Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1
Open accessAbstract
Damage, Signal, Maneuver: Cellular processes, such as transcription and DNA repair, require modification and manipulation of chromosomally associated proteins by a diverse set of chromatin remodeling complexes. The mechanisms by which cells regulate chromatin remodeling are not completely understood. During the response elicited by DNA damage, the addition of poly(ADP-ribose) to chromatin is associated with chromatin decondensation, which is thought to promote efficient DNA repair. Ahel et al. (p. 1240 , published online 30 July 2009) have identified a chromatin remodeling enzyme as a DNA damage-response protein, which binds poly(ADP-ribose).
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- Authors
- Ahel, D., Hořejší, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., Owen-Hughes, T., & Boulton, S. J.
- Affiliations
- DNA Damage Response Laboratory, Clare Hall, London Research Institute, South Mimms EN6 3LD, UK.
- University of Dundee (GB)
- University of Cambridge (GB)
- University of Manchester (GB)
- Protein Analysis and Proteomics Laboratory, Clare Hall, London Research Institute, South Mimms EN6 3LD, UK.
- Genetic Recombination Laboratory, Clare Hall, London Research Institute, South Mimms EN6 3LD, UK.
- Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
- Corresponding author
- Wiechens, Nicola
- Polo, Sophie E.
- Boulton, Simon J.
- ORCID
- Venue
- Science
- Published
- 2009-09-04
- Volume
- 325
- Issue
- 5945
- Pages
- 1240-1243
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3443743
- OpenAlex
- W1978727518
- Cited by
- 588
- References
- 38
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 29 · 2023: 25 · 2022: 32 · 2021: 37 · 2020: 35 · 2019: 28 · 2018: 26 · 2017: 38 · 2016: 38 · 2015: 36 · 2014: 36 · 2013: 47 · 2012: 58
- FWCI
- 18.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Funders
- Wellcome Trust (064414)
- Cancer Research UK (A3549, 11224, A5290)
- National Institute for Health and Care Research
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- poly(ADP-ribose), ALC1, CHD1L, chromatin remodeling, DNA repair, DNA damage response, PARP1, nucleosome sliding, histone modifications, post-translational modification, DNA damage sensitivity
- MeSH terms
- Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase-1, Adenosine Triphosphatases, Adenosine Triphosphate, Cell Line, Chromatin, DNA Damage, DNA Repair, DNA Helicases, DNA-Binding Proteins, Humans, Hydrogen Peroxide, Kinetics, Nucleosomes, Phleomycins, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerases, Radiation, Ionizing, Recombinant Proteins, Protein Structure, Tertiary, Chromatin Assembly and Disassembly, Immunoprecipitation, Mutant Proteins
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