Thaler, Joshua P.

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,857

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

Kim, F., Pham, M., Luttrell, I., Bannerman, D. D., Tupper, J., Thaler, J., Hawn, T. R., Raines, E. W., & Schwartz, M. W. (2007) · Circulation Research

Adipokines, Inflammation, and Metabolic DiseasesAtherosclerosis and Cardiovascular Diseases

Cited by 584

Microglial inflammatory signaling orchestrates the hypothalamic immune response to dietary excess and mediates obesity susceptibility.

Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., Gerritse, I., Fasnacht, R., Barres, B. A., Thaler, J. P., et al. (2017) · Cell Metabolism

Neuroinflammation and Neurodegeneration MechanismsRegulation of Appetite and Obesity

Cited by 477

Hormonal and Metabolic Mechanisms of Diabetes Remission after Gastrointestinal Surgery

Thaler, J. P., & Cummings, D. E. (2009) · Endocrinology

Bariatric Surgery and OutcomesDiabetes Treatment and Management

Cited by 443

Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9

Thaler, J., Harrison, K., Sharma, K., Lettieri, K., Kehrl, J., & Pfaff, S. L. (1999) · Neuron

Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Cited by 354

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

Thaler, J. P., & Schwartz, M. W. (2010) · Endocrinology

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 313

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

Douglass, J. D., Dorfman, M. D., Fasnacht, R., Shaffer, L. D., & Thaler, J. P. (2017) · Molecular Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 248

Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia

German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 169

Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes

German, J. P., Wisse, B. E., Thaler, J. P., Oh-I, S., Sarruf, D. A., Ogimoto, K., Kaiyala, K. J., Fischer, J. D., Matsen, M. E., Taborsky, G. J., et al. (2010) · Diabetes

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 159

Hypothalamic inflammation and energy homeostasis: Resolving the paradox

Thaler, J. P., Choi, S. J., Schwartz, M. W., & Wisse, B. E. (2010) · Frontiers in Neuroendocrinology

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 144

BDNF Action in the Brain Attenuates Diabetic Hyperglycemia via Insulin-Independent Inhibition of Hepatic Glucose Production

Meek, T. H., Wisse, B. E., Thaler, J. P., Guyenet, S. J., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2013) · Diabetes

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 80