Clark, William

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Vizioli, M. G., Liu, T., Miller, K. N., Robertson, N. A., Gilroy, K., Lagnado, A. B., Perez-Garcia, A., Kiourtis, C., Dasgupta, N., Lei, X., et al. (2020) · Genes & Development

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 359

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 261

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Flanagan, D. J., Pentinmikko, N., Luopajärvi, K., Willis, N. J., Gilroy, K., Raven, A. P., Mcgarry, L., Englund, J. I., Webb, A. T., Scharaw, S., et al. (2021) · Nature

Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

Cited by 255

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

Sakamaki, J.-I., Wilkinson, S., Hahn, M., Tasdemir, N., O’Prey, J., Clark, W., Hedley, A., Nixon, C., Long, J. S., New, M., et al. (2017) · Molecular Cell

Autophagy in Disease and TherapyProtein Degradation and Inhibitors

Cited by 249

CSF1R(+) macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype

Candido, J. B., Morton, J. P., Bailey, P., Campbell, A. D., Karim, S. A., Jamieson, T., Lapienyte, L., Gopinathan, A., Clark, W., McGhee, E. J., et al. (2018) · Cell Reports

Immune cells in cancerPancreatic and Hepatic Oncology Research

Cited by 224

Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma

Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu, R., Whyte, D., Hedley, A., Laing, S., Kruspig, B., Upstill-Goddard, R., Shaw, R., et al. (2020) · Cancer Discovery

Pancreatic and Hepatic Oncology Researchinterferon and immune responses

Cited by 182

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

Rai, T. S., Cole, J. J., Nelson, D. M., Dikovskaya, D., Faller, W. J., Vizioli, M. G., Hewitt, R. N., Anannya, O., McBryan, T., Manoharan, I., et al. (2014) · Genes & Development

Genomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

Cited by 162

The ERBB network facilitates KRAS-driven lung tumorigenesis

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., et al. (2018) · Science Translational Medicine

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 111

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

Dikovskaya, D., Cole, J. J., Mason, S. M., Nixon, C., Karim, S. A., McGarry, L., Clark, W., Hewitt, R. N., Sammons, M. A., Zhu, J., et al. (2015) · Cell Reports

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 89

Relative Toxicity of Cardiotonic Agents: Some Induce More Cardiac and Skeletal Myocyte Apoptosis and Necrosis In Vivo Than Others

Burniston, J. G., Ellison, G. M., Clark, W. A., Goldspink, D. F., & Tan, L.-B. (2005) · Cardiovascular Toxicology

Cell death mechanisms and regulationCardiac electrophysiology and arrhythmias

Cited by 35

Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration

May, S., Müller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Vande Voorde, J., et al. (2023) · Journal of Hepatology

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 13