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Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

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Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by CYP3A4

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Relevance of In Vitro Metabolism Models to PET Radiotracer Development: Prediction of In Vivo Clearance in Rats from Microsomal Stability Data

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In Vitro–In Vivo Extrapolation of Hepatic Biotransformation Data for Fish. III. An In-depth Case Study with Pyrene

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Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors

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Proof of Concept of an All-in-One System for Measuring Hepatic Influx, Egress, and Metabolic Clearance Based on the Extended Clearance Concept

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Integrated Lead Optimization: Translational Models as We Advance Toward the Clinic

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In vitro-in vivo extrapolation of human hepatic and renal clearance

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Extracellular Matrix Abnormalities in Major Psychoses: CS-6 Expression in Human Dermal Fibroblasts

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Impact of POR and cytochrome b5 variability on the genotype-phenotype discordance of CYP2A6 and CYP2D6: A quantitative analysis in Chinese human livers

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Predicting intrinsic clearance using deep learning-based drug-metabolic enzyme interaction features on an IVIVE-harmonized endpoint dataset

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PBPK Modeling Investigation of IVIVE–Observed Pharmacokinetic Divergence for VU0467319: A Mechanistic Refinement Workflow for Low-Solubility Compounds

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BindingDB Entry 50000287: Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

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Which unbound fraction should we use in the well-stirred model for more accurately predicting hepatic clearance of drugs for humans?

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Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

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