Association of DNA methylation differences with schizophrenia in an Epigenome-Wide association study
Open accessAbstract
IMPORTANCE: DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk. OBJECTIVE: To scan genome-wide DNA methylation data to identify differentially methylated CpGs between SZ cases and controls. DESIGN, SETTING, AND PARTICIPANTS: Epigenome-wide association study begun in 2008 using DNA methylation levels of 456 513 CpG loci measured on the Infinium HumanMethylation450 array (Illumina) in a consortium of case-control studies for initial discovery and in an independent replication set. Primary analyses used general linear regression, adjusting for age, sex, race/ethnicity, smoking, batch, and cell type heterogeneity. The discovery set contained 689 SZ cases and 645 controls (n = 1334), from 3 multisite consortia: the Consortium on the Genetics of Endophenotypes in Schizophrenia, the Project among African-Americans To Explore Risks for Schizophrenia, and the Multiplex Multigenerational Family Study of Schizophrenia. The replication set contained 247 SZ cases and 250 controls (n = 497) from the Genomic Psychiatry Cohort. MAIN OUTCOMES AND MEASURES: Identification of differentially methylated positions across the genome in SZ cases compared with controls. RESULTS: Of the 689 case participants in the discovery set, 477 (69%) were men and 258 (37%) were non-African American; of the 645 controls, 273 (42%) were men and 419 (65%) were non-African American. In our replication set, cases/controls were 76% male and 100% non-African American. We identified SZ-associated methylation differences at 923 CpGs in the discovery set (false discovery rate, <0.2). Of these, 625 showed changes in the same direction including 172 with P < .05 in the replication set. Some replicated differentially methylated positions are located in a top-ranked SZ region from genome-wide association study analyses. CONCLUSIONS AND RELEVANCE: This analysis identified 172 replicated new associations with SZ after careful correction for cell type heterogeneity and other potential confounders. The overlap with previous genome-wide association study data can provide potential insights into the functional relevance of genetic signals for SZ.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892 · see citing works
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
Aryee, M. J., Jaffe, A. E., Bravo, H. C., Ladd‐Acosta, C., Feinberg, A. P., Hansen, K. D., & Irizarry, R. A. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu049 · Cited by 4,423 · see citing works
Self-citationDNA methylation arrays as surrogate measures of cell mixture distribution
Houseman, E. A., Accomando, W. P., Koestler, D. C., Christensen, B. C., Marsit, C. J., Nelson, H. H., Wiencke, J. K., & Kelsey, K. T. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-86 · Cited by 3,175 · see citing works
Saha, S., Chant, D., & McGrath, J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.10.1123 · Cited by 2,065 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Genome-wide association study identifies five new schizophrenia loci
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011) · Nature Genetics · doi:10.1038/ng.940 · Cited by 1,919 · see citing works
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Multicenter Genetic Studies of Schizophrenia Consortium, Ripke, S., Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., Bergen, S. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2742 · Cited by 1,496 · see citing works
Rare chromosomal deletions and duplications increase risk of schizophrenia
The International Schizophrenia Consortium (2008) · Nature · doi:10.1038/nature07239 · Cited by 1,475 · see citing works
A polygenic burden of rare disruptive mutations in schizophrenia
Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O’Dushlaine, C., Chambert, K., Bergen, S. E., Kähler, A., et al. (2014) · Nature · doi:10.1038/nature12975 · Cited by 1,385 · see citing works
Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease
Seshadri, S. (2010) · JAMA · doi:10.1001/jama.2010.574 · Cited by 1,219 · see citing works
Genetic architectures of psychiatric disorders: the emerging picture and its implications
Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
Jaffe, A. E., & Irizarry, R. A. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r31 · Cited by 1,067 · see citing works
Self-citationReinius, L. E., Acevedo, N., Joerink, M., Pershagen, G., Dahlén, S., Greco, D., Söderhäll, C., Scheynius, A., & Kere, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041361 · Cited by 1,019 · see citing works
Liu, Y., Aryee, M. J., Padyukov, L., Fallin, M. D., Hesselberg, E., Rúnarsson, Á. R., Reinius, L. E., Acevedo, N., Taub, M. A., Ronninger, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2487 · Cited by 974 · see citing works
Self-citationRates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959-1961
Clair, D. S. (2005) · JAMA · doi:10.1001/jama.294.5.557 · Cited by 817 · see citing works
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works
Lipton, J. O., & Şahin, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.034 · Cited by 732 · see citing works
Joubert, B. R., Håberg, S. E., Nilsen, R. M., Wang, X., Vollset, S. E., Murphy, S. K., Huang, Z., Hoyo, C., Midttun, Ø., Cupul-Uicab, L. A., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205412 · Cited by 716 · see citing works
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Lunnon, K., Smith, R., Hannon, E., De Jager, P. L., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3782 · Cited by 574 · see citing works
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.0207e04 · Cited by 521 · see citing works
Meta-Analysis of the Association of Urbanicity With Schizophrenia
Vassos, E., Pedersen, C. B., Murray, R. M., Collier, D. A., & Lewis, C. M. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs096 · Cited by 510 · see citing works
Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460 · see citing works
Increased exonic de novo mutation rate in individuals with schizophrenia
Girard, S. L., Gauthier, J., Noreau, A., Xiong, L., Zhou, S., Jouan, L., Dionne-Laporte, A., Spiegelman, D., Henrion, E., Diallo, O., et al. (2011) · Nature Genetics · doi:10.1038/ng.886 · Cited by 438 · see citing works
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
Jepsen, K., Solum, D., Zhou, T., McEvilly, R. J., Kim, H., Glass, C. K., Hermanson, O., & Rosenfeld, M. G. (2007) · Nature · doi:10.1038/nature06270 · Cited by 399 · see citing works
Kapogiannis, D., Boxer, A. L., Schwartz, J. B., Abner, E. L., Biragyn, A., Masharani, U. B., Frassetto, L. A., Petersen, R. C., Miller, B. L., & Goetzl, E. J. (2014) · The FASEB Journal · doi:10.1096/fj.14-262048 · Cited by 345 · see citing works
Effects of Amino Acid Feedings in Schizophrenic Patients Treated with Iproniazid
Pollin, W., Cardon, P. V., & Kety, S. S. (1961) · Science · doi:10.1126/science.133.3446.104 · Cited by 340 · see citing works
McCarthy, S. E., Gillis, J., Kramer, M., Lihm, J., Yoon, S. C., Berstein, Y., Mistry, M., Pavlidis, P., Solomon, R., Ghiban, E., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.29 · Cited by 332 · see citing works
Arion, D., Unger, T. L., Lewis, D. A., Levitt, P. R., & Mirnics, K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.021 · Cited by 328 · see citing works
A common brain network links development, aging, and vulnerability to disease
Douaud, G., Groves, A. R., Tamnes, C. K., Westlye, L. T., Duff, E. P., Engvig, A., Walhovd, K. B., James, A., Gass, A., Monsch, A. U., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410378111 · Cited by 317 · see citing works
Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients
Wockner, L. F., Noble, E. P., Lawford, B. R., Young, R. M., Morris, C. P., Whitehall, V., & Voisey, J. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.111 · Cited by 306 · see citing works
Genes, environment and schizophrenia
Tsuang, M. T., Stone, W. S., & Faraone, S. V. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.40.s18 · Cited by 304 · see citing works
Obstetric Complications and the Risk of Schizophrenia
Dalman, C., Allebeck, P., Cullberg, J., Grünewald, C., & Köster, M. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.234 · Cited by 291 · see citing works
Prenatal Nutritional Deficiency and Risk of Adult Schizophrenia
Brown, A. S., & Susser, E. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn096 · Cited by 290 · see citing works
Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized
Bienvenu, T., & Chelly, J. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1878 · Cited by 289 · see citing works
Obstetric complications and risk of schizophrenia
Thomas, H. V., Dalman, C., David, A. S., Gentz, J., Lewis, G., & Allebeck, P. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.5.409 · Cited by 277 · see citing works
Neurocognitive Endophenotypes in a Multiplex Multigenerational Family Study of Schizophrenia
Gur, R. E., Nimgaonkar, V. L., Almasy, L. A., Calkins, M. E., Ragland, J. D., Pogue‐Geile, M. F., Kanes, S., Blangero, J., & Gur, R. C. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.5.813 · Cited by 273 · see citing works
Self-citationEpigenome-wide differences in pathology-free regions of multiple sclerosis–affected brains
Huynh, J. L., Garg, P., Thin, T. H., Yoo, S., Dutta, R., Trapp, B. D., Haroutunian, V. H., Zhu, J., Donovan, M. J., Sharp, A. J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3588 · Cited by 273 · see citing works
Aberg, K. A., McClay, J. L., Nerella, S., Clark, S., Kumar, G., Chen, W., Khachane, A. N., Xie, L., Hudson, A., Gao, G., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3730 · Cited by 248 · see citing works
The Dutch Famine and schizophrenia spectrum disorders
Hoek, H. W., Brown, A. S., & Susser, E. (1998) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s001270050068 · Cited by 244 · see citing works
Maternal Infection and Schizophrenia: Implications for Prevention
Brown, A. S., & Patterson, P. H. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq146 · Cited by 216 · see citing works
Animal Models of Neuropsychiatric Disorders
Fernando, A. B. P., & Robbins, T. W. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104454 · Cited by 216 · see citing works
Nicodemus, K. K., Marenco, S., Batten, A. J., Vakkalanka, R., Egan, M. F., Straub, R. E., & Weinberger, D. R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002153 · Cited by 192 · see citing works
Self-citationThe role of seladin‐1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo
Crameri, A., Biondi, E., Kuehnle, K., Lütjohann, D., Thelen, K., Perga, S., Dotti, C. G., Nitsch, R. M., Ledesma, M. D., & Mohajeri, M. H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600938 · Cited by 170 · see citing works
Çağlayan, Ş., Takagi‐Niidome, S., Liao, F., Carlo, A.-S., Schmidt, V., Burgert, T., Kitago, Y., Füchtbauer, E., Füchtbauer, A. C., Holtzman, D. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007747 · Cited by 169 · see citing works
Calkins, M. E., Dobie, D. J., Cadenhead, K. S., D, A. O. M., Freedman, R., Green, M. F., Greenwood, T. A., Gur, R. E., Gur, R. C., Light, G. A., et al. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl044 · Cited by 160 · see citing works
Self-citationYuan, P., Zhou, R., Wang, Y., Li, X., Li, J., Chen, G., Guitart, X., & Manji, H. K. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.017 · Cited by 160 · see citing works
Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
Pidsley, R., Viana, J., Hannon, E., Spiers, H., Troakes, C., Al-Saraj, S., Mechawar, N., Turecki, G., Schalkwyk, L. C., Bray, N. J., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0483-2 · Cited by 157 · see citing works
Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress
Manolopoulos, K. N., Klotz, L.-O., Korsten, P., Bornstein, S. R., & Barthel, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.17 · Cited by 150 · see citing works
Methylation Patterns in Whole Blood Correlate With Symptoms in Schizophrenia Patients
Liu, J., Chen, J., Ehrlich, S., Walton, E., White, T. J. H., Perrone‐Bizzozero, N. I., Bustillo, J., Turner, J. A., & Calhoun, V. D. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt080 · Cited by 134 · see citing works
Chen, C., Zhang, C., Cheng, L., Reilly, J. L., Bishop, J. R., Sweeney, J. A., Chen, H., Gershon, E. S., & Liu, C. (2014) · Bipolar Disorders · doi:10.1111/bdi.12255 · Cited by 105 · see citing works
Nishioka, M., Bundo, M., Koike, S., Takizawa, R., Kakiuchi, C., Araki, T., Kasai, K., & Iwamoto, K. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2012.140 · Cited by 101 · see citing works
CpG Sites Associated with Cigarette Smoking: Analysis of Epigenome-Wide Data from the Sister Study
Harlid, S., Xu, Z., Panduri, V., Sandler, D. P., & Taylor, J. A. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307480 · Cited by 100 · see citing works
Genome-scale neurogenetics: methodology and meaning
McCarroll, S. A., Feng, G., & Hyman, S. E. (2014) · Nature Neuroscience · doi:10.1038/nn.3716 · Cited by 87 · see citing works
Nho, K. T., Corneveaux, J. J., Kim, S., Lin, H., Risacher, S. L., Shen, L., Swaminathan, S., Ramanan, V. K., Liu, Y., Foroud, T., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.24 · Cited by 81 · see citing works
DNA Methylation Signatures of Peripheral Leukocytes in Schizophrenia
Kinoshita, M., Numata, S., Tajima, A., Shimodera, S., Ono, S., Imamura, A., Iga, J., Watanabe, S., Kikuchi, K., Kubo, H., et al. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8198-6 · Cited by 78 · see citing works
The genomic psychiatry cohort: Partners in discovery
Pato, M. T., Sobell, J. L., Medeiros, H., Abbott, C., Sklar, B. M., Buckley, P. F., Bromet, E. J., Escamilla, M., Fanous, A. H., Lehrer, D. S., et al. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32160 · Cited by 76 · see citing works
Self-citationCdc37/Hsp90 Protein Complex Disruption Triggers an Autophagic Clearance Cascade for TDP-43 Protein
Jinwal, U. K., Abisambra, J. F., Zhang, J., Dharia, S. P., O’Leary, J. C., Patel, T., Braswell, K., Jani, T., Gestwicki, J. E., & Dickey, C. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.367268 · Cited by 75 · see citing works
Neurocognitive Endophenotypes in a Multiplex Multigenerational Family Study of Schizophrenia
Gur, R. E. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.5.813 · Cited by 72 · see citing works
Self-citationNumata, S., Ye, T., Herman, M., & Lipska, B. K. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00280 · Cited by 70 · see citing works
Suzuki, R., Ferris, H. A., Chee, M. J. S., Maratos–Flier, E., & Kahn, C. R. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001532 · Cited by 70 · see citing works
Maccarrone, G., Ditzen, C., Yassouridis, A., Rewerts, C., Uhr, M., Uhlén, M., Holsboer, F., & Turck, C. W. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.07.021 · Cited by 68 · see citing works
The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia
Roig, B., Virgos, C., Franco, N., Martorell, L., Valero, J., Costas, J., Carracedo, A., Labad, A., & Vilella, E. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001995 · Cited by 56 · see citing works
Aberrant DNA Methylation of Blood in Schizophrenia by Adjusting for Estimated Cellular Proportions
Kinoshita, M., Numata, S., Tajima, A., Ohi, K., Hashimoto, R., Shimodera, S., Imoto, I., Takeda, M., & Ohmori, T. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8319-5 · Cited by 42 · see citing works
Aliyu, M. H., Calkins, M. E., Swanson, C. L., Lyons, P. D., Savage, R. M., May, R., Wiener, H. W., Devlin, B., Nimgaonkar, V. L., Ragland, J. D., et al. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.06.027 · Cited by 38 · see citing works
Self-citationChacón, P. J., del Marco, À., Arévalo, M., Domínguez-Giménez, P., García‐Segura, L. M., & Rodrı́guez-Tébar, A. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.11.006 · Cited by 33 · see citing works
The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation
Hou, P., Liu, G., Zhao, Y., Shi, Z., Zheng, Q., Bu, G., Xu, H., & Zhang, Y.-W. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.005 · Cited by 32 · see citing works
Meltzer, H. Y., Brennan, M. D., Woodward, N. D., & Jayathilake, K. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.08.029 · Cited by 32 · see citing works
Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia
Stephens, S. H., Franks, A. L., Berger, R., Palionyte, M., Fingerlin, T. E., Wagner, B. D., Logel, J., D, A. O. M., Ross, R. G., Freedman, R., et al. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32834c0c33 · Cited by 30 · see citing works
A Novel Role for hGas7b in Microtubular Maintenance
Akiyama, H., Gotoh, A., Shin, R., Koga, T., Ohashi, T., Sakamoto, W., Harada, A., Arai, H., Sawa, A., Uchida, C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.035998 · Cited by 28 · see citing works
Rates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959???1961
Clair, D. S., Xu, M., Wang, P., et al. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000193836.67986.f0 · Cited by 19 · see citing works
Chen, W., Khachane, A. N., Kumar, G., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/mb31-vb14 · Cited by 18 · see citing works
Association between PNPO and schizophrenia in the Japanese population
Song, H., Ueno, S., Numata, S., Iga, J., Shibuya‐Tayoshi, S., Nakataki, M., Tayoshi, S., Yamauchi, K., Sumitani, S., Tomotake, T., et al. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.08.004 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Braun, P. R., Han, S., Hing, B., Nagahama, Y., Gaul, L. N., Heinzman, J. T., Grossbach, A. J., Close, L., Dlouhy, B. J., Howard, M. A., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0376-y · Cited by 467 · see citing works
Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality
García-Gutiérrez, M. S., Navarrete, F., Sala, F., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00432 · Cited by 331 · see citing works
Histone Acetylome-wide Association Study of Autism Spectrum Disorder
Sun, W., Poschmann, J., Cruz-Herrera del Rosario, R., Parikshak, N. N., Hajan, H. S., Kumar, V., Ramasamy, R., Belgard, T. G., Elanggovan, B., Wong, C. C. Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.031 · Cited by 306 · see citing works
Mazza, M. G., Lucchi, S., Rossetti, A., & Clerici, M. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1583371 · Cited by 191 · see citing works
Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0601-3 · Cited by 168 · see citing works
Hannon, E., Dempster, E. L., Mansell, G., Burrage, J., Bass, N., Bohlken, M. M., Corvin, A., Curtis, C. J., Dempster, D., Di Forti, M., et al. (2021) · eLife · doi:10.7554/elife.58430 · Cited by 132 · see citing works
“Two of our experiment-wide significant schizophrenia-associated DMPs (cg00390724 and cg09868768) overlapped with those reported in a previous smaller whole blood schizophrenia EWAS performed by Montano et al., 2016 with the same direction of effect; of note, 119 (71.3”
InfluentialLogue, M. W., Smith, A. K., Wolf, E. J., Maniates, H., Stone, A., Schichman, S. A., McGlinchey, R. E., Milberg, W., & Miller, M. W. (2017) · Epigenomics · doi:10.2217/epi-2017-0078 · Cited by 139 · see citing works
Epigenetic Research in Neuropsychiatric Disorders: the “Tissue Issue”
Bakulski, K. M., Halladay, A., Hu, V. W., Mill, J., & Fallin, M. D. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0083-4 · Cited by 127 · see citing works
Self-citationDNA methylation signatures in panic disorder
Iurato, S., Carrillo-Roa, T., Arloth, J., Czamara, D., Diener-Hölzl, L., Lange, J., Müller-Myhsok, B., Binder, E. B., & Erhardt, A. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0026-1 · Cited by 70 · see citing works
Can epigenetics shine a light on the biological pathways underlying major mental disorders?
Alameda, L., Trotta, G., Quigley, H., Rodriguez, V., Gadelrab, R., Dwir, D., Dempster, E., Wong, C. C. Y., & Forti, M. D. (2022) · Psychological Medicine · doi:10.1017/s0033291721005559 · Cited by 60 · see citing works
“An EWAS by Montano et al. (Montano et al. 2016) found differences in DNAm in genes involved in T-cell development in the blood of SCZ patients (ZC3H12D, TCF3, and IKZF4); other EWAS have also reported an enrichment in the immune system pathway by differently methylated genes (FR2B, PIK3R3, INPP5D,…”
BackgroundInfluentialEpigenetic profiling of human brain differential DNA methylation networks in schizophrenia
Lee, S.-A., & Huang, K.-C. (2016) · BMC Medical Genomics · doi:10.1186/s12920-016-0229-y · Cited by 46 · see citing works
Evaluation of chromatin accessibility in prefrontal cortex of schizophrenia cases and controls
Bryois, J., Garrett, M. E., Song, L., Safi, A., Giusti-Rodriguez, P., Johnson, G. D., Demur, A. B., Fullard, J. F., Roussos, P., Sklar, P., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/141986 · Cited by 7 · see citing works
- Authors
- Montano, C., Taub, M. A., Jaffe, A., Briem, E., Feinberg, J. I., Trygvadottir, R., Idrizi, A., Runarsson, A., Berndsen, B., Gur, R. C., Moore, T. M., Perry, R. T., Fugman, D., Sabunciyan, S., Yolken, R. H., Hyde, T. M., Kleinman, J. E., Sobell, J. L., Pato, C. N., Pato, M. T., Go, R. C., Nimgaonkar, V., Weinberger, D. R., Braff, D., Gur, R. E., Fallin, M. D., & Feinberg, A. P.
- Affiliations
- Medical Scientist Training Program and Predoctoral Training Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland2Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland
- Johns Hopkins University (US)
- Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland
- University of Pennsylvania (US)
- University of Alabama at Birmingham (US)
- Rutgers University Cell and DNA Repository, Piscataway, New Jersey
- Lieber Institute for Brain Development (US)
- University of Southern California (US)
- University of Pittsburgh (US)
- University of California San Diego (US)
- Corresponding author
- Feinberg, Andrew P.
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2016-05-01
- Volume
- 73
- Issue
- 5
- Pages
- 506
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC6353566
- OpenAlex
- W2338895517
- Cited by
- 180
- References
- 75
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 12 · 2023: 13 · 2022: 23 · 2021: 23 · 2020: 19 · 2019: 19 · 2018: 17 · 2017: 23 · 2016: 12
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (U01MH085265, U01MH085270, U01MH085281, U01MH085269, U24MH068457, R01MH085548, U01MH085264)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- schizophrenia, DNA methylation, differentially methylated CpGs, epigenome-wide association study
- MeSH terms
- Adult, Black or African American, Female, Genetic Markers, Humans, Male, Phenotype, Psychotic Disorders, Schizophrenia, Sex Factors, CpG Islands, DNA Methylation, Epigenesis, Genetic, Genome-Wide Association Study, Genetic Loci, Epigenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
