Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)
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Background/Aims: We aimed to determine whether the concentration of serum C-reactive protein (CRP) is associated with cognitive function in an adult Japanese population. Methods: Participants of this cross-sectional study were from a subgroup of the Project in Sado for Total Health (PROST; n = 454; mean age, 70.5 years). The cognitive state was evaluated using the Mini-Mental State Examination (MMSE), and those with an MMSE score <24 were considered ‘cognitively declined'. Concentrations of serum high-sensitivity CRP were measured. Multiple logistic regression analysis was used to calculate odds ratios (ORs) for cognitive decline, adjusting for the covariates of age, sex, BMI, disease history, and APOE allele. Results: Of the 454 participants, 94 (20.7%) were cognitively declined. Relative to the lowest (first) quartile of CRP concentration, adjusted ORs were 1.29 (95% CI 0.61-2.75) for the second, 1.78 (95% CI 0.82-3.86) for the third, and 3.05 (95% CI 1.45-6.42) for the highest (fourth) quartiles (p for trend = 0.018). When data were stratified by sex, the association between CRP concentration and cognitive decline was observed only in women. Conclusion: Our findings suggest an association between higher CRP concentration and lower cognitive function. Chronic inflammation may affect cognitive function in adults, in particular women.
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The present study revealed a clear association between serum CRP concentration and cognitive impairment in a community-dwelling elderly population in Japan.
“The present study revealed a clear association between serum CRP concentration and cognitive impairment in a community-dwelling elderly population in Japan [54].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [54]
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- Authors
- Watanabe, Y., Kitamura, K., Nakamura, K., Sanpei, K., Wakasugi, M., Yokoseki, A., Onodera, O., Ikeuchi, T., Kuwano, R., Momotsu, T., Narita, I., & Endo, N.
- Affiliations
- Niigata University (JP)
- Sado General Hospital (JP)
- Brain Research Institute, Niigata University (JP)
- Corresponding author
- Nakamura, Kazutoshi
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders Extra
- Publisher
- S. Karger AG
- Published
- 2016-01-19
- Volume
- 6
- Issue
- 1
- Pages
- 10-19
- ISSN
- 1664-5464 (ISSN-L)
- PMC
- PMC4772636
- OpenAlex
- W2285257942
- Cited by
- 65
- References
- 67
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 9 · 2023: 13 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 4 · 2017: 3 · 2016: 3
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Dementia and Geriatric Cognitive Disorders Extra (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (15K15335)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- C-reactive protein, cognitive decline, chronic inflammation, high-sensitivity CRP, Mini-Mental State Examination, sex differences, older adults, APOE alleles, dementia risk
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