Comment on “ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.”
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Cramer et al . (Reports, 23 March 2012, p. 1503; published online 9 February 2012) demonstrates short-term bexarotene treatment clearing preexisting β-amyloid deposits from the brains of APP/PS1ΔE9 mice with low amyloid burden, providing a rationale for repurposing this anticancer agent as an Alzheimer’s disease (AD) therapeutic. Using a nearly identical treatment regimen, we were unable to detect any evidence of drug efficacy despite demonstration of target engagement.
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The therapeutic effects of RXR agonists, especially bexarotene, varied widely in follow-up studies.
“the therapeutic effects of RXR agonists, especially bexarotene, varied widely in follow-up studies (13, 14, 15, 16)”
From Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes (2024) · cites this paper as [15]
The effects of bexarotene have been variable in most follow-up studies.
“the effects of bexarotene have been variable in most follow-up studies (13, 14, 15, 16)”
From Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes (2024) · cites this paper as [15]
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ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
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Neuroinflammation in Alzheimer's disease
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Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes
Komai, M., Noda, Y., Ikeda, A., Kaneshiro, N., Kamikubo, Y., Sakurai, T., Uehara, T., & Takasugi, N. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100510 · Cited by 13 · see citing works
- Authors
- Price, A. R., Xu, G., Siemienski, Z. B., Smithson, L. A., Borchelt, D. R., Golde, T. E., & Felsenstein, K. M.
- Affiliations
- University of Florida (US)
- Corresponding author
- Price, Ashleigh R.
- Xu, Guilian
- Felsenstein, Kevin M.
- Venue
- Science
- Published
- 2013-05-24
- Volume
- 340
- Issue
- 6135
- Pages
- 924-924
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972229580
- Cited by
- 138
- References
- 4
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 22 · 2015: 27 · 2014: 30 · 2013: 13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- bexarotene, apolipoprotein E, amyloid-beta clearance, Alzheimer's disease, drug repurposing, target engagement, drug efficacy, amyloid plaques
- MeSH terms
- Alzheimer Disease, Animals, Apolipoproteins E, Brain, Male, Tetrahydronaphthalenes, Amyloid beta-Peptides
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