Skehel, Mark

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

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Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

Ahel, D., Hořejší, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., et al. (2009) · Science

DNA Repair MechanismsPARP inhibition in cancer therapy

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Molecular mechanism of APC/C activation by mitotic phosphorylation

Zhang, S., Chang, L., Alfieri, C., Zhang, Z., Yang, J., Maslen, S., Skehel, M., & Barford, D. (2016) · Nature

Microtubule and mitosis dynamicsUbiquitin and proteasome pathways

Cited by 203

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

Close, P., East, P., Dirac-Svejstrup, A. B., Hartmann, H., Heron, M., Maslen, S., Chariot, A., Söding, J., Skehel, M., & Svejstrup, J. Q. (2012) · Nature

RNA Research and SplicingGenomics and Chromatin Dynamics

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Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

Panayiotou, R., Miralles, F., Pawlowski, R., Diring, J., Flynn, H. R., Skehel, M., & Treisman, R. (2016) · eLife

Protein Kinase Regulation and GTPase SignalingGenomics and Chromatin Dynamics

Cited by 79

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

Liu, Y., Bunney, T. D., Khosa, S., Macé, K., Beckenbauer, K., Askwith, T., Maslen, S., Stubbs, C., de Oliveira, T. M., Sader, K., et al. (2020) · EBioMedicine

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

Ensinck, I., Maman, A., Albihlal, W. S., Lassandro, M., Salzano, G., Sideri, T., Howell, S. A., Calvani, E., Patel, H., Bushkin, G., et al. (2023) · eLife

RNA modifications and cancerRNA Research and Splicing

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A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms

Subtil, F. T., Machado, T. F., Douglas, H., Kirkpatrick, J. M., Skehel, M., Garza-Garcia, A., & de Carvalho, L. P. S. (2026) · eLife

Antibiotic Resistance in BacteriaTuberculosis Research and Epidemiology

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