Hirst, Warren D.

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

Booth, H. D. E., Hirst, W. D., & Wade-Martins, R. (2017) · Trends in Neurosciences

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 633

The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

Riddell, D. R., Zhou, H., Comery, T. A., Kouranova, E., Lo, C. F., Warwick, H. K., Ring, R. H., Kirksey, Y., Aschmies, S., Xu, J., et al. (2007) · Molecular and Cellular Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 244

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Henry, A. G., Aghamohammadzadeh, S., Samaroo, H., Chen, Y., Mou, K., Needle, E., & Hirst, W. D. (2015) · Human Molecular Genetics

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 235

Perspective on the current state of the LRRK2 field

Taymans, J.-M., Fell, M., Greenamyre, T., Hirst, W. D., Mamais, A., Padmanabhan, S., Peter, I., Rideout, H., & Thaler, A. (2023) · npj Parkinson's Disease

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 153

Mitochondrial dysfunction in astrocytes: A role in Parkinson’s disease?

Bantle, C. M., Hirst, W. D., Weihofen, A., & Shlevkov, E. (2021) · Frontiers in Cell and Developmental Biology

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 95

The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release

Apicco, D. J., Shlevkov, E., Nezich, C. L., Tran, D. T., Guilmette, E., Nicholatos, J. W., Bantle, C. M., Chen, Y., Glajch, K. E., Abraham, N. A., et al. (2021) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 64