An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
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Key Points: Hematopoietic stem cell aging associates with stable transcriptional alterations. Somatic cell reprogramming reverses functional defects associated with hematopoietic aging.
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Old hematopoietic progenitors turned into iPSCs and then into new HSCs in chimeric embryos showed fully rejuvenated hematopoietic activity.
“This possibility has been supported in part by studies in which aged hematopoietic progenitors were reprogrammed to produce iPSCs. These iPSCs were then used to create new HSCs in a chimeric embryo system and yielded complete rejuvenation of hematopoietic activity183.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [183]
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- Authors
- Wahlestedt, M., Norddahl, G. L., Sten, G., Ugale, A., Frisk, M.-A. M., Mattsson, R., Deierborg, T., Sigvardsson, M., & Bryder, D.
- Affiliations
- Lund University (SE)
- Immunology Section,
- Transgenic Core Facility, and
- Linköping University (SE)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-05-23
- Volume
- 121
- Issue
- 21
- Pages
- 4257-4264
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1972698198
- Cited by
- 106
- References
- 39
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 20 · 2015: 12 · 2014: 10 · 2013: 1
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- green
- lup.lub.lu.se
- Licence
- other-oa
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cell aging, epigenetic aging, induced pluripotent stem cells, hematopoietic progenitor cells, blastocyst complementation, HSC transplantation, chimeras, self-renewal
- MeSH terms
- Animals, Cell Differentiation, Hematopoietic Stem Cells, Mice, Inbred C57BL, Transcription, Genetic, Telomere, Cellular Senescence, Hematopoietic Stem Cell Transplantation, Gene Expression Regulation, Developmental, Totipotent Stem Cells, Epigenesis, Genetic, Mice, Genome-Wide Association Study
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