfano, L., Berry, K., Church, K., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1706198 · Cited by 2,381 · see citing works
Chan, K. Y., Jang, M. J., Yoo, B. B., Greenbaum, A., Ravi, N., Wu, W.-L., Sánchez-Guardado, L., Lois, C., Mazmanian, S. K., Deverman, B. E., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4593 · Cited by 1,578 · see citing works
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
Foust, K. D., Nurre, E., Montgomery, C. L., Hernandez, A., Chan, C. M., & Kaspar, B. K. (2009) · Nature Biotechnology · doi:10.1038/nbt.1515 · Cited by 1,456 · see citing works
Kordower, J. H., Emborg, M. E., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J. L., Chen, E., Palfi, S., Roitberg, B. Z., et al. (2000) · Science · doi:10.1126/science.290.5492.767 · Cited by 1,244 · see citing works
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
Deverman, B. E., Pravdo, P. L., Simpson, B. P., Kumar, S. R., Chan, K. Y., Banerjee, A., Wu, W.-L., Yang, B., Huber, N., Pasca, S. P., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3440 · Cited by 1,061 · see citing works
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Tuszynski, M. H., Thal, L., Pay, M., Salmon, D. P., U, H. S., Bakay, R., Patel, P., Blesch, A., Vahlsing, H. L., Ho, G., et al. (2005) · Nature Medicine · doi:10.1038/nm1239 · Cited by 1,050 · see citing works
Self-citationNagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., Conner, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1912 · Cited by 1,034 · see citing works
Self-citationKaplitt, M. G., Leone, P., Samulski, R. J., Xiao, X., Pfaff, D. W., O’Malley, K. L., & During, M. J. (1994) · Nature Genetics · doi:10.1038/ng1094-148 · Cited by 1,031 · see citing works
DeFelipe, J., & Fariñas, I. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90015-7 · Cited by 975 · see citing works
Marks, W. J., Bartus, R. T., Siffert, J. O., Davis, C. S., Lozano, A. M., Boulis, N. M., Vitek, J. L., Stacy, M. A., Turner, D. A., Verhagen, L., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70254-4 · Cited by 685 · see citing works
Gray, S. J., Matagne, V., Bachaboina, L., Yadav, S., Ojeda, S. R., & Samulski, R. J. (2011) · Molecular Therapy · doi:10.1038/mt.2011.72 · Cited by 501 · see citing works
Xu, X., Roby, K. D., & Callaway, E. M. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22229 · Cited by 429 · see citing works
The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice
Hordeaux, J., Wang, Q., Katz, N., Buza, E. L., Bell, P., & Wilson, J. M. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.01.018 · Cited by 426 · see citing works
Gray, S. J., Nagabhushan Kalburgi, S., McCown, T. J., & Jude Samulski, R. (2013) · Gene Therapy · doi:10.1038/gt.2012.101 · Cited by 377 · see citing works
Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates
Samaranch, L., Salegio, E. A., San Sebastian, W., Kells, A. P., Foust, K. D., Bringas, J. R., Lamarre, C., Forsayeth, J., Kaspar, B. K., & Bankiewicz, K. S. (2012) · Human Gene Therapy · doi:10.1089/hum.2011.200 · Cited by 299 · see citing works
Meyer, K., Ferraiuolo, L., Schmelzer, L., Braun, L., McGovern, V., Likhite, S., Michels, O., Govoni, A., Fitzgerald, J., Morales, P., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2014.210 · Cited by 286 · see citing works
Long-Term Clinical Improvement in MPTP-Lesioned Primates after Gene Therapy with AAV-hAADC
Bankiewicz, K. S., Forsayeth, J., Eberling, J. L., Sánchez‐Pernaute, R., Pivirotto, P., Bringas, J., Herscovitch, P., Carson, R. E., Eckelman, W. C., Reutter, B. W., et al. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.05.005 · Cited by 282 · see citing works
Kordower, J. H., Herzog, C. D., Dass, B., Bakay, R. A. E., Stansell, J., Gasmi, M., & Bartus, R. T. (2006) · Annals of Neurology · doi:10.1002/ana.21032 · Cited by 251 · see citing works
Gritti, I., Henny, P., Galloni, F., Mainville, L., Mariotti, M., & Jones, B. E. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.024 · Cited by 201 · see citing works
Fu, H., Muenzer, J., Samulski, R. J., Breese, G. R., Sifford, J., Zeng, X., & McCarty, D. M. (2003) · Molecular Therapy · doi:10.1016/j.ymthe.2003.08.021 · Cited by 181 · see citing works
Schuster, D. J., Dykstra, J. A., Riedl, M. S., Kitto, K. F., Belur, L. R., McIvor, R. S., Elde, R. P., Fairbanks, C. A., & Vulchanova, L. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00042 · Cited by 177 · see citing works
Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice
Nagahara, A. H., Mateling, M., Kovács, I., Wang, L., Eggert, S., Rockenstein, E. M., Koo, E. H., Masliah, E., & Tuszynski, M. H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5195-12.2013 · Cited by 176 · see citing works
Self-citationMatsuzaki, Y., Konno, A., Mochizuki, R., Shinohara, Y., Nitta, K., Okada, Y., & Hirai, H. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2017.11.049 · Cited by 173 · see citing works
Gene therapy for pain: Results of a phase I clinical trial
Fink, D. J., Wechuck, J., Mata, M. M., Glorioso, J. C., Goss, J. R., Krisky, D. M., & Wolfe, D. P. (2011) · Annals of Neurology · doi:10.1002/ana.22446 · Cited by 172 · see citing works
Samaranch, L., Salegio, E. A., Sebastián, W. S., Kells, A. P., Bringas, J. R., Forsayeth, J., & Bankiewicz, K. S. (2013) · Human Gene Therapy · doi:10.1089/hum.2013.005 · Cited by 155 · see citing works
Hinderer, C., Bell, P., Katz, N., Vite, C. H., Louboutin, J.-P., Bote, E., Yu, H., Zhu, Y., Casal, M. L., Bagel, J., et al. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.026 · Cited by 141 · see citing works
Vulchanova, L., Schuster, D. J., Belur, L. R., Riedl, M. S., Podetz-Pedersen, K. M., Kitto, K. F., Wilcox, G. L., McIvor, R. S., & Fairbanks, C. A. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-31 · Cited by 114 · see citing works
(2010) · Oxford University Press eBooks · doi:10.1093/med/9780199204854.001.1 · Cited by 113 · see citing works
Zhao, L., Gottesdiener, A. J., Parmar, M., Li, M., Kaminsky, S. M., Chiuchiolo, M. J., Sondhi, D., Sullivan, P. M., Holtzman, D. M., Crystal, R. G., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.020 · Cited by 107 · see citing works
Bey, K., Ciron, C., Dubreil, L., Deniaud, J., Ledevin, M., Cristini, J., Blouin, V., Aubourg, P. R., & Colle, M.-A. (2017) · Gene Therapy · doi:10.1038/gt.2017.18 · Cited by 73 · see citing works
Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain
Murlidharan, G., Crowther, A., Reardon, R. A., Song, J., & Asokan, A. (2016) · JCI Insight · doi:10.1172/jci.insight.88034 · Cited by 72 · see citing works
Self-citationHordeaux, J., Dubreil, L., Deniaud, J., Iacobelli, F., Moreau, S., Ledevin, M., Guiner, C. L., Blouin, V., Duff, J. L., Mendes-Madeira, A., et al. (2015) · Gene Therapy · doi:10.1038/gt.2014.121 · Cited by 47 · see citing works
Carty, N., Nash, K. R., Brownlow, M. L., Cruite, D., Wilcock, D. M., Selenica, M. B., Lee, D. C., Gordon, M. N., & Morgan, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059626 · Cited by 45 · see citing works
Bucher, T., Dubreil, L., Colle, M.-A., Maquigneau, M., Deniaud, J., Ledevin, M., Moullier, P., & Joussemet, B. (2014) · Gene Therapy · doi:10.1038/gt.2014.16 · Cited by 40 · see citing works
Matsuzaki, Y., Konno, A., Mukai, R., Honda, F., Hirato, M., Yoshimoto, Y., & Hirai, H. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9777-6 · Cited by 24 · see citing works
Bangaru, M. L. Y., Meng, J., Kaiser, D. J., Yu, H., Fischer, G. J., Hogan, Q. H., & Hudmon, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.007 · Cited by 21 · see citing works
Arterial vascularisation of the anterior perforated substance.
Sen, T., Af, E., Hi, A., Karahan, S. T., & Tüccar, E. (2011) · PubMed · Cited by 12 · see citing works
Mowiol embedding mediumPreprint
(2010) · Cold Spring Harbor Protocols · doi:10.1101/pdb.rec12110 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [42]G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates (Academic Press, ed. 6, 2007).
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Lohela, T. J., Lilius, T. O., & Nedergaard, M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00500-9 · Cited by 246 · see citing works
Liguore, W. A., Domire, J. S., Button, D. A., Wang, Y., Dufour, B. D., Srinivasan, S., & McBride, J. L. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.07.017 · Cited by 148 · see citing works
Castle, M. J., Baltanás, F. C., Kovács, I., Nagahara, A. H., Barba, D., & Tuszynski, M. H. (2020) · Human Gene Therapy · doi:10.1089/hum.2019.367 · Cited by 119 · see citing works
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Johnston, S., Parylak, S. L., Kim, S., Mac, N., Lim, C., Gallina, I., Bloyd, C., Newberry, A., Saavedra, C. D., Novak, O., et al. (2021) · eLife · doi:10.7554/elife.59291 · Cited by 87 · see citing works
Chen, X., Lim, D. A., Lawlor, M. W., Dimmock, D., Vite, C. H., Lester, T. L., Tavakkoli, F., Sadhu, C., Prasad, S., & Gray, S. J. (2023) · Human Gene Therapy · doi:10.1089/hum.2022.163 · Cited by 68 · see citing works
Micro/nanosystems for controllable drug delivery to the brain
Tian, M., Ma, Z., & Yang, G. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100548 · Cited by 60 · see citing works
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases
Germain, N. D., Chung, W. K., & Sarmiere, P. D. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101148 · Cited by 59 · see citing works
Chatterjee, D., Marmion, D. J., McBride, J. L., Manfredsson, F. P., Butler, D., Messer, A. C., & Kordower, J. H. (2021) · Gene Therapy · doi:10.1038/s41434-021-00244-y · Cited by 54 · see citing works
Xu, L., Yao, S., Ding, Y. E., Xie, M., Feng, D., Sha, P., Tan, L., Bei, F., & Yao, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05661-2 · Cited by 48 · see citing works
Overcoming delivery barriers in immunotherapy for glioblastoma
Rui, Y., & Green, J. J. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01008-2 · Cited by 42 · see citing works
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Zhou, K., Han, J., Wang, Y., Zhang, Y., & Zhu, C. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.988914 · Cited by 38 · see citing works
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Hampson, D. R., Hooper, A. W. M., & Niibori, Y. (2019) · Brain Sciences · doi:10.3390/brainsci9020032 · Cited by 36 · see citing works
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Ravi, B., Chan-Cortés, M. H., & Sumner, C. J. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-070119-115459 · Cited by 37 · see citing works
Beharry, A. W., Gong, Y., Kim, J. C., Hanlon, K. S., Nammour, J., Hieber, K., Eichler, F., Cheng, M. L., Stemmer-Rachamimov, A. O., Stanković, K. M., et al. (2021) · Human Gene Therapy · doi:10.1089/hum.2021.069 · Cited by 34 · see citing works
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Limia, C. E. G., Baird, M., Schwartz, M., Saxena, S., Meyer, K., & Wein, N. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12121979 · Cited by 23 · see citing works
Viral vectors for neuronal cell type-specific visualization and manipulations
Liu, Y., Hegarty, S. V., Winter, C. C., Wang, F., & He, Z. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.03.011 · Cited by 21 · see citing works
Arotçarena, M.-L., Doveró, S., Biendon, N., Dutheil, N., Planche, V., Bézard, E., & Dehay, B. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.762209 · Cited by 21 · see citing works
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Weinholtz, C. A., & Castle, M. J. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24774 · Cited by 19 · see citing works
Self-citationChandran, J. S., Chowdhury, E. A., Perkinton, M. S., Jamier, T., Sutton, D., Wu, S., Dobson, C., Shah, D. K., Chessell, I. P., & Meno‐Tetang, G. M. L. (2022) · Gene Therapy · doi:10.1038/s41434-022-00346-1 · Cited by 18 · see citing works
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Santoscoy, M. C., Espinoza, P., de la Cruz, D., Mahamdeh, M., Starr, J. R., Patel, N. J., & Maguire, C. A. (2023) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2023.05.001 · Cited by 13 · see citing works
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Morrill, N. K., Joly‐Amado, A., Li, Q., Prabhudeva, S., Weeber, E. J., & Nash, K. R. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114170 · Cited by 5 · see citing works
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Cona, A., Newbold, E. J., Kesmen, D., Snape, R., Danner, J., White, N., Borden, W., Iseson, A., Schanz, S. J., Chandler-Militello, D., et al. (2026) · Nature Biotechnology · doi:10.1038/s41587-026-03185-2 · Cited by 1 · see citing works
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Wilson, R. J., Badley, J. R., & Lein, P. J. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3969-6_4 · Cited by 1 · see citing works
Cona, A., Newbold, E. J., Kesmen, D., Snape, R., Danner, J., White, N., Borden, W., Iseson, A., Schanz, S. J., Chandler-Militello, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.03.662612 · Cited by 1 · see citing works
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Balasubramanya, V. (2019) · Materials and Methods · doi:10.13070/mm.en.9.2852
造船業が目指すイノベーション : シナリオプラニングと新たなイノベーションの創出( これからの海洋産業を考える)
児玉, 義., 青山, 和., 松井, 裕., 境澤, 省., & 小磯, 康. (2013) · 咸臨 : 日本船舶海洋工学会誌
Li, A., Wang, Q., Rogers, R. C., Herman, G., Ritter, R. C., & Ritter, S. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00079.2023
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- Authors
- Castle, M. J., Cheng, Y., Asokan, A., & Tuszynski, M. H.
- Affiliations
- University of California San Diego (US)
- Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
- University of North Carolina at Chapel Hill (US)
- United States Department of Veterans Affairs (US)
- Corresponding author
- Castle, Michael J.
- Tuszynski, Mark H.
- Venue
- Science Advances
- Published
- 2018-11-02
- Volume
- 4
- Issue
- 11
- Pages
- eaau9859-eaau9859
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC6235539
- OpenAlex
- W2901280365
- Cited by
- 41
- References
- 39
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 3 · 2019: 4 · 2013: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Science Advances (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- Funders
- National Institutes of Health (AG10435, AG043416, T32AG000216, R01NS099371)
- Alzheimer’s Association (Zenith Award, AARF-16-443284)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- intrathecal gene delivery, AAV9, animal positioning, Trendelenburg position, cerebrospinal fluid, cortical gene expression, neuronal transduction, Alzheimer's disease, stroke, traumatic brain injury
- MeSH terms
- Dependovirus, Animals, Brain, Female, Genetic Vectors, Injections, Spinal, Rats, Inbred F344, Genetic Therapy, Gene Transfer Techniques, Green Fluorescent Proteins, Rats
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