Cunningham, John T.

mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

Cunningham, J. T., Rodgers, J. T., Arlow, D. H., Vazquez, F., Mootha, V. K., & Puigserver, P. (2007) · Nature

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 1,488

Translation control of the immune checkpoint in cancer and its therapeutic targeting

Xu, Y., Poggio, M., Jin, H. Y., Shi, Z., Forester, C. M., Wang, Y., Stumpf, C. R., Xue, L., Devericks, E., So, L., et al. (2019) · Nature Medicine

Cancer Immunotherapy and BiomarkersRNA and protein synthesis mechanisms

Cited by 261

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

Cunningham, J. T., Moreno, M. V., Lodi, A., Ronen, S. M., & Ruggero, D. (2014) · Cell

Biochemical and Molecular ResearchRNA and protein synthesis mechanisms

Cited by 260

The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex

Karki, B. R., MacMillan, A. C., Vicente-Muñoz, S., Greis, K. D., Romick, L. E., & Cunningham, J. T. (2025) · Nature Communications

Biochemical and Molecular ResearchRNA and protein synthesis mechanisms

Cited by 11

Evolutionary origins and innovations sculpting the mammalian PRPS enzyme complex

Karki, B. R., Macmillan, A. C., Vicente-Muñoz, S., Greis, K. D., Romick, L. E., & Cunningham, J. T. (2024) · Nature Communications

Biochemical and Molecular ResearchRNA and protein synthesis mechanisms

Cited by 11