Ikeuchi, Takeshi

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., et al. (2020) · Nature Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 1,150

Structure-based classification of tauopathies

Shi, Y., Zhang, W., Yang, Y., Murzin, A. G., Falcon, B., Kotecha, A., van Beers, M., Tarutani, A., Kametani, F., Garringer, H. J., et al. (2021) · Nature

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 878

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

the Dominantly Inherited Alzheimer Network, Barthélemy, N. R., Li, Y., Joseph-Mathurin, N., Gordon, B. A., Hassenstab, J., Benzinger, T. L. S., Buckles, V., Fagan, A. M., Perrin, R. J., et al. (2020) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 651

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

Hara, K., Shiga, A., Fukutake, T., Nozaki, H., Miyashita, A., Yokoseki, A., Kawata, H., Koyama, A., Arima, K., Takahashi, T., et al. (2009) · New England Journal of Medicine

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 460

TDP ‐ 43 mutation in familial amyotrophic lateral sclerosis

Yokoseki, A., Shiga, A., Tan, C., Tagawa, A., Kaneko, H., Koyama, A., Eguchi, H., Tsujino, A., Ikeuchi, T., Kakita, A., et al. (2008) · Annals of Neurology

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 373

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Dube, U., Del-Aguila, J. L., Li, Z., Budde, J. P., Jiang, S., Hsu, S., Ibanez, L., Fernandez, M. V., Farias, F., Norton, J., et al. (2019) · Nature Neuroscience

Circular RNAs in diseasesAlzheimer's disease research and treatments

Cited by 345

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., et al. (2022) · Nature

Cerebrospinal fluid and hydrocephalusNeuroinflammation and Neurodegeneration Mechanisms

Cited by 325

CSF1R -related leukoencephalopathy: A major player in primary microgliopathies

Konno, T., Kasanuki, K., Ikeuchi, T., Dickson, D. W., & Wszolek, Z. K. (2018) · Neurology

Neuroinflammation and Neurodegeneration MechanismsCerebrovascular and genetic disorders

Cited by 208

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

Miyashita, A., Koike, A., Jun, G., Wang, L.-S., Takahashi, S., Matsubara, E., Kawarabayashi, T., Shoji, M., Tomita, N., Arai, H., et al. (2013) · PLoS ONE

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 196

Clinical and genetic characterization of adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF 1R mutation

Konno, T., Yoshida, K., Mizuno, T., Kawarai, T., Tada, M., Nozaki, H., Ikeda, S. ‐., Nishizawa, M., Onodera, O., Wszolek, Z. K., et al. (2017) · European Journal of Neurology

Neuroinflammation and Neurodegeneration MechanismsHereditary Neurological Disorders

Cited by 179

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

Johnson, E. C. B., Bian, S., Haque, R. U., Carter, E. K., Watson, C. M., Gordon, B. A., Ping, L., Duong, D. M., Epstein, M. P., McDade, E., et al. (2023) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 170

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk

Shigemizu, D., Mitsumori, R., Akiyama, S., Miyashita, A., Morizono, T., Higaki, S., Asanomi, Y., Hara, N., Tamiya, G., Kinoshita, K., et al. (2021) · Translational Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 80

State‐of‐the‐art of lumbar puncture and its place in the journey of patients with Alzheimer's disease

Hampel, H., Shaw, L. M., Aisen, P., Chen, C., Lleó, A., Iwatsubo, T., Iwata, A., Yamada, M., Ikeuchi, T., Jia, J., et al. (2022) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 77

Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin looping

Kikuchi, M., Hara, N., Hasegawa, M., Miyashita, A., Kuwano, R., Ikeuchi, T., & Nakaya, A. (2019) · BMC Medical Genomics

Alzheimer's disease research and treatmentsGenomics and Chromatin Dynamics

Cited by 74

APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer’s Disease Risk in a Multiracial Sample

Choi, K., Lee, J., Gunasekaran, T., Kang, S., Lee, W., Jeong, J., Lim, H., Zhang, X., Zhu, C., Won, S.-Y., et al. (2019) · Journal of Clinical Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 72

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids

Tada, M., Konno, T., Tada, M., Tezuka, T., Miura, T., Mezaki, N., Okazaki, K., Arakawa, M., Itoh, K., Yamamoto, T., et al. (2016) · Annals of Neurology

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 70

Lack of Genetic Association Between TREM2 and Late-Onset Alzheimer's Disease in a Japanese Population

Miyashita, A., Wen, Y., Kitamura, N., Matsubara, E., Kawarabayashi, T., Shoji, M., Tomita, N., Furukawa, K., Arai, H., Asada, T., et al. (2014) · Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 69

Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology

Morris, J. C., Weiner, M., Xiong, C., Beckett, L., Coble, D., Saito, N., Aisen, P. S., Allegri, R., Benzinger, T. L. S., Berman, S. B., et al. (2022) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 68

Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)

Watanabe, Y., Kitamura, K., Nakamura, K., Sanpei, K., Wakasugi, M., Yokoseki, A., Onodera, O., Ikeuchi, T., Kuwano, R., Momotsu, T., et al. (2016) · Dementia and Geriatric Cognitive Disorders Extra

Dementia and Cognitive Impairment ResearchAdipokines, Inflammation, and Metabolic Diseases

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Genetics of Alzheimer’s disease: An East Asian perspective

Miyashita, A., Kikuchi, M., Hara, N., & Ikeuchi, T. (2023) · Journal of Human Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 64

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Boerwinkle, A. H., Gordon, B. A., Wisch, J., Flores, S., Henson, R. L., Butt, O. H., McKay, N., Chen, C. D., Benzinger, T. L. S., Fagan, A. M., et al. (2023) · The Lancet Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 55

A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

Asanomi, Y., Shigemizu, D., Miyashita, A., Mitsumori, R., Mori, T., Hara, N., Ito, K., Niida, S., Ikeuchi, T., & Ozaki, K. (2019) · Molecular Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Enhanced Accumulation of Phosphorylated α-Synuclein and Elevated β-Amyloid 42/40 Ratio Caused by Expression of the Presenilin-1 ΔT440 Mutant Associated with Familial Lewy Body Disease and Variant Alzheimer's Disease

Kaneko, H., Kakita, A., Kasuga, K., Nozaki, H., Ishikawa, A., Miyashita, A., Kuwano, R., Ito, G., Iwatsubo, T., Takahashi, H., et al. (2007) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 44

ApoE-isoform-dependent cellular uptake of amyloid-β is mediated by lipoprotein receptor LR11/SorLA

Yajima, R., Tokutake, T., Koyama, A., Kasuga, K., Tezuka, T., Nishizawa, M., & Ikeuchi, T. (2015) · Biochemical and Biophysical Research Communications

Alzheimer's disease research and treatmentsCellular transport and secretion

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