Saudou, Frédéric

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

Gauthier, L. R., Charrin, B. C., Borrell-Pagès, M., Dompierre, J. P., Rangone, H., Cordelières, F. P., De Mey, J., MacDonald, M. E., Leßmann, V., Humbert, S., et al. (2004) · Cell

Genetic Neurodegenerative DiseasesHereditary Neurological Disorders

Cited by 1,178

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., et al. (2020) · Nature Reviews Drug Discovery

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 1,003

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

Dompierre, J. P., Godin, J. D., Charrin, B. C., Cordelières, F. P., King, S. J., Humbert, S., & Saudou, F. (2007) · The Journal of Neuroscience

Genetic Neurodegenerative DiseasesHistone Deacetylase Inhibitors Research

Cited by 792

Potential function for the Huntingtin protein as a scaffold for selective autophagy

Ochaba, J., Lukacsovich, T., Csikos, G., Zheng, S., Margulis, J., Salazar, L., Mao, K., Lau, A. L., Yeung, S. Y., Humbert, S., et al. (2014) · Proceedings of the National Academy of Sciences

Genetic Neurodegenerative DiseasesAutophagy in Disease and Therapy

Cited by 308

Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

Keryer, G., Pineda, J. R., Liot, G., Kim, J., Dietrich, P., Benstaali, C., Smith, K., Cordelières, F. P., Spassky, N., Ferrante, R. J., et al. (2011) · Journal of Clinical Investigation

Genetic and Kidney Cyst DiseasesGenetic Neurodegenerative Diseases

Cited by 168

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin

Rangone, H., Poizat, G., Troncoso, J., Ross, C. A., MacDonald, M. E., Saudou, F., & Humbert, S. (2004) · European Journal of Neuroscience

Genetic Neurodegenerative DiseasesGenetics and Neurodevelopmental Disorders

Cited by 144

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport

Hinckelmann, M.-V., Virlogeux, A., Niehage, C., Poujol, C., Choquet, D., Hoflack, B., Zala, D., & Saudou, F. (2016) · Nature Communications

Cellular transport and secretionMicrotubule and mitosis dynamics

Cited by 103

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Galvan, L., Francelle, L., Gaillard, M.-C., de Longprez, L., Carrillo-de Sauvage, M.-A., Liot, G., Cambon, K., Stimmer, L., Luccantoni, S., Flament, J., et al. (2018) · Brain

Genetic Neurodegenerative DiseasesGenetics and Neurodevelopmental Disorders

Cited by 47

Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin

Agasse, F., Mendez-David, I., Christaller, W., Carpentier, R., Braz, B. Y., David, D. J., Saudou, F., & Humbert, S. (2020) · Cell Reports

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 43

Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning

Vitet, H., Bruyère, J., Xu, H., Séris, C., Brocard, J., Abada, Y.-S., Delatour, B., Scaramuzzino, C., Venance, L., & Saudou, F. (2023) · eLife

Neuroscience and Neuropharmacology ResearchGenetic Neurodegenerative Diseases

Cited by 13