Hallifax, David

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies

Hewitt, N. J., Gómez Lechón, M. J., Houston, J. B., Hallifax, D., Brown, H. S., Maurel, P., Kenna, J. G., Gustavsson, L., Lohmann, C., Skonberg, C., et al. (2007) · Drug Metabolism Reviews

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 735

Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs

Hallifax, D., & Houston, J. B. (2012) · Journal of Pharmaceutical Sciences

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 60

Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

Hallifax, D., Turlizzi, E., Zanelli, U., & Houston, J. B. (2012) · European Journal of Pharmaceutical Sciences

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 26