Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works

Prevalence and Trends in Obesity Among US Adults, 1999-2008

Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works

Inflammation and insulin resistance

Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works

Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects

Sjöström, L., Narbro, K., Sjöström, C. D., Karason, K., Larsson, B., Wedel, H., Lystig, T., Sullivan, M., Bouchard, C., Carlsson, B., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066254 · Cited by 4,668 · see citing works

Annual Medical Spending Attributable To Obesity: Payer-And Service-Specific Estimates

Finkelstein, E. A., Trogdon, J. G., Cohen, J. W., & Dietz, W. H. (2009) · Health Affairs · doi:10.1377/hlthaff.28.5.w822 · Cited by 2,956 · see citing works

Long-term mortality after gastric bypass surgery

Adams, T. D., Gress, R. E., Smith, S. C., Halverson, R. C., Simper, S. C., Rosamond, W. D., LaMonte, M. J., Stroup, A. M., & Hunt, S. C. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066603 · Cited by 2,572 · see citing works

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350 · see citing works

Insulin sensitivity: Modulation by nutrients and inflammation

Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191 · see citing works

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D. E., Tsukumo, D. M. L., Anhe, G., Amaral, M. E., Takahashi, H. K., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2760-08.2009 · Cited by 1,125 · see citing works

Mechanisms of leptin action and leptin resistance.

Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074 · see citing works

Nutrient sensing and inflammation in metabolic diseases

Hotamisligil, G. S., & Erbay, E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2449 · Cited by 1,040 · see citing works

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

Lumeng, C. N., DeYoung, S. M., Bodzin, J. L., & Saltiel, A. R. (2007) · Diabetes · doi:10.2337/db06-1076 · Cited by 1,016 · see citing works

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

Ozcan, L., Ergin, A. S., Lu, A., Chung, J., Sarkar, S., Nie, D., Myers, M. G., & Ozcan, U. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.004 · Cited by 875 · see citing works

Comparison of Strategies for Sustaining Weight Loss<subtitle>The Weight Loss Maintenance Randomized Controlled Trial</subtitle>

Svetkey, L. P. (2008) · JAMA · doi:10.1001/jama.299.10.1139 · Cited by 748 · see citing works

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737 · see citing works

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651 · see citing works

Neuronal PTP1B regulates body weight, adiposity and leptin action

Bence, K. K., Delibegovic, M., Xue, B., Gorgun, C. Z., Hotamisligil, G. S., Neel, B. G., & Kahn, B. B. (2006) · Nature Medicine · doi:10.1038/nm1435 · Cited by 633 · see citing works

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

Posey, K. A., Clegg, D. J., Printz, R. L., Byun, J., Morton, G. J., Vivekanandan-Giri, A., Pennathur, S., Baskin, D. G., Heinecke, J. W., Woods, S. C., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90377.2008 · Cited by 586 · see citing works

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

Kim, F., Pham, M., Luttrell, I., Bannerman, D. D., Tupper, J., Thaler, J., Hawn, T. R., Raines, E. W., & Schwartz, M. W. (2007) · Circulation Research · doi:10.1161/circresaha.106.142851 · Cited by 584 · see citing works

Genetics of Obesity in Humans

Farooqi, I. S., & O’Rahilly, S. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0040 · Cited by 583 · see citing works

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490 · see citing works

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

Kleinridders, A., Schenten, D., Könner, A. C., Belgardt, B. F., Mauer, J., Okamura, T., Wunderlich, F. T., Medzhitov, R., & Brüning, J. C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.013 · Cited by 483 · see citing works

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.01.009 · Cited by 436 · see citing works

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

Moraes, J. C., Coope, A., Morari, J., Cintra, D. E., Roman, E. A., Pauli, J. R., Romanatto, T., Carvalheira, J. B. C., de Oliveira, A. L. R., Saad, M. J. A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005045 · Cited by 427 · see citing works

Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones

Rosenbaum, M., Murphy, E. M., Heymsfield, S. B., Matthews, D. E., & Leibel, R. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.5.2391 · Cited by 407 · see citing works

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.

Zabolotny, J. M., Kim, Y.-B., Welsh, L. A., Kershaw, E. E., Neel, B. G., & Kahn, B. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800061200 · Cited by 404 · see citing works

Attenuation of leptin and insulin signaling by SOCS proteins

Howard, J. K., & Flier, J. S. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.09.007 · Cited by 371 · see citing works

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

Benoit, S. C., Kemp, C. J., Elias, C. F., Abplanalp, W., Herman, J. P., Migrenne, S., Lefevre, A.-L., Cruciani-Guglielmacci, C., Magnan, C., Yu, F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36714 · Cited by 351 · see citing works

Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat

Davis, J. E., Gabler, N. K., Walker‐Daniels, J., & Spurlock, M. E. (2008) · Obesity · doi:10.1038/oby.2008.210 · Cited by 334 · see citing works

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00026.x · Cited by 289 · see citing works

High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

ZHANG, X., Dong, F., Ren, J. T., Driscoll, M., & Culver, B. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.10.011 · Cited by 280 · see citing works

Update on Obesity

Bessesen, D. H. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0520 · Cited by 255 · see citing works

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome

Fessler, M. B., Rudel, L. L., & Brown, J. M. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832fa5c4 · Cited by 248 · see citing works

Defense of differfing body weight set points in diet-induced obese and resistant rats

Levin, B. E., & Keesey, R. E. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.2.r412 · Cited by 245 · see citing works

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39620 · Cited by 214 · see citing works

Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

Ernst, M. B., Wunderlich, C. M., Hess, S., Paehler, M., Mesaros, A., Koralov, S. B., Kleinridders, A., Husch, A., Münzberg, H., Hampel, B., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5712-08.2009 · Cited by 185 · see citing works

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

Reed, A. S., Unger, E. K., Olofsson, L. E., Piper, M. L., Myers, M. G., & Xu, A. W. (2010) · Diabetes · doi:10.2337/db09-1024 · Cited by 176 · see citing works

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

Belgardt, B., Mauer, J., Wunderlich, F. T., Ernst, M. B., Pál, M., Spohn, G., Brönneke, H. S., Brodesser, S., Hampel, B., Schauss, A. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001796107 · Cited by 168 · see citing works

Human IL6 enhances leptin action in mice

Sadagurski, M., Norquay, L., Farhang, J., D’Aquino, K. E., Copps, K. D., & White, M. F. (2009) · Diabetologia · doi:10.1007/s00125-009-1580-8 · Cited by 161 · see citing works

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

White, C. L., Whittington, A., Barnes, M. J., Wang, Z., Bray, G. A., & Morrison, C. D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90513.2008 · Cited by 146 · see citing works

Hypothalamic inflammation and energy homeostasis: Resolving the paradox

Thaler, J. P., Choi, S. J., Schwartz, M. W., & Wisse, B. E. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.002 · Cited by 144 · see citing works

An Integrative View of Obesity

Wisse, B. E., Kim, F., & Schwartz, M. W. (2007) · Science · doi:10.1126/science.1148032 · Cited by 138 · see citing works

Molecular physiology of weight regulation in mice and humans

Leibel, R. L. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.245 · Cited by 138 · see citing works

TNF-α acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient—Effects on leptin and insulin signaling pathways

Romanatto, T., Cesquini, M., do Amaral, M. E. C., Roman, É. A., Moraes, J. C., Torsoni, M. A., Cruz-Neto, A. P., & Velloso, L. A. (2007) · Peptides · doi:10.1016/j.peptides.2007.03.006 · Cited by 131 · see citing works

Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

Picardi, P. K., Calegari, V. C., Prada, P. O., Moraes, J. C., ARAUJO, E. P. D., Gomes‐Marcondes, M. C. C., Ueno, M., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2008) · Endocrinology · doi:10.1210/en.2007-1506 · Cited by 127 · see citing works

Role of the hypothalamic–pituitary–thyroid axis in metabolic regulation by JNK1Preprint

Sabio, G., Cavanagh, J., Barrett, T., Jung, D. Y., Ko, H. J., Ong, H., Morel, C., Mora, A., Reilly, J., Kim, J. K., et al. (2010) · Genes & Development · doi:10.1101/gad.1878510 · Cited by 117 · see citing works

Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids

Choi, S. J., Kim, F., Schwartz, M. W., & Wisse, B. E. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00006.2010 · Cited by 73 · see citing works

Changes in Hypothalamically Mediated Acute-Phase Inflammatory Responses to Lipopolysaccharide in Diet-Induced Obese Rats

Pohl, J., Woodside, B. C., & Luheshi, G. N. (2009) · Endocrinology · doi:10.1210/en.2009-0526 · Cited by 72 · see citing works

Modulation of central leptin sensitivity and energy balance in a rat model of diet‐induced obesity

Fam, B. C., Morris, M. J., Hansen, M. J., Kebede, M. A., Andrikopoulos, S., Proietto, J., & Thorburn, A. W. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00653.x · Cited by 71 · see citing works

Atypical Protein Kinase C Activity in the Hypothalamus Is Required for Lipopolysaccharide-Mediated Sickness Responses

Thaler, J. P., Choi, S. J., Sajan, M. P., Ogimoto, K., Hồng, N. T., Matsen, M. E., Benoit, S. C., Wisse, B. E., Farese, R. V., & Schwartz, M. W. (2009) · Endocrinology · doi:10.1210/en.2009-0509 · Cited by 26 · see citing works

The effect of anti‐inflammatory (aspirin and/or statin) therapy on body weight in Type 2 diabetic individuals: EAT, a retrospective study

Boaz, M., Lisy, L., Zandman‐Goddard, G., & Wainstein, J. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02747.x · Cited by 22 · see citing works

Inflammatory links between obesity and metabolic disease

Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743 · see citing works

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works

Immune system to brain signaling: Neuropsychopharmacological implications

Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195 · see citing works

Obesity and neuroinflammation: A pathway to cognitive impairment

Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 788 · see citing works

Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?

Eckel, R. H., Kahn, S. E., Ferrannini, E., Goldfine, A. B., Nathan, D. M., Schwartz, M. W., Smith, R. J., & Smith, S. R. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0585 · Cited by 560 · see citing works

The role of fatty acids in insulin resistance

Sears, B., & Perry, M. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0123-1 · Cited by 557 · see citing works

Neurological consequences of obesity

O’Brien, P. D., Hinder, L. M., Callaghan, B. C., & Feldman, E. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30084-4 · Cited by 535 · see citing works

An Integrated View of Immunometabolism

Lee, Y. S., Wollam, J., & Olefsky, J. M. (2018) · Cell · doi:10.1016/j.cell.2017.12.025 · Cited by 440 · see citing works

The menace of obesity to depression and anxiety prevalence

Fulton, S., Décarie-Spain, L., Fioramonti, X., Guiard, B., & Nakajima, S. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.10.005 · Cited by 441 · see citing works

Leptin and the Central Nervous System Control of Glucose Metabolism

Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works

Obesity and male infertility: Mechanisms and management

Leisegang, K., Sengupta, P., Agarwal, A. K., & Henkel, R. (2020) · Andrologia · doi:10.1111/and.13617 · Cited by 311 · see citing works

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

Diano, S., Liu, Z.-W., Jeong, J. K., Dietrich, M. O., Ruan, H., Kim, E., Suyama, S., Kelly, K., Gyengési, E., Arbiser, J. L., et al. (2011) · Nature Medicine · doi:10.1038/nm.2421 · Cited by 268 · see citing works

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Cai, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256 · see citing works

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

Williams, K. W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E. D., Deng, Z., Gao, Y., Liu, T., Sohn, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.002 · Cited by 251 · see citing works

Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?

Eckel, R. H., Kahn, S. E., Ferrannini, E., Goldfine, A. B., Nathan, D. M., Schwartz, M. W., Smith, R. J., & Smith, S. R. (2011) · Diabetes Care · doi:10.2337/dc11-0447 · Cited by 249 · see citing works

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

Milanski, M., Arruda, A. P., Coope, A., Ignácio-Souza, L. M., Nuñez, C. E. C., Roman, E. A., Romanatto, T., Pascoal, L. B., Caricilli, A. M., Torsoni, M. A., et al. (2012) · Diabetes · doi:10.2337/db11-0390 · Cited by 225 · see citing works

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

Thaler, J. P., Guyenet, S. J., Dorfman, M. D., Wisse, B. E., & Schwartz, M. W. (2013) · Diabetes · doi:10.2337/db12-1605 · Cited by 203 · see citing works

Structural Brain Changes Associated with Overweight and Obesity

Apo, E. G., Mondragón‐Maya, A., Ferrari-Díaz, M., & Silva‐Pereyra, J. (2021) · Journal of Obesity · doi:10.1155/2021/6613385 · Cited by 203 · see citing works

The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats

Davidson, T. L., Monnot, A. D., Neal, A. U., Martin, A., Horton, J., & Zheng, W. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.05.015 · Cited by 202 · see citing works

Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood

Sasaki, A., de Vega, W. C., St-Cyr, S., Pan, P., & McGowan, P. O. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.044 · Cited by 194 · see citing works

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

Cai, D., & Liu, T. (2012) · Aging · doi:10.18632/aging.100431 · Cited by 189 · see citing works

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works

Chronic disease risk among adults with cerebral palsy: the role of premature sarcopoenia, obesity and sedentary behaviour

Peterson, M. D., Gordon, P. M., & Hurvitz, E. A. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01052.x · Cited by 176 · see citing works

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus

Guilherme, A., Henriques, F. D. S., Bedard, A. H., & Czech, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0165-y · Cited by 173 · see citing works

High-fat diet feeding differentially affects the development of inflammation in the central nervous system

Guillemot‐Legris, O., Masquelier, J., Everard, A., Cani, P. D., Alhouayek, M., & Muccioli, G. G. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0666-8 · Cited by 168 · see citing works

Hypothalamic inflammation: a double‐edged sword to nutritional diseases

Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 159 · see citing works

Partial Reversibility of Hypothalamic Dysfunction and Changes in Brain Activity After Body Mass Reduction in Obese Subjects

van de Sande‐Lee, S., Pereira, F., Cintra, D. E., Fernandes, P. T., Cardoso, A. R., Garlipp, C. R., Chaim, É. A., Pareja, J. C., Geloneze, B., Li, L. M., et al. (2011) · Diabetes · doi:10.2337/db10-1614 · Cited by 148 · see citing works

Neuroinflammatory basis of metabolic syndrome

Purkayastha, S., & Cai, D. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.005 · Cited by 146 · see citing works

Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

Nerurkar, P. V., Johns, L. M., Buesa, L. M., Kipyakwai, G. K., Volper, E. M., Sato, R., Shah, P. A., Fehér, D., Williams, P. G., & Nerurkar, V. R. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-64 · Cited by 145 · see citing works

Hypothalamic syndrome

Müller, H. L., Tauber, M., Lawson, E. A., Özyurt, J., Bison, B., Martinez-Barbera, J.-P., Puget, S., Merchant, T. E., & van Santen, H. M. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00351-z · Cited by 144 · see citing works

Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance

Benzler, J., Ganjam, G. K., Pretz, D., Oelkrug, R., Koch, C. E., Legler, K., Stöhr, S., Culmsee, C., Williams, L. M., & Tups, A. (2015) · Diabetes · doi:10.2337/db14-0093 · Cited by 129 · see citing works

Dim light at night exaggerates weight gain and inflammation associated with a high-fat diet in male mice

Fonken, L. K., Lieberman, R. A., Weil, Z. M., & Nelson, R. J. (2013) · Endocrinology · doi:10.1210/en.2013-1121 · Cited by 125 · see citing works

Molecular Mechanisms Underlying Obesity-Induced Hypothalamic Inflammation and Insulin Resistance: Pivotal Role of Resistin/TLR4 Pathways

Benomar, Y., & Taouis, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00140 · Cited by 131 · see citing works

Exercise protects against high-fat diet-induced hypothalamic inflammation

Yi, C., Al–Massadi, O., Donelan, E. M., Lehti, M., Weber, J., Ress, C., Trivedi, C. J., Müller, T. D., Woods, S. C., & Hofmann, S. M. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.021 · Cited by 121 · see citing works

Serum trace elements in obese Egyptian children: a case–control study

Azab, S. F. A., Saleh, S. H. A., Elsaeed, W. F., Elshafie, M. A., Sherief, L. M., & Esh, A. M. H. (2014) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-40-20 · Cited by 119 · see citing works

Thyroid Hormone Signaling and Homeostasis During Aging

Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117 · see citing works

Obesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive system

Leisegang, K., Henkel, R., & Agarwal, A. (2019) · American Journal of Reproductive Immunology · doi:10.1111/aji.13178 · Cited by 122 · see citing works

Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis

Goldsammler, M., Merhi, Z. O., & Büyük, E. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0366-6 · Cited by 117 · see citing works

Insulin Signaling and Insulin Resistance

BEALE, E. G. (2013) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3182746f95 · Cited by 115 · see citing works

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

Ryan, K. K., Woods, S. C., & Seeley, R. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.013 · Cited by 112 · see citing works

Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin Action

Lindtner, C., Scherer, T., Zieliński, E., Filatova, N., Faßhauer, M., Tonks, N. K., Puchowicz, M., & Buettner, C. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005123 · Cited by 112 · see citing works

Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction

Stoeckel, L. E., Arvanitakis, Z., Gandy, S., Small, D. M., Kahn, C. R., Pascual‐Leone, Á., Pawlyk, A. C., Sherwin, R., & Smith, P. (2016) · F1000Research · doi:10.12688/f1000research.8300.2 · Cited by 112 · see citing works

Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiota

Tian, P., Li, B., He, C., Song, W., Hou, A., Tian, S., Meng, X., Li, K., & Shan, Y. (2016) · Food & Function · doi:10.1039/c6fo00831c · Cited by 111 · see citing works

Ginseng and obesity

Li, Z., & Ji, G. E. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2016.12.005 · Cited by 109 · see citing works

Menopause, obesity and inflammation: interactive risk factors for Alzheimer’s disease

Christensen, A., & Pike, C. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00130 · Cited by 108 · see citing works

Metabolic syndrome induces inflammation and impairs gonadotropin-releasing hormone neurons in the preoptic area of the hypothalamus in rabbits

Morelli, A., Sarchielli, E., Comeglio, P., Filippi, S., Vignozzi, L., Marini, M., Rastrelli, G., Maneschi, E., Cellai, I., Persani, L., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.017 · Cited by 107 · see citing works

The Use of Functional MRI to Study Appetite Control in the CNS

Silva, A. D., Salem, V., Matthews, P. M., & Dhillo, W. S. (2012) · Experimental Diabetes Research · doi:10.1155/2012/764017 · Cited by 105 · see citing works

Glucose homeostasis, obesity and diabetes

Bano, G. (2013) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.02.007 · Cited by 104 · see citing works

Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery

Scott, W. R., & Batterham, R. L. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2011 · Cited by 99 · see citing works

Obesity, inflammation and cognition

Spyridaki, E. C., Avgoustinaki, P. D., & Margioris, A. N. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.05.004 · Cited by 97 · see citing works

Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

Liu, C., Fonken, L. K., Wang, A., Maiseyeu, A., Bai, Y., Wang, T.-Y., Maurya, S. K., Ko, Y.-A., Periasamy, M., Dvonch, T. J., et al. (2014) · Particle and Fibre Toxicology · doi:10.1186/s12989-014-0053-5 · Cited by 96 · see citing works

Exercise Reshapes the Brain: Molecular, Cellular, and Structural Changes Associated with Cognitive Improvements

Augusto‐Oliveira, M., Arrifano, G. D. P., Leal-Nazaré, C. G., Santos-Sacramento, L., Lopes-Araújo, A., Royes, L. F. F., & Lopez, M. E. C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03492-8 · Cited by 104 · see citing works

Chronic high fat feeding increases anxiety-like behaviour and reduces transcript abundance of glucocorticoid signalling genes in the hippocampus of female rats

Sivanathan, S., Thavartnam, K., Arif, S., Elegino, T., & McGowan, P. O. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.036 · Cited by 93 · see citing works

Hypothalamic Obesity in Craniopharyngioma Patients: Disturbed Energy Homeostasis Related to Extent of Hypothalamic Damage and Its Implication for Obesity Intervention

Roth, C. L. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4091774 · Cited by 90 · see citing works

Obesity and sex interact in the regulation of Alzheimer's disease

Moser, V. A., & Pike, C. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.021 · Cited by 89 · see citing works

Long Feeding High-Fat Diet Induces Hypothalamic Oxidative Stress and Inflammation, and Prolonged Hypothalamic AMPK Activation in Rat Animal Model

Cavaliere, G., Viggiano, E., Trinchese, G., Filippo, C. D., Messina, A., Monda, V., Valenzano, A. A., Cincione, R. I., Zammit, C., Cimmino, F., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00818 · Cited by 90 · see citing works

Resistance to type 2 diabetes mellitus: a matter of hormesis?

Kolb, H., & Eizirik, D. L. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.158 · Cited by 86 · see citing works

Diet-Induced Obesity and the Mechanism of Leptin Resistance

Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_16 · Cited by 87 · see citing works

Anti‐aging drugs reduce hypothalamic inflammation in a sex‐specific manner

Sadagurski, M., Cady, G., & Miller, R. A. (2017) · Aging Cell · doi:10.1111/acel.12590 · Cited by 82 · see citing works

Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance

Benomar, Y., Amine, H., Crépin, D., Rifai, S. A., Riffault, L., Gertler, A., & Taouis, M. (2016) · Diabetes · doi:10.2337/db15-1029 · Cited by 81 · see citing works

Neuroanatomical Framework of the Metabolic Control of Reproduction

Hill, J. W., & Elias, C. F. (2018) · Physiological Reviews · doi:10.1152/physrev.00033.2017 · Cited by 79 · see citing works

High-fat diet exposure induces IgG accumulation in hypothalamic microglia

Yi, C., Tschöp, M. H., Woods, S. C., & Hofmann, S. M. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009464 · Cited by 78 · see citing works

Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N

Dalby, M. J., Aviello, G., Ross, A., Walker, A. W., Barrett, P., & Morgan, P. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-33928-4 · Cited by 75 · see citing works

Variations in Adipokine GenesAdipoQ,Lep, andLepRAre Associated with Risk for Obesity-Related Metabolic Disease: The Modulatory Role of Gene-Nutrient Interactions

Enns, J. E., Taylor, C. G., & Zahradka, P. C. (2011) · Journal of Obesity · doi:10.1155/2011/168659 · Cited by 75 · see citing works

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

van Dijk, G., van Heijningen, S., Reijne, A. C., Nyakas, C., van der Zee, E. A., & Eisel, U. L. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00173 · Cited by 75 · see citing works

Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-term

Ziko, I., Luca, S. N. D., Dinan, T., Barwood, J. M., Sominsky, L., Cai, G., Kenny, R., Stokes, L., Jenkins, T. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.014 · Cited by 73 · see citing works

Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy

Peterson, M. D., Gordon, P. M., Hurvitz, E. A., & Burant, C. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00338.2012 · Cited by 73 · see citing works

Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview

Dulloo, A. G., & Montani, J.-P. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01032.x · Cited by 72 · see citing works

Diabetes-related alterations in the enteric nervous system and its microenvironment

Bagyánszki, M. (2012) · World Journal of Diabetes · doi:10.4239/wjd.v3.i5.80 · Cited by 71 · see citing works

Leptin and zinc relation : In regulation of food intake and immunity

Baltacı, A. K., & Moğulkoç, R. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105579 · Cited by 68 · see citing works

Higher body mass index is linked to altered hypothalamic microstructure

Thomas, K., Beyer, F., Lewe, G., Zhang, R., Schindler, S., Schönknecht, P., Stümvoll, M., Villringer, A., & Witte, A. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-53578-4 · Cited by 67 · see citing works

The Nervous System and Metabolic Dysregulation: Emerging Evidence Converges on Ketogenic Diet Therapy

Ruskin, D. N., & Masino, S. A. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00033 · Cited by 67 · see citing works

Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei.

de Kloet, A. D., Pioquinto, D. J., Nguyen, D., Wang, L., Smith, J. A., Hiller, H., & Sumners, C. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.016 · Cited by 66 · see citing works

Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein‐positive cells and microglia in male mice

Cansell, C., Stobbe, K., Sanchez, C., Thuc, O. L., Mosser, C., Fradj, S. B., Leredde, J., Lebeaupin, C., Debayle, D., Fleuriot, L., et al. (2020) · Glia · doi:10.1002/glia.23882 · Cited by 69 · see citing works

Emerging role of glial cells in the control of body weight

García‐Cáceres, C., Fuente-Martín, E., Argente, J., & Chowen, J. A. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.07.001 · Cited by 65 · see citing works

“White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction

Stoeckel, L. E., Arvanitakis, Z., Gandy, S., Small, D. M., Kahn, C. R., Pascual‐Leone, Á., Pawlyk, A. C., Sherwin, R., & Smith, P. (2016) · F1000Research · doi:10.12688/f1000research.8300.1 · Cited by 64 · see citing works

Neuroinflammation in obesity: circulating lipopolysaccharide-binding protein associates with brain structure and cognitive performance

Moreno‐Navarrete, J. M., Blasco, G., Puig, J., Biarnés, C., Rivero, M., Gich, J., Fernández‐Aranda, F., Garre‐Olmo, J., Ramió‐Torrentà, L., Alberich‐Bayarri, Á., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.162 · Cited by 63 · see citing works

Green Tea Polyphenol (−)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice

Mao, L., Hochstetter, D., Yao, L., Zhao, Y., Zhou, J., Wang, Y., & Xu, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205081 · Cited by 62 · see citing works

Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes

Guitton, J., Bandet, C. L., Mariko, M. L., Tan, S., Bourron, O., Benomar, Y., Hajduch, É., & Stunff, H. L. (2020) · Cells · doi:10.3390/cells9071682 · Cited by 61 · see citing works

Obesity-induced increases in sympathetic nerve activity: Sex matters

Brooks, V. L., Shi, Z., Holwerda, S. W., & Fadel, P. J. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.11.006 · Cited by 61 · see citing works

Brain insulin action in schizophrenia: Something borrowed and something new

Agarwal, S. M., Caravaggio, F., Costa-Dookhan, K. A., Castellani, L. N., Kowalchuk, C., Asgariroozbehani, R., Graff‐Guerrero, A., & Hahn, M. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.010 · Cited by 59 · see citing works

White matter integrity differences in obesity: A meta-analysis of diffusion tensor imaging studies

Daoust, J., Schaffer, J., Zeighami, Y., Dagher, A., García‐García, I., & Michaud, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.020 · Cited by 59 · see citing works

Impaired fear extinction retention and increased anxiety-like behaviours induced by limited daily access to a high-fat/high-sugar diet in male rats: Implications for diet-induced prefrontal cortex dysregulation

Baker, K., & Reichelt, A. C. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.10.002 · Cited by 58 · see citing works

Insulin Resistance in Brain and Possible Therapeutic Approaches

Çetinkalp, Ş., Simsir, I. Y., & Ertek, S. (2014) · Current Vascular Pharmacology · doi:10.2174/1570161112999140206130426 · Cited by 58 · see citing works

Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity

Fourrier, C., Bosch‐Bouju, C., Boursereau, R., Sauvant, J., Aubert, A., Capuron, L., Ferreira, G., Layé, S., & Castanon, N. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.316 · Cited by 55 · see citing works

Hypothalamic Damage Is Associated With Inflammatory Markers and Worse Cognitive Performance in Obese Subjects

Puig, J., Blasco, G., Daunis‐i‐Estadella, P., Molina, X., Xifra, G., Ricart, W., Pedraza, S., Fernández‐Aranda, F., & Fernández‐Real, J. M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2682 · Cited by 57 · see citing works

A hypothesis linking the energy demand of the brain to obesity risk

Kuzawa, C. W., & Blair, C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816908116 · Cited by 56 · see citing works

The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective

Roger, C., Lasbleiz, A., Guye, M., Dutour, A., Gaborit, B., & Ranjeva, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.760914 · Cited by 55 · see citing works

PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction

Acosta-Martínez, M. (2012) · Front. Endocrin. · doi:10.3389/fendo.2011.00110 · Cited by 56 · see citing works

Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging

Yin, Z., Raj, D. D. A., Schaafsma, W., van der Heijden, R. A., Kooistra, S. M., Reijne, A. C., Zhang, X., Moser, J., Brouwer, N., Heeringa, P., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00065 · Cited by 56 · see citing works

The immune remodel: Weight loss-mediated inflammatory changes to obesity

Phillips, C. L., & Grayson, B. E. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219900185 · Cited by 56 · see citing works

Oxidative stress in pathologies of male reproductive disorders

Agarwal, A., Leisegang, K., & Sengupta, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815972-9.00002-0 · Cited by 40 · see citing works

Hypothalamic Apelin/Reactive Oxygen Species Signaling Controls Hepatic Glucose Metabolism in the Onset of Diabetes

Drougard, A., Duparc, T., Brénachot, X., Carneiro, L., Gouazé, A., Fournel, A., Geurts, L., Cadoudal, T., Prats, A., Pénicaud, L., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5182 · Cited by 54 · see citing works

Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia

Tran, D. Q., Tse, E. K., Kim, M. H., & Belsham, D. D. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.05.015 · Cited by 54 · see citing works

Global obesity research trends during 1999 to 2017

Zhao, N., Tao, K., Wang, G., & Xia, Z. (2019) · Medicine · doi:10.1097/md.0000000000014132 · Cited by 54 · see citing works

Mechanistic insight into high-fat diet-induced metabolic inflammation in the arcuate nucleus of the hypothalamus

Ullah, R., Rauf, N., Nabi, G., Shen, Y., Yu-Dong, Z., & Fu, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112012 · Cited by 58 · see citing works

High-fat diet and neuroinflammation: The role of mitochondria

Song, M., Bai, Y., & Song, F. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107615 · Cited by 54 · see citing works

Phlorofucofuroeckol B suppresses inflammatory responses by down-regulating nuclear factor κB activation via Akt, ERK, and JNK in LPS-stimulated microglial cells

Yu, D.-K., Lee, B., Kwon, M., Yoon, N., Shin, T., Kim, N.-G., Choi, J., & Kim, H. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.08.028 · Cited by 50 · see citing works

Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation

Khan, S. A., Ali, A., Khan, S. A., Zahran, S. A., Damanhouri, G. A., Azhar, E. I., & Qadri, I. (2014) · Mediators of Inflammation · doi:10.1155/2014/502749 · Cited by 52 · see citing works

Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

Thaler, J. P., & Schwartz, M. W. (2010) · Endocrine Reviews · doi:10.1210/edrv.31.4.9998 · Cited by 19 · see citing works

Does Hypothalamic Inflammation Cause Obesity?

Wisse, B. E., & Schwartz, M. W. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.003 · Cited by 62 · see citing works

Diet-Induced Inflammation of the Hypothalamus in Obesity

Velloso, L. A., ARAUJO, E. P. D., & de Souza, C. T. (2008) · NeuroImmunoModulation · doi:10.1159/000153423 · Cited by 135 · see citing works

Hypothalamic inflammation in obesity and metabolic disease

Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88878 · Cited by 474 · see citing works

Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding

Oh‐I, S., Thaler, J. P., Ogimoto, K., Wisse, B. E., Morton, G. J., & Schwartz, M. W. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00026.2010 · Cited by 62 · see citing works