Loeffler, Dirk

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 689

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, Á. M., Schnell, A., Hexel, K., et al. (2015) · Cell Stem Cell

Platelet Disorders and TreatmentsHematopoietic Stem Cell Transplantation

Cited by 471

PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 91

Inflammatory signals directly instruct PU.1 in HSCs via TNF

Etzrodt, M., Ahmed, N., Hoppe, P. S., Loeffler, D., Skylaki, S., Hilsenbeck, O., Kokkaliaris, K. D., Kaltenbach, H.-M., Stelling, J., Nerlov, C., et al. (2019) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 67

Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm

Strasser, M. K., Hoppe, P. S., Loeffler, D., Kokkaliaris, K. D., Schroeder, T., Theis, F. J., & Marr, C. (2018) · Nature Communications

Gene Regulatory Network AnalysisHematopoietic Stem Cell Transplantation

Cited by 26

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation

Ahmed, N., Etzrodt, M., Dettinger, P., Kull, T., Loeffler, D., Hoppe, P. S., Chavez, J. S., Zhang, Y., Camargo Ortega, G., Hilsenbeck, O., et al. (2022) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 9

PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation

Chavez, J., Rabe, J. L., Higa, K., Loeffler, D., Nouraiz, A., Mills, T., Idler, B. M., Stevens, B. M., Fleenor, C., Nerlov, C., et al. (2019) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 1