Hie, Brian

Evolutionary-scale prediction of atomic level protein structure with a language model

Lin, Z., Akin, H., Rao, R., Hie, B., Zhu, Z., Lu, W., Smetanin, N., Verkuil, R., Kabeli, O., Shmueli, Y., et al. (2022) · Science

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 5,990

Sequence modeling and design from molecular to genome scale with Evo

Nguyen, E., Poli, M., Durrant, M. G., Thomas, A. W., Kang, B., Sullivan, J., Ng, M. Y., Lewis, A., Patel, A., Lou, A., et al. (2024) · Science

Genomics and Phylogenetic StudiesMachine Learning in Bioinformatics

Cited by 592

Sequence modeling and design from molecular to genome scale with Evo

Nguyen, E., Poli, M., Durrant, M. G., Kang, B., Katrekar, D., Li, D. B., Bartie, L. J., Thomas, A. W., King, S. H., Brixi, G., et al. (2024) · Science

Genomics and Phylogenetic StudiesMachine Learning in Bioinformatics

Cited by 580

Learning the language of viral evolution and escape

Hie, B., Zhong, E. D., Berger, B., & Bryson, B. (2021) · Science

vaccines and immunoinformatics approachesEvolution and Genetic Dynamics

Cited by 361

Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design

Hie, B., Bryson, B. D., & Berger, B. (2020) · Cell Systems

Computational Drug Discovery MethodsMachine Learning in Materials Science

Cited by 154

Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk

Tehranchi, A. K., Myrthil, M., Martin, T., Hie, B. L., Golan, D., & Fraser, H. B. (2016) · Cell

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 120

Realizing private and practical pharmacological collaboration

Hie, B., Cho, H., & Berger, B. (2018) · Science

Computational Drug Discovery MethodsPrivacy-Preserving Technologies in Data

Cited by 76

Semantic mining of functional de novo genes from a genomic language model

Merchant, A. T., King, S. H., Nguyen, E., & Hie, B. L. (2024) · Nature

CRISPR and Genetic EngineeringGenomics and Phylogenetic Studies

Cited by 35

BHLHE40 Regulates Myeloid Cell Polarization Through IL‐10–Dependent and –Independent Mechanisms

Hendrix, S. V., Mreyoud, Y., McNehlan, M. E., Smirnov, A., Chavez, S. M., Hie, B., Chamberland, M. M., Bradstreet, T. R., Webber, A. M., Kreamalmeyer, D., et al. (2024) · The Journal of Immunology

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 7

Mechanistic Design and Scaling of Hybrid Architectures

Poli, M., Thomas, A. W., Nguyen, E., Ponnusamy, P., Deiseroth, B., Kersting, K., Suzuki, T., Hie, B., Ermon, S., Ré, C., et al. (2024) · arXiv

Topic ModelingNatural Language Processing Techniques

Cited by 4