NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687 · see citing works

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

Morin, P. J., Sparks, A. B., Kořínek, V., Barker, N., Clevers, H. C., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.275.5307.1787 · Cited by 3,983 · see citing works

Crypt stem cells as the cells-of-origin of intestinal cancer

Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A. R., Sansom, O. J., & Clevers, H. C. (2008) · Nature · doi:10.1038/nature07602 · Cited by 2,159 · see citing works

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951 · see citing works

APC mutations occur early during colorectal tumorigenesis

Powell, S. M., Zilz, N. D., Beazer-barclay, Y. D., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., & Kinzler, K. W. (1992) · Nature · doi:10.1038/359235a0 · Cited by 1,925 · see citing works

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

Moser, A. R., Pitot, H. C., & Dove, W. F. (1990) · Science · doi:10.1126/science.2296722 · Cited by 1,591 · see citing works

Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene

Harada, N., Tamai, Y., Ishikawa, T., Sauer, B., Takaku, K., Oshima, M., & Taketo, M. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5931 · Cited by 1,198 · see citing works

Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium

Marjou, F. E., Janssen, K., Chang, B. H., Li, M., Hindie, V., Chan, L., Louvard, D., Chambon, P., METZGER, D., & Robine, S. (2004) · genesis · doi:10.1002/gene.20042 · Cited by 1,044 · see citing works

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Koo, B., Spit, M., Jordens, I., Low, T. Y., Stange, D. E., van de Wetering, M., van Es, J. H., Mohammed, S., Heck, A. J. R., Maurice, M. M., et al. (2012) · Nature · doi:10.1038/nature11308 · Cited by 991 · see citing works

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Hao, H.-X., Xie, Y., Zhang, Y., Charlat, O., Oster, E., Avello, M., Lei, H., Mickanin, C., Liu, D., Ruffner, H., et al. (2012) · Nature · doi:10.1038/nature11019 · Cited by 962 · see citing works

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., et al. (2016) · Nature · doi:10.1038/nature19768 · Cited by 935 · see citing works

The landscape of somatic mutation in normal colorectal epithelial cells

Lee-Six, H., Olafsson, S., Ellis, P., Osborne, R. J., Sanders, M. A., Moore, L., Georgakopoulos, N., Torrente, F., Noorani, A., Goddard, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1672-7 · Cited by 747 · see citing works

Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene

Shibata, H., Toyama, K., Shioya, H., Ito, M., Hirota, M., Hasegawa, S., Matsumoto, H., Takano, H., Akiyama, T., Toyoshima, K., et al. (1997) · Science · doi:10.1126/science.278.5335.120 · Cited by 605 · see citing works

dMyc Transforms Cells into Super-Competitors

Moreno, E., & Basler, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00262-4 · Cited by 597 · see citing works

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

Blache, P., van de Wetering, M., Duluc, I., Domon–Dell, C., Berta, P., Freund, J., Clevers, H. C., & Jay, P. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311021 · Cited by 507 · see citing works

Notum deacylates Wnt proteins to suppress signalling activity

Kakugawa, S., Langton, P. F., Zebisch, M., Howell, S. A., Chang, T.-H., Liu, Y., Feizi, T., Bineva‐Todd, G., O’Reilly, N., Snijders, A. P., et al. (2015) · Nature · doi:10.1038/nature14259 · Cited by 447 · see citing works

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

Vermeulen, L., Morrissey, E. R., van der Heijden, M., Nicholson, A. M., Sottoriva, A., Buczacki, S. J. A., Kemp, R., Tavaré, S., & Winton, D. J. (2013) · Science · doi:10.1126/science.1243148 · Cited by 397 · see citing works

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Pentinmikko, N., Iqbal, S., Mana, M., Andersson, S., Cognetta, A. B., Suciu, R. M., Roper, J., Luopajärvi, K., Markelin, E., Gopalakrishnan, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1383-0 · Cited by 271 · see citing works

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

Snippert, H. J. G., Schepers, A. G., van Es, J. H., Simons, B. D., & Clevers, H. C. (2013) · EMBO Reports · doi:10.1002/embr.201337799 · Cited by 239 · see citing works

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

van Neerven, S. M., de Groot, N. E., Nijman, L. E., Scicluna, B. P., van Driel, M. S., Lecca, M. C., Warmerdam, D. O., Kakkar, V., Moreno, L. F., Vieira Braga, F. A., et al. (2021) · Nature · doi:10.1038/s41586-021-03558-4 · Cited by 211 · see citing works

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

Takeuchi, O., Fisher, J. K., Suh, H., Harada, H., Malynn, B. A., & Korsmeyer, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504783102 · Cited by 205 · see citing works

SOX9 Maintains Reserve Stem Cells and Preserves Radioresistance in Mouse Small Intestine

Roche, K. C., Gracz, A. D., Liu, X. F., Newton, V. A., Akiyama, H., & Magness, S. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.004 · Cited by 179 · see citing works

Steep Differences in Wingless Signaling Trigger Myc-Independent Competitive Cell Interactions

Vincent, J., Kolahgar, G., Gagliardi, M. E., & Piddini, E. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.021 · Cited by 139 · see citing works

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Huels, D. J., Bruens, L., Hodder, M. C., Cammareri, P., Campbell, A. D., Ridgway, R. A., Gay, D. M., Solar-Abboud, M., Faller, W. J., Nixon, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03426-2 · Cited by 100 · see citing works

Phase III Randomized Trial Assessing Rofecoxib in the Adjuvant Setting of Colorectal Cancer: Final Results of the VICTOR Trial

Midgley, R. S., McConkey, C. C., Johnstone, E. C., Dunn, J., Smith, J. L., Grumett, S. A., Julier, P., Iveson, C., Yanagisawa, Y., Warren, B. F., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.29.6244 · Cited by 99 · see citing works

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Gay, D. M., Ridgway, R. A., Müller, M., Hodder, M. C., Hedley, A., Clark, W. A., Leach, J. D. G., Jackstadt, R., Nixon, C., Huels, D. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08586-3 · Cited by 94 · see citing works

A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

Schmidt, S., Gay, D. M., Uthe, F. W., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M. E., Bryson, S., Warrander, F., Erhard, F., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0408-0 · Cited by 94 · see citing works

NOTUM inhibition increases endocortical bone formation and bone strength

Brommage, R., Liu, J., Vogel, P., Mseeh, F., Thompson, A. Y., Potter, D., Shadoan, M. K., Hansen, G. M., Jeter-Jones, S. L., Cui, J., et al. (2019) · Bone Research · doi:10.1038/s41413-018-0038-3 · Cited by 75 · see citing works

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Kleeman, S. O., Koelzer, V. H., Jones, H. J. S., Vázquez, E. G., Belnoue-Davis, H. L., East, J. E., Arnold, R. R., Koppens, M. A. J., Blake, A., Domingo, E., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-319126 · Cited by 73 · see citing works

The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

Pollard, P. J., Deheragoda, M. G., Segditsas, S., Lewis, A., Rowan, A., Howarth, K. M., Willis, L., Nye, E. L., Reed, A. E. M., Mandir, N., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.058 · Cited by 61 · see citing works

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., et al. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.92 · Cited by 57 · see citing works

Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase

Tarver, J. E., Pabba, P. K., Barbosa, J., Han, Q., Gardyan, M. W., Brommage, R., Thompson, A. Y., Schmidt, J. M., Wilson, A., He, W., et al. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.02.021 · Cited by 41 · see citing works

Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum

Canal, F., Charawi, S., Grimber, G., Houbron, C., Drouet, V., Colnot, S., Terris, B., Cavard, C., & Perret, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150997 · Cited by 19 · see citing works

Oral squamous cell carcinomas: state of the field and emerging directions

Tan, Y., Wang, Z., Xu, M., Li, B., Huang, Z., Qin, S., Nice, E. C., Tang, J., & Huang, C. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00249-w · Cited by 924 · see citing works

Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

Joanito, I., Wirapati, P., Zhao, N., Nawaz, Z., Yeo, G., Lee, F., Eng, C. L. P., Macalinao, D. C., Kahraman, M., Srinivasan, H., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01100-4 · Cited by 434 · see citing works

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 440 · see citing works

Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

Song, P., Gao, Z., Bao, Y., Chen, L., Huang, Y., Liu, Y., Dong, Q., & Wei, X. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01563-4 · Cited by 382 · see citing works

Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution

Yang, D., Jones, M. G., Naranjo, S., Rideout, W. M., Min, K. H., Ho, R., Wu, W., Replogle, J. M., Page, J. L., Quinn, J. J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.04.015 · Cited by 333 · see citing works

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

van Neerven, S. M., de Groot, N. E., Nijman, L. E., Scicluna, B. P., van Driel, M. S., Lecca, M. C., Warmerdam, D. O., Kakkar, V., Moreno, L. F., Vieira Braga, F. A., et al. (2021) · Nature · doi:10.1038/s41586-021-03558-4 · Cited by 211 · see citing works

Organoid cultures for cancer modeling

Yan, H. H. N., Chan, A., Lai, F. P.-L., & Leung, S. Y. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.05.012 · Cited by 163 · see citing works

Mechanistic insights into Wnt–β-catenin pathway activation and signal transduction

Maurice, M. M., & Angers, S. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00823-y · Cited by 161 · see citing works

Cell competition in development, homeostasis and cancer

van Neerven, S. M., & Vermeulen, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00538-y · Cited by 154 · see citing works

Impact of risk factors on early cancer evolution

Weeden, C. E., Hill, W., Lim, E. L., Gronroos, E. C., & Swanton, C. (2023) · Cell · doi:10.1016/j.cell.2023.03.013 · Cited by 143 · see citing works

The translational challenges of precision oncology

Pich, O., Bailey, C., Watkins, T. B. K., Zaccaria, S., Jamal‐Hanjani, M., & Swanton, C. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.04.002 · Cited by 111 · see citing works

Cell competition in intratumoral and tumor microenvironment interactions

Parker, T. M., Gupta, K., Palma, A. M., Yekelchyk, M., Fisher, P. B., Grossman, S. R., Won, K., Madan, E., Moreno, E., & Gogna, R. (2021) · The EMBO Journal · doi:10.15252/embj.2020107271 · Cited by 102 · see citing works

Understanding and targeting prostate cancer cell heterogeneity and plasticity

Tang, D. G. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.11.001 · Cited by 102 · see citing works

Hallmarks of stemness in mammalian tissues

Beumer, J., & Clevers, H. C. (2024) · Cell stem cell · doi:10.1016/j.stem.2023.12.006 · Cited by 91 · see citing works

Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review

Mesgari, H., Esmaelian, S., Nasiri, K., Ghasemzadeh, S., Doroudgar, P., & Payandeh, Z. (2023) · Cancers · doi:10.3390/cancers15235600 · Cited by 81 · see citing works

Emerging strategies to investigate the biology of early cancer

Zhou, R., Tang, X., & Wang, Y. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00754-y · Cited by 70 · see citing works

The gut–liver axis: host microbiota interactions shape hepatocarcinogenesis

Silveira, M. A. D., Bilodeau, S., Greten, T. F., Wang, X. W., & Trinchieri, G. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.02.009 · Cited by 66 · see citing works

One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

Geurts, M. H., Gandhi, S., Boretto, M. G., Akkerman, N., Derks, L. L. M., van Son, G., Celotti, M., Harshuk-Shabso, S., Peci, F., Begthel, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40701-3 · Cited by 66 · see citing works

Retrograde movements determine effective stem cell numbers in the intestine

Azkanaz, M., Corominas‐Murtra, B., Ellenbroek, S. I. J., Bruens, L., Webb, A., Laskaris, D., Oost, K. C., Lafirenze, S. J. A., Annusver, K., Messal, H. A., et al. (2022) · Nature · doi:10.1038/s41586-022-04962-0 · Cited by 66 · see citing works

Tumour heterogeneity and evolutionary dynamics in colorectal cancer

Chan, D. K. H., & Buczacki, S. J. A. (2021) · Oncogenesis · doi:10.1038/s41389-021-00342-x · Cited by 60 · see citing works

The Role of WNT Pathway Mutations in Cancer Development and an Overview of Therapeutic Options

Groenewald, W., Lund, A. H., & Gay, D. M. (2023) · Cells · doi:10.3390/cells12070990 · Cited by 62 · see citing works

Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets

Tate, E. W., Soday, L., de la Lastra, A. L., Wang, M., & Lin, H. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00666-x · Cited by 61 · see citing works

New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer

Caliceti, C., Punzo, A., Silla, A., Simoni, P., Roda, G., & Hrelia, S. (2022) · Nutrients · doi:10.3390/nu14142964 · Cited by 52 · see citing works

Intestinal stem cell dynamics in homeostasis and cancer

Ramadan, R., van Driel, M. S., Vermeulen, L., & van Neerven, S. M. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.01.011 · Cited by 49 · see citing works

Current strategies with implementation of three-dimensional cell culture: the challenge of quantification

Temple, J., Velliou, E. G., Shehata, M., Lévy, R., & Gupta, P. (2022) · Interface Focus · doi:10.1098/rsfs.2022.0019 · Cited by 51 · see citing works

Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening

Luo, Z., Wang, B., Luo, F., Guo, Y., Jiang, N., Wei, J., Wang, X., Tseng, Y., Chen, J., Zhao, B. T., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03034-y · Cited by 47 · see citing works

Opinion: more mouse models and more translation needed for ALS

Fisher, E., Greensmith, L., Malaspina, A., Fratta, P., Hanna, M. G., Schiavo, G., Isaacs, A. M., Orrell, R. W., Cunningham, T. J., & Acevedo‐Arozena, A. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00619-2 · Cited by 42 · see citing works

Injury prevents Ras mutant cell expansion in mosaic skin

Gallini, S., Annusver, K., Rahman, N.-T., Gonzalez, D. G., Yun, S., Matte-Martone, C. C., Xin, T., Lathrop, E., Suozzi, K. C., Kasper, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06198-y · Cited by 41 · see citing works

Dietary and metabolic effects on intestinal stem cells in health and disease

Shay, J. E. S., & Yilmaz, Ö. H. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00980-7 · Cited by 42 · see citing works

BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC

Wang, S., Cheng, H., Li, M., Gao, D., Wu, H., Zhang, S., Huang, Y., & Guo, K. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06870-9 · Cited by 41 · see citing works

APC and P53 mutations synergise to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

Tian, Y., Wang, X., Cramer, Z., Rhoades, J. H., Estep, K. N., Ma, X., Adams‐Tzivelekidis, S., Katona, B. W., Johnson, F. B., Yu, Z., et al. (2023) · Gut · doi:10.1136/gutjnl-2022-329140 · Cited by 40 · see citing works

TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling

Pagano, E., Romano, B., Cicia, D., Iannotti, F. A., Venneri, T., Lucariello, G., Nanì, M. F., Cattaneo, F., Cicco, P. D., D'Armiento, M. R., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15960 · Cited by 41 · see citing works

Somatic Mutation: What Shapes the Mutational Landscape of Normal Epithelia?

Fowler, J. C., & Jones, P. H. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0145 · Cited by 40 · see citing works

Therapeutic Potential of Naturally Occurring Small Molecules to Target the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer

Oliveira, L. F. S., Predes, D., Borges, H. L., & Abreu, J. G. (2022) · Cancers · doi:10.3390/cancers14020403 · Cited by 37 · see citing works

Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition

Flanagan, D. J., Woodcock, S. A., Phillips, C., Eagle, C., & Sansom, O. J. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108179 · Cited by 35 · see citing works

Pleiotropic effects of DCLK1 in cancer and cancer stem cells

Chhetri, D., Vengadassalapathy, S., Venkadassalapathy, S., Balachandran, V., Umapathy, V. R., Veeraraghavan, V. P., Jayaraman, S., Patil, S., Iyaswamy, A., Palaniyandi, K., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.965730 · Cited by 34 · see citing works

Colorectal cancer initiation: Understanding early-stage disease for intervention

Jiang, C., Zhou, Q., Yi, K., Yuan, Y., & Xie, X. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216831 · Cited by 34 · see citing works

The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

Marongiu, F., & DeGregori, J. V. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13275 · Cited by 35 · see citing works

The Roles of Secreted Wnt Ligands in Cancer

Werner, J., Boonekamp, K. E., Zhan, T., & Boutros, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065349 · Cited by 36 · see citing works

Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7

Sui, Y., Jiang, H., Kellogg, C. M., Oh, S., & Janknecht, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1122238 · Cited by 32 · see citing works

Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells

Madan, E., Palma, A. M., Vudatha, V., Kumar, A., Bhoopathi, P., Wilhelm, J., Bernaś, T., Martin, P. C. N., Bilolikar, G., Gogna, A., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02453-3 · Cited by 31 · see citing works

Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis

Sadien, I. D., Adler, S., Mehmed, S., Bailey, S., Sawle, A., Couturier, D., Eldridge, M., Adams, D. J., Kemp, R., Lourenço, F. C., et al. (2024) · Nature · doi:10.1038/s41586-024-08053-0 · Cited by 30 · see citing works

Phenotypic heterogeneity and plasticity in colorectal cancer metastasis

Ogden, S., Metic, N., Leylek, O., Smith, E. A., Berner, A., Baker, A., Uddin, I., Buzzetti, M., Gerlinger, M., Graham, T. A., et al. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100881 · Cited by 30 · see citing works

Cell competition and cancer from Drosophila to mammals

Cong, B., & Cagan, R. L. (2024) · Oncogenesis · doi:10.1038/s41389-023-00505-y · Cited by 30 · see citing works

RNA‐binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA

Xia, R. M., Liu, T., Li, W. G., & Xu, X. Q. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.383 · Cited by 29 · see citing works

Colorectal Cancer Stem Cells: An Overview of Evolving Methods and Concepts

Angelis, M. L. D., Francescangeli, F., Zeuner, A., & Baiocchi, M. (2021) · Cancers · doi:10.3390/cancers13235910 · Cited by 28 · see citing works

Noncoding RNA circBtnl1 suppresses self‐renewal of intestinal stem cells via disruption of Atf4 mRNA stability

Guo, H., Zhang, J., Jiang, Z., Zhu, X., Yang, J., Mu, R., Du, Y., Tian, Y., Zhu, P., & Fan, Z. (2023) · The EMBO Journal · doi:10.15252/embj.2022112039 · Cited by 27 · see citing works

Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?

de Pellegars-Malhortie, A., Lasorsa, L., Mazard, T., Granier, F., & Prévostel, C. (2024) · Pharmaceuticals · doi:10.3390/ph17070949 · Cited by 26 · see citing works

Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease

Colozza, G., Park, S., & Koo, B. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00854-5 · Cited by 25 · see citing works

A comprehensive analysis of the microbiota composition and host driver gene mutations in colorectal cancer

Yuan, D., Tao, Y., Wang, H., Wang, J., Cao, Y., Cao, G., Pan, S., & Yu, Z. (2022) · Investigational New Drugs · doi:10.1007/s10637-022-01263-1 · Cited by 25 · see citing works

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

Heino, S., Fang, S., Lähde, M., Hogstrom, J. M., Nassiri, S., Campbell, A. D., Flanagan, D. J., Raven, A., Hodder, M. C., Nasreddin, N., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj0512 · Cited by 24 · see citing works

Development and Validation of a Novel Histone Acetylation-Related Gene Signature for Predicting the Prognosis of Ovarian Cancer

Dai, Q., & Ye, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.793425 · Cited by 24 · see citing works

Multiomics of Colorectal Cancer Organoids Reveals Putative Mediators of Cancer Progression Resulting from SMAD4 Inactivation

Dijkstra, J. J., Neikes, H. K., Rezaeifard, S., Ma, X., Voest, E. E., Tauriello, D. V. F., & Vermeulen, M. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00551 · Cited by 23 · see citing works

Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors

Oka, T., Higa, T., Sugahara, O., Koga, D., Nakayama, S., & Nakayama, K. I. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2578 · Cited by 23 · see citing works

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential

Wang, Y., Mao, A., Liu, J., Li, P., Zheng, S., Tong, T., Li, Z., Zhang, H., Ma, L., Lin, J., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.07.016 · Cited by 23 · see citing works

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

Avraham‐Davidi, I., Mages, S., Klughammer, J., Moriel, N., Imada, S., Hofree, M., Murray, E. M., Chen, J. H., Pelka, K., Mehta, A., et al. (2025) · eLife · doi:10.1101/2022.10.02.508492 · Cited by 22 · see citing works

Colorectal cancer liver metastasis: genomic evolution and crosstalk with the liver microenvironment

Liu, Q.-L., Zhou, H., Zhou, Z., & Chen, H. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10107-0 · Cited by 22 · see citing works

Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development

Sun, X., Chen, Z., Guo, X., Wang, J., Ge, M., Wong, S. Z. H., Wang, T., Li, S., Yao, M., Johnston, L. A., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.03.016 · Cited by 22 · see citing works

Transforming cancer cells for long-term living with cancer: An inspiring new approach

Jiang, M., Gu, D.-N., Liu, F.-R., Lin, C.-J., & Tian, L. (2023) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2023.02.03 · Cited by 21 · see citing works

Tumor Promoters and Opportunities for Molecular Cancer Prevention

Hill, W., Weeden, C. E., & Swanton, C. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0128 · Cited by 21 · see citing works

Chromosomal Instability, Selection and Competition: Factors That Shape the Level of Karyotype Intra-Tumor Heterogeneity

van den Bosch, T., Derks, S., & Miedema, D. M. (2022) · Cancers · doi:10.3390/cancers14204986 · Cited by 21 · see citing works

A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease

Waddell, S. H., Yao, Y., Olaizola, P., Walker, A., Jarman, E. J., Gournopanos, K., Grãdinaru, A., Christodoulou, E., Gautier, P. E., Boerrigter, M. M., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abq5930 · Cited by 19 · see citing works

Crypt density and recruited enhancers underlie intestinal tumour initiation

Gaynor, L. T., Singh, H., Tie, G., Badarinath, K., Madha, S., Mancini, A., Bhattacharya, S., Hoshino, M., de Sauvage, F. J., Murata, K., et al. (2025) · Nature · doi:10.1038/s41586-024-08573-9 · Cited by 20 · see citing works

Microphysiological systems to study colorectal cancer: state-of-the-art

Ramos, P., Carvalho, M. R., Chen, W., Yan, L., Zhang, C., He, Y., Reis, R. L., & Oliveira, J. M. (2023) · Biofabrication · doi:10.1088/1758-5090/acc279 · Cited by 20 · see citing works

Multi-label transcriptional classification of colorectal cancer reflects tumor cell population heterogeneity

Cascianelli, S., Barbera, C., Ulla, A. A., Grassi, E., Lupo, B., Pasini, D., Bertotti, A., Trusolino, L., Médico, E., Isella, C., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01176-5 · Cited by 20 · see citing works

Integrated whole transcriptome and small RNA analysis revealed multiple regulatory networks in colorectal cancer

Shaath, H., Toor, S. M., Nada, M. A., Elkord, E., & Alajez, N. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-93531-y · Cited by 20 · see citing works

Precancerous niche remodelling dictates nascent tumour persistence

Skrupskelyte, G., Arias, J. E. R., Ajith, H., Dang, Y., Rossetti, D., Han, S., Tang, M. K. S., Béjar, M. T., Colom, B., Fowler, J. C., et al. (2026) · Nature · doi:10.1038/s41586-026-10157-8 · Cited by 26 · see citing works

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Steadman, D., Atkinson, B. N., Zhao, Y., Willis, N. J., Frew, S., Monaghan, A. E., Patel, C., Armstrong, E., Costelloe, K., Magno, L., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01735 · Cited by 19 · see citing works

Somatic Mutations in Normal Tissues: Calm before the Storm

Rahal, Z., Scheet, P. A., & Kadara, H. N. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1508 · Cited by 19 · see citing works

Cell competition, cooperation, and cancer

Marongiu, F., Cheri, S., & Laconi, E. (2021) · Neoplasia · doi:10.1016/j.neo.2021.08.001 · Cited by 18 · see citing works

Colon cancer transcriptome

Mokhtari, K., Peymani, M., Rashidi, M., Hushmandi, K., Ghaedi, K., Taheriazam, A., & Hashemi, M. (2023) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2023.04.002 · Cited by 18 · see citing works

Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention

Kelson, C. O., & Zaytseva, Y. Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1343061 · Cited by 18 · see citing works

Cell competition in primary and metastatic colorectal cancer

van Luyk, M. E., García, A. K., Λάμπρου, Μ., & Suijkerbuijk, S. J. E. (2024) · Oncogenesis · doi:10.1038/s41389-024-00530-5 · Cited by 18 · see citing works

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

Willis, N. J., Mahy, W., Sipthorp, J., Zhao, Y., Woodward, H. L., Atkinson, B. N., Bayle, E. D., Svensson, F., Frew, S., Jeganathan, F., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00162 · Cited by 18 · see citing works

Somatic Mutations in Normal Tissues: New Perspectives on Early Carcinogenesis

Herms, A., & Jones, P. H. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-061421-012447 · Cited by 17 · see citing works

Structural Insights into Notum Covalent Inhibition

Zhao, Y., Svensson, F., Steadman, D., Frew, S., Monaghan, A. E., Bictash, M., Moreira, T., Chalk, R., Lu, W., Fish, P. V., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00701 · Cited by 17 · see citing works

An expanded view of cell competition

Khandekar, A., & Ellis, S. J. (2024) · Development · doi:10.1242/dev.204212 · Cited by 16 · see citing works

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Reissland, M., Hartmann, O., Tauch, S., Bugter, J. M., Prieto-Garcia, C., Schulte, C., Loebbert, S., Solvie, D., Bitman-Lotan, E., Narain, A., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03141-x · Cited by 16 · see citing works

Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

Jacquemin, G., Wurmser, A., Huyghe, M., Sun, W., Homayed, Z., Merle, C., Perkins, M., Qasrawi, F., Richon, S., Dingli, F., et al. (2022) · eLife · doi:10.7554/elife.76541 · Cited by 16 · see citing works

Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

Nakai, K., Lin, H., Yamano, S., Tanaka, S., Kitamoto, S., Saitoh, H., Sakuma, K., Kurauchi, J., Akter, E., Konno, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42774-6 · Cited by 14 · see citing works

Decay of driver mutations shapes the landscape of intestinal transformation

Lourenço, F. C., Sadien, I. D., Wong, K., Adler, S., Sawle, A., Santana, L. S., Hazelwood, L. D., Giavara, G., Nicholson, A. M., Eldridge, M., et al. (2025) · Nature · doi:10.1038/s41586-025-09762-w · Cited by 14 · see citing works

The logistics of Wnt production and delivery

Alvarez‐Rodrigo, I., Willnow, D., & Vincent, J. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.01.006 · Cited by 12 · see citing works

Wound-healing plasticity enables clonal expansion of founder progenitor cells in colitis

Liu, C. Y., Girish, N., Gomez, M. L., Kalski, M., Bernard, J. K., Simons, B. D., & Polk, D. B. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.08.011 · Cited by 14 · see citing works

Prognosis of recurrence after complete resection in early-stage lung adenocarcinoma based on molecular alterations: a systematic review and meta-analysis

Zhou, C., Jing, Z., Liu, W., Ma, Z., Liu, S., & Fang, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-42851-2 · Cited by 14 · see citing works

YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling

Sui, H. X., Deng, W., Chai, Q., Han, B., Zhang, Y., Wei, Z., Li, Z., Wang, T., Feng, J., Yuan, M., et al. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.11.008 · Cited by 13 · see citing works

Clonal cell states link Barrett’s esophagus and esophageal adenocarcinomaPreprint

Gier, R. A., Hueros, R. A. R., Rong, J., DeMarshall, M., Karakasheva, T. A., Muir, A. B., Falk, G. W., Zhang, N. R., & Shaffer, S. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.26.525564 · Cited by 13 · see citing works

Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging

Zhang, Z., Wan, Q., Zhu, Y., Ye, J., Fu, F., Fan, X., Chen, H., Ren, G., Jiang, W., Guo, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61070-z · Cited by 12 · see citing works

Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer

Easwaran, H., & Weeraratna, A. T. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00868-x · Cited by 14 · see citing works

Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

LaBella, K. A., Hsu, W.-H., Li, J., Qi, Y., Liu, Y., Liu, J., Wu, C.-C., Liu, Y., Song, Z., Lin, Y., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.03.020 · Cited by 12 · see citing works

Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer

Mouillet‐Richard, S., Gougèlet, A., Passet, B., Brochard, C., Corre, D. L., Pitasi, C. L., Joubel, C., Sroussi, M., Gallois, C., Lavergne, J., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05164-0 · Cited by 12 · see citing works

Cell competition promotes metastatic intestinal cancer through a multistage process

García, A. K., Ledesma-Terrón, M., Λάμπρου, Μ., Vriend, J., van Luyk, M. E., & Suijkerbuijk, S. J. E. (2024) · iScience · doi:10.1016/j.isci.2024.109718 · Cited by 12 · see citing works

Establishment of a novel mouse model of colorectal cancer by orthotopic transplantation

Chen, C., Fu, Q., Wang, L., Tanaka, S., & Imajo, M. (2025) · BMC Cancer · doi:10.1186/s12885-025-13834-5 · Cited by 12 · see citing works

The CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial

Linssen, J. D. G., van Neerven, S. M., Aelvoet, A. S., Elbers, C. C., Vermeulen, L., & Dekker, E. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02442-3 · Cited by 12 · see citing works

Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium

Gasnier, M., Lim, H. Y. G., & Barker, N. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.01.001 · Cited by 14 · see citing works

Pathophysiology of colitis-associated colorectal cancer

Neufert, C. F., & Neurath, M. F. (2026) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-026-01197-6 · Cited by 11 · see citing works

Upregulation of Fatty Acid Synthase Increases Activity of β-Catenin and Expression of NOTUM to Enhance Stem-like Properties of Colorectal Cancer Cells

Kelson, C. O., Tessmann, J. W., Geisen, M. E., He, D., Wang, C., Gao, T., Evers, B. M., & Zaytseva, Y. Y. (2024) · Cells · doi:10.3390/cells13191663 · Cited by 11 · see citing works

Reflected stemness as a potential driver of the tumour microenvironment

Rodrigues, F. S., Ciccarelli, F. D., & Malanchi, I. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.04.007 · Cited by 11 · see citing works

Rational Construction of a Novel Bioluminescent Substrate for Sensing the Tumor-Associated Hydrolase Notum

Song, L.-L., Sun, M., Shi, J., Tian, Z., Song, Y., Liu, H., Zhao, S., Yin, H., & Ge, G. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c00633 · Cited by 11 · see citing works

Hepatic zonation determines tumorigenic potential of mutant β-catenin

Raven, A., Gilroy, K. L., Jin, H., Waldron, J. A., Leslie, H., Munro, J., Hall, H., Ridgway, R. A., Ford, C. A., Gulhan, D., et al. (2025) · Nature · doi:10.1038/s41586-025-09733-1 · Cited by 10 · see citing works

Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity

Atkinson, B. N., Willis, N. J., Zhao, Y., Patel, C., Frew, S., Costelloe, K., Magno, L., Svensson, F., Jones, E. Y., & Fish, P. V. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115132 · Cited by 10 · see citing works

Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition

van Driel, M. S., Linssen, J. D. G., Flanagan, D. J., Vlahov, N., Nijman, L. E., de Groot, N. E., Elbers, C. C., Köster, J., Sansom, O. J., Vermeulen, L., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.06.008 · Cited by 5 · see citing works

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

van Neerven, S. M., de Groot, N. E., Nijman, L. E., Scicluna, B. P., van Driel, M. S., Lecca, M. C., Warmerdam, D. O., Kakkar, V., Moreno, L. F., Vieira Braga, F. A., et al. (2021) · Nature · doi:10.1038/s41586-021-03558-4 · Cited by 211 · see citing works

Editors' Selections from Relevant Scientific Publications

(2021) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-10-hfl

APC and P53 mutations synergise to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

Tian, Y., Wang, X., Cramer, Z., Rhoades, J. H., Estep, K. N., Ma, X., Adams‐Tzivelekidis, S., Katona, B. W., Johnson, F. B., Yu, Z., et al. (2023) · Gut · doi:10.1136/gutjnl-2022-329140 · Cited by 40 · see citing works

NOTUM-mediated stem cell competition in CRC

Gupta, P., & Das, T. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00827-6 · Cited by 1 · see citing works