Bateman, Randall J.

BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease

Lim, Y. Y., Hassenstab, J., Cruchaga, C., Goate, A., Fagan, A. M., Benzinger, T. L. S., Maruff, P., Snyder, P. J., Masters, C. L., Allegri, R., et al. (2016) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 76

A randomized controlled study to evaluate the effect of bexarotene on amyloid‐β and apolipoprotein E metabolism in healthy subjects

Ghosal, K., Haag, M., Verghese, P. B., West, T., Veenstra, T., Braunstein, J. B., Bateman, R. J., Holtzman, D. M., & Landreth, G. E. (2016) · Alzheimer's & Dementia: Translational Research & Clinical Interventions

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 73

Acute γ-Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-β Production to Alternative APP Fragments without Amyloid-β Rebound

Cook, J. J., Wildsmith, K. R., Gilberto, D. B., Holahan, M. A., Kinney, G. G., Mathers, P. D., Michener, M. S., Price, E. A., Shearman, M. S., Simon, A. J., et al. (2010) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 72

Comparative analysis of Alzheimer's disease cerebrospinal fluid biomarkers measurement by multiplex SOMAscan platform and immunoassay‐based approach

Timsina, J., Gomez-Fonseca, D., Wang, L., Do, A., Western, D., Alvarez, I., Aguilar, M., Pastor, P., Henson, R. L., Herries, E., et al. (2022) · Journal of Alzheimer’s Disease

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 68

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

for the Dominantly Inherited Alzheimer Network (DIAN), Twohig, D., Rodriguez-Vieitez, E., Sando, S. B., Berge, G., Lauridsen, C., Møller, I., Grøntvedt, G. R., Bråthen, G., Patra, K., et al. (2018) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 68

Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology

Morris, J. C., Weiner, M., Xiong, C., Beckett, L., Coble, D., Saito, N., Aisen, P. S., Allegri, R., Benzinger, T. L. S., Berman, S. B., et al. (2022) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 68

Recapitulation of Endogenous 4R Tau Expression and Formation of Insoluble Tau in Directly Reprogrammed Human Neurons

Capano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J.-S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., et al. (2022) · Cell Stem Cell

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 65

Comparative analytical performance of multiple plasma Aβ42 and Aβ40 assays and their ability to predict positron emission tomography amyloid positivity

Zicha, S., Bateman, R. J., Shaw, L. M., Zetterberg, H., Bannon, A. W., Horton, W. A., Baratta, M., Kolb, H. C., Dobler, I., Mordashova, Y., et al. (2023) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 58

Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group

Su, Y., Blazey, T. M., Owen, C. J., Christensen, J. J., Friedrichsen, K., Joseph-Mathurin, N., Wang, Q., Hornbeck, R. C., Ances, B. M., Snyder, A. Z., et al. (2016) · PLOS ONE

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 56

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

The Dominantly Inherited Alzheimer Network (DIAN), Li, Z., Del-Aguila, J. L., Dube, U., Budde, J., Martinez, R., Black, K., Xiao, Q., Cairns, N. J., Dougherty, J. D., et al. (2018) · Genome Medicine

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 56

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Boerwinkle, A. H., Gordon, B. A., Wisch, J., Flores, S., Henson, R. L., Butt, O. H., McKay, N., Chen, C. D., Benzinger, T. L. S., Fagan, A. M., et al. (2023) · The Lancet Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 55

In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

Wildsmith, K. R., Basak, J. M., Patterson, B. W., Pyatkivskyy, Y., Kim, J., Yarasheski, K. E., Wang, J. X., Mawuenyega, K. G., Jiang, H., Parsadanian, M., et al. (2012) · PLoS ONE

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 54

Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma

Baker-Nigh, A. T., Mawuenyega, K. G., Bollinger, J. G., Ovod, V., Kasten, T., Franklin, E. E., Liao, F., Jiang, H., Holtzman, D., Cairns, N. J., et al. (2016) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 54

Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways

Elbert, D. L., Patterson, B. W., Lucey, B. P., Benzinger, T. L. S., & Bateman, R. J. (2022) · Communications Biology

Alzheimer's disease research and treatmentsCerebrospinal fluid and hydrocephalus

Cited by 53

Testing the amyloid cascade hypothesis: Prevention trials in autosomal dominant Alzheimer disease

Levin, J., Vöglein, J., Quiroz, Y. T., Bateman, R. J., Ghisays, V., Lopera, F., McDade, E., Reiman, E., Tariot, P. N., & Morris, J. C. (2022) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 40

Using Alzheimer's disease blood tests to accelerate clinical trial enrollment

Schindler, S. E., Li, Y., Li, M., Despotis, A., Park, E., Vittert, L., Hamilton, B. H., Womack, K. B., Saef, B., Holtzman, D. M., et al. (2023) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 38

Another step forward in blood-based diagnostics for Alzheimer’s disease

Bateman, R. J., Barthélemy, N. R., & Horie, K. (2020) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 37

Longitudinal Relationships of White Matter Hyperintensities and Alzheimer Disease Biomarkers Across the Adult Life Span

Luo, J., Ma, Y., Agboola, F. J., Grant, E., Morris, J. C., McDade, E., Fagan, A. M., Benzinger, T. L. S., Hassenstab, J., Bateman, R. J., et al. (2023) · Neurology

Dementia and Cognitive Impairment ResearchCerebrovascular and genetic disorders

Cited by 35

Method for the simultaneous quantitation of apolipoprotein E isoforms using tandem mass spectrometry

Wildsmith, K. R., Han, B., & Bateman, R. J. (2009) · Analytical Biochemistry

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 31

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Basak, J. M., Kim, J., Pyatkivskyy, Y., Wildsmith, K. R., Jiang, H., Parsadanian, M., Patterson, B. W., Bateman, R. J., & Holtzman, D. M. (2012) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsAdvanced Proteomics Techniques and Applications

Cited by 27

Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease

Garbarino, V. R., Palavicini, J. P., Melendez, J., Barthelemy, N. R., He, Y., Kautz, T. F., Lopez-Cruzan, M., Mathews, J. J., Xu, P., Zhang, B., et al. (2025) · Neurotherapeutics

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

Cited by 26

Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery

Yoon, H., Belmonte, K. C., Kasten, T., Bateman, R., & Kim, J. (2017) · Scientific Reports

MicroRNA in disease regulationExtracellular vesicles in disease

Cited by 26

[O2–17–01]: RESULTS OF A PHASE 1, SINGLE ASCENDING DOSE, PLACEBO‐CONTROLLED STUDY OF ABBV‐8E12 IN PATIENTS WITH PROGRESSIVE SUPRANUCLEAR PALSY AND PHASE 2 STUDY DESIGN IN EARLY ALZHEIMER's DISEASE

Budur, K., West, T., Braunstein, J. B., Fogelman, I., Bordelon, Y. M., Litvan, I., Roberson, E. D., Hu, H., Verghese, P. B., Bateman, R. J., et al. (2017) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 12

Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype

Lawler, P. E., Bollinger, J. G., Schindler, S. E., Hodge, C. R., Iglesias, N. J., Krishnan, V., Coulton, J. B., Li, Y., Holtzman, D. M., & Bateman, R. J. (2023) · Analytical Biochemistry

Alzheimer's disease research and treatmentsGlycosylation and Glycoproteins Research

Cited by 12