Kleinman, Joel E.

Spatio-temporal transcriptome of the human brain

Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A. M. M., Pletikos, M., Meyer, K. A., Sedmak, G., et al. (2011) · Nature

Single-cell and spatial transcriptomicsRNA Research and Splicing

Cited by 2,084

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics

Neurotransmitter Receptor Influence on BehaviorPharmacogenetics and Drug Metabolism

Cited by 1,675

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

Maynard, K. R., Collado-Torres, L., Weber, L. M., Uytingco, C., Barry, B. K., Williams, S. R., Catallini, J. L., Tran, M. N., Besich, Z., Tippani, M., et al. (2021) · Nature Neuroscience

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 1,222

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Jo, J., Xiao, Y., Sun, A. X., Cukuroglu, E., Tran, H.-D., Göke, J., Tan, Z. Y., Saw, T. Y., Tan, C.-P., Lokman, H., et al. (2016) · Cell Stem Cell

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 861

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

Li, M., Santpere, G., Imamura Kawasawa, Y., Evgrafov, O. V., Gulden, F. O., Pochareddy, S., Sunkin, S. M., Li, Z., Shin, Y., Zhu, Y., et al. (2018) · Science

Genetics and Neurodevelopmental DisordersGenomics and Chromatin Dynamics

Cited by 810

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

Colantuoni, C., Lipska, B. K., Ye, T., Hyde, T. M., Tao, R., Leek, J. T., Colantuoni, E. A., Elkahloun, A. G., Herman, M. M., Weinberger, D. R., et al. (2011) · Nature

Genetic Associations and EpidemiologyGenomics and Chromatin Dynamics

Cited by 685

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

Jaffe, A. E., Gao, Y., Deep-Soboslay, A., Tao, R., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2016) · Nature Neuroscience

Epigenetics and DNA MethylationSchizophrenia research and treatment

Cited by 511

Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures

Zeng, H., Shen, E. H., Hohmann, J. G., Oh, S. W., Bernard, A., Royall, J. J., Glattfelder, K. J., Sunkin, S. M., Morris, J. A., Guillozet-Bongaarts, A. L., et al. (2012) · Cell

Single-cell and spatial transcriptomicsNeuroscience and Neuropharmacology Research

Cited by 426

Candidate endophenotypes for genetic studies of suicidal behavior

Mann, J. J., Arango, V. A., Avenevoli, S., Brent, D. A., Champagne, F. A., Clayton, P., Currier, D., Dougherty, D. M., Haghighi, F., Hodge, S. E., et al. (2009) · Biological Psychiatry

Suicide and Self-Harm StudiesGenetic Associations and Epidemiology

Cited by 398

DNA methylation signatures in development and aging of the human prefrontal cortex

Numata, S., Ye, T., Hyde, T. M., Guitart-Navarro, X., Tao, R., Wininger, M., Colantuoni, C., Weinberger, D. R., Kleinman, J. E., & Lipska, B. K. (2012) · The American Journal of Human Genetics

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 364

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

The BrainSeq Consortium, Jaffe, A. E., Straub, R. E., Shin, J. H., Tao, R., Gao, Y., Collado-Torres, L., Kam-Thong, T., Xi, H. S., Quan, J., et al. (2018) · Nature Neuroscience

Schizophrenia research and treatmentGenetic Associations and Epidemiology

Cited by 364

Catechol- O -Methyltransferase Genotype and Dopamine Regulation in the Human Brain

Akil, M., Kolachana, B. S., Rothmond, D. A., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2003) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Cited by 325

Molecular and cellular reorganization of neural circuits in the human lineage

Sousa, A. M. M., Zhu, Y., Raghanti, M. A., Kitchen, R. R., Onorati, M., Tebbenkamp, A. T. N., Stutz, B., Meyer, K. A., Li, M., Kawasawa, Y. I., et al. (2017) · Science

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 253

Sex differences in glutamate receptor gene expression in major depression and suicide

Gray, A. L., Hyde, T. M., Deep-Soboslay, A., Kleinman, J. E., & Sodhi, M. S. (2015) · Molecular Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 250

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

Yoon, K.-J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N.-S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., et al. (2014) · Cell Stem Cell

Genomic variations and chromosomal abnormalitiesSchizophrenia research and treatment

Cited by 240

Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain

Tran, M. N., Maynard, K. R., Spangler, A., Huuki, L. A., Montgomery, K. D., Sadashivaiah, V., Tippani, M., Barry, B. K., Hancock, D. B., Hicks, S. C., et al. (2021) · Neuron

Single-cell and spatial transcriptomicsNeurotransmitter Receptor Influence on Behavior

Cited by 219

APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms

Conejero-Goldberg, C., Gomar, J. J., Bobes-Bascaran, T., Hyde, T. M., Kleinman, J. E., Herman, M. M., Chen, S., Davies, P., & Goldberg, T. E. (2014) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 199

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

Nakata, K., Lipska, B. K., Hyde, T. M., Ye, T., Newburn, E. N., Morita, Y., Vakkalanka, R., Barenboim, M., Sei, Y., Weinberger, D. R., et al. (2009) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentRNA Research and Splicing

Cited by 182

Association of DNA methylation differences with schizophrenia in an Epigenome-Wide association study

Montano, C., Taub, M. A., Jaffe, A., Briem, E., Feinberg, J. I., Trygvadottir, R., Idrizi, A., Runarsson, A., Berndsen, B., Gur, R. C., et al. (2016) · JAMA Psychiatry

Epigenetics and DNA MethylationSchizophrenia research and treatment

Cited by 180

Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs

Lipska, B. K., Peters, T., Hyde, T. M., Halim, N., Horowitz, C., Mitkus, S., Weickert, C. S., Matsumoto, M., Sawa, A., Straub, R. E., et al. (2006) · Human Molecular Genetics

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 168

Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness

Perlman, W. R., Webster, M. J., Kleinman, J. E., & Weickert, C. S. (2004) · Biological Psychiatry

Stress Responses and CortisolEstrogen and related hormone effects

Cited by 163

Developmental regulation of human cortex transcription and its clinical relevance at single base resolution

Jaffe, A. E., Shin, J., Collado-Torres, L., Leek, J. T., Tao, R., Li, C., Gao, Y., Jia, Y., Maher, B. J., Hyde, T. M., et al. (2015) · Nature Neuroscience

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 156

Age-related differences in glucocorticoid receptor mRNA levels in the human brain

Perlman, W. R., Webster, M. J., Herman, M. M., Kleinman, J. E., & Weickert, C. S. (2007) · Neurobiology of Aging

Stress Responses and CortisolEstrogen and related hormone effects

Cited by 152

Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy

Law, A. J., Wang, Y., Sei, Y., O’Donnell, P., Piantadosi, P., Papaleo, F., Straub, R. E., Huang, W., Thomas, C. J., Vakkalanka, R., et al. (2012) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 147