Xu, Guilian

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H.-C., Xu, G., Koliatsos, V. E., et al. (2005) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R., & Savonenko, A. V. (2005) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Comment on “ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.”

Price, A. R., Xu, G., Siemienski, Z. B., Smithson, L. A., Borchelt, D. R., Golde, T. E., & Felsenstein, K. M. (2013) · Science

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Amyloid precursor protein increases cortical neuron size in transgenic mice

Oh, E. S., Savonenko, A. V., King, J. F., Fangmark Tucker, S. M., Rudow, G. L., Xu, G., Borchelt, D. R., & Troncoso, J. C. (2009) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

Xu, G., Ran, Y., Fromholt, S. E., Fu, C., Yachnis, A. T., Golde, T. E., & Borchelt, D. R. (2015) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation

Koller, E. J., Ibanez, K. R., Vo, Q., McFarland, K. N., Gonzalez De La Cruz, E., Zobel, L., Williams, T., Xu, G., Ryu, D., Patel, P., et al. (2022) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Receptor-Associated Protein (RAP) Plays a Central Role in Modulating Aβ Deposition in APP/PS1 Transgenic Mice

Xu, G., Karch, C., Li, N., Lin, N., Fromholt, D., Gonzales, V., & Borchelt, D. R. (2008) · PLoS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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