Recapitulation of Endogenous 4R Tau Expression and Formation of Insoluble Tau in Directly Reprogrammed Human Neurons
Open accessAbstract
Tau is a microtubule-binding protein expressed in neurons, and the equal ratios between 4-repeat (4R) and 3-repeat (3R) isoforms are maintained in normal adult brain function. Dysregulation of 3R:4R ratio causes tauopathy, and human neurons that recapitulate tau isoforms in health and disease will provide a platform for elucidating pathogenic processes involving tau pathology. We carried out extensive characterizations of tau isoforms expressed in human neurons derived by microRNA-induced neuronal reprogramming of adult fibroblasts. Transcript and protein analyses showed that miR neurons expressed all six isoforms with the 3R:4R isoform ratio equivalent to that detected in human adult brains. Also, miR neurons derived from familial tauopathy patients with a 3R:4R ratio altering mutation showed increased 4R tau and the formation of insoluble tau with seeding activity. Our results collectively demonstrate the utility of miRNA-induced neuronal reprogramming to recapitulate endogenous tau regulation comparable with the adult brain in health and disease.
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The miRNA+TFs approach generated a highly enriched neuronal population as previously characterized by single cell and bulk RNA-seq and electrically active cells in 2D culture, showing inward and outward currents and multiple action potentials measured by whole-cell recording.
“This miRNA+TFs approach generated a highly enriched neuronal population as previously characterized by single cell and bulk RNA-seq (20, 28, 29) and electrically active cells in 2D culture, showing inward and outward currents and multiple action potentials measured by whole-cell recording (Fig. S1A).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [20]
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Experimental — accuracy not yet measuredFetal neurons and iPSCs-derived neurons primarily express 3R-tau.
“However, fetal neurons and iPSCs-derived neurons primarily express 3R-tau (20, 21)”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [20]
This miRNA-induced neuronal state can synergize with additional transcription factors to generate disease-relevant neuronal subtypes that recapitulate age-dependent neuropathology, including primary tauopathy and adult-onset neurodegeneration of Huntington's disease.
“This miRNA-induced neuronal state can synergize with additional transcription factors (TFs) to generate disease-relevant neuronal subtypes that recapitulate age-dependent neuropathology (26, 28, 30, 31), including primary tauopathy and adult-onset neurodegeneration of Huntington’s disease (20, 32, 33).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [20]
Methanol fixation has previously been used to remove soluble proteins, including tau.
“Methanol fixation has previously been used to remove soluble proteins, including tau (20, 46).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [20]
MiR-9/9*−124-induced neurons are primarily composed of neurons as previously characterized by single-cell RNA-seq.
“MiR-9/9*−124-induced neurons are primarily composed of neurons as previously characterized by single-cell RNA-seq (20, 29).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [20]
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889 · see citing works
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288 · see citing works
Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,816 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049 · see citing works
deepTools2: a next generation web server for deep-sequencing data analysis
Ramírez, F., Ryan, D. P., Grüning, B., Bhardwaj, V., Kilpert, F., Richter, A. S., Heyne, S., Dündar, F., & Manke, T. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw257 · Cited by 8,096 · see citing works
Massively parallel digital transcriptional profiling of single cells
Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353 · see citing works
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055 · see citing works
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755 · see citing works
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
MacLean, B., Tomazela, D. M., Shulman, N., Chambers, M., Finney, G. L., Frewen, B., Kern, R., Tabb, D. L., Liebler, D. C., & MacCoss, M. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq054 · Cited by 4,697 · see citing works
deepTools: a flexible platform for exploring deep-sequencing data
Ramírez, F., Dündar, F., Diehl, S., Grüning, B. A., & Manke, T. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku365 · Cited by 3,738 · see citing works
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498 · see citing works
Self-citationGoedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492 · see citing works
Transmission and spreading of tauopathy in transgenic mouse brain
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803 · see citing works
Mapping RNA‐seq Reads with STAR
Dobin, A., & Gingeras, T. (2015) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1114s51 · Cited by 1,265 · see citing works
Propagation of Tau Misfolding from the Outside to the Inside of a Cell
Frost, B., Jacks, R. L., & Diamond, M. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808759200 · Cited by 1,252 · see citing works
A three-dimensional human neural cell culture model of Alzheimer’s disease
Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D’Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., et al. (2014) · Nature · doi:10.1038/nature13800 · Cited by 1,195 · see citing works
Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., & Crowther, R. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03390.x · Cited by 1,037 · see citing works
Trans-Synaptic Spread of Tau Pathology In Vivo
Liu, L., Drouet, V., Wu, J., Witter, M. P., Small, S. A., Clelland, C. L. T., & Duff, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031302 · Cited by 994 · see citing works
Self-citationGoedert, M., & Jakes, R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07870.x · Cited by 929 · see citing works
MicroRNA-mediated conversion of human fibroblasts to neurons
Yoo, A. S., Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R. E., Tsien, R. W., & Crabtree, G. R. (2011) · Nature · doi:10.1038/nature10323 · Cited by 919 · see citing works
Self-citationAnnotation-free quantification of RNA splicing using LeafCutter
Li, Y. I., Knowles, D. A., Humphrey, J., Barbeira, A. N., Dickinson, S. P., Im, H. K., & Pritchard, J. K. (2018) · Nature Genetics · doi:10.1038/s41588-017-0004-9 · Cited by 765 · see citing works
Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J. R., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.001 · Cited by 765 · see citing works
Proteopathic tau seeding predicts tauopathy in vivo
Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M., & Diamond, M. I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411649111 · Cited by 696 · see citing works
Self-citationthe Dominantly Inherited Alzheimer Network, Barthélemy, N. R., Li, Y., Joseph-Mathurin, N., Gordon, B. A., Hassenstab, J., Benzinger, T. L. S., Buckles, V., Fagan, A. M., Perrin, R. J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0781-z · Cited by 651 · see citing works
Self-citationSeeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles
Guo, J. L., & Lee, V. M.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209296 · Cited by 636 · see citing works
Developmentally regulated expression of specific tau sequences
Kosik, K. S., Orecchio, L. D., Bakalis, S., & Neve, R. L. (1989) · Neuron · doi:10.1016/0896-6273(89)90077-9 · Cited by 598 · see citing works
Tau Kinetics in Neurons and the Human Central Nervous System
Sato, C., Barthélemy, N. R., Mawuenyega, K. G., Patterson, B. W., Gordon, B. A., Jockel-Balsarotti, J., Sullivan, M., Crisp, M. J., Kasten, T., Kirmess, K. M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.015 · Cited by 586 · see citing works
Self-citationRejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
Lapasset, L., Milhavet, O., Prieur, A., Besnard, E., Babled, A., Aït-Hamou, N., Leschik, J., Pellestor, F., Ramirez, J.-M., De Vos, J., et al. (2011) · Genes & Development · doi:10.1101/gad.173922.111 · Cited by 570 · see citing works
Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
Gabel, H. W., Kinde, B., Stroud, H., Gilbert, C. S., Harmin, D. A., Kastan, N. R., Hemberg, M., Ebert, D. H., & Greenberg, M. E. (2015) · Nature · doi:10.1038/nature14319 · Cited by 569 · see citing works
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development
Yoo, A. S., Staahl, B. T., Chen, L., & Crabtree, G. R. (2009) · Nature · doi:10.1038/nature08139 · Cited by 537 · see citing works
Self-citationHimmler, A., Drechsel, D. N., Kirschner, M. W., & Martin, D. W. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1381-1388.1989 · Cited by 535 · see citing works
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
Gamerdinger, M., Hajieva, P., Kaya, A. M., Wolfrum, U., Hartl, F. U., & Behl, C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.29 · Cited by 522 · see citing works
Zhao, C., Sun, G., Li, S., & Shi, Y. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1576 · Cited by 521 · see citing works
Ghetti, B. F., Oblak, A. L., Boeve, B. F., Johnson, K. A., Dickerson, B. C., & Goedert, M. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12213 · Cited by 440 · see citing works
Guo, J. L., Narasimhan, S., Changolkar, L., He, Z., Stieber, A., Zhang, B., Gathagan, R. J., Iba, M., McBride, J. D., Trojanowski, J. Q., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160833 · Cited by 440 · see citing works
Topoisomerases facilitate transcription of long genes linked to autism
King, I. F. G., Yandava, C., Mabb, A. M., Hsiao, J. S., Huang, H., Pearson, B. L., Calabrese, J. M., Starmer, J., Parker, J. S., Magnuson, T., et al. (2013) · Nature · doi:10.1038/nature12504 · Cited by 430 · see citing works
Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons.
Li, X., Zuo, X., Jing, J., Ma, Y., Wang, J., Liu, D., Zhu, J., Du, X., Xiong, L., Du, Y., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.06.003 · Cited by 428 · see citing works
Merry, D. E., Novack, D. V., Hickey, W. F., & Korsmeyer, S. J. (1994) · Development · doi:10.1242/dev.120.2.301 · Cited by 426 · see citing works
Marone, M., Mozzetti, S., Ritis, D. G. D., Pierelli, L., & Scambia, G. (2001) · Biological Procedures Online · doi:10.1251/bpo20 · Cited by 329 · see citing works
Duff, K., Knight, H., Refolo, L. M., Sanders, S., Yu, X., Picciano, M., Malester, B., Hutton, M. L., Adamson, J., Goedert, M., et al. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0279 · Cited by 311 · see citing works
Self-citationGrover, A., Houlden, H., Baker, M. C., Adamson, J. L., Lewis, J. M., Prihar, G., Pickering-Brown, S. M., Duff, K., & Hutton, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15134 · Cited by 300 · see citing works
Self-citationGeneration of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts
Victor, M. B., Richner, M., Hermanstyne, T. O., Ransdell, J. L., Sobieski, C., Deng, P.-Y., Klyachko, V. A., Nerbonne, J. M., & Yoo, A. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.016 · Cited by 295 · see citing works
Self-citationMolecular Pathogenesis of the Tauopathies
Götz, J., Halliday, G., & Nisbet, R. M. (2019) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012936 · Cited by 276 · see citing works
Victor, M. B., Richner, M., Olsen, H. E., Lee, S. W., Monteys, A. M., Ma, C., Huh, C. J., Zhang, B., Davidson, B. L., Yang, X. W., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0075-7 · Cited by 246 · see citing works
Self-citationAge-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients
Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.004 · Cited by 240 · see citing works
Microtubules gate tau condensation to spatially regulate microtubule functions
Tan, R., Lam, A. J., Tan, T., Han, J., Nowakowski, D. W., Vershinin, M., Simó, S., Ori-McKenney, K. M., & McKenney, R. J. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0375-5 · Cited by 231 · see citing works
Barthélemy, N. R., Bateman, R. J., Hirtz, C., Marin, P., Becher, F., Sato, C., Gabelle, A., & Lehmann, S. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00596-4 · Cited by 229 · see citing works
Self-citationTau in neurodegenerative disease
Gao, Y.-L., Wang, N., Sun, F.-R., Cao, X.-P., Zhang, W., & Yu, J.-T. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.04.23 · Cited by 222 · see citing works
Widespread splicing changes in human brain development and aging
Mazin, P., Xiong, J., Liu, X., Yan, Z., Zhang, X., Li, M., He, L., Somel, M., Yuan, Y., Phoebe Chen, Y., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2012.67 · Cited by 216 · see citing works
Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts
Huh, C. J., Zhang, B., Victor, M. B., Dahiya, S., Batista, L. F., Horvath, S., & Yoo, A. S. (2016) · eLife · doi:10.7554/elife.18648 · Cited by 213 · see citing works
Self-citationZerbino, D. R., Johnson, N., Juettemann, T., Wilder, S. P., & Flicek, P. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt737 · Cited by 199 · see citing works
Transmission of tauopathy strains is independent of their isoform composition
He, Z., McBride, J. D., Xu, H. W., Changolkar, L. N., Kim, S., Zhang, B., Narasimhan, S., Gibbons, G. S., Guo, J., Kozak, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13787-x · Cited by 177 · see citing works
Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes
Siahaan, V., Krattenmacher, J., Hyman, A. A., Diez, S., Hernández-Vega, A., Lansky, Z., & Braun, M. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0374-6 · Cited by 169 · see citing works
Cavaloc, Y., Popielarz, M., Fuchs, J.-P., Gattoni, R. C., & Stévenin, J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06554.x · Cited by 156 · see citing works
Kwak, S. S., Washicosky, K. J., Brand, E., von Maydell, D., Aronson, J., Kim, S., Capen, D. E., Cetinbas, M., Sadreyev, R., Ning, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15120-3 · Cited by 151 · see citing works
Sposito, T., Preza, E., Mahoney, C. J., Setó-Salvia, N., Ryan, N. S., Morris, H. R., Arber, C., Devine, M. J., Houlden, H., Warner, T. T., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv246 · Cited by 148 · see citing works
Self-citationAbernathy, D. G., Kim, W. K., McCoy, M. J., Lake, A. M., Ouwenga, R., Lee, S. W., Xing, X., Li, D., Lee, H. J., Heuckeroth, R. O., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.08.002 · Cited by 145 · see citing works
Self-citationDefining the nature of human pluripotent stem cell progeny
Patterson, M., Chan, D. N., Ha, I., Case, D., Cui, Y., Handel, B. V., Mikkola, H. K., & Lowry, W. E. (2012) · Cell Research · doi:10.1038/cr.2011.133 · Cited by 145 · see citing works
Cell-Type-Specific Repression by Methyl-CpG-Binding Protein 2 Is Biased toward Long Genes
Sugino, K., Hempel, C. M., Okaty, B. W., Arnson, H. A., Kato, S., Dani, V. S., & Nelson, S. B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2674-14.2014 · Cited by 127 · see citing works
Wang, J., Gao, Q., Wang, Y., Lafyatis, R., Stamm, S., & Andreadis, A. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02232.x · Cited by 126 · see citing works
Encyclopedia of Movement Disorders
(2010) · Elsevier eBooks · doi:10.1016/c2009-1-03732-0 · Cited by 120 · see citing works
A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies
Karch, C. M., Kao, A. W., Karydas, A., Onanuga, K., Martinez, R., Argouarch, A., Wang, C., Huang, C., Sohn, P. D., Bowles, K. R., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.09.006 · Cited by 119 · see citing works
Self-citationAltered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes
Ishigaki, S., Fujioka, Y., Okada, Y., Riku, Y., Udagawa, T., Honda, D., Yokoi, S., Endo, K., Ikenaka, K., Takagi, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.013 · Cited by 115 · see citing works
Tan, S.-L., Ohtsuka, T., González, A., & Kageyama, R. (2012) · Genes to Cells · doi:10.1111/gtc.12009 · Cited by 108 · see citing works
BAG3 facilitates the clearance of endogenous tau in primary neurons
Lei, Z., Brizzee, C. O., & Johnson, G. V. W. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.012 · Cited by 107 · see citing works
Transforming growth factor‐βl as a regulator of the serpins/t‐PA axis in cerebral ischemia
Docagne, F., Nicole, O., Marti, H. H., MacKenzie, E. T., Buisson, A., & Vivien, D. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.11.1315 · Cited by 106 · see citing works
Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry
Furman, J. L., Holmes, B. B., & Diamond, M. I. (2015) · Journal of Visualized Experiments · doi:10.3791/53205 · Cited by 95 · see citing works
Ehrlich, M., Hallmann, A.-L., Reinhardt, P., Araúzo-Bravo, M. J., Korr, S., Röpke, A., Psathaki, O. E., Ehling, P., Meuth, S. G., Oblak, A. L., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.06.001 · Cited by 94 · see citing works
MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons
Richner, M., Victor, M. B., Liu, Y., Abernathy, D. G., & Yoo, A. S. J. (2015) · Nature Protocols · doi:10.1038/nprot.2015.102 · Cited by 89 · see citing works
Self-citationUsing Human iPSC-Derived Neurons to Model TAU Aggregation
Verheyen, A., Diels, A., Dijkmans, J., Oyelami, T., Meneghello, G., Mertens, L., Versweyveld, S., Borgers, M., Buist, A., Peeters, P., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0146127 · Cited by 86 · see citing works
Hefti, M. M., Farrell, K. W., Kim, S., Bowles, K. R., Fowkes, M. E., Raj, T., & Crary, J. F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195771 · Cited by 86 · see citing works
The plasminogen activation system in neuroinflammation
Mehra, A., Ali, C., Parcq, J., Vivien, D., & Docagne, F. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.011 · Cited by 81 · see citing works
Jiang, S., Wen, N., Li, Z., Dube, U., Del Aguila, J., Budde, J., Martinez, R., Hsu, S., Fernandez, M. V., Cairns, N. J., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0319-z · Cited by 73 · see citing works
Self-citationQuantitative analysis of tau isoform transcripts in sporadic tauopathies
Connell, J. W., Rodriguez-Martin, T., Gibb, G. M., Kahn, N. M., Grierson, A. J., Hanger, D. P., Revesz, T., Lantos, P. L., Anderton, B. H., & Gallo, J.-M. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.02.014 · Cited by 70 · see citing works
Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing
Kang, M.-J., Chung, Y. H., Hwang, C., Murata, M., Fujimoto, T., Mook-Jung, I.-H., Ik, C., & Park, W. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.16 · Cited by 68 · see citing works
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs
Cates, K., McCoy, M. J., Kwon, J.-S., Liu, Y., Abernathy, D. G., Zhang, B., Liu, S., Gontarz, P., Kim, W. K., Chen, S., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2020.08.015 · Cited by 67 · see citing works
Self-citationVerheyen, A., Diels, A., Reumers, J., Hoorde, K. V., den Wyngaert, I. V., d’Ydewalle, C. V. O., Bondt, A. D., Kuijlaars, J., Muynck, L. D., Hoogt, R. D., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.022 · Cited by 66 · see citing works
Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
Horie, K., Barthélemy, N. R., Mallipeddi, N., Li, Y., Franklin, E. E., Perrin, R. J., Bateman, R. J., & Sato, C. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01019-z · Cited by 62 · see citing works
Self-citationRegulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A
Ding, S., Shi, J., Qian, W., Iqbal, K., Grundke, I., Gong, C., & Liu, F. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.021 · Cited by 61 · see citing works
Beevers, J. E., Lai, M. C., Collins, E., Booth, H., Zambon, F., Parkkinen, L., Vowles, J., Cowley, S. A., Wade‐Martins, R., & Caffrey, T. M. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.005 · Cited by 53 · see citing works
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Thompson, C. H., Ben‐Shalom, R., Bender, K. J., & George, A. L. (2020) · The Journal of General Physiology · doi:10.1085/jgp.201912442 · Cited by 51 · see citing works
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Tanner, M. K., Tang, Z., & Thornton, C. A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab022 · Cited by 46 · see citing works
Antiabong, J. F., Ngoepe, M. G., & Abechi, A. S. (2016) · Veterinary World · doi:10.14202/vetworld.2016.935-939 · Cited by 45 · see citing works
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Lu, Y.-L., & Yoo, A. S. J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00522 · Cited by 41 · see citing works
Self-citationKatsikoudi, A., Ficulle, E., Cavallini, A., Sharman, G. J., Guyot, A., Zagnoni, M., Eastwood, B. J., Hutton, M. L., & Bose, S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013325 · Cited by 35 · see citing works
Self-citationHa, T.-Y., Choi, Y. R., Noh, H. R., Cha, S., Kim, J.-B., & Park, S. M. (2021) · Molecular Brain · doi:10.1186/s13041-021-00834-2 · Cited by 31 · see citing works
LONGO: an R package for interactive gene length dependent analysis for neuronal identity
McCoy, M. J., Paul, A. J., Victor, M. B., Richner, M., Gabel, H. W., Gong, H., Yoo, A. S. J., & Ahn, T.-H. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty243 · Cited by 28 · see citing works
Self-citationGeneration of Human Neurons by microRNA-Mediated Direct Conversion of Dermal Fibroblasts
Church, V. A., Cates, K. L., Capano, L. S., Aryal, S., Kim, W. K., & Yoo, A. S. J. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1084-8_6 · Cited by 24 · see citing works
Self-citationMicrotubules Gate Tau Condensation to Spatially Regulate Microtubule FunctionsPreprint
Tan, R., Lam, A. J., Tan, T. C., Han, J. S., Nowakowski, D. W., Vershinin, M. D., Simó, S., Ori-McKenney, K. M., & McKenney, R. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/423376 · Cited by 22 · see citing works
MicroRNA-dependent genetic networks during neural development
Abernathy, D. G., & Yoo, A. S. J. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1899-4 · Cited by 21 · see citing works
Self-citationSensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry
Furman, J. L., Holmes, B. B., & Diamond, M. I. (2015) · Journal of Visualized Experiments · doi:10.3791/53205-v · Cited by 16 · see citing works
Kovács, G. G., & Gelpí, E. (2012) · Clinical Neuropathology · doi:10.5414/np300512 · Cited by 14 · see citing works
Braak, H., & Tredici, K. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374105-9.00269-0 · Cited by 10 · see citing works
Mahali, S. K., & Karch, C. M. M. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.058727 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D’Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, (2014b). A three-dimensional human neural cell culture model of Alzheimer’s disease. Nature 515, 274– 278. 10.1038/nature13800. 25307057 PMC4366007 · DOI · Paper page
- Goedert M, and Jakes R (1990b). Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. The EMBO Journal 9, 4225– 4230. 10.1002/j.1460-2075.1990.tb07870.x. 2124967 PMC552204 · DOI · Paper page
Cited by
Sorted by citations
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Bravo, C. P., Naguib, S. A., & Gan, L. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00753-9 · Cited by 245 · see citing works
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Kampmann, M. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00806-0 · Cited by 138 · see citing works
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Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01623-y · Cited by 94 · see citing works
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Bravo, C., Giani, A. M., Madero‐Pérez, J., Zhao, Z., Wan, Y., Samelson, A. J., Wong, M. Y., Evangelisti, A., Cordes, E., Fan, L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.015 · Cited by 81 · see citing works
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Sun, Z., Kwon, J.-S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., et al. (2024) · Science · doi:10.1126/science.adl2992 · Cited by 77 · see citing works
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Cerneckis, J., Bu, G., & Shi, Y. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.05.007 · Cited by 61 · see citing works
Drouin‐Ouellet, J., Legault, E. M., Nilsson, F., Pircs, K., Bouquety, J., Petit, F., Shrigley, S., Birtele, M., Pereira, M., Storm, P., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.08.010 · Cited by 47 · see citing works
de Luzy, I. R., Lee, M. K., Mobley, W. C., & Studer, L. (2024) · Nature Aging · doi:10.1038/s43587-024-00586-3 · Cited by 36 · see citing works
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Traxler, L., Lucciola, R., Herdy, J. R., Jones, J. R., Mertens, J., & Gage, F. H. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00815-0 · Cited by 34 · see citing works
Aversano, S., Caiazza, C., & Caiazzo, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1069482 · Cited by 33 · see citing works
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Iwata‐Endo, K., Sahashi, K., Kawai, K., Fujioka, Y., Okada, Y., Watanabe, E., Iwade, N., Ishibashi, M., Mohammad, M., Aldoghachi, A. F., et al. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102503 · Cited by 14 · see citing works
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Self-citationGuruacharya, A., Härtung, T., dos Reis, R. S., Moreira, N. C. D. S., Attisano, L., Bolognin, S., Iqbal, K., & Rajbanshi, B. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.103051
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- Authors
- Capano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J.-S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., Bateman, R. J., Houlden, H., Morimoto, R. I., Holtzman, D. M., Duff, K. E., & Yoo, A. S.
- Affiliations
- Washington University in St. Louis (US)
- UK Dementia Research Institute (GB)
- Northwestern University (US)
- Corresponding author
- Duff, Karen E.
- Yoo, Andrew S.
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 29
- Issue
- 6
- Pages
- 918-932.e8
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC9176216
- OpenAlex
- W4281653848
- Cited by
- 65
- References
- 98
- Citations by year
- 2026: 18 · 2025: 16 · 2024: 18 · 2023: 9 · 2022: 4
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- SSRN Electronic Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Columbia University
- Eisai
- Desert Research Institute
- Cure Alzheimer's Fund
- Alzheimer's Disease Research Center, University of Pittsburgh (P50 AG05691)
- Medical Research Council
- Eli Lilly and Company
- Alzheimer's Society
- Roche
- Alzheimer’s Research UK
- National Institutes of Health (T32 GM007067)
- Alzheimer’s Disease Research Center, University of Washington (P30 AG066444)
- National Institute on Aging (RF1AG056296)
- Edward Mallinckrodt Jr Foundation
- National Institute of Neurological Disorders and Stroke (AG063521, K01AG062796, R01 NS095773, R01NS107488)
- University of Washington
- Institute of Clinical and Translational Sciences (UL1TR002345)
- Wellcome Trust (R56 NS110890)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau protein, 4R tau, tauopathy, human neurons, microtubule-binding protein
- MeSH terms
- Adult, Humans, Neurons, tau Proteins, Protein Isoforms, Tauopathies, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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