Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Open accessAbstract
The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm. When glucose levels are limited, ketone bodies generated in the liver and lactate derived from exercising skeletal muscle can also become important energy substrates for the brain. In neurodegenerative disorders of ageing, brain glucose metabolism deteriorates in a progressive, region-specific and disease-specific manner - a problem that is best characterized in Alzheimer disease, where it begins presymptomatically. This Review discusses the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energetics. The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes.
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The brain alone consumes 20% of the total energy required by the body, and central nervous system mitochondria meet a majority of this massive energy requirement for the brain.
“The brain alone consumes 20% of the total energy required by the body, and central nervous system (CNS) mitochondria meet a majority of this massive energy requirement for the brain”
From Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism (2026) · cites this paper as Cunnane et al. 2020
Impaired brain energetics is a core feature across neurodegenerative diseases, including AD, PD, ALS, FTD, and HD.
“impaired brain energetics is a core feature across neurodegenerative diseases, including AD, PD, ALS, FTD, and HD.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [574]
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Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes
Wiviott, S. D., Raz, I., Bonaca, M. P., Mosenzon, O., Kato, E. T., Cahn, A., Silverman, M. G., Zelniker, T. A., Kuder, J. F., Murphy, S. A., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812389 · Cited by 6,382 · see citing works
AMPK: guardian of metabolism and mitochondrial homeostasis
Herzig, S., & Shaw, R. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.95 · Cited by 4,094 · see citing works
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689 · see citing works
The mechanisms of action of metformin
Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia · doi:10.1007/s00125-017-4342-z · Cited by 2,287 · see citing works
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954 · see citing works
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597 · see citing works
Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2018.05.003 · Cited by 1,474 · see citing works
Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy
Mercuri, E., Darras, B. T., Chiriboga, C. A., Day, J. W., Campbell, C., Connolly, A. M., Iannaccone, S. T., Kirschner, J., Kuntz, N. L., Saito, K., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1710504 · Cited by 1,433 · see citing works
Lactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298 · see citing works
Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173 · see citing works
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
Olson, C. A., Vuong, H. E., Yano, J. M., Liang, Q. Y., Nusbaum, D. J., & Hsiao, E. Y. (2018) · Cell · doi:10.1016/j.cell.2018.04.027 · Cited by 1,057 · see citing works
Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001 · see citing works
Myelination of the Nervous System: Mechanisms and Functions
Nave, K., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 1,000 · see citing works
Self-citationSaudou, F., & Humbert, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.003 · Cited by 945 · see citing works
Self-citationExercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935 · see citing works
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2018) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 877 · see citing works
Mitochondria as a therapeutic target for common pathologies
Murphy, M. P., & Hartley, R. C. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.174 · Cited by 832 · see citing works
Self-citationMulti-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition
Martorell, A. J., Paulson, A. L., Suk, H.-J., Abdurrob, F., Drummond, G. T., Guan, W., Young, J. Z., Kim, D. N.-W., Kritskiy, O., Barker, S. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.014 · Cited by 798 · see citing works
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772 · see citing works
Brain metabolism in health, aging, and neurodegeneration
Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752 · see citing works
Self-citationMetabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Xie, Z., Zhang, D., Chung, D., Tang, Z., Huang, H., Dai, L., Qi, S., Li, J., Colak, G., Chen, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.036 · Cited by 744 · see citing works
Ferrannini, E., Baldi, S., Frascerra, S., Astiarraga, B., Heise, T., Bizzotto, R., Mari, A., Pieber, T. R., & Muscelli, E. (2016) · Diabetes · doi:10.2337/db15-1356 · Cited by 713 · see citing works
Vascular dysfunction—The disregarded partner of Alzheimer's disease
Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.222 · Cited by 711 · see citing works
AUTACs: Cargo-Specific Degraders Using Selective Autophagy
Takahashi, D., Moriyama, J., Nakamura, T., Miki, E., Takahashi, E., Sato, A., Akaike, T., Itto-Nakama, K., & Arimoto, H. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.009 · Cited by 675 · see citing works
Disturbed mitochondrial dynamics and neurodegenerative disorders
Burté, F., Carelli, V., Chinnery, P. F., & Yu‐Wai‐Man, P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.228 · Cited by 659 · see citing works
Shining light on the head: Photobiomodulation for brain disorders
Hamblin, M. R. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.09.002 · Cited by 630 · see citing works
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D’Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., et al. (2017) · Nature · doi:10.1038/nature25143 · Cited by 630 · see citing works
Intermittent metabolic switching, neuroplasticity and brain health
Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.156 · Cited by 624 · see citing works
Self-citationPerimenopause as a neurological transition state
Brinton, R. D., Yao, J., Yin, F., Mack, W. J., & Cadenas, E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.82 · Cited by 612 · see citing works
Self-citationDistinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex
Tomassy, G. S., Berger, D. R., Chen, H.-H., Kasthuri, N., Hayworth, K. J., Vercelli, A., Seung, H. S., Lichtman, J. W., & Arlotta, P. (2014) · Science · doi:10.1126/science.1249766 · Cited by 600 · see citing works
Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism
Saab, A. S., Tzvetavona, I. D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H. M., Huang, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.016 · Cited by 590 · see citing works
Self-citationGDF15 mediates the effects of metformin on body weight and energy balance
Coll, A. P., Chen, M., Taskar, P., Rimmington, D., Patel, S., Tadross, J. A., Cimino, I., Yang, M., Welsh, P., Virtue, S., et al. (2020) · Nature · doi:10.1038/s41586-019-1911-y · Cited by 584 · see citing works
Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications
Penninx, B. W. J. H., & Lange, S. M. M. (2018) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2018.20.1/bpenninx · Cited by 566 · see citing works
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Morland, C., Andersson, K. A., Haugen, Ø. P., Hadzic, A., Kleppa, L., Gille, A., Rinholm, J. E., Palibrk, V., Diget, E. H., Kennedy, L. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15557 · Cited by 559 · see citing works
Self-citationPromoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Boland, B., Yu, W. H., Corti, O., Mollereau, B., Henriques, A., Bézard, E., Pastores, G., Rubinsztein, D. C., Nixon, R. A., Duchen, M. R., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.109 · Cited by 552 · see citing works
Self-citationMookerjee, S. A., Gerencser, A. A., Nicholls, D. G., & Brand, M. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.774471 · Cited by 550 · see citing works
Henderson, S. T., Vogel, J. L., Barr, L. J., Garvin, F., Jones, J. J., & Costantini, L. C. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-31 · Cited by 548 · see citing works
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
Bartzokis, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.007 · Cited by 546 · see citing works
El Hayek, L., Khalifeh, M., Zibara, V., Abi Assaad, R., Emmanuel, N., Karnib, N., El-Ghandour, R., Nasrallah, P., Bilen, M., Ibrahim, P., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1661-18.2019 · Cited by 539 · see citing works
Effects of β-hydroxybutyrate on cognition in memory-impaired adults
Reger, M. A., Henderson, S. T., Hale, C. M., Cholerton, B., Baker, L. D., Watson, G. S., Hyde, K., Chapman, D., & Craft, S. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00087-3 · Cited by 510 · see citing works
D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
Tieu, K., Perier, C., Caspersen, C., Teismann, P., Wu, D.-C., Yan, S.-D., Naini, A., Vila, M., Jackson-Lewis, V., Ramasamy, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318797 · Cited by 497 · see citing works
Gejl, M., Gjedde, A., Egefjord, L., Møller, A., Hansen, S. B., Vang, K., Rodell, A., Brændgaard, H., Gottrup, H., Schacht, A., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00108 · Cited by 480 · see citing works
Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718819115 · Cited by 472 · see citing works
Self-citationEvidence for brain glucose dysregulation in Alzheimer’s disease
An, Y., Varma, V., Varma, S., Casanova, R., Dammer, E., Pletnikova, O., Chia, C. W., Egan, J. M., Ferrucci, L., Troncoso, J., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.09.011 · Cited by 454 · see citing works
ApoE4: an emerging therapeutic target for Alzheimer’s disease
Safieh, M., Korczyn, A. D., & Michaelson, D. M. (2019) · BMC Medicine · doi:10.1186/s12916-019-1299-4 · Cited by 449 · see citing works
McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432 · see citing works
Self-citationStekovic, S., Hofer, S. J., Tripolt, N., Aon, M. A., Royer, P., Pein, L., Stadler, J. T., Pendl, T., Prietl, B., Url, J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.016 · Cited by 412 · see citing works
Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin
Moore, E. M., Mander, A. G., Ames, D. J., Kotowicz, M. A., Carne, R. P., Brodaty, H., Woodward, M., Boundy, K. L., Ellis, K. A., Bush, A. I., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0229 · Cited by 405 · see citing works
An evolutionary perspective on immunometabolism
Wang, A., Luan, H. H., & Medzhitov, R. M. (2019) · Science · doi:10.1126/science.aar3932 · Cited by 394 · see citing works
Athauda, D., & Foltynie, T. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.013 · Cited by 383 · see citing works
Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice
Ou, Z., Kong, X., Sun, X., He, X., Zhang, L., Gong, Z., Huang, J., Xu, B., Long, D., Li, J., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.12.009 · Cited by 370 · see citing works
Dietary ketosis enhances memory in mild cognitive impairment
Krikorian, R., Shidler, M. D., Dangelo, K. N., Couch, S. C., Benoit, S. C., & Clegg, D. J. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.10.006 · Cited by 365 · see citing works
Kashiwaya, Y., Bergman, C., Lee, J.-H., Wan, R., King, M. T., Mughal, M. R., Okun, E., Clarke, K., Mattson, M. P., & Veech, R. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.023 · Cited by 363 · see citing works
Self-citationEffects of the Insulin Sensitizer Metformin in Alzheimer Disease
Koenig, A. M., Mechanic-Hamilton, D. J., Xie, S. X., Combs, M., Cappola, A. R., Xie, L., Detre, J. A., Wolk, D. A., & Arnold, S. E. (2017) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000202 · Cited by 352 · see citing works
Gong, B., Pan, Y., Vempati, P., Zhao, W., Knable, L., Ho, L., Wang, J., Sastre, M., Ono, K., Sauve, A. A., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.005 · Cited by 345 · see citing works
Schöndorf, D. C., Ivanyuk, D., Baden, P., Sanchez-Martinez, A., De Cicco, S., Yu, C., Giunta, I., Schwarz, L. K., Di Napoli, G., Panagiotakopoulou, V., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.009 · Cited by 337 · see citing works
Craft, S., Claxton, A., Baker, L. D., Hanson, A. J., Cholerton, B., Trittschuh, E. H., Dahl, D., Caulder, E., Neth, B., Montine, T. J., et al. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161256 · Cited by 335 · see citing works
GLUT4 Mobilization Supports Energetic Demands of Active Synapses
Ashrafi, G., Wu, Z., Farrell, R. J., & Ryan, T. A. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.020 · Cited by 328 · see citing works
Loss of Brain Aerobic Glycolysis in Normal Human Aging
Goyal, M. S., Vlassenko, A. G., Blazey, T. M., Su, Y., Couture, L. E., Durbin, T. J., Bateman, R. J., Benzinger, T. L.-S., Morris, J. C., & Raichle, M. E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.010 · Cited by 318 · see citing works
Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes
Baglioni, P. (2019) · New England Journal of Medicine · doi:10.1056/nejmc1902837 · Cited by 316 · see citing works
The Therapeutic Potential of Metformin in Neurodegenerative Diseases
Rotermund, C., Machetanz, G., & Fitzgerald, J. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00400 · Cited by 310 · see citing works
Gene therapy for neurological disorders: progress and prospects
Deverman, B. E., Ravina, B. M., Bankiewicz, K. S., Paul, S. M., & Sah, D. W. Y. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.110 · Cited by 306 · see citing works
Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice
Ma, D., Wang, A. C., Parikh, I. J., Green, S. J., Hoffman, J. D., Chlipala, G. E., Murphy, M. P., Sokola, B. S., Bauer, B., Hartz, A. M. S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25190-5 · Cited by 300 · see citing works
Self-citationThe Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s Disease
Forny‐Germano, L., Felice, F. G. D., & Vieira, M. N. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01027 · Cited by 298 · see citing works
Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial
Phillips, M. C. L., Murtagh, D. K. J., Gilbertson, L. J., Asztely, F. J. S., & Lynch, C. D. P. (2018) · Movement Disorders · doi:10.1002/mds.27390 · Cited by 292 · see citing works
Campbell, J. M., Stephenson, M. D., de Courten, B., Chapman, I., Bellman, S. M., & Aromataris, E. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180263 · Cited by 292 · see citing works
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
Zhao, N., Liu, C.-C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M., & Bu, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.003 · Cited by 289 · see citing works
Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases
Cai, R., Zhang, Y., Simmering, J. E., Schultz, J. L., Li, Y., Fernandez-Carasa, I., Consiglio, A., Raya, A., Polgreen, P. M., Narayanan, N. S., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129987 · Cited by 286 · see citing works
Luchsinger, J. A., Perez, T., Chang, H., Mehta, P., Steffener, J., Pradabhan, G., Ichise, M., Manly, J., Devanand, D. P., & Bagiella, E. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150493 · Cited by 285 · see citing works
Bakker, A., Albert, M., Krauss, G. L., Speck, C. L., & Gallagher, M. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.02.009 · Cited by 284 · see citing works
The role of type 2 diabetes in neurodegeneration
Verdile, G., Fuller, S. J., & Martins, R. N. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.008 · Cited by 276 · see citing works
Ota, M., Matsuo, J., Ishida, I., Takano, H., Yokoi, Y., Hori, H., Yoshida, S., Ashida, K., Nakamura, K., Takahashi, T., et al. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2018.10.048 · Cited by 276 · see citing works
Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease
Taylor, M., Sullivan, D. K., Mahnken, J. D., Burns, J. M., & Swerdlow, R. H. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.11.002 · Cited by 273 · see citing works
Self-citationFu, S., Wang, J., Xue, W.-J., Liu, H., Liu, B.-R., Zeng, Y., Li, S., Huang, B., Lv, Q.-K., Wang, W., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0230-3 · Cited by 269 · see citing works
The interneuron energy hypothesis: Implications for brain disease
Kann, O. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.005 · Cited by 266 · see citing works
Self-citationUnhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases
Spielman, L. J., Gibson, D. L., & Klegeris, A. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.08.005 · Cited by 266 · see citing works
The metabolic face of migraine — from pathophysiology to treatment
Gross, E. C., Martinez, M. L., Fischer, D., Sándor, P. S., & Schoenen, J. E. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0255-4 · Cited by 263 · see citing works
Energy metabolism in ALS: an underappreciated opportunity?
Vandoorne, T., Bock, K. D., & Bosch, L. V. D. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1835-x · Cited by 260 · see citing works
Baek, S. H., Park, S. J., Jeong, J. I., Kim, S. H., Han, J., Kyung, J. W., Baik, S.-H., Choi, Y., Choi, B. Y., Park, J. S., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2385-16.2017 · Cited by 258 · see citing works
Croteau, E., Castellano, C. A., Fortier, M., Bocti, C., Fulop, T., Paquet, N., & Cunnane, S. C. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.07.004 · Cited by 258 · see citing works
Self-citationVelliquette, R. A., O'Connor, T., & Vassar, R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2350-05.2005 · Cited by 254 · see citing works
Retinal metabolism: A comparative look at energetics in the retina
Country, M. W. (2017) · Brain Research · doi:10.1016/j.brainres.2017.07.025 · Cited by 254 · see citing works
Erratum: Gene therapy for neurological disorders: progress and prospects
Deverman, B. E., Ravina, B. M., Bankiewicz, K. S., Paul, S. M., & Sah, D. W. Y. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.158 · Cited by 248 · see citing works
Yuzwa, S. A., & Vocadlo, D. J. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00038b · Cited by 247 · see citing works
Targeting pericytes for therapeutic approaches to neurological disorders
Cheng, J., Korte, N., Nortley, R., Sethi, H., Tang, Y., & Attwell, D. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1893-0 · Cited by 245 · see citing works
Levine, P. M., Galesic, A., Balana, A. T., Mahul‐Mellier, A., Navarro, M. X., Leon, C. A. D., Lashuel, H. A., & Pratt, M. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808845116 · Cited by 240 · see citing works
Mosconi, L., Rahman, A., Diaz, I., Wu, X. L., Scheyer, O., Hristov, H., Vallabhajosula, S., Isaacson, R., de Leon, M. J., & Brinton, R. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207885 · Cited by 239 · see citing works
Self-citationSubjective memory complaints, education, and risk of Alzheimer's disease
van Oijen, M., de Jong, F. J., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.01.011 · Cited by 238 · see citing works
Non‐signalling energy use in the brain
Engl, E., & Attwell, D. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282517 · Cited by 230 · see citing works
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 230 · see citing works
The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia
Yang, L., Wang, H., Liu, L., & Xie, A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00073 · Cited by 228 · see citing works
Cunnane, S. C., Courchesne‐Loyer, A., Vandenberghe, C., St‐Pierre, V., Fortier, M., Hennebelle, M., Croteau, É., Bocti, C., Fülöp, T., & Castellano, C. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00053 · Cited by 224 · see citing works
Self-citationThe Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
Olson, C. A., Vuong, H. E., Yano, J. M., Liang, Q. Y., Nusbaum, D. J., & Hsiao, E. Y. (2018) · Cell · doi:10.1016/j.cell.2018.06.051 · Cited by 224 · see citing works
Fülöp, T., Larbi, A., & Witkowski, J. M. (2019) · Gerontology · doi:10.1159/000497375 · Cited by 221 · see citing works
A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment
Fortier, M., Castellano, C., Croteau, É., Langlois, F., Bocti, C., St‐Pierre, V., Vandenberghe, C., Bernier, M., Roy, M., Descoteaux, M., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.12.017 · Cited by 220 · see citing works
Self-citationWhat Happens with the Circuit in Alzheimer's Disease in Mice and Humans?
Zott, B., Busche, M. A., Sperling, R. A., & Konnerth, A. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061725 · Cited by 215 · see citing works
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease
Zeitler, B., Froelich, S., Marlen, K., Shivak, D. A., Yu, Q., Li, D., Pearl, J. R., Miller, J. C., Zhang, L., Paschon, D. E., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0478-3 · Cited by 215 · see citing works
Uddin, M. S., Kabir, M. T., Al Mamun, A., Abdel-Daim, M. M., Barreto, G. E., & Ashraf, G. M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1237-z · Cited by 212 · see citing works
Wingo, A. P., Dammer, E. B., Breen, M. S., Logsdon, B. A., Duong, D. M., Troncosco, J. C., Thambisetty, M., Beach, T. G., Serrano, G. E., Reiman, E. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09613-z · Cited by 211 · see citing works
The energetic brain—A review from students to students
Bordone, M. P., Salman, M. M., Titus, H. E., Amini, E., Andersen, J. V., Chakraborti, B., Diuba, A. V., Dubouskaya, T. G., Ehrke, E., Espindola de Freitas, A., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14829 · Cited by 205 · see citing works
Jha, M. K., & Morrison, B. M. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.009 · Cited by 203 · see citing works
Hölscher, C. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.040 · Cited by 201 · see citing works
Zilberter, Y., & Zilberter, M. Y. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24064 · Cited by 199 · see citing works
Mitochondrial dynamics and transport in Alzheimer's disease
Flannery, P. J., & Trushina, E. V. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.06.009 · Cited by 198 · see citing works
Self-citationIntermediates of Metabolism: From Bystanders to Signalling Molecules
Haas, R., Cucchi, D., Smith, J., Pucino, V., Macdougall, C. E., & Mauro, C. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.02.003 · Cited by 193 · see citing works
Neth, B., Mintz, A., Whitlow, C. T., Jung, Y., Sai, K., Register, T., Kellar, D., Lockhart, S., Hoscheidt, S., Maldjian, J., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.09.015 · Cited by 191 · see citing works
Self-citationWu, L., Zhang, X., & Zhao, L. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.2262-17.2018 · Cited by 185 · see citing works
Al-Zaidy, S. A., Kolb, S. J., Lowes, L., Alfano, L. N., Shell, R., Church, K. R., Nagendran, S., Sproule, D. M., Feltner, D. E., Wells, C., et al. (2019) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-190403 · Cited by 185 · see citing works
A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis
Hasan‐Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, L. J., Storm‐Mathisen, J., & Bergersen, L. H. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2588-6 · Cited by 182 · see citing works
Self-citationNuriel, T., Angulo, S. L., Khan, U., Ashok, A., Chen, Q., Figueroa, H. Y., Emrani, S., Liu, L., Herman, M., Barrett, G., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01444-0 · Cited by 181 · see citing works
Self-citationDellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., & Marcotulli, E. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0016-9 · Cited by 181 · see citing works
The genetic architecture of mitochondrial dysfunction in Parkinson’s disease
Larsen, S. B., Hanss, Z., & Krüger, R. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2768-8 · Cited by 181 · see citing works
Influence of young adult cognitive ability and additional education on later-life cognition
Kremen, W. S., Beck, A., Elman, J. A., Gustavson, D. E., Reynolds, C. A., Tu, X. M., Sanderson-Cimino, M. E., Panizzon, M. S., Vuoksimaa, E., Toomey, R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811537116 · Cited by 180 · see citing works
Gundersen, V., Storm‐Mathisen, J., & Bergersen, L. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00024.2014 · Cited by 172 · see citing works
Self-citationMańczak, M., Kandimalla, R. J. L., Yin, X., & Reddy, P. H. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy335 · Cited by 170 · see citing works
Courchesne-Loyer, A., Croteau, E., Castellano, C.-A., St-Pierre, V., Hennebelle, M., & Cunnane, S. C. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16669366 · Cited by 169 · see citing works
Self-citationBerman, M. H., Halper, J. P., Nichols, T. W., Jarrett, H., Lundy, A., & Huang, J. H. (2017) · Journal of Neurology and Neuroscience · doi:10.21767/2171-6625.1000176 · Cited by 168 · see citing works
Işık, A. T., Soysal, P., Yay, A., & Usarel, C. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.12.010 · Cited by 166 · see citing works
Klosinski, L. P., Yao, J., Yin, F., Fonteh, A. N., Harrington, M. G., Christensen, T. A., Trushina, E. V., & Brinton, R. D. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.11.002 · Cited by 164 · see citing works
Self-citationGut-Brain Glucose Signaling in Energy Homeostasis
Soty, M., Gautier‐Stein, A., Rajas, F., & Mithieux, G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.032 · Cited by 163 · see citing works
Self-citationAstrocytic glycogen metabolism in the healthy and diseased brain
Bak, L. K., Walls, A. B., Schousboe, A., & Waagepetersen, H. S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.803239 · Cited by 163 · see citing works
Bayliss, J. A., Lemus, M. B., Stark, R., dos Santos, V. V., Thompson, A., Rees, D. J., Galić, S., Elsworth, J. D., Kemp, B. E., Davies, J. S., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4373-15.2016 · Cited by 161 · see citing works
Self-citationPage, K. A., Williamson, A., Yu, N., McNay, E. C., Dzuira, J. D., McCrimmon, R. J., & Sherwin, R. S. (2009) · Diabetes · doi:10.2337/db08-1557 · Cited by 159 · see citing works
Zambon, F., Cherubini, M., Fernandes, H. J. R., Lang, C., Ryan, B. J., Volpato, V., Bengoa‐Vergniory, N., Vingill, S., Attar, M., Booth, H., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz038 · Cited by 156 · see citing works
Metformin selectively targets redox control of complex I energy transduction
Cameron, A., Logie, L., Patel, K. A., Erhardt, S., Bacon, S., Middleton, P. K., Harthill, J. E., Forteath, C., Coats, J. T., Kerr, C., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.018 · Cited by 153 · see citing works
Microglia-Specific Metabolic Changes in Neurodegeneration
Aldana, B. I. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.03.006 · Cited by 153 · see citing works
Polyzos, A. A., Lee, D. Y., Datta, R., Hauser, M., Budworth, H., Holt, A., Mihalik, S. J., Goldschmidt, P., Frankel, K. A., Trego, K. S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.004 · Cited by 152 · see citing works
Monitoring ATP dynamics in electrically active white matter tracts
Trevisiol, A., Saab, A. S., Winkler, U., Marx, G., Imamura, H., Möbius, W., Kusch, K., Nave, K.-A., & Hirrlinger, J. (2017) · eLife · doi:10.7554/elife.24241 · Cited by 151 · see citing works
Self-citationBido, S., Soria, F. N., Fan, R. Z., Bézard, E., & Tieu, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-07181-0 · Cited by 151 · see citing works
Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ
Ta, T., Dikmen, H. O., Schilling, S., Chausse, B., Lewen, A., Hollnagel, J., & Kann, O. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813562116 · Cited by 151 · see citing works
Self-citationBaumgart, M., Priebe, S., Groth, M., Hartmann, N., Menzel, U., Pandolfini, L., Koch, P., Felder, M., Ristow, M., Englert, C., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.01.014 · Cited by 147 · see citing works
Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 146 · see citing works
Self-citationThe glucose transporter type 1 (Glut1) syndromes
Koch, H., & Weber, Y. G. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.06.010 · Cited by 144 · see citing works
Karnib, N., El-Ghandour, R., Hayek, L. E., Nasrallah, P., Khalifeh, M., Barmo, N., Jabre, V., Ibrahim, P., Bilen, M., Stephan, J. S., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0313-z · Cited by 144 · see citing works
Salehpour, F., Ahmadian, N., Rasta, S. H., Farhoudi, M., Karimi, P., & Sadigh‐Eteghad, S. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.025 · Cited by 141 · see citing works
Neuroketotherapeutics: A modern review of a century-old therapy
Koppel, S. J., & Swerdlow, R. H. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.05.019 · Cited by 140 · see citing works
Self-citationMiquel, E., Cassina, A., Palma, L. M., Souza, J. M., Bolatto, C., Rodríguez-Bottero, S., Logan, A., Smith, R. A. J., Murphy, M. P., Barbeito, L., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.019 · Cited by 139 · see citing works
Self-citationCortical hypermetabolism in MCI subjects: a compensatory mechanism?
Ashraf, A., Fan, Z., Brooks, D. J., & Edison, P. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2919-z · Cited by 136 · see citing works
Xu, Q., Zhang, Y., Zhang, X., Liu, L., Zhou, B., Mo, R., Li, Y., Li, H., Li, F., Yang, T., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.10.017 · Cited by 136 · see citing works
Zhao, W., Varghese, M., Vempati, P., Dzhun, A., Cheng, A., Wang, J., Lange, D. J., Bilski, A. E., Faravelli, I., & Pasinetti, G. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049191 · Cited by 135 · see citing works
Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease
Croteau, E., Castellano, C.-A., Richard, M. A., Fortier, M., Nugent, S., Lepage, M., Duchesne, S., Whittingstall, K., Turcotte, É. E., Bocti, C., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180202 · Cited by 135 · see citing works
Self-citationCunnane, S. C., & Crawford, M. A. (2014) · Journal of Human Evolution · doi:10.1016/j.jhevol.2014.05.001 · Cited by 134 · see citing works
Self-citationHow to reprogram microglia toward beneficial functions
Fumagalli, M., Lombardi, M., Gressèns, P., & Verderio, C. (2018) · Glia · doi:10.1002/glia.23484 · Cited by 134 · see citing works
Sayed, N. H., Fathy, N., Kortam, M. A., Rabie, M. A., Mohamed, A. F., & Kamel, A. S. E. D. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00805-5 · Cited by 134 · see citing works
Tai, J., Liu, W., Li, Y., Li, L., & Hölscher, C. (2017) · Brain Research · doi:10.1016/j.brainres.2017.10.012 · Cited by 133 · see citing works
Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets
Vieira, M. N. N., Lima‐Filho, R. A. S., & Felice, F. G. D. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.014 · Cited by 131 · see citing works
Ahmed, R. M., Irish, M., Piguet, O., Halliday, G. M., Ittner, L. M., Farooqi, I. S., Hodges, J. R., & Kiernan, M. C. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00380-4 · Cited by 130 · see citing works
Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases
Clemmensen, C., Finan, B., Müller, T. D., DiMarchi, R. D., Tschöp, M. H., & Hofmann, S. M. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0118-x · Cited by 129 · see citing works
Briston, T., & Hicks, A. R. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180025 · Cited by 129 · see citing works
Nakamura, T., Watanabe, A., Fujino, T., Hosono, T., & Michikawa, M. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-35 · Cited by 124 · see citing works
Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease
Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S. S., Dey, P. N., Chen, C., Monteiro, O., et al. (2018) · eLife · doi:10.7554/elife.38744 · Cited by 117 · see citing works
Insulin regulates POMC neuronal plasticity to control glucose metabolism
Dodd, G. T., Michael, N. J., Lee, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z., Cowley, M. A., et al. (2018) · eLife · doi:10.7554/elife.38704 · Cited by 116 · see citing works
The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies
Arenaza‐Urquijo, E. M., Przybelski, S. A., Lesnick, T. G., Graff‐Radford, J., Machulda, M. M., Knopman, D. S., Schwarz, C. G., Lowe, V. J., Mielke, M. M., Petersen, R. C., et al. (2019) · Brain · doi:10.1093/brain/awz037 · Cited by 112 · see citing works
Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P. S., Pinto, M., Jin, L., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.03.009 · Cited by 110 · see citing works
Self-citationLactate administration reproduces specific brain and liver exercise‐related changes
Lezi, E., Lu, J., Selfridge, J. E., Burns, J. M., & Swerdlow, R. H. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12394 · Cited by 110 · see citing works
Self-citationZhao, Y., Sun, X., Hu, D., Prosdocimo, D. A., Hoppel, C. L., Jain, M. K., Ramachandran, R., & Qi, X. (2019) · Nature Communications · doi:10.1038/s41467-019-09291-x · Cited by 109 · see citing works
Pawlosky, R. J., Kemper, M. F., Kashiwaya, Y., King, M. T., Mattson, M. P., & Veech, R. L. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13958 · Cited by 108 · see citing works
Self-citationDeng‐Bryant, Y., Prins, M. L., Hovda, D. A., & Harris, N. G. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1822 · Cited by 104 · see citing works
Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4
Pearson-Leary, J., Jahagirdar, V., Sage, J., & McNay, E. C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.033 · Cited by 104 · see citing works
Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport
Hinckelmann, M.-V., Virlogeux, A., Niehage, C., Poujol, C., Choquet, D., Hoflack, B., Zala, D., & Saudou, F. (2016) · Nature Communications · doi:10.1038/ncomms13233 · Cited by 103 · see citing works
Self-citationCao, B., Rosenblat, J. D., Brietzke, E. M., Park, C., Lee, Y. L., Musial, N., Pan, Z., Mansur, R. B., & McIntyre, R. S. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13373 · Cited by 103 · see citing works
Li, H., Liu, C.-C., Zheng, H., & Huang, T. Y. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0139-3 · Cited by 103 · see citing works
Orr, A. L., Kim, C., Jimenez-Morales, D., Newton, B. W., Johnson, J. R., Krogan, N. J., Swaney, D. L., & Mahley, R. W. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181184 · Cited by 103 · see citing works
In Vivo Mitochondrial and Glycolytic Impairments in Patients with Alzheimer Disease
Terada, T., Obi, T., Bunai, T., Matsudaira, T., Yoshikawa, E., Ando, I., Futatsubashi, M., Tsukada, H., & Ouchi, Y. (2020) · Neurology · doi:10.1212/wnl.0000000000009249 · Cited by 103 · see citing works
Triheptanoin improves brain energy metabolism in patients with Huntington disease
Adanyeguh, I. M., Rinaldi, D., Henry, P., Caillet, S., Valabrègue, R., Dürr, A., & Mochel, F. (2015) · Neurology · doi:10.1212/wnl.0000000000001214 · Cited by 102 · see citing works
Matthews, D. C., Lerman, H., Lukic, A., Andrews, R. D., Mirelman, A., Wernick, M. N., Giladi, N., Strother, S. C., Evans, K. C., Cedarbaum, J. M., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.08.006 · Cited by 100 · see citing works
St‐Pierre, V., Vandenberghe, C., Lowry, C.-M., Fortier, M., Castellano, C., Wagner, J. R., & Cunnane, S. C. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00046 · Cited by 100 · see citing works
Self-citationTefera, T. W., & Borges, K. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00611 · Cited by 99 · see citing works
Marin‐Valencia, I., Good, L. B., Ma, Q., Malloy, C. R., & Pascual, J. M. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.151 · Cited by 98 · see citing works
The Contribution of Ketone Bodies to Basal and Activity-Dependent Neuronal Oxidation in Vivo
Chowdhury, G. M. I., Jiang, L., Rothman, D. L., & Behar, K. L. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.77 · Cited by 97 · see citing works
Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V. V., et al. (2013) · Aging Cell · doi:10.1111/acel.12186 · Cited by 97 · see citing works
Hyder, F., Hermán, P., Bailey, C. J., Møller, A., Globinsky, R., Fulbright, R. K., Rothman, D. L., & GJEDDE, A. H. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15625349 · Cited by 97 · see citing works
Silva, M. D. F., Dias, K. S. T., Gontijo, V. S., Ortiz, C. J. C., & Viegas, C. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180111101843 · Cited by 96 · see citing works
Gene Therapy for ALS—A Perspective
Cappella, M., Ciotti, C., Cohen-Tannoudji, M., & Biferi, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184388 · Cited by 96 · see citing works
Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS
Xin, L., İpek, Ö., Beaumont, M., Shevlyakova, M., Christinat, N., Masoodi, M., Greenberg, N., Rolf Gruetter, A., & Cuenoud, B. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00062 · Cited by 93 · see citing works
Brandt, J., Buchholz, A. S., Henry-Barron, B. J., Vizthum, D., Avramopoulos, D., & Cervenka, M. C. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180995 · Cited by 93 · see citing works
Glucagon like peptide-1 (GLP-1) likes Alzheimer’s disease
Simsir, I. Y., Soyaltın, U. E., & Çetinkalp, Ş. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.03.002 · Cited by 92 · see citing works
Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate
Vadder, F. D., & Mithieux, G. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0542 · Cited by 92 · see citing works
Self-citationZilberter, M. Y., Ivanov, A., Ziyatdinova, S., Mukhtarov, M. R., Malkov, A., Alpár, A., Tortoriello, G., Botting, C. H., Fülöp, L., Osypov, A. A., et al. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12127 · Cited by 91 · see citing works
Semaglutide: review and place in therapy for adults with type 2 diabetes
Goldenberg, R. M., & Steen, O. (2019) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2018.05.008 · Cited by 91 · see citing works
Cheng, A., Wang, J., Ghena, N., Zhao, Q., Perone, I., King, T. M., Veech, R. L., Gorospe, M., Wan, R., & Mattson, M. P. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1446-19.2019 · Cited by 91 · see citing works
Self-citationSavitt, D., & Jankovic, J. J. (2019) · Drugs · doi:10.1007/s40265-019-01104-1 · Cited by 89 · see citing works
C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis
Allen, S. P., Hall, B., Woof, R., Francis, L. I., Gatto, N., Shaw, A. C., Myszczynska, M. A., Hemingway, J., Coldicott, I., Willcock, A., et al. (2019) · Brain · doi:10.1093/brain/awz302 · Cited by 89 · see citing works
G lia in brain energy metabolism: A perspective
Barros, L. F., Brown, A. M., & Swanson, R. A. (2018) · Glia · doi:10.1002/glia.23316 · Cited by 89 · see citing works
Ngo, S. T., Steyn, F. J., Huang, L., Mantovani, S., Pfluger, C. M., Woodruff, T. M., O’Sullivan, J. D., Henderson, R. D., & McCombe, P. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.06.053 · Cited by 88 · see citing works
Zhao, F., Fang, F., Qiao, P., Yan, N., Gao, D., & Yan, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8360738 · Cited by 88 · see citing works
Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks
Correia, S. C., Perry, G. L., & Moreira, P. I. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.010 · Cited by 88 · see citing works
Self-citationRoe, C. R., & Brunengraber, H. (2015) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2015.10.005 · Cited by 87 · see citing works
Lin, Y., Wang, K., Ma, C., Wang, X., Gong, Z., Zhang, R., Zang, D., & Cheng, Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00227 · Cited by 87 · see citing works
Upregulation of GPR109A in Parkinson’s Disease
Wakade, C. G., Chong, R. K. Y., Bradley, E., Thomas, B., & Morgan, J. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109818 · Cited by 86 · see citing works
McColgan, P., Gregory, S., Seunarine, K. K., Razi, A., Papoutsi, M., Johnson, E. B., Dürr, A., Roos, R. A. C., Leavitt, B. R., Holmans, P., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.019 · Cited by 86 · see citing works
Avgerinos, K., Egan, J., Mattson, M., & Kapogiannis, D. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.101001 · Cited by 86 · see citing works
Self-citationConsequences of Metabolic Disruption in Alzheimer's Disease Pathology
Ryu, J. C., Zimmer, E. R., Rosa‐Neto, P., & Yoon, S. O. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00755-y · Cited by 84 · see citing works
Ari, C., Poff, A. M., Held, H. E., Landon, C. S., Goldhagen, C. R., Mavromates, N., & D’Agostino, D. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103526 · Cited by 82 · see citing works
Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP
Vardjan, N., Chowdhury, H. H., Horvat, A., Velebit, J., Malnar, M., Muhič, M., Kreft, M., KRIVEC, S. G., Bobnar, S. T., Miš, K., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00148 · Cited by 81 · see citing works
Self-citationRuskin, D. N., Ross, J. L., Kawamura, M., Ruiz, T., Geiger, J. D., & Masino, S. A. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.001 · Cited by 78 · see citing works
Post hoc analysis of the Exenatide‐ PD trial—Factors that predict response
Athauda, D. S., Maclagan, K., Budnik, N., Zampedri, L., Hibbert, S., Avilés-Olmos, I., Chowdhury, K., Skene, S. S., Limousin, P. D., & Foltynie, T. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14096 · Cited by 77 · see citing works
Batista, A. F., Bodart‐Santos, V., Felice, F. G. D., & Ferreira, S. T. (2018) · CNS Drugs · doi:10.1007/s40263-018-0593-6 · Cited by 77 · see citing works
Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof
McDonald, T., Puchowicz, M., & Borges, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00274 · Cited by 77 · see citing works
Jalewa, J., Sharma, M. K., & Hölscher, C. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13736 · Cited by 75 · see citing works
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Hallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789 · see citing works
Mitochondrial dysfunction: mechanisms and advances in therapy
Yao, Z., Li, H., Liao, P., Chen, L., Pan, Y., Zheng, Y., Zhang, C., Liu, D., Zheng, M., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01839-8 · Cited by 1,274 · see citing works
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease
Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654 · see citing works
Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580 · see citing works
Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases
Jensen, N. J., Wodschow, H. Z., Nilsson, M., & Rungby, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228767 · Cited by 450 · see citing works
Yin, F. (2023) · The FEBS Journal · doi:10.1111/febs.16344 · Cited by 441 · see citing works
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration.
Andersen, J. V., Markussen, K., Jakobsen, E., Schousboe, A., Waagepetersen, H., Rosenberg, P., & Aldana, B. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108719 · Cited by 331 · see citing works
Association between age at diabetes onset and subsequent risk of dementia
Barbiellini Amidei, C., Fayosse, A., Dumurgier, J., Machado-Fragua, M. D., Tabak, A. G., van Sloten, T., Kivimäki, M., Dugravot, A., Sabia, S., & Singh-Manoux, A. (2021) · JAMA · doi:10.1001/jama.2021.4001 · Cited by 355 · see citing works
Mi, Y., Qi, G., Vitali, F., Shang, Y., Raikes, A. C., Wang, T., Jin, Y., Brinton, R. D., Gu, H., & Yin, F. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00756-4 · Cited by 343 · see citing works
Self-citationLee, J., & Kim, H.-J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.931536 · Cited by 310 · see citing works
Metabolic and Signaling Roles of Ketone Bodies in Health and Disease
Puchalska, P., & Crawford, P. A. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-111120-111518 · Cited by 290 · see citing works
Energy matters: presynaptic metabolism and the maintenance of synaptic transmission
Li, S., & Sheng, Z. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00535-8 · Cited by 273 · see citing works
Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration
Cheng, X., Huang, N., & Sheng, Z. (2022) · Neuron · doi:10.1016/j.neuron.2022.03.015 · Cited by 253 · see citing works
Andersen, J. V., Schousboe, A., & Verkhratsky, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102331 · Cited by 259 · see citing works
Dewanjee, S., Chakraborty, P., Bhattacharya, H., Chacko, L., Singh, B., Chaudhary, A., Javvaji, K., Pradhan, S. R., Vallamkondu, J., Dey, A., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.032 · Cited by 235 · see citing works
Glucose metabolic crosstalk and regulation in brain function and diseases
Zhang, S., Lachance, B. B., Mattson, M. P., & Jia, X. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102089 · Cited by 205 · see citing works
Self-citationA ketogenic drink improves cognition in mild cognitive impairment: Results of a 6‐month RCT
Fortier, M., Castellano, C., St‐Pierre, V., Myette‐Côté, É., Langlois, F., Roy, M., Morin, M., Bocti, C., Fülöp, T., Godin, J., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12206 · Cited by 190 · see citing works
Self-citationMitochondrial Dysfunction in Alzheimers Disease: Opportunities forDrug Development
Bhatia, S., Rawal, R., Sharma, P., Singh, T., Singh, M., & Singh, V. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210517114016 · Cited by 196 · see citing works
Zheng, J., Xie, Y., Ren, L., Qi, L., Wu, L., Pan, X., Zhou, J., Zhou, C., & Liu, L. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101180 · Cited by 185 · see citing works
Chamberlain, K. A., Huang, N., Xie, Y., Licausi, F., Li, S., Li, Y., & Sheng, Z. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.011 · Cited by 180 · see citing works
Intranasal Insulin for Alzheimer’s Disease
Hallschmid, M. (2021) · CNS Drugs · doi:10.1007/s40263-020-00781-x · Cited by 182 · see citing works
Adenosine signalling to astrocytes coordinates brain metabolism and function
Theparambil, S. M., Kopach, O., Braga, A., Nizari, S., Hosford, P. S., Sági‐Kiss, V., Hadjihambi, A., Konstantinou, C., Esteras, N., del Arroyo, A. G., et al. (2024) · Nature · doi:10.1038/s41586-024-07611-w · Cited by 168 · see citing works
Microglia and lipids: how metabolism controls brain innate immunity
Chausse, B., Kakimoto, P. A., & Kann, O. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.08.001 · Cited by 181 · see citing works
Self-citationSun, Y., Zhang, H., Zhang, X., Wang, W., Chen, Y., Cai, Z., Wang, Q., Wang, J., & Shi, Y. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102690 · Cited by 151 · see citing works
The role of mitophagy in the regulation of mitochondrial energetic status in neurons
Han, S., Zhang, M., Jeong, Y. Y., Margolis, D. J., & Cai, Q. (2021) · Autophagy · doi:10.1080/15548627.2021.1907167 · Cited by 151 · see citing works
Andersen, J. V., & Schousboe, A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15811 · Cited by 151 · see citing works
Synapses: The Brain’s Energy-Demanding Sites
Faria‐Pereira, A., & Morais, V. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073627 · Cited by 145 · see citing works
Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
Ding, P.-F., Zhang, H., Wang, J., Gao, Y., Mao, J.-N., Hang, C., & Li, W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1092431 · Cited by 139 · see citing works
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
Silva, B., Mantha, O. L., Schor, J., Pascual, A., Plaçais, P.-Y., Pavlowsky, A., & Préat, T. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00528-6 · Cited by 138 · see citing works
Rehman, M. U., Sehar, N., Dar, N. J., Khan, A., Arafah, A., Rashid, S., Rashid, S. M., & Ganaie, M. A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104961 · Cited by 130 · see citing works
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
Asadollahi, E., Trevisiol, A., Saab, A. S., Looser, Z. J., Dibaj, P., Ebrahimi, R., Kusch, K., Ruhwedel, T., Möbius, W., Jahn, O., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01749-6 · Cited by 130 · see citing works
Self-citationMitochondrial complex I as a therapeutic target for Alzheimer's disease
Trushina, E. V., Trushin, S., & Hasan, M. F. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.11.003 · Cited by 130 · see citing works
Self-citationBrain Metabolic Alterations in Alzheimer’s Disease
Ardanaz, C. G., Ramírez, M. J., & Solas, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073785 · Cited by 130 · see citing works
Wang, Z.-J., Li, X.-R., Chai, S.-F., Li, W.-R., Li, S., Hou, M., Li, J.-L., Ye, Y.-C., Cai, H.-Y., Hölscher, C., et al. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109716 · Cited by 125 · see citing works
ESPEN guideline on nutrition and hydration in dementia – Update 2024
Volkert, D., Beck, A. M., Irving, G. F., Frühwald, T., Hooper, L., Keller, H., Porter, J. A., Rothenberg, E. M., Suominen, M. H., Wirth, R., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.04.039 · Cited by 121 · see citing works
Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine
Duo, Y., Han, L., Yang, Y., Wang, Z., Wang, L., Chen, J., Xiang, Z., Yoon, J., Luo, G., & Tang, B. Z. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00244 · Cited by 119 · see citing works
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
Fontana, L., Ghezzi, L., Cross, A. H., & Piccio, L. M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190086 · Cited by 116 · see citing works
Han, H., Zhao, Y., Du, J., Wang, S., Yang, X., Li, W., Song, J., Zhang, S., Zhang, Z., Tan, Y., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00390-4 · Cited by 116 · see citing works
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain
Bennett, H. C., Zhang, Q., Wu, Y.-T., Manjila, S. B., Chon, U., Shin, D., Vanselow, D. J., Pi, H.-J., Drew, P. J., & Kim, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-50559-8 · Cited by 109 · see citing works
Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113 · see citing works
Cheng, G., Liu, Y., Ma, R., Cheng, G., Guan, Y., Chen, X., Wu, Z., & Chen, T. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00847-z · Cited by 110 · see citing works
Deng, D., Cui, Y., Gan, S., Xie, Z., Cui, S., Cao, K., Wang, S., Shi, G., Yang, L., Bai, S., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154395 · Cited by 109 · see citing works
Lactate metabolism in neurodegenerative diseases
Yang, C., Pan, R., Guan, F., & Yuan, Z. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.374142 · Cited by 109 · see citing works
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases
Jiang, Z., Yin, X., Wang, M., Chen, T., Wang, Y., Gao, Z., & Wang, Z. (2022) · Aging and Disease · doi:10.14336/ad.2021.1217 · Cited by 109 · see citing works
Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies
Wu, Q., Wang, Y., Liu, J., Guan, X., Chang, X., Liu, Z., & Liu, R. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106650 · Cited by 109 · see citing works
Jang, J., Kim, S. R., Lee, J. E., Lee, S.-Y., Son, H. J., Choe, W., Yoon, K., Kim, S. S., Yeo, E., & Kang, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010124 · Cited by 107 · see citing works
Wang, Z., Wang, C., Yuan, B., Liu, L., Zhang, H., Zhu, M., Chai, H., Peng, J., Huang, Y. H., Zhou, S., et al. (2025) · Microbiome · doi:10.1186/s40168-024-02001-w · Cited by 112 · see citing works
A Potential Link Between Visceral Obesity and Risk of Alzheimer’s Disease
Al-Kuraishy, H. M., Al-Gareeb, A. I., Alsayegh, A. A., Hakami, Z. H., Khamjan, N. A., Saad, . M., Batiha, G. E., & WAARD, M. M. D. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03817-4 · Cited by 106 · see citing works
Andersen, J. V., Skotte, N. H., Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, E. W., Diaz-delCastillo, M., Sun, R. C., et al. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04237-y · Cited by 104 · see citing works
Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA
Liu, Y., Ren, X., Fan, C., Wu, W., Zhang, W., & Wang, Y. (2022) · Foods · doi:10.3390/foods11131883 · Cited by 109 · see citing works
Hwang, C. Y., Choe, W., Yoon, K., Ha, J., Kim, S. S., Yeo, E., & Kang, I. (2022) · Nutrients · doi:10.3390/nu14224932 · Cited by 105 · see citing works
Altered Metabolism in Alzheimer Disease Brain: Role of Oxidative Stress
Rummel, N. G., & Butterfield, D. A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0177 · Cited by 105 · see citing works
Focusing on mitochondria in the brain: from biology to therapeutics
Song, N., Mei, S., Wang, X.-X., Hu, G., & Lu, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00409-w · Cited by 102 · see citing works
Jadiya, P., Garbincius, J. F., & Elrod, J. W. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01224-4 · Cited by 94 · see citing works
Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Yang, S., Park, J. H., & Lu, H.-C. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00634-3 · Cited by 94 · see citing works
Austad, S. N., Ballinger, S. W., Buford, T. W., Carter, C. S., Smith, D. L., Darley-Usmar, V. M., & Zhang, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.06.014 · Cited by 93 · see citing works
Glucose metabolism, neural cell senescence and Alzheimer's disease
Wang, Q., Duan, L., Li, X., Wang, Y., Guo, W., Guan, F., & Ma, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084351 · Cited by 90 · see citing works
Schilling, S., Chausse, B., Dikmen, H. O., Almouhanna, F., Hollnagel, J., Lewen, A., & Kann, O. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.013 · Cited by 91 · see citing works
Self-citationAndersen, J. V., Westi, E. W., Jakobsen, E., Urruticoechea, N., Borges, K., & Aldana, B. I. (2021) · Molecular Brain · doi:10.1186/s13041-021-00842-2 · Cited by 89 · see citing works
Glial Glutamine Homeostasis in Health and Disease
Andersen, J. V., & Schousboe, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03771-1 · Cited by 88 · see citing works
Qian, K., Bao, X., Li, Y., Wang, P., Guo, Q., Yang, P., Xu, S., Yu, F., Meng, R., Cheng, Y., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c05795 · Cited by 87 · see citing works
Mehta, R. I., & Schneider, J. A. (2021) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000912 · Cited by 84 · see citing works
Dietary nutrition for neurological disease therapy: Current status and future directions
Mao, X., Yin, X., Guan, Q.-W., Xia, Q., Yang, N., Zhou, H., Liu, Z., & Jin, W. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107861 · Cited by 84 · see citing works
Oxygen metabolism abnormality and Alzheimer's disease: An update
Liu, G., Yang, C., Wang, X., Chen, X., Wang, Y., & Le, W. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102955 · Cited by 83 · see citing works
The roles of microglia and astrocytes in neuroinflammation of Alzheimer’s disease
Han, J., Zhang, Z., Zhang, P., Yu, Q., Cheng, Q., Lu, Z., & Zong, S. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1575453 · Cited by 87 · see citing works
Neurotoxic β-amyloid oligomers cause mitochondrial dysfunction—the trigger for PANoptosis in neurons
Meng, X., Song, Q., Liu, Z., Liu, X., Wang, Y., & Liu, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1400544 · Cited by 78 · see citing works
Carelli, S., Rey, F., Ottolenghi, S., Zuccotti, G., & Samaja, M. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.322430 · Cited by 78 · see citing works
Salcedo, C., Andersen, J. V., Vinten, K. T., Pinborg, L. H., Waagepetersen, H. S., Freude, K., & Aldana, B. I. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.736580 · Cited by 77 · see citing works
Wong, J. H., Barron, A. M., & Abdullah, J. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.687935 · Cited by 79 · see citing works
From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions
Lee, T. H.-Y., & Yau, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010201 · Cited by 76 · see citing works
Wang, C., Zheng, D., Weng, F., Jin, Y., & He, L. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06025-0 · Cited by 76 · see citing works
Chaulagain, B., Gothwal, A., Lamptey, R. N. L., Trivedi, R., Mahanta, A. K., Layek, B., & Singh, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032710 · Cited by 82 · see citing works
Han, F. Y., Conboy-Schmidt, L., Quist‐Rybachuk, G., Volk, H. A., Zanghi, B. M., Pan, Y., & Borges, K. (2021) · Epilepsia · doi:10.1111/epi.16972 · Cited by 76 · see citing works
Zhang, Q., Song, Q., Yu, R., Wang, A., Jiang, G., Huang, Y., Chen, J., Xu, J., Wang, D., Chen, H., et al. (2023) · Advanced Science · doi:10.1002/advs.202204596 · Cited by 74 · see citing works
Emerging Roles of Endothelial Nitric Oxide in Preservation of Cognitive Health
Katusic, Z. S., d’Uscio, L. V., & He, T. (2023) · Stroke · doi:10.1161/strokeaha.122.041444 · Cited by 73 · see citing works
Galizzi, G., & Carlo, M. D. (2022) · Biology · doi:10.3390/biology11060943 · Cited by 76 · see citing works
He, Y., Wang, K., Su, N., Yuan, C., Zhang, N., Hu, X., Fu, Y., & Zhao, F. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70099 · Cited by 73 · see citing works
Stojakovic, A., Trushin, S., Sheu, A., Khalili, L., Chang, S.-Y., Li, X., Christensen, T., Salisbury, J. L., Geroux, R. E., Gateno, B., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01584-y · Cited by 72 · see citing works
Self-citationLi, H., Kou, B., Yuan, Y., Chai, Y., & Yuan, R. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113758 · Cited by 71 · see citing works
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Jennings, A., Cunnane, S. C., & Minihane, A. M. (2020) · BMJ · doi:10.1136/bmj.m2269 · Cited by 69 · see citing works
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Tang, D., Tang, Q., Huang, W., Zhang, Y., Tian, Y., & Fu, X. (2023) · Advanced Science · doi:10.1002/advs.202204487 · Cited by 71 · see citing works
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Rhea, E. M., Leclerc, M., Yassine, H. N., Capuano, A. W., Tong, H., Petyuk, V. A., Macauley, S. L., Fioramonti, X., Carmichael, O., Calon, F., et al. (2023) · Aging and disease · doi:10.14336/ad.2023.0814 · Cited by 70 · see citing works
Wang, Y., Li, P., Xu, Y., Feng, L., Fang, Y., Song, G., Li, X., Zhu, Z., Wang, W., Mei, Q., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03303-4 · Cited by 71 · see citing works
Liang, Z., Currais, A. J. M., Soriano‐Castell, D., Schubert, D. A., & Maher, P. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107749 · Cited by 70 · see citing works
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Wang, Y., Ge, M., Wang, J., Xu, Y., Wang, N., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08114-w · Cited by 75 · see citing works
Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules
Wang, T., Tian, X., Kim, H. B., Jang, Y., Huang, Z., Na, C. H., & Wang, J. (2022) · Nature Communications · doi:10.1038/s41467-022-33079-1 · Cited by 67 · see citing works
Lactate Supply Overtakes Glucose When Neural Computational and Cognitive Loads Scale Up
Dembitskaya, Y., Piette, C., Siaume‐Perez, S., Berry, H., Magistretti, P. J., & Venance, L. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212004119 · Cited by 69 · see citing works
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 68 · see citing works
Metabolic Crosstalk between Liver and Brain: From Diseases to Mechanisms
Yang, X., Qiu, K., Jiang, Y., Huang, Y., Zhang, Y., & Liao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147621 · Cited by 69 · see citing works
The Brain–Gut Axis, an Important Player in Alzheimer and Parkinson Disease: A Narrative Review
Caradonna, E., Nemni, R., Bifone, A., Gandolfo, P., Costantino, L., Giordano, L., Mormone, E., Macula, A., Cuomo, M., Difruscolo, R., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144130 · Cited by 68 · see citing works
The metabolic costs of cognition
Jamadar, S. D., Behler, A., Deery, H. A., & Breakspear, M. J. (2025) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2024.11.010 · Cited by 68 · see citing works
Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans
Cuenoud, B. M., İpek, Ö., Shevlyakova, M., Beaumont, M., Cunnane, S. C., Rolf Gruetter, A., & Xin, L. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.609517 · Cited by 67 · see citing works
Self-citationAberrant energy metabolism in Alzheimer’s disease
Yu, L., Jin, J., Xu, Y., & Zhu, X. (2022) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2022-0024 · Cited by 66 · see citing works
Organelle‐Targeting Nanoparticles
Soukar, J., Peppas, N., & Gaharwar, A. (2025) · Advancement of science · doi:10.1002/advs.202411720 · Cited by 67 · see citing works
Pathophysiology of Lipid Droplets in Neuroglia
Smolič, T., Zorec, R., & Vardjan, N. (2021) · Antioxidants · doi:10.3390/antiox11010022 · Cited by 69 · see citing works
Decourt, B., D’Souza, G. X., Shi, J., Ritter, A., Suazo, J., & Sabbagh, M. N. (2022) · Aging and disease · doi:10.14336/ad.2021.0529 · Cited by 69 · see citing works
Chen, W., Guo, C., Feng, H., & Chen, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.615451 · Cited by 63 · see citing works
Disentangling the Relationship Between Chronic Kidney Disease and Cognitive Disorders
Kelly, D., & Rothwell, P. M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.830064 · Cited by 66 · see citing works
- Authors
- Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., Eckert, A., Harvey, J., Jeggo, R., Jhamandas, J. H., Kann, O., la Cour, C. M., Martin, W. F., Mithieux, G., Moreira, P. I., Murphy, M. P., Nave, K.-A., Nuriel, T., Oliet, S. H. R., Saudou, F., Mattson, M. P., Swerdlow, R. H., & Millan, M. J.
- Affiliations
- Université de Sherbrooke (CA)
- Mayo Clinic (US)
- University of Oslo (NO)
- Heinrich Heine University Düsseldorf (DE)
- Monash University (AU)
- Weill Cornell Medicine (US)
- University of Arizona (US)
- University of Basel (CH)
- University of Dundee (GB)
- Institut de Recherches Internationales Servier (France) (FR)
- University of Alberta (CA)
- Heidelberg University (DE)
- Inserm (FR)
- University of Coimbra (PT)
- University of Cambridge (GB)
- Columbia University Irving Medical Center (US)
- Université de Bordeaux (FR)
- Johns Hopkins University (US)
- University of Kansas (US)
- Corresponding author
- Cunnane, Stephen C.
- Millan, Mark J.
- ORCID
- Cunnane, Stephen C.
- Trushina, Eugenia
- Morland, Cecilie
- Prigione, Alessandro
- Andrews, Zane B.
- Bergersen, Linda H.
- Brinton, Roberta D.
- Eckert, Anne
- Harvey, Jenni
- Jhamandas, Jack H.
- Kann, Oliver
- Martin, William F.
- Mithieux, Gilles
- Moreira, Paula I.
- Murphy, Michael P.
- Nave, Klaus-Armin
- Nuriel, Tal
- Oliet, Stéphane H. R.
- Saudou, Frédéric
- Mattson, Mark P.
- Swerdlow, Russell H.
- Millan, Mark J.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2020-07-24
- Volume
- 19
- Issue
- 9
- Pages
- 609-633
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC7948516
- OpenAlex
- W3044114834
- Cited by
- 1,003
- References
- 317
- Citations by year
- 2026: 174 · 2025: 203 · 2024: 175 · 2023: 174 · 2022: 146 · 2021: 112 · 2020: 19
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Funders
- National Science Foundation (P30 AG035982, R37AG053589, R01AG057931)
- Alzheimer's Association (P30AG035982)
- Wellcome Trust (110159/Z/ 15/Z, /Z/15/Z)
- Alzheimer's Society
- European Commission (PEst-C/SAU/LA0001/2013, HORIZON2020)
- Deutsche Forschungsgemeinschaft (CRC 1134)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A, 179294)
- Servier
- National Institutes of Health (UIDB/04539/2020, 7r21ag064479-03, 1rf1ag062135-01, AG035982, AG026572)
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé
- Medical Research Council (MC_UU_00015/3, U105663142, MC-U105663142)
- National Health and Medical Research Council (1154974)
- National Institute on Aging (AG026572, RF1AG059093, R21 AG064479, AG035982, RF1-AG062135, P30AG035982, R15AG050292, R01AG061194, RO1AG062135, R01AG057931, RF1AG55549, R01AG060733, RF1AG055549, R37AG053589, P01AG026572)
- National Institute of Neurological Disorders and Stroke (R01NS107265, UH3NS113776)
- H2020 European Research Council (834317)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- brain energy metabolism, Alzheimer's disease, glucose metabolism, oxidative phosphorylation, aerobic glycolysis, ketone bodies, mitochondrial dysfunction, insulin sensitivity, RNA therapeutics, lifestyle intervention, treatment options
- MeSH terms
- Aging, Animals, Brain, Energy Metabolism, Glycolysis, Humans, Oxidative Phosphorylation, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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