Graeber, Thomas G.

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

Zaretsky, J. M., Garcia-Diaz, A., Shin, D. S., Escuin-Ordinas, H., Hugo, W., Hu-Lieskovan, S., Torrejon, D. Y., Abril-Rodriguez, G., Sandoval, S., Barthly, L., et al. (2016) · New England Journal of Medicine

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management

Cited by 3,237

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Lloyd-Price, J., Arze, C., Ananthakrishnan, A. N., Schirmer, M., Avila-Pacheco, J., Poon, T. W., Andrews, E., Ajami, N. J., Bonham, K. S., Brislawn, C. J., et al. (2019) · Nature

Gut microbiota and healthInflammatory Bowel Disease

Cited by 3,143

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature

Cell death mechanisms and regulationCancer, Hypoxia, and Metabolism

Cited by 2,300

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Garcia-Diaz, A., Shin, D. S., Moreno, B. H., Saco, J., Escuin-Ordinas, H., Rodriguez, G. A., Zaretsky, J. M., Sun, L., Hugo, W., Wang, X., et al. (2017) · Cell Reports

Cancer Immunotherapy and Biomarkersinterferon and immune responses

Cited by 1,942

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Poulikakos, P. I., Persaud, Y., Janakiraman, M., Kong, X., Ng, C., Moriceau, G., Shi, H., Atefi, M., Titz, B., Gabay, M. T., et al. (2011) · Nature

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 1,454

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

Shin, D. S., Zaretsky, J. M., Escuin-Ordinas, H., Garcia-Diaz, A., Hu-Lieskovan, S., Kalbasi, A., Grasso, C. S., Hugo, W., Sandoval, S., Torrejon, D. Y., et al. (2017) · Cancer Discovery

Cancer Immunotherapy and Biomarkersinterferon and immune responses

Cited by 1,337

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells

Rohle, D., Popovici-Muller, J., Palaskas, N., Turcan, S., Grommes, C., Campos, C., Tsoi, J., Clark, O., Oldrini, B., Komisopoulou, E., et al. (2013) · Science

Glioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

Cited by 1,153

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

Tsoi, J., Robert, L., Paraiso, K., Galvan, C., Sheu, K. M., Lay, J., Wong, D. J. L., Atefi, M., Shirazi, R., Wang, X., et al. (2018) · Cancer Cell

Ferroptosis and cancer prognosisMelanoma and MAPK Pathways

Cited by 938

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

Müller, J., Krijgsman, O., Tsoi, J., Robert, L., Hugo, W., Song, C., Kong, X., Possik, P. A., Cornelissen-Steijger, P. D. M., Foppen, M. H. G., et al. (2014) · Nature Communications

Melanoma and MAPK PathwaysLung Cancer Treatments and Mutations

Cited by 639

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

Kidani, Y., Elsaesser, H., Hock, M. B., Vergnes, L., Williams, K. J., Argus, J. P., Marbois, B. N., Komisopoulou, E., Wilson, E. B., Osborne, T. F., et al. (2013) · Nature Immunology

T-cell and B-cell ImmunologyCancer, Lipids, and Metabolism

Cited by 552

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Krall, A. S., Xu, S., Graeber, T. G., Braas, D., & Christofk, H. R. (2016) · Nature Communications

Amino Acid Enzymes and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 504

Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures

Plaisier, S. B., Taschereau, R., Wong, J. A., & Graeber, T. G. (2010) · Nucleic Acids Research

Bioinformatics and Genomic NetworksGene expression and cancer classification

Cited by 468

Lactate dehydrogenase activity drives hair follicle stem cell activation

Flores, A., Schell, J., Krall, A. S., Jelinek, D., Miranda, M., Grigorian, M., Braas, D., White, A. C., Zhou, J. L., Graham, N. A., et al. (2017) · Nature Cell Biology

Hair Growth and DisordersCancer, Hypoxia, and Metabolism

Cited by 301

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

TeSlaa, T., Chaikovsky, A. C., Lipchina, I., Escobar, S. L., Hochedlinger, K., Huang, J., Graeber, T. G., Braas, D., & Teitell, M. A. (2016) · Cell Metabolism

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 287

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells

Ploper, D., Taelman, V. F., Robert, L., Perez, B. S., Titz, B., Chen, H.-W., Graeber, T. G., von Euw, E., Ribas, A., & De Robertis, E. M. (2015) · Proceedings of the National Academy of Sciences

Wnt/β-catenin signaling in development and cancerCalcium signaling and nucleotide metabolism

Cited by 228

Targeted inhibition of EGFR and glutaminase induces metabolic crisis in EGFR mutant lung cancer

Momcilovic, M., Bailey, S. T., Lee, J. T., Fishbein, M. C., Magyar, C., Braas, D., Graeber, T., Jackson, N. J., Czernin, J., Emberley, E., et al. (2017) · Cell Reports

Cancer, Hypoxia, and MetabolismLung Cancer Treatments and Mutations

Cited by 157

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

Chen, Z., Shojaee, S., Buchner, M., Geng, H., Lee, J. W., Klemm, L., Titz, B., Graeber, T. G., Park, E., Tan, Y. X., et al. (2015) · Nature

Acute Lymphoblastic Leukemia researchT-cell and B-cell Immunology

Cited by 149

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells

Wu, T.-H., Sagullo, E., Case, D., Zheng, X., Li, Y., Hong, J. S., TeSlaa, T., Patananan, A. N., McCaffery, J. M., Niazi, K., et al. (2016) · Cell Metabolism

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 131

B-cell-specific diversion of glucose carbon utilization reveals a unique vulnerability in B cell malignancies

Xiao, G., Chan, L. N., Klemm, L., Braas, D., Chen, Z., Geng, H., Zhang, Q. C., Aghajanirefah, A., Cosgun, K. N., Sadras, T., et al. (2018) · Cell

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 129