Hay, Nissim

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 4,181

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Jeon, S.-M., Chandel, N. S., & Hay, N. (2012) · Nature

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 1,132

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R. B., & Hay, N. (2001) · Genes & Development

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 961

The two TORCs and Akt

Bhaskar, P. T., & Hay, N. (2007) · Developmental Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 798

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

Nogueira, V., Park, Y., Chen, C.-C., Xu, P.-Z., Chen, M.-L., Tonic, I., Unterman, T., & Hay, N. (2008) · Cancer Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 780

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

Hahn-Windgassen, A., Nogueira, V., Chen, C.-C., Skeen, J. E., Sonenberg, N., & Hay, N. (2005) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 539

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

DeWaal, D., Nogueira, V., Terry, A. R., Patra, K. C., Jeon, S.-M., Guzman, G., Au, J., Long, C. P., Antoniewicz, M. R., & Hay, N. (2018) · Nature Communications

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 525

Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt

Liu, S.-L., Wang, Z.-G., Hu, Y., Xin, Y., Singaram, I., Gorai, S., Zhou, X., Shim, Y., Min, J.-H., Gong, L.-W., et al. (2018) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 141

The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts

Todorovicç, V., Chen, C.-C., Hay, N., & Lau, L. F. (2005) · The Journal of Cell Biology

Connective Tissue Growth Factor ResearchCell death mechanisms and regulation

Cited by 132

Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice

Ding, L., Biswas, S., Morton, R. E., Smith, J. D., Hay, N., Byzova, T. V., Febbraio, M., & Podrez, E. A. (2012) · Cell Metabolism

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 83

Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis

Khanal, S., Liu, Y., Bamidele, A. O., Wixom, A. Q., Washington, A. M., Jalan-Sakrikar, N., Cooper, S. A., Vuckovic, I., Zhang, S., Zhong, J., et al. (2024) · Science Advances

Liver physiology and pathologyExtracellular vesicles in disease

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