Brookes, Sharon

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts.

McConnell, B. B., Starborg, M., Brookes, S., & Peters, G. (1998) · Current Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 314

INK4a‐deficient human diploid fibroblasts are resistant to RAS‐induced senescence

Brookes, S., Rowe, J., Ruas, M., Llanos, S., Clark, P. A., Lomax, M., James, M. C., Vatcheva, R., Bates, S., Vousden, K. H., et al. (2002) · The EMBO Journal

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 220

Biallelic Mutations in p16INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts

Huot, T. J., Rowe, J., Harland, M., Drayton, S., Brookes, S., Gooptu, C., Purkis, P., Fried, M., Bataille, V., Hara, E., et al. (2002) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 107

Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts

Pemberton, H., Anderton, E., Patel, H., Brookes, S., Chandler, H., Palermo, R., Stock, J., Rodriguez-Niedenführ, M., Racek, T., de Breed, L., et al. (2014) · Genome Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 50

Ribosomal S6 kinase 1 regulates ‘inflammaging’ via the senescence secretome

Gallage, S., Irvine, E. E., Pedroni, S. M. A., Barragan Avila, J. E., Khadayate, S., Pombo, J., Brookes, S., Heide, D., Dharmalingham, G., Choudhury, A. I., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 31

XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence

Innes, A. J., Sun, B., Wagner, V., Brookes, S., McHugh, D., Pombo, J., Porreca, R. M., Dharmalingam, G., Vernia, S., Zuber, J., et al. (2021) · Genes & Development

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 30