Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Open accessAbstract
Infections are associated with extensive platelet consumption, representing a high risk for health. However, the mechanism coordinating the rapid regeneration of the platelet pool during such stress conditions remains unclear. Here, we report that the phenotypic hematopoietic stem cell (HSC) compartment contains stem-like megakaryocyte-committed progenitors (SL-MkPs), a cell population that shares many features with multipotent HSCs and serves as a lineage-restricted emergency pool for inflammatory insults. During homeostasis, SL-MkPs are maintained in a primed but quiescent state, thus contributing little to steady-state megakaryopoiesis. Even though lineage-specific megakaryocyte transcripts are expressed, protein synthesis is suppressed. In response to acute inflammation, SL-MkPs become activated, resulting in megakaryocyte protein production from pre-existing transcripts and a maturation of SL-MkPs and other megakaryocyte progenitors. This results in an efficient replenishment of platelets that are lost during inflammatory insult. Thus, our study reveals an emergency machinery that counteracts life-threatening platelet depletions during acute inflammation.
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The SLAM compartment is known to contain HSC-like CD41hi SLAM cells that can rapidly enter the cell cycle in response to acute inflammatory stress.
“which is known to contain HSC-like CD41hi SLAM cells that can rapidly enter the cell cycle in response to acute inflammatory stress (Haas et al., 2015).”
From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Haas et al., 2015
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BackgroundMicroenvironmental contributions to hematopoietic stem cell aging
Ho, Y., & Méndez‐Ferrer, S. (2019) · Haematologica · doi:10.3324/haematol.2018.211334 · Cited by 149 · see citing works
“found that acute inflammation induces proliferation of the stem cell-like megakaryocyte progenitor to quickly replenish platelet loss, and the process is in part mediated through the interferon family.(85) Despite the well-known lymphocyte deficiency associated with aging, only the frequency and function (but not the…”
BackgroundThe biology of the platelet with special reference to inflammation wound healing and immunity
Nurden, A. T. (2017) · Frontiers in bioscience · doi:10.2741/4613 · Cited by 133 · see citing works
“In addition, Haas et al (172 have defined a normally quiescent hematopoietic stem cell-like progenitor that in situations of acute inflammation becomes primed and allows a rapid replenishment of platelets during inflammatory insult.”
The early life education of the immune system: Moms, microbes and (missed) opportunities
Jain, N. (2020) · Gut microbes · doi:10.1080/19490976.2020.1824564 · Cited by 106 · see citing works
The mechanisms of pathological extramedullary hematopoiesis in diseases
Yang, X., Chen, D., Long, H., & Zhu, B. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03450-w · Cited by 109 · see citing works
Petrillo, C., Thorne, L. G., Unali, G., Schiroli, G., Giordano, A., Piras, F., Cuccovillo, I., Petit, S. J., Ahsan, F., Noursadeghi, M., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.008 · Cited by 102 · see citing works
“There is increasing evidence that HSPC are responsive to type-I interferon (IFN)-mediated innate immune signaling (Essers et al., 2009; Haas et al., 2015; Hirche et al., 2017; Nagai et al., 2006).”
BackgroundRegulation of myelopoiesis by proinflammatory cytokines in infectious diseases
Chiba, Y., Mizoguchi, I., Hasegawa, H., Ohashi, M., Orii, N., Nagai, T., Sugahara, M., Miyamoto, Y., Xu, M., Owaki, T., et al. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2724-5 · Cited by 99 · see citing works
“Because infections are also associated with a high risk of extensive platelet consumption, the mechanism coordinating the rapid regeneration of the platelet pool during infection using poly(I:C) was investigated [28].”
BackgroundPlatelet-derived extracellular vesicles infiltrate and modify the bone marrow during inflammation.
French, S. L., Butov, K. R., Allaeys, I., Cañas, J., Morad, G., Davenport, P. E., Laroche, A., Trubina, N., Italiano, J., Moses, M., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001758 · Cited by 100 · see citing works
“Conversely, inflammatory signaling can trigger thrombocytosis via increased differentiation of MKs from HSCs in the BM.(1,2) PEVs are increased in inflammatory conditions and are able to reprogram various cell types via different pathways.”
BackgroundInfluentialTransferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis
Wang, S., He, X.-Y., Wu, Q., Jiang, L., Chen, L., Yu, Y., Zhang, P., Huang, X., Wang, J., Ju, Z., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.224899 · Cited by 99 · see citing works
Training the Fetal Immune System Through Maternal Inflammation—A Layered Hygiene Hypothesis
Apostol, A. C., Jensen, K. D. C., & Beaudin, A. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00123 · Cited by 100 · see citing works
“At the top of the hematopoietic hierarchy, adult HSCs have been documented to respond directly to systemic viral (169) and bacterial infections (170), as well as to a host of inflammatory cytokines, including type I and type II interferons (171– 174), IL-1β (175), IL-27 (176), and TNF-α (173, 177), and specific TLR li…”
BackgroundPU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201169 · Cited by 91 · see citing works
Self-citationSashida, G., Wang, C., Tomioka, T., Oshima, M., Aoyama, K., Kanai, A., Mochizuki‐Kashio, M., Harada, H., Shimoda, K., & Iwama, A. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151121 · Cited by 105 · see citing works
“A mild reduction in Ezh2 expression was also observed in LSKs, suggesting leaky expression of Cre in HSPCs, probably in a portion of HSPCs whose cell fate is biased to the megakaryocytic lineage (Yamamoto et al., 2013; Haas et al., 2015).”
BackgroundMade to order: emergency myelopoiesis and demand-adapted innate immune cell production
Swann, J. W., Olson, O. C., & Passegue, E. A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00998-7 · Cited by 99 · see citing works
“Similarly, differentiation of erythroid progenitors can be inhibited by the alarmin IL-33 during chronic inflammation 88 , whereas apoptosis of erythroid progenitors can be increased by IL-22 (ref.”
Modulation of megakaryopoiesis and platelet production during inflammation.
Couldwell, G. C., & Machlus, K. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.05.008 · Cited by 88 · see citing works
Poscablo, D. M., Worthington, A. K., Smith‐Berdan, S., Rommel, M. G. E., Manso, B. A., Adili, R., Mok, L., Reggiardo, R. E., Cool, T., Mogharrab, R., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.018 · Cited by 116 · see citing works
“9 Although the differentiation path from HSCs to MkPs may be altered upon in vitro or in vivo stress and upon aging, 10–12 we and others have shown that in young, unperturbed mice, MkPs and Plts, like all other adult hematopoietic lineages, arise via a Flk2+ differentiation stage (Figure 1A; top…”
BackgroundTrained immunity: induction of an inflammatory memory in disease
Schlüter, T., van Elsas, Y., Priem, B., Ziogas, A., & Netea, M. G. (2025) · Cell Research · doi:10.1038/s41422-025-01171-y · Cited by 89 · see citing works
Li, Y., Kong, W., Yang, W., Patel, R. M., Casey, E. B., Okeyo-Owuor, T., White, J. M., Porter, S. N., Morris, S. A., & Magee, J. A. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.08.001 · Cited by 88 · see citing works
“During adulthood, acute type I IFN stimulation promotes HSC proliferation andmegakaryocyte activation, whereas chronic stimulation promotes HSC quiescence (Essers et al., 2009; Haas et al., 2015; Pietras et al., 2014; Walter et al., 2015).”
BackgroundClonality in context: hematopoietic clones in their marrow environment
Cooper, J. N., & Young, N. S. (2017) · Blood · doi:10.1182/blood-2017-07-794362 · Cited by 96 · see citing works
“11 alter normal hematopoiesis and remain an underappreciated force to shape clonal architecture.(89,90)”
BackgroundCrosstalk Between Platelets and Microbial Pathogens
Li, C.-L., Li, J., & Ni, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01962 · Cited by 84 · see citing works
“, TNF-α and IL-6) induced by certain microbial infections are capable of enhancing platelet production by triggering acute emergency megakaryopoiesis (18, 141).”
BackgroundGrigoriou, M., Banos, A., Filia, A., Pavlidis, P., Giannouli, S., Karali, V., Nikolopoulos, D., Pieta, A., Bertsias, G. K., Verginis, P., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215782 · Cited by 96 · see citing works
Extramedullary Hematopoiesis of the Liver and Spleen
Cenariu, D., Iluta, S., Zimta, A., Petrushev, B., Qian, L., Dirzu, N., Tomuleasa, C., Bumbea, H., & Zaharie, F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245831 · Cited by 82 · see citing works
“Acute inflammation triggers rapid maturation of megakaryocyte progenitors, and increased platelet production by direct implication of both mTOR and STAT1 signaling pathways in megakaryopoiesis [28].”
BackgroundNakamura‐Ishizu, A., Matsumura, T., Stumpf, P. S., Umemoto, T., Takizawa, H., Takihara, Y., O'Neil, A., Majeed, A., MacArthur, B. D., & Suda, T. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.059 · Cited by 100 · see citing works
“pIpC-induced IFN signaling modulates protein synthesis in a manner that subsequently activates Mk-biased progenitors, resulting in rapid Mk and platelet formation (Haas et al., 2015).”
BackgroundGrinenko, T., Eugster, A., Thielecke, L., Ramasz, B., Krüger, A., Dietz, S., Glauche, I., Gerbaulet, A., Bonin, M. V., Başak, O., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04188-7 · Cited by 87 · see citing works
Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression
Valet, C., Magnen, M., Qiu, L., Cleary, S., Wang, K. M., Ranucci, S., Grockowiak, E., Boudra, R., Conrad, C., Seo, Y., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153920 · Cited by 80 · see citing works
“Sepsis commonly provokes thrombocytopenia, which leads to emergency platelet production to avoid bleeding (37).”
BackgroundDifferentiation-based model of hematopoietic stem cell functions and lineage pathways
Höfer, T., & Rodewald, H.-R. (2018) · Blood · doi:10.1182/blood-2018-03-791517 · Cited by 94 · see citing works
Yin and Yang: The dual effects of interferons on hematopoiesis
Demerdash, Y., Kain, B., Essers, M. A. G., & King, K. Y. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.02.002 · Cited by 76 · see citing works
“Nevertheless, we have shown that IFNα rapidly activates a posttranscriptional megakaryopoietic program in stem-like megakaryocyte-committed progenitor (SL-MkPs), leading to efficient replenishment of platelets that are lost during inflammatory insults [51].”
BackgroundSelf-citationQuantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells
Raffel, S., Klimmeck, D., Falcone, M., Demir, A., Pouya, A., Zeisberger, P., Lutz, C., Tinelli, M., Bischel, O. E., Bullinger, L., et al. (2020) · Blood · doi:10.1182/blood.2019003654 · Cited by 88 · see citing works
Self-citationKinetics of adult hematopoietic stem cell differentiation in vivo
Upadhaya, S., Sawai, C. M., Papalexi, E., Rashidfarrokhi, A., Jang, G., Chattopadhyay, P. K., Satija, R., & Reizis, B. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180136 · Cited by 83 · see citing works
“, 2018), in inflammatory conditions (Haas et al., 2015), or in human HSC/progenitor culture (Notta et al.”
Rao, T. N., Hansen, N., Stetka, J., Luque Paz, D., Kalmer, M., Hilfiker, J., Endele, M., Ahmed, N., Kubovcakova, L., Rybarikova, M., et al. (2021) · Blood · doi:10.1182/blood.2020005563 · Cited by 72 · see citing works
Self-citationNiche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
Renders, S., Svendsen, A. F., Panten, J., Rama, N., Maryanovich, M., Sommerkamp, P., Ladel, L., Redavid, A. R., Gibert, B., Lazare, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20801-0 · Cited by 83 · see citing works
Self-citationCytokine control of megakaryopoiesis
Behrens, K., & Alexander, W. (2018) · Growth Factors · doi:10.1080/08977194.2018.1498487 · Cited by 68 · see citing works
“…of in vivo studies and proteomics has identified stem-like Mk-committed progenitors (SL-MkPs), that remain quiescent during steady state but become active, initiate translation of Mk transcripts and differentiate directly into MkPs, in situations of acute platelet need (Haas et al., 2015).”
BackgroundAntigen presentation safeguards the integrity of the hematopoietic stem cell pool
Hernández-Malmierca, P., Vonficht, D., Schnell, A., Uckelmann, H., Bollhagen, A., Mahmoud, M., Landua, S.-L., van der Salm, E., Trautmann, C. L., Raffel, S., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.04.007 · Cited by 67 · see citing works
Self-citationDysregulated hematopoiesis in bone marrow marks severe COVID-19
Wang, X., Wen, Y., Xie, X., Liu, Y., Tan, X.-H., Cai, Q.-X., Zhang, Y.-W., Cheng, L., Xu, G., Zhang, S., et al. (2021) · Cell Discovery · doi:10.1038/s41421-021-00296-9 · Cited by 67 · see citing works
Obesity-induced inflammation: The impact of the hematopoietic stem cell niche
Bowers, E., & Singer, K. (2021) · JCI Insight · doi:10.1172/jci.insight.145295 · Cited by 67 · see citing works
Infection-adapted emergency hematopoiesis promotes visceral leishmaniasis
Abidin, B., Hammami, A., Stäger, S., & Heinonen, K. M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006422 · Cited by 66 · see citing works
Differentiation route determines the functional outputs of adult megakaryopoiesis
Li, J., Liu, J., Li, Y., Chen, L. V., Cheng, H., Li, Y., Cheng, T., Wang, Q., & Zhou, B. O. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.006 · Cited by 80 · see citing works
Hirche, C., Frenz, T., Haas, S., Döring, M., Borst, K., Tegtmeyer, P.-K., Brizić, I., Jordan, S., Keyser, K., Chhatbar, C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.063 · Cited by 65 · see citing works
“, 2011), most notably the synthetic RNA polyinosinic:polycytidylic acid (poly(I:C)) (Essers et al., 2009; Haas et al., 2015), were shown to induce cell cycle activation and differentiation of LT-HSCs.”
BackgroundMethodInfluentialSelf-citationIdentification of unipotent megakaryocyte progenitors in human hematopoiesis
Miyawaki, K., Iwasaki, H., Jiromaru, T., Kusumoto, H., Yurino, A., Sugio, T., Uehara, Y., Odawara, J., Daitoku, S., Kunisaki, Y., et al. (2017) · Blood · doi:10.1182/blood-2016-09-741611 · Cited by 76 · see citing works
Differentiation therapy for myeloid malignancies: beyond cytotoxicity
Stubbins, R. J., & Karsan, A. (2021) · Blood Cancer Journal · doi:10.1038/s41408-021-00584-3 · Cited by 63 · see citing works
“The administration of β-glucan has been shown to result in the expansion of myeloid-biased progenitors, and progenitor cells previously exposed to β-glucan retain an increased myeloid potential upon rechallenge, demonstrating that inflammatory stimuli can permanently imprint the latter differentiation programs of HSCs…”
BackgroundInfluentialMolecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
Zhang, L., Mack, R. M., Breslin, P., & Zhang, J. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00994-z · Cited by 78 · see citing works
A comprehensive transcriptome signature of murine hematopoietic stem cell aging
Svendsen, A., Yang, D., Kim, K., Lazare, S., Skinder, N., Zwart, E., Mura-Meszaros, A., Ausema, A., von Eyss, B., de Haan, G., et al. (2020) · bioRxiv · doi:10.1101/2020.08.10.244434 · Cited by 63
Psaila, B., & Mead, A. J. (2019) · Blood · doi:10.1182/blood-2018-11-835371 · Cited by 75 · see citing works
Tong, J., Sun, T., Ma, S., Zhao, Y., Ju, M., Gao, Y., Zhu, P., Tan, P., Fu, R., Zhang, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.026 · Cited by 18 · see citing works
“We propose a model in which JAK2V617F mutation occurs in Mk-primed HSCs, leading to expansion of this population and hypersensitivity to IFN signaling, which promotes Mk lineage differentiation.”
InfluentialIron and platelets: A subtle, under‐recognized relationship
Brissot, É., Troadec, M., Loréal, O., & Brissot, P. (2021) · American Journal of Hematology · doi:10.1002/ajh.26189 · Cited by 60 · see citing works
“progenitors that rapidly replenishes the platelet pool during acute inflammation.(75) Thrombopoietin may be involved in this thrombopoiesis activation mechanism through its stimulation by IL-6.”
BackgroundEnvironmental influences on clonal hematopoiesis
King, K. Y., Huang, Y., Nakada, D., & Goodell, M. A. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.12.005 · Cited by 74 · see citing works
“In other studies, IFNα has been shown to preferentially stimulate a stem cell-like megakaryocyte progenitor (Haas et al., 2015), whereas histamine signaling affects a certain subclass of HSCs (Chen et al.”
BackgroundGuillamot, M., Ouazia, D., Dolgalev, I., Yeung, S. T., Kourtis, N., Dai, Y., Corrigan, K., Zea-Redondo, L., Saraf, A., Florens, L. A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0454-6 · Cited by 70 · see citing works
Smith, J. N. P., Kanwar, V. S., & MacNamara, K. C. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00330 · Cited by 61 · see citing works
“Since type I IFNs drive cell cycle entry and differentiation of other HSPC subsets (13, 104), they may also impact the development of CD8+ memory T cells from memory stem T cells and contribute to the etiology of infection-induced and iatrogenic BM failure through the modulation of T cell populations.”
BackgroundInfluentialStress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and Maintenance
Clapes, T., Lefkopoulos, S., & Trompouki, E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00487 · Cited by 59 · see citing works
“Type I IFN can also regulate emergency megakaryopoiesis by upregulating megakaryocytic proteins in HSCs that already transcribe mRNAs of the megakaryocytic program (42).”
BackgroundAdult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction
Sanada, C. D., Xavier-Ferrucio, J. M., Lu, Y.-C., Min, E., Zhang, P., Zou, S., Kang, E. Y., Zhang, M., Zerafati, G., Gallagher, P. G., et al. (2016) · Blood · doi:10.1182/blood-2016-01-693705 · Cited by 74 · see citing works
Fate Mapping and Quantitation of Hematopoiesis In Vivo.
Höfer, T., Busch, K., Klapproth, K., & Rodewald, H. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112019 · Cited by 59 · see citing works
Hernandez, G., Mills, T. S., Rabe, J. L., Chavez, J. S., Kuldanek, S., Kirkpatrick, G., Noetzli, L., Jubair, W. K., Zanche, M., Myers, J. R., et al. (2020) · Haematologica · doi:10.3324/haematol.2018.197210 · Cited by 58 · see citing works
“Despite some heterogeneity between individual mice, we also did not observe a significant increase in the abundance of CD41-expressing (CD41) HSC, which rapidly differentiate into megakaryocytes in the context of inflammation (Figure 2H, I).(17,18) Likewise, the numbers of short-term HSC (HSC; LSK Flk2CD48CD150) were…”
BackgroundBernitz, J. M., Daniel, M. G., Fstkchyan, Y. S., & Moore, K. (2017) · Blood · doi:10.1182/blood-2016-11-752923 · Cited by 58 · see citing works
Suo, M., Rommelfanger, M. K., Chen, Y., Amro, E. M., Han, B., Chen, Z., Szafranski, K., Chakkarappan, S. R., Boehm, B. O., MacLean, A. L., et al. (2022) · Blood · doi:10.1182/blood.2021012197 · Cited by 57 · see citing works
Sommerkamp, P., Altamura, S., Renders, S., Narr, A., Ladel, L., Zeisberger, P., Eiben, P. L., Fawaz, M., Rieger, M., Cabezas-Wallscheid, N., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.003 · Cited by 57 · see citing works
“Analyzing our previously generated sHSC and pHSC proteome dataset (Haas et al., 2015), we identified 36 proteins encoded byDAPAS genes to be detected bymass spectrometry analysis (Figure S6F).”
MethodSelf-citationNormal Hematopoiesis Is a Balancing Act of Self-Renewal and RegenerationPreprint
Olson, O. C., Kang, Y.-A., & Passegue, E. A. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035519 · Cited by 78 · see citing works
Inflammation, Aging and Hematopoiesis: A Complex Relationship
Bousounis, P., Bergo, V., & Trompouki, E. (2021) · Cells · doi:10.3390/cells10061386 · Cited by 55 · see citing works
“that a lineage-primed population of HSCs designated stem-like megakaryocyte-committed progenitors (SL-MkPs) rapidly restores platelets after infection [44].”
BackgroundBone marrow inflammation in haematological malignancies
de Jong, M. M. E., Chen, L., Raaijmakers, M. H. G. P., & Cupedo, T. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01003-x · Cited by 54 · see citing works
“In myelofibrosis, a disease characterized by progressive deposition of reticulin fibres in the bone marrow, inflammageing-related changes induce megakaryocyte-biased haematopoiesis 211,212 .”
Xie, S. Z., Kaufmann, K., Wang, W.-J., Chan-Seng-Yue, M., Gan, O., Laurenti, E., Garcia-Prat, L., Takayanagi, S.-I., Ng, S. W. K., Xu, C., et al. (2020) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-20-0155 · Cited by 54 · see citing works
“These phenotypes are reminiscent of those observed in chronic inflammation–induced myelopoiesis models (22, 42).”
BackgroundSelf-citationMattes, K., Vellenga, E., & Schepers, H. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.102814 · Cited by 58 · see citing works
- Authors
- Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, Á. M., Schnell, A., Hexel, K., Santarella-Mellwig, R., Blaszkiewicz, S., Kuck, A., Geiger, H., Milsom, M. D., Steinmetz, L. M., Schroeder, T., Trumpp, A., Krijgsveld, J., & Essers, M. A. G.
- Affiliations
- German Cancer Research Center (DE)
- European Molecular Biology Laboratory (DE)
- ETH Zurich (CH)
- Cincinnati Children's Hospital Medical Center (US)
- Stanford Medicine (US)
- Corresponding author
- Essers, Marieke A.G.
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 17
- Issue
- 4
- Pages
- 422-434
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1787222452
- Cited by
- 471
- References
- 0
- Citations by year
- 2026: 27 · 2025: 43 · 2024: 39 · 2023: 42 · 2022: 58 · 2021: 59 · 2020: 55 · 2019: 46 · 2018: 43 · 2017: 29 · 2016: 27 · 2015: 1
- FWCI
- 26.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Deutsches Krebsforschungszentrum
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- megakaryopoiesis, acute inflammation, megakaryocyte progenitors, platelet depletion, platelet consumption, protein synthesis inhibition, megakaryocyte maturation
- MeSH terms
- Animals, Blood Platelets, Hematopoietic Stem Cells, Inflammation, Cell Lineage, Thrombopoiesis, Cell Proliferation, Mice, Megakaryocyte Progenitor Cells
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