Halazonetis, Thanos D.

Genomic instability — an evolving hallmark of cancer

Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsCancer Genomics and Diagnostics

Cited by 2,397

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,009

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,986

An Oncogene-Induced DNA Damage Model for Cancer Development

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,851

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

Huyen, Y., Zgheib, O., DiTullio Jr, R. A., Gorgoulis, V. G., Zacharatos, P., Petty, T. J., Sheston, E. A., Mellert, H. S., Stavridi, E. S., & Halazonetis, T. D. (2004) · Nature

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 884

Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53

Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D. (2000) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 805

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

Liu, L., Scolnick, D. M., Trievel, R. C., Zhang, H. B., Marmorstein, R., Halazonetis, T. D., & Berger, S. L. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 776

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

Barlev, N. A., Liu, L., Chehab, N. H., Mansfield, K., Harris, K. G., Halazonetis, T. D., & Berger, S. L. (2001) · Molecular Cell

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 710

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

Chehab, N. H., Malikzay, A., Stavridi, E. S., & Halazonetis, T. D. (1999) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 583

SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

Peschiaroli, A., Dorrello, N. V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N. E., & Pagano, M. (2006) · Molecular Cell

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 289

Oncogene-induced senescence: the bright and dark side of the response

Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Current Opinion in Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 257

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

Velimezi, G., Liontos, M., Vougas, K., Roumeliotis, T., Bartkova, J., Sideridou, M., Dereli-Oz, A., Kocylowski, M., Pateras, I. S., Evangelou, K., et al. (2013) · Nature Cell Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 131

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23

MacPherson, D., Kim, J., Kim, T., Rhee, B. K., van Oostrom, C. T., DiTullio, R. A., Venere, M., Halazonetis, T. D., Bronson, R., de Vries, A., et al. (2004) · The EMBO Journal

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 124

Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer

Halazonetis, T. D. (2004) · DNA repair

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 53