Cited by 106Hematopoietic Stem Cell TransplantationPluripotent Stem Cells ResearchMesenchymal stem cell research

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

Open access
Wahlestedt, Martin, Norddahl, Gudmundur L., Sten, Gerd, Ugale, Amol, Frisk, Mary-Ann Micha, Mattsson, Ragnar, Deierborg, Tomas, Sigvardsson, Mikael +1 more·2013·Blood

Abstract

Key Points: Hematopoietic stem cell aging associates with stable transcriptional alterations. Somatic cell reprogramming reverses functional defects associated with hematopoietic aging.

Integrity signals

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Crossref · 10.1182/blood-2012-11-469080

Cites

39 of 39 references verified0 citation errors · 0 not checkable

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  • Old hematopoietic progenitors turned into iPSCs and then into new HSCs in chimeric embryos showed fully rejuvenated hematopoietic activity.

    “This possibility has been supported in part by studies in which aged hematopoietic progenitors were reprogrammed to produce iPSCs. These iPSCs were then used to create new HSCs in a chimeric embryo system and yielded complete rejuvenation of hematopoietic activity183.”

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Authors
Wahlestedt, M., Norddahl, G. L., Sten, G., Ugale, A., Frisk, M.-A. M., Mattsson, R., Deierborg, T., Sigvardsson, M., & Bryder, D.
Affiliations
  • Lund University (SE)
  • Immunology Section,
  • Transgenic Core Facility, and
  • Linköping University (SE)
Venue
Blood
Published
2013-05-23
Volume
121
Issue
21
Pages
4257-4264
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W1972698198
Cited by
106
References
39
Citations by year
2026: 1 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 20 · 2015: 12 · 2014: 10 · 2013: 1
FWCI
10.28
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
hematopoietic stem cell aging, epigenetic aging, induced pluripotent stem cells, hematopoietic progenitor cells, blastocyst complementation, HSC transplantation, chimeras, self-renewal
MeSH terms
Animals, Cell Differentiation, Hematopoietic Stem Cells, Mice, Inbred C57BL, Transcription, Genetic, Telomere, Cellular Senescence, Hematopoietic Stem Cell Transplantation, Gene Expression Regulation, Developmental, Totipotent Stem Cells, Epigenesis, Genetic, Mice, Genome-Wide Association Study

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