Sigvardsson, Mikael

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

Beerman, I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman, I. L., Bryder, D., & Rossi, D. J. (2010) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 711

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy

Pronk, C. J. H., Rossi, D. J., Månsson, R., Attema, J. L., Norddahl, G. L., Chan, C. K. F., Sigvardsson, M., Weissman, I. L., & Bryder, D. (2007) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 671

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

Norddahl, G. L., Pronk, C. J., Wahlestedt, M., Sten, G., Nygren, J. M., Ugale, A., Sigvardsson, M., & Bryder, D. (2011) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationMitochondrial Function and Pathology

Cited by 249

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia

Somasundaram, R., Prasad, M. A. J., Ungerbäck, J., & Sigvardsson, M. (2015) · Blood

Acute Lymphoblastic Leukemia researchT-cell and B-cell Immunology

Cited by 135

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

Wahlestedt, M., Norddahl, G. L., Sten, G., Ugale, A., Frisk, M.-A. M., Mattsson, R., Deierborg, T., Sigvardsson, M., & Bryder, D. (2013) · Blood

Hematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

Cited by 106

Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

Ungerbäck, J., Hosokawa, H., Wang, X., Strid, T., Williams, B. A., Sigvardsson, M., & Rothenberg, E. V. (2018) · Genome Research

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 77

Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif

Siponen, M. I., Wisniewska, M., Lehtiö, L., Johansson, I., Svensson, L., Raszewski, G., Nilsson, L., Sigvardsson, M., & Berglund, H. (2010) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsProtein Structure and Dynamics

Cited by 34

A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5

Gamez-Garcia, A., Espinosa-Alcantud, M., Bueno-Costa, A., Alari-Pahissa, E., Marazuela-Duque, A., Thackray, J. K., Ray, C., Berenguer, C., Kumari, P., Bech, J. J., et al. (2024) · Nature Immunology

Sirtuins and Resveratrol in MedicineT-cell and B-cell Immunology

Cited by 22