Gewirtz, Andrew T.

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,068

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., & Gewirtz, A. T. (2015) · Nature

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 2,055

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmén-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., et al. (2014) · Gut

Inflammatory Bowel DiseaseGut microbiota and health

Cited by 1,004

Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics

Li, J.-Y., Chassaing, B., Tyagi, A. M., Vaccaro, C., Luo, T., Adams, J., Darby, T. M., Weitzmann, M. N., Mulle, J. G., Gewirtz, A. T., et al. (2016) · Journal of Clinical Investigation

Gut microbiota and healthBone Metabolism and Diseases

Cited by 643

Cutting edge: impaired toll-like receptor expression and function in aging

Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J., & Sambhara, S. (2002) · The Journal of Immunology

Immune Response and InflammationImmune responses and vaccinations

Cited by 626

Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation

Chassaing, B., Van de Wiele, T., De Bodt, J., Marzorati, M., & Gewirtz, A. T. (2017) · Gut

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 590

Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans

Hagan, T., Cortese, M., Rouphael, N., Boudreau, C., Linde, C., Maddur, M. S., Das, J., Wang, H., Guthmiller, J., Zheng, N.-Y., et al. (2019) · Cell

Gut microbiota and healthImmune responses and vaccinations

Cited by 572

Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

Carvalho, F. A., Koren, O., Goodrich, J. K., Johansson, M. E. V., Nalbantoglu, I., Aitken, J. D., Su, Y., Chassaing, B., Walters, W. A., González, A., et al. (2012) · Cell Host & Microbe

Gut microbiota and healthInflammatory Bowel Disease

Cited by 548

Dysregulation of inflammatory responses by chronic circadian disruption

Castanon-Cervantes, O., Wu, M., Ehlen, J. C., Paul, K., Gamble, K. L., Johnson, R. L., Besing, R. C., Menaker, M., Gewirtz, A. T., & Davidson, A. J. (2010) · The Journal of Immunology

Circadian rhythm and melatoninSleep and Work-Related Fatigue

Cited by 542

TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination

Oh, J. Z., Ravindran, R., Chassaing, B., Carvalho, F. A., Maddur, M. S., Bower, M., Hakimpour, P., Gill, K. P., Nakaya, H. I., Yarovinsky, F., et al. (2014) · Immunity

Immune Response and InflammationImmune responses and vaccinations

Cited by 541

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Singh, V., Yeoh, B. S., Chassaing, B., Xiao, X., Saha, P., Aguilera Olvera, R., Lapek, J. D., Zhang, L., Wang, W.-B., Hao, S., et al. (2018) · Cell

Gut microbiota and healthMicrobial Metabolites in Food Biotechnology

Cited by 532

Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf

Amer, A., Franchi, L., Kanneganti, T.-D., Body-Malapel, M., Özören, N., Brady, G., Meshinchi, S., Jagirdar, R., Gewirtz, A., Akira, S., et al. (2006) · Journal of Biological Chemistry

Legionella and Acanthamoeba researchInflammasome and immune disorders

Cited by 453

Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling

Anitha, M., Vijay–Kumar, M., Sitaraman, S. V., Gewirtz, A. T., & Srinivasan, S. (2012) · Gastroenterology

Gastrointestinal motility and disordersGut microbiota and health

Cited by 397

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

Mills, R. H., Dulai, P. S., Vázquez-Baeza, Y., Sauceda, C., Daniel, N., Gerner, R. R., Batachari, L. E., Malfavon, M., Zhu, Q., Weldon, K., et al. (2022) · Nature Microbiology

Gut microbiota and healthInflammatory Bowel Disease

Cited by 385

Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome

Chassaing, B., Compher, C., Bonhomme, B., Liu, Q., Tian, Y., Walters, W., Nessel, L., Delaroque, C., Hao, F., Gershuni, V., et al. (2022) · Gastroenterology

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 347

Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice

Chassaing, B., Ley, R. E., & Gewirtz, A. T. (2014) · Gastroenterology

Gut microbiota and healthImmune Response and Inflammation

Cited by 326

Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis

Viennois, E., Merlin, D., Gewirtz, A. T., & Chassaing, B. (2017) · Cancer Research

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 268

IL-6 Induces NF-κB Activation in the Intestinal Epithelia

Wang, L., Walia, B., Evans, J., Gewirtz, A. T., Merlin, D., & Sitaraman, S. V. (2003) · The Journal of Immunology

NF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

Cited by 243

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

Fulde, M., Sommer, F., Chassaing, B., van Vorst, K., Dupont, A., Hensel, M., Basic, M., Klopfleisch, R., Rosenstiel, P., Bleich, A., et al. (2018) · Nature

Gut microbiota and healthImmune Response and Inflammation

Cited by 206

Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5

Clasen, S. J., Bell, M. E. W., Lee, D.-H., Henseler, Z. M., Borbón, A., de la Cuesta-Zuluaga, J., Parys, K., Zou, J., Youngblut, N. D., Gewirtz, A. T., et al. (2022) · Science Immunology

Immune Response and InflammationGut microbiota and health

Cited by 117

Microbiota-Inducible Innate Immune Siderophore Binding Protein Lipocalin 2 Is Critical for Intestinal Homeostasis

Singh, V., Yeoh, B. S., Chassaing, B., Zhang, B., Saha, P., Xiao, X., Awasthi, D., Shashidharamurthy, R., Dikshit, M., Gewirtz, A., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology

Inflammatory Bowel DiseaseGut microbiota and health

Cited by 117

Liver Fibrosis Occurs Through Dysregulation of MyD88-Dependent Innate B-Cell Activity

Thapa, M., Chinnadurai, R., Velazquez, V. M., Tedesco, D., Elrod, E., Han, J., Sharma, P., Ibegbu, C., Gewirtz, A., Anania, F., et al. (2015) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 101

The microbiota influences cell death and microglial colonization in the perinatal mouse brain

Castillo-Ruiz, A., Mosley, M., George, A. J., Mussaji, L. F., Fullerton, E. F., Ruszkowski, E. M., Jacobs, A. J., Gewirtz, A. T., Chassaing, B., & Forger, N. G. (2018) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsGut microbiota and health

Cited by 91

Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters

Partrick, K. A., Chassaing, B., Beach, L. Q., McCann, K. E., Gewirtz, A. T., & Huhman, K. L. (2018) · Behavioural Brain Research

Gut microbiota and healthTryptophan and brain disorders

Cited by 83