Biallelic Mutations in p16INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.

Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650 · see citing works

Regulation of p53 stability by Mdm2

Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · see citing works

Production of high-titer helper-free retroviruses by transient transfection.

Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267 · see citing works

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

Pinkel, D., Segraves, R., Sudar, D., Clark, S. M., Poole, I., Kowbel, D., Collins, C. C., Kuo, W.-L., Chen, C., Zhai, Y., et al. (1998) · Nature Genetics · doi:10.1038/2524 · Cited by 2,238 · see citing works

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Morgenstern, J. P., & Land, H. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3587 · Cited by 2,099 · see citing works

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626 · see citing works

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81079-x · Cited by 1,585 · see citing works

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566 · see citing works

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

Stott, F. J., Bates, S., James, M. C., McConnell, B. B., Starborg, M., Brookes, S., Palmero, I., Ryan, K. M., Hara, E., Vousden, K. H., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5001 · Cited by 1,165 · see citing works

The INK4a/ARF network in tumour suppression

Sherr, C. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096061 · Cited by 984 · see citing works

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Lin, A. W., Barradas, M., Stone, J. C., van Aelst, L., Serrano, M., & Lowe, S. W. (1998) · Genes & Development · doi:10.1101/gad.12.19.3008 · Cited by 945 · see citing works

p14ARF links the tumour suppressors RB and p53

Bates, S., Phillips, A. C., Clark, P. A., Stott, F., Peters, G., Ludwig, R. L., & Vousden, K. H. (1998) · Nature · doi:10.1038/25867 · Cited by 918 · see citing works

The p16INK4a/CDKN2A tumor suppressor and its relatives

Ruas, M., & Peters, G. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(98)00017-1 · Cited by 911 · see citing works

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

Sharpless, N. E., Bardeesy, N., Lee, K.-H., Carrasco, D., Castrillon, D. H., Aguirre, A. J., Wu, E. A., Horner, J. W., & DePinho, R. A. (2001) · Nature · doi:10.1038/35092592 · Cited by 848 · see citing works

Senescence of human fibroblasts induced by oncogenic Raf

Zhu, J., Woods, D., McMahon, M., & Bishop, J. M. (1998) · Genes & Development · doi:10.1101/gad.12.19.2997 · Cited by 826 · see citing works

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosisPreprint

Müller, H., Bracken, A. P., Vernell, R., Moroni, M. C., Christians, F. C., Grassilli, E., Prosperini, E., Vigo, E., Oliner, J. D., & Helin, K. (2001) · Genes & Development · doi:10.1101/gad.864201 · Cited by 752 · see citing works

Cellular Senescence

Sherr, C. J., & DePinho, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00046-5 · Cited by 745 · see citing works

Regulation of p16 <i> ^CDKN2 </i> Expression and Its Implications for Cell Immortalization and Senescence

Hara, E., Smith, R., Parry, D., Tahara, H., Stone, S., & Peters, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.859 · Cited by 733 · see citing works

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

Ohtani, N., Zebedee, Z., Huot, T. J. G., Stinson, J. A., Sugimoto, M., Ohashi, Y., Sharrocks, A. D., Peters, G., & Hara, E. (2001) · Nature · doi:10.1038/35059131 · Cited by 654 · see citing works

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

Krimpenfort, P., Quon, K. C., Mooi, W. J., Loonstra, A., & Berns, A. (2001) · Nature · doi:10.1038/35092584 · Cited by 568 · see citing works

PML is induced by oncogenic <i>ras</i> and promotes premature senescence

Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., & Lowe, S. W. (2000) · Genes &amp; Development · doi:10.1101/gad.14.16.2015 · Cited by 536 · see citing works

The INK4A/ARF locus and its two gene products.

Sharpless, N. E., & DePinho, R. A. (1999) · Current Opinion in Genetics &amp; Development · doi:10.1016/s0959-437x(99)80004-5 · Cited by 533 · cited 1× · see citing works

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

Russo, A. A., Tong, L., Lee, J.-O., Jeffrey, P. D., & Pavletich, N. P. (1998) · Nature · doi:10.1038/26155 · Cited by 524 · see citing works

Regulation of p53 stability

Ashcroft, M. A., & Vousden, K. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203012 · Cited by 407 · see citing works

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

Wright, W. E., & Shay, J. W. (2000) · Nature Medicine · doi:10.1038/78592 · Cited by 398 · see citing works

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

Soufir, N. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.2.209 · Cited by 383 · see citing works

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

Robertson, K. D., & Jones, P. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6457 · Cited by 352 · see citing works

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts.

McConnell, B. B., Starborg, M., Brookes, S., & Peters, G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70137-x · Cited by 314 · see citing works

Genes involved in senescence and immortalization

Lundberg, A. S., Hahn, W. C., Gupta, P., & Weinberg, R. A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00155-1 · Cited by 313 · see citing works

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

Gruis, N. A., van der Velden, P. A., Sandkuijl, L. A., Prins, D. E. M., Weaver-Feldhaus, J., Kamb, A., Bergman, W., & Frants, R. R. (1995) · Nature Genetics · doi:10.1038/ng0795-351 · Cited by 309 · see citing works

A germline deletion of p14ARF but not CDKN2A in a melanoma-neural system tumour syndrome family

Randerson‐Moor, J. A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.1.55 · Cited by 280 · see citing works

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus

Llanos, S., Clark, P. A., Rowe, J., & Peters, G. G. (2001) · Nature Cell Biology · doi:10.1038/35074506 · Cited by 252 · see citing works

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

Midgley, C., Desterro, J. M. P., Saville, M. K., Howard, S. F., Sparks, A., Hay, R. T., & Lane, D. P. (2000) · Oncogene · doi:10.1038/sj.onc.1203593 · Cited by 250 · see citing works

INK4a‐deficient human diploid fibroblasts are resistant to RAS‐induced senescence

Brookes, S., Rowe, J., Ruas, M., Llanos, S., Clark, P. A., Lomax, M., James, M. C., Vatcheva, R., Bates, S., Vousden, K. H., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf289 · Cited by 220 · see citing works

Role of p14^ARF in Replicative and Induced Senescence of Human Fibroblasts

Wei, W., Hemmer, R. M., & Sedivy, J. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.6748-6757.2001 · Cited by 217 · see citing works

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

Brotherton, D. H., Dhanaraj, V., Wick, S., Brizuela, L., Domaille, P. J., Volyanik, E., Xu, X., Parisini, E., Smith, B. O., Archer, S. J., et al. (1998) · Nature · doi:10.1038/26164 · Cited by 210 · see citing works

Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells

Sedivy, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9078 · Cited by 182 · see citing works

p16Ink4a in Melanocyte Senescence and Differentiation

Sviderskaya, E. V. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.6.446 · Cited by 177 · see citing works

A melanoma-associated germline mutation in exon 1β inactivates p14ARF

Rizos, H., Puig, S., Bádenas, C., Malvehy, J., Darmanian, A., Jiménez, L., Milà, M., & Kefford, R. F. (2001) · Oncogene · doi:10.1038/sj.onc.1204728 · Cited by 171 · see citing works

Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts.

Wei, S., Wei, S., & Sedivy, J. M. (1999) · PubMed · Cited by 166 · see citing works

Germline Mutations of the CDKN2 Gene in UK Melanoma Families

Harland, M., Meloni, R., Gruis, N. A., Pinney, E., Brookes, S., Spurr, N. K., Frischauf, A., Bataille, V. A., Peters, G., Cuzick, J. M., et al. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.12.2061 · Cited by 141 · see citing works

Risky immortalization by telomerase

Wang, J., Hannon, G. J., & Beach, D. (2000) · Nature · doi:10.1038/35015674 · Cited by 133 · see citing works

Immortalisation and transformation revisited

Drayton, S. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00271-4 · Cited by 126 · see citing works

Differential effects of p19 Arf and p16 Ink4a loss on senescence of murine bone marrow-derived preB cells and macrophages

Randle, D. H., Zindy, F., Sherr, C. J., & Roussel, M. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171217498 · Cited by 108 · see citing works

Analysis of Genomic Integrity and p53-Dependent G1Checkpoint in Telomerase-Induced Extended-Life-Span Human Fibroblasts

Vaziri, H., Squire, J. A., Pandita, T. K., Bradley, G., Kuba, R. M., Zhang, H., Gulyás, S., Hill, R. P., Nolan, G. P., & Benchimol, S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2373 · Cited by 104 · see citing works

Contribution of two independent MDM2-binding domains in p14ARF to p53 stabilization

Lohrum, M. A. E., Ashcroft, M. A., Kubbutat, M. H. G., & Vousden, K. H. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00472-3 · Cited by 91 · see citing works

Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information

Ruas, M., Brookes, S., McDonald, N. Q., & Peters, G. G. (1999) · Oncogene · doi:10.1038/sj.onc.1202918 · Cited by 74 · see citing works

p16INK4A and p15INK4B gene deletions in primary leukemias

Haidar, M., Cao, X., Manshouri, T., Chan, L. L., Glassman, A. B., Kantarjian, H., Keating, M. J., Beran, M., & Albitar, M. X. (1995) · Blood · doi:10.1182/blood.v86.1.311.bloodjournal861311 · Cited by 71 · see citing works

Genetic heterogeneity in familial malignant melanoma

MacGeoch, C., Newton‐Bishop, J., Batallle, V., Bishop, D. T., Frischauf, A.-M., Melonl, R., Cuzlck, J., Plnney, E., & Spurr, N. K. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.12.2195 · Cited by 63 · see citing works

Mutation testing in melanoma families: INK4A, CDK4 and INK4D

Newton‐Bishop, J., Harland, M., Bennett, D. C., Bataille, V. A., Goldstein, A. M., Tucker, M. A., Ponder, B. A. J., Cuzick, J. M., Selby, P., & Bishop, D. T. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690354 · Cited by 61 · see citing works

Ankyrin for clues about the function 0fp16INK4a

McDonald, N. Q., & Peters, G. G. (1998) · Nature Structural Biology · doi:10.1038/nsb0298-85 · Cited by 11 · see citing works

Chromosome-specific telomeric associations in Chinese hamster embryonic cells

Slijepčević, P., Xiao, Y., & Natarajan, A. T. (2000) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(200005)28:1 · Cited by 8 · see citing works

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works

Ink4a/Arf expression is a biomarker of aging

Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works

The Regulation of INK4/ARF in Cancer and Aging

Kim, W. Y., & Sharpless, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.10.003 · Cited by 1,009 · see citing works

Comparative biology of mouse versus human cells: modelling human cancer in mice

Rangarajan, A., & Weinberg, R. A. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1235 · Cited by 567 · see citing works

Species- and cell type-specific requirements for cellular transformation

Rangarajan, A., Hong, S. J., Gifford, A., & Weinberg, R. A. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.07.009 · Cited by 555 · see citing works

INK4a/ARF: A multifunctional tumor suppressor locus

Sharpless, N. E. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.08.021 · Cited by 442 · see citing works

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

Gray-Schopfer, V. C., Cheong, S. C., Chong, H., Chow, J., Moss, T., Abdel-Malek, Z. A., Marais, R., Wynford-Thomas, D., & Bennett, D. C. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603283 · Cited by 394 · see citing works

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

Song, M. S., Carracedo, A., Salmena, L., Song, S. J., Egia, A., Malumbres, M., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2010.12.020 · Cited by 375 · see citing works

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

Astle, M. V., Hannan, K. M., Ng, P. Y., Lee, R. S., George, A. J., Hsu, A. K., Haupt, Y., Hannan, R. D., & Pearson, R. B. (2012) · Oncogene · doi:10.1038/onc.2011.394 · Cited by 295 · see citing works

Senescence, apoptosis and therapy — cutting the lifelines of cancer

Schmitt, C. A. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1044 · Cited by 295 · see citing works

p38 MAP Kinase's Emerging Role as a Tumor Suppressor

Bulavin, D. V., & Fornace, A. J. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)92005-2 · Cited by 290 · see citing works

The p16&lt;SUP&gt;INK4a&lt;/SUP&gt;-RB pathway : molecular link between cellular senescence and tumor suppression

Ohtani, N., Yamakoshi, K., Takahashi, A., & Hara, E. (2004) · The Journal of Medical Investigation · doi:10.2152/jmi.51.146 · Cited by 276 · see citing works

Cellular senescence and cancer treatment

Schmitt, C. A. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.005 · Cited by 254 · see citing works

The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis

Sharpless, N. E., Ramsey, M. R., Balasubramanian, P., Castrillon, D. H., & DePinho, R. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207074 · Cited by 224 · see citing works

The tumor-suppressive functions of the human INK4A locus

Voorhoeve, P. M., & Agami, R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00223-x · Cited by 194 · see citing works

p16 Is Required for hSNF5 Chromatin Remodeler-induced Cellular Senescence in Malignant Rhabdoid Tumor Cells

Oruetxebarria, I., Venturini, F., Kekarainen, T., Houweling, A., Zuijderduijn, L. M. P., Mohd-Sarip, A., Vries, R. G. J., Hoeben, R. C., & Verrijzer, C. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309333200 · Cited by 160 · see citing works

Regulation of growth arrest in senescence: Telomere damage is not the end of the story

Herbig, U., & Sedivy, J. M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.002 · Cited by 159 · see citing works

The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

Li, M., Shin, Y.-H., Hou, L., Huang, X., Wei, Z., Klann, E., & Zhang, P. (2008) · Nature Cell Biology · doi:10.1038/ncb1768 · Cited by 156 · see citing works

Ink4a/Arf links senescence and aging

Sharpless, N. E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.025 · Cited by 142 · see citing works

Molecular signature of oncogenic ras-induced senescence

Mason, D. X., Jackson, T. J., & Lin, A. W. (2004) · Oncogene · doi:10.1038/sj.onc.1208172 · Cited by 127 · see citing works

p16/Cyclin-Dependent Kinase Inhibitor 2A Deficiency in Human Melanocyte Senescence, Apoptosis, and Immortalization: Possible Implications for Melanoma Progression

Sviderskaya, E. V., Gray‐Schopfer, V. C., Hill, S. P., Smit, N. P. M., Evans-Whipp, T. J., BOND, J. A., Hill, L., Bataille, V. A., Peters, G., Kipling, D., et al. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.10.723 · Cited by 123 · see citing works

The Ets transcription factors of the PEA3 group: Transcriptional regulators in metastasis

de Launoit, Y., Baert, J., Chotteau‐Lelièvre, A., Monté, D., Coutte, L., Mauën, S., Firlej, V., Degerny, C., & Verreman, K. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.02.002 · Cited by 115 · see citing works

Cellular senescence: Its role in tumor suppression and aging

Ohtani, N., Mann, D. J., & Hara, E. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01123.x · Cited by 113 · see citing works

Frequent p16-Independent Inactivation of p14ARF in Human Melanoma

Freedberg, D. E., Rigas, S. H., Russak, J. E., Gai, W., Kaplow, M., Osman, I., Turner, F., Randerson‐Moor, J. A., Houghton, A. N., BUSAM, K. J., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn157 · Cited by 110 · see citing works

Consistent expression of the stem cell renewal factor BMI‐1 in primary and metastatic melanoma

Mihic‐Probst, D., Kuster, A., Kilgus, S., Bode‐Lesniewska, B., Ingold‐Heppner, B., Leung, C., Storz, M., Seifert, B., Marino, S., Schraml, P., et al. (2007) · International Journal of Cancer · doi:10.1002/ijc.22891 · Cited by 106 · see citing works

Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5

Ohtani, N., Brennan, P., Gaubatz, S., Sanij, E., Hertzog, P. J., Wolvetang, E. J., Ghysdael, J., Rowe, M., & Hara, E. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302085 · Cited by 103 · see citing works

Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence

Benanti, J. A., & Galloway, D. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2842-2852.2004 · Cited by 103 · see citing works

Down-Regulation of DUSP6 Expression in Lung Cancer

Okudela, K., Yazawa, T., Woo, T., Sakaeda, M., Ishii, J., Mitsui, H., Shimoyamada, H., Sato, H., Tajiri, M., Ogawa, N., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080489 · Cited by 102 · see citing works

Involvement of the INK4a/Arf gene locus in senescence

Collins, C. J., & Sedivy, J. M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00048.x · Cited by 113 · see citing works

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo

Sharpless, N. E., Kannan, K., Xu, J., Bosenberg, M., & Chin, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206809 · Cited by 97 · see citing works

Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

Drayton, S., Rowe, J., Jones, R., Vatcheva, R., Heavens, D., Marshall, J. F., Fried, M., & Peters, G. G. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00242-3 · Cited by 94 · see citing works

Lentivector-Mediated Transfer of Bmi-1 and Telomerase in Muscle Satellite Cells Yields a Duchenne Myoblast Cell Line with Long-Term Genotypic and Phenotypic Stability

Cudré-Mauroux, C., Occhiodoro, T., König, S., Salmon, P., Bernheim, L., & Trono, D. (2003) · Human Gene Therapy · doi:10.1089/104303403322495034 · Cited by 86 · see citing works

Contribution of p16INK4a to replicative senescence of human fibroblasts

Brookes, S., Rowe, J., del Arroyo, A. G., BOND, J. A., & Peters, G. G. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.035 · Cited by 83 · see citing works

Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts

Lindström, M. S., & Wiman, K. G. (2003) · Oncogene · doi:10.1038/sj.onc.1206659 · Cited by 77 · see citing works

Oncogene-Induced Senescence Does Not Require the p16INK4a or p14ARF Melanoma Tumor Suppressors

Haferkamp, S., Scurr, L. L., Becker, T. M., Frausto, M., Kefford, R. F., & Rizos, H. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.5 · Cited by 79 · see citing works

The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence

Haferkamp, S., Tran, S. L., Becker, T. M., Scurr, L. L., Kefford, R. F., & Rizos, H. (2009) · Aging · doi:10.18632/aging.100051 · Cited by 77 · see citing works

A mutation hotspot at the p14ARF splice site

Harland, M., Taylor, C., Chambers, P. A., Kukalizch, K., Randerson‐Moor, J. A., Gruis, N. A., de Snoo, F. A., ter Huurne, J., Goldstein, A. M., Tucker, M. A., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208678 · Cited by 73 · see citing works

p16INK4a‐induced senescence is disabled by melanoma‐associated mutations

Haferkamp, S., Becker, T. M., Scurr, L. L., Kefford, R. F., & Rizos, H. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00422.x · Cited by 60 · see citing works

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression

Kua, H. Y., Liu, H., Leong, W. F., Li, L., Jia, D., Ma, G., Hu, Y., Wang, X., Chau, J. F. L., Chen, Y., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2528 · Cited by 57 · see citing works

CDK4 and CDK6 Delay Senescence by Kinase-Dependent and p16INK4a-Independent Mechanisms

Ruas, M., Gregory, F. J., Jones, R., Poolman, R. A., Starborg, M., Rowe, J., Brookes, S., & Peters, G. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02286-06 · Cited by 57 · see citing works

Ha-RasG12V induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction

Takaoka, M., Harada, H., Deramaudt, T. B., Oyama, K., Andl, C. D., Johnstone, C. N., Rhoades, B., Enders, G. H., Opitz, O. G., & Nakagawa, H. (2004) · Oncogene · doi:10.1038/sj.onc.1207923 · Cited by 54 · see citing works

Molecular events in kidney ageing

Famulski, K. S., & Halloran, P. F. (2005) · Current Opinion in Nephrology and Hypertension · doi:10.1097/01.mnh.0000165890.60254.4e · Cited by 53 · see citing works

The Molecular Scaffold Kinase Suppressor of Ras 1 Is a Modifier of Ras V12 -Induced and Replicative Senescence

Kortum, R. L., Johnson, H. J., Costanzo, D. L., Volle, D. J., Razidlo, G. L., Fusello, A. M., Shaw, A. S., & Lewis, R. E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2202-2214.2006 · Cited by 51 · see citing works

Myc Down-regulation as a Mechanism to Activate the Rb Pathway in STAT5A-induced Senescence

Mallette, F. A., Gaumont-Leclerc, M.-F., Huot, G., & Ferbeyre, G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707074200 · Cited by 51 · see citing works

Familial melanoma: a complex disorder leading to controversy on DNA testing

de Snoo, F. A., Bergman, W., & Gruis, N. A. (2003) · Familial Cancer · doi:10.1023/a:1025758527675 · Cited by 49 · see citing works

The Minimal Set of Genetic Alterations Required for Conversion of Primary Human Fibroblasts to Cancer Cells in the Subrenal Capsule Assay

Sun, B., Chen, M., Hawks, C. L., Pereira‐Smith, O. M., & Hornsby, P. J. (2005) · Neoplasia · doi:10.1593/neo.05172 · Cited by 49 · see citing works

A CDKN2A Mutation in Familial Melanoma that Abrogates Binding of p16INK4a to CDK4 but not CDK6

Jones, R., Ruas, M., Gregory, F. J., Moulin, S., Delia, D., Manoukian, S., Rowe, J., Brookes, S., & Peters, G. G. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1528 · Cited by 49 · see citing works

KRAS gene mutations in lung cancer: Particulars established and issues unresolved

Okudela, K., Woo, T., & Kitamura, H. (2010) · Pathology International · doi:10.1111/j.1440-1827.2010.02580.x · Cited by 45 · see citing works

Differential Oncogenic Ras Signaling and Senescence in Tumor Cells

Bihani, T., Mason, D. X., Jackson, T. J., Chen, S. C., Boettner, B., & Lin, A. W. (2004) · Cell Cycle · doi:10.4161/cc.3.9.1146 · Cited by 41 · see citing works

Locus-specific databases and recommendations to strengthen their contribution to the classification of variants in cancer susceptibility genes

Greenblatt, M. S., Brody, L. C., Foulkes, W. D., Genuardi, M., Hofstra, R. M. W., Olivier, M., Plon, S. E., Sijmons, R. H., Sinilnikova, O. M., Spurdle, A. B., et al. (2008) · Human Mutation · doi:10.1002/humu.20889 · Cited by 43 · see citing works

Intronic sequence variants of the CDKN2A gene in melanoma pedigrees

Harland, M., Taylor, C., Bass, S., Churchman, M., Randerson‐Moor, J. A., Holland, E. A., Mann, G. J., Bishop, D. T., & Newton‐Bishop, J. (2005) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20177 · Cited by 42 · see citing works

Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence

Shin, J., Yang, J., Lee, J. C., & Baek, K. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.08.014 · Cited by 40 · see citing works

DPY30 regulates pathways in cellular senescence through ID protein expression

Simboeck, E., Gutiérrez, A., Cozzuto, L., Beringer, M., Caizzi, L., Keyes, W. M., & Croce, L. D. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.159 · Cited by 39 · see citing works

Oncogenic transformation of human cells: shortcomings of rodent model systems

Akagi, T. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.001 · Cited by 37 · see citing works

Inactivation of p16 , with Retention of pRB and p53/p21 Function, in Human MRC5 Fibroblasts That Overcome a Telomere-independent Crisis during Immortalization

Taylor, L. M., James, A. C., Schuller, C. E., Brce, J., Lock, R. B., & MacKenzie, K. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402388200 · Cited by 36 · see citing works

Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis

Zhao, Y., Zhang, Y., Yang, Z., Li, A., & Dong, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.148 · Cited by 31 · see citing works

Cloning and characterization of cellular senescence-associated genes in human fibroblasts by suppression subtractive hybridization

Guo, S., Zhang, Z., & Tong, T. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.044 · Cited by 32 · see citing works

Dissecting the Senescence-like Program in Tumor Cells Activated by Ras Signaling

Bihani, T., Chicas, A., Lo, C. P.-K., & Lin, A. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608127200 · Cited by 29 · see citing works

The Molecular Basis of Melanomagenesis and the Metastatic Phenotype

CROWSON, A. N., MAGRO, C. M. J., Miller, A. J., & Mihm, M. C. (2007) · Seminars in Oncology · doi:10.1053/j.seminoncol.2007.09.007 · Cited by 29 · see citing works

RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence

López-Vicente, L., Pons, B., Coch, L., Teixidó, C., Hernández‐Losa, J., Armengol, G., & y Cajal, S. R. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr003 · Cited by 28 · see citing works

A single Mediterranean, possibly Jewish, origin for the Val59Gly CDKN2A mutation in four melanoma-prone families

Yakobson, E., Eisenberg, S., Isacson, R., Halle, D., Levy‐Lahad, E., Catane, R., Safro, M. G., Sobolev, V. M., Huot, T. J. G., Peters, G. G., et al. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200961 · Cited by 28 · see citing works

p16 INK 4a deficiency promotes DNA hyper‐replication and genetic instability in melanocytes

Fung, C., Pupo, G. M., Scolyer, R. A., Kefford, R. F., & Rizos, H. (2013) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12062 · Cited by 22 · see citing works

Chronic NF-κB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response

Batsi, C., Markopoulou, S., Vartholomatos, G., Georgiou, I. A., Kanavaros, P., Gorgoulis, V. G., Marcu, K. B., & Kolettas, E. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.04.002 · Cited by 22 · see citing works

Thymomegaly, Microsplenia, and Defective Homeostatic Proliferation of Peripheral Lymphocytes in p51-Ets1 Isoform-Specific Null Mice

Higuchi, T., Bartel, F. O., Masuya, M., Deguchi, T., Henderson, K. W., Li, R., Muise‐Helmericks, R. C., Kern, M. J., Watson, D. K., & Spyropoulos, D. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01871-06 · Cited by 22 · see citing works

Malignant Melanoma–a Genetic Overview

Bloethner, S., Scherer, D., Drechsel, M., Hemminki, K., & Kumar, R. (2009) · Actas Dermo-Sifiliográficas · doi:10.1016/s0001-7310(09)73167-9 · Cited by 19 · see citing works

The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication

Zannetti, C., Mondini, M., Andrea, M. D., Caposio, P., Hara, E., Peters, G. G., Gribaudo, G., Gariglio, M., & Landolfo, S. (2006) · Virology · doi:10.1016/j.virol.2006.01.042 · Cited by 19 · see citing works

MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts

Zhang, F., Zakaria, S. M., Tabor, V., Singh, M., Tronnersjö, S., Goodwin, J., Selivanova, G., Bártek, J., Castell, A., & Larsson, L. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1553339 · Cited by 18 · see citing works

Genes and pathways involved in senescence bypass identified by functional genetic screens

Roupakia, E., Markopoulos, G. S., & Kolettas, E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111432 · Cited by 18 · see citing works

Histone Chaperone Jun Dimerization Protein 2 (JDP2): Role in Cellular Senescence and Aging

Huang, Y., Saito, S., & Yokoyama, K. K. (2010) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/s1607-551x(10)70081-4 · Cited by 19 · see citing works

A population of BJ fibroblasts escaped from Ras-induced senescence susceptible to transformation

Kohsaka, S., Sasai, K., Takahashi, K., Akagi, T., Tanino, M. A., Kimura, T., Nishihara, H., & Tanaka, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.06.082 · Cited by 16 · see citing works

The role of replicative senescence in cancer and human ageing: utility (or otherwise) of murine models

Smith, S. K., & Kipling, D. (2004) · Cytogenetic and Genome Research · doi:10.1159/000078219 · Cited by 17 · see citing works

Molecular Mechanisms of Cellular Senescence

Becker, T. M., & Haferkamp, S. (2013) · InTech eBooks · doi:10.5772/54120 · Cited by 14 · see citing works

Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines

Eguchi, T., Itadani, H., Shimomura, T., Kawanishi, N., Hirai, H., & Kotani, H. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1159 · Cited by 13 · see citing works

New founder germline mutations of CDKN2A in melanoma‐prone families and multiple primary melanoma development in a patient receiving levodopa treatment

Kannengiesser, C., Dalle, S., Leccia, M. ‐., Avril, M.-F., Bonadona, V., Chompret, A., Lasset, C., Leroux, D., Thomas, L., Lesueur, F., et al. (2007) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20461 · Cited by 13 · see citing works

Unraveling the Complexity of Endocrine Resistance in Breast Cancer by Functional Genomics

Swanton, C., & Downward, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.021 · Cited by 11 · see citing works

Novel CDKN2A Mutations Detected in Western Swedish Families with Hereditary Malignant Melanoma

Erlandson, A., Appelqvist, F., Wennberg, A., Holm, J., & Enerbäck, C. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700718 · Cited by 10 · see citing works

Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence

Ito, T., & Igaki, T. (2021) · Science Signaling · doi:10.1126/scisignal.aaz3578 · Cited by 9 · see citing works

Expression of p16INK4A variants in senescent human fibroblasts independent of protein phosphorylation

Weebadda, W. K. C., Jackson, T. J., & Lin, A. W. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20372 · Cited by 9 · see citing works

In vitro and in vivo tumor growth inhibition by a p16‐mimicking peptide in p16INK4A‐defective, pRb‐positive human melanoma cells

Noonan, D. M., Severino, A., Morini, M., Tritarelli, A., Manente, L., D’Agnano, I., Starace, G., Baldi, A., Lombardi, D., Albini, A., et al. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20182 · Cited by 9 · see citing works

The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake?

del Arroyo, A. G., & Peters, G. G. (2005) · Advances in experimental medicine and biology · doi:10.1007/1-4020-3764-3_8 · Cited by 8 · see citing works

p16 Ink4a Interferes with Abelson Virus Transformation by Enhancing Apoptosis

Sachs, Z., Sharpless, N. E., DePinho, R. A., & Rosenberg, N. E. (2004) · Journal of Virology · doi:10.1128/jvi.78.7.3304-3311.2004 · Cited by 8 · see citing works

Differential Proteomic Analysis of Human Placenta‐Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan‐Coated Surface

Wong, T., Chen, Y.-H., Liu, S.-H., Solís, M. A., Yu, C.-H., Chang, C., & Huang, L. L. H. (2015) · Stem Cells International · doi:10.1155/2016/2809192 · Cited by 7 · see citing works

Protein dynamics analysis identifies candidate cancer driver genes and mutations in TCGA data

Sayılgan, J. F., Haliloǧlu, T., & Gönen, M. (2021) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26054 · Cited by 7 · see citing works

Stress-Induced Senescence

Hornsby, P. J. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1075-2_4 · Cited by 7 · see citing works

The Genetics of Melanoma

Gray‐Schopfer, V. C., & Bennett, D. C. (2006) · Wiley eBooks · doi:10.1002/9780470987100.ch24 · Cited by 5 · see citing works

Familial Melanoma Genes, Melanocyte Immortalization, and Melanoma Initiation

Bennett, D. C. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-994-3_10 · Cited by 5 · see citing works

In vitro behavior and UV response of melanocytes derived from carriers of CDKN 2A mutations and MC 1R variants

Hernando, B., Swope, V. B., Guard, S. E., Starner, R. J., Choi, K., Anwar, A., Cassidy, P. B., Leachman, S. A., Kadekaro, A. L., Bennett, D. C., et al. (2018) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12732 · Cited by 3 · see citing works

The ARF protein in tumor suppression: lessons from mouse models and human tumors

Rodríguez, I. P. (2004) · Clinical & Translational Oncology · doi:10.1007/bf02710031 · Cited by 2 · see citing works

Cell Death in Response to Genotoxic Stress and DNA Damage

Lopez‐Bergami, P., & Ronai, Z. A. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511976094.008 · Cited by 2 · see citing works

Regulation of Cellular Senescence by the Retinoblastoma Pathway

Becker, T. M., & Rizos, H. (2003) · Springer eBooks · doi:10.1007/978-94-017-0669-8_9 · Cited by 2 · see citing works

The Biology of Melanoma Progression

CROWSON, A. N., MAGRO, C. M. J., & Mihm, M. C. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-994-3_20 · Cited by 2 · see citing works

Malignant Transformation of Melanocytic Nevi

Marzuka-Alcalá, A., & Tsao, H. (2012) · Springer eBooks · doi:10.1007/978-3-642-28397-0_12 · Cited by 1 · see citing works

Tet Methylcytosine Dioxygenase 3 Promotes Cardiovascular Senescence by DNA 5‐Hydroxymethylcytosine‐Mediated Sp1 Transcription Factor Expression

Dang, Y., Ma, J., Ling, S., Wang, S., Guo, H., Liu, J., Ji, G., & Xu, J. (2025) · MedComm · doi:10.1002/mco2.70261 · Cited by 1 · see citing works

Role of Jun dimerization protein 2 (JDP2) in cellular senescence

Huang, Y., Lee, I.-L., Tsai, Y.-F., Saito, S., Lin, Y., Chiou, S., Tsai, E., & Yokoyama, K. K. (2010) · Inflammation and Regeneration · doi:10.2492/inflammregen.30.507 · Cited by 1 · see citing works

p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?

Sharpless, N. E. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_9

THE MECHANISM OF TUMORIGENESIS IN THE IMMORTALIZED HUMAN PANCREATIC CELL LINES: CELL CULTURE MODELS OF HUMAN PANCREATIC CANCER

Chang, Z. (2011) · Digital Commons-TMC (Texas Medical Center)

Epigenetic regulation of p16 Ink4a and Arf by JDP2 in cellular senescence

Nakade, K., Wasylyk, B., & Yokoyama, K. K. (2010) · BioMolecular Concepts · doi:10.1515/bmc.2010.008

TRANSCRIPTOME STUDIES OF CELL-FATE AND AGING

Larsson, O. S. (2005) · Figshare

A Telomere-Independent Process?

Sharpless, N. E. (2008)

Studying the Effect of Low Doses of Ionization Radiation on Senescence in Human Lung Fibroblasts.

Kabilan, U. (2020) · uO Research (University of Ottawa) · doi:10.20381/ruor-25207

INK4a‐deficient human diploid fibroblasts are resistant to RAS‐induced senescence

Brookes, S., Rowe, J., Ruas, M., Llanos, S., Clark, P. A., Lomax, M., James, M. C., Vatcheva, R., Bates, S., Vousden, K. H., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf289 · Cited by 220 · see citing works

Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

Drayton, S., Rowe, J., Jones, R., Vatcheva, R., Heavens, D., Marshall, J. F., Fried, M., & Peters, G. G. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00242-3 · Cited by 94 · see citing works

Neoplastic transformation of p16INK4a-deficient human fibroblasts by co-operating cellular oncogenes

Drayton, S. (2003) · Doctoral thesis, UCL (University College London).

Neoplastic transformation of p16INK4a - deficient human fibroblast by co-operating cellular oncogenes.

Drayton, S. (2003) · UCL Discovery (University College London)

Direct evidence from siRNA-directed “knock down” that p16INK4a is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation

Bond, J., Jones, C., Haughton, M., DeMicco, C., Kipling, D., & Wynford-Thomas, D. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.021 · Cited by 49 · see citing works