Varmus, Harold E.

A New Initiative on Precision Medicine

Collins, F. S., & Varmus, H. (2015) · New England Journal of Medicine

Science, Research, and MedicineCancer Genomics and Diagnostics

Cited by 5,202

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

Pao, W., Miller, V., Zakowski, M., Doherty, J., Politi, K., Sarkaria, I., Singh, B., Heelan, R., Rusch, V., Fulton, L., et al. (2004) · Proceedings of the National Academy of Sciences

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 4,338

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

Pao, W., Miller, V. A., Politi, K. A., Riely, G. J., Somwar, R., Zakowski, M. F., Kris, M. G., & Varmus, H. (2005) · PLoS Medicine

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 3,527

Somatic mutations affect key pathways in lung adenocarcinoma

Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature

Lung Cancer Treatments and MutationsCancer Genomics and Diagnostics

Cited by 2,681

Toward a Shared Vision for Cancer Genomic Data

Grossman, R. L., Heath, A. P., Ferretti, V., Varmus, H. E., Lowy, D. R., Kibbe, W. A., & Staudt, L. M. (2016) · New England Journal of Medicine

Cancer Genomics and DiagnosticsResearch Data Management Practices

Cited by 1,680

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

STEHELIN, D., VARMUS, H. E., BISHOP, J. M., & VOGT, P. K. (1976) · Nature

T-cell and Retrovirus StudiesAnimal Virus Infections Studies

Cited by 1,321

Characterizing the cancer genome in lung adenocarcinoma

Weir, B. A., Woo, M. S., Getz, G., Perner, S., Ding, L., Beroukhim, R., Lin, W. M., Province, M. A., Kraja, A., Johnson, L. A., et al. (2007) · Nature

Cancer Genomics and DiagnosticsLung Cancer Treatments and Mutations

Cited by 1,105

Characterization of ribosomal frameshifting in HIV-1 gag-pol expression

Jacks, T., Power, M. D., Masiarz, F. R., Luciw, P. A., Barr, P. J., & Varmus, H. E. (1988) · Nature

RNA and protein synthesis mechanismsHIV Research and Treatment

Cited by 966

Rescuing US biomedical research from its systemic flaws

Alberts, B., Kirschner, M. W., Tilghman, S., & Varmus, H. (2014) · Proceedings of the National Academy of Sciences

Health and Medical Research ImpactsResearch, Science, and Academia

Cited by 817

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

Alitalo, K., Schwab, M., Lin, C. C., Varmus, H. E., & Bishop, J. M. (1983) · Proceedings of the National Academy of Sciences

Genomic variations and chromosomal abnormalitiesNeuroendocrine Tumor Research Advances

Cited by 761

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

Barretina, J., Taylor, B. S., Banerji, S., Ramos, A. H., Lagos-Quintana, M., DeCarolis, P. L., Shah, K., Socci, N. D., Weir, B. A., Ho, A., et al. (2010) · Nature Genetics

Sarcoma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 735

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

Fisher, G. H., Wellen, S. L., Klimstra, D., Lenczowski, J. M., Tichelaar, J. W., Lizak, M. J., Whitsett, J. A., Koretsky, A., & Varmus, H. E. (2001) · Genes & Development

Protein Kinase Regulation and GTPase SignalingCancer-related Molecular Pathways

Cited by 582

Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor orto down-regulation of the receptors

Politi, K., Zakowski, M. F., Fan, P.-D., Schonfeld, E. A., Pao, W., & Varmus, H. E. (2006) · Genes & Development

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 478

Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein

Brown, P. O., Bowerman, B., Varmus, H. E., & Bishop, J. M. (1989) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentT-cell and Retrovirus Studies

Cited by 399

A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor

Bates, P., Young, J. A. T., & Varmus, H. E. (1993) · Cell

T-cell and Retrovirus StudiesHIV Research and Treatment

Cited by 355

Mutations associated with familial melanoma impair p16INK4 function

Ranade, K., Hussussian, C. J., Sikorski, R. S., Varmus, H. E., Goldstein, A. M., Tucker, M. A., Serrano, M., Hannon, G. J., Beach, D., & Dracopoli, N. C. (1995) · Nature Genetics

Cancer-related Molecular PathwaysCutaneous Melanoma Detection and Management

Cited by 280

Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection

Pryciak, P. M., & Varmus, H. E. (1992) · Cell

Genomics and Chromatin DynamicsVirus-based gene therapy research

Cited by 273

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection

Leavitt, A. D., Robles, G., Alesandro, N., & Varmus, H. E. (1996) · Journal of Virology

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 232

DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes

Müller, H. P., & Varmus, H. E. (1994) · The EMBO Journal

Genomics and Chromatin DynamicsDNA and Nucleic Acid Chemistry

Cited by 202

Mutational landscape of EGFR- , MYC- , and Kras- driven genetically engineered mouse models of lung adenocarcinoma

McFadden, D. G., Politi, K., Bhutkar, A., Chen, F. K., Song, X., Pirun, M., Santiago, P. M., Kim-Kiselak, C., Platt, J. T., Lee, E., et al. (2016) · Proceedings of the National Academy of Sciences

Cancer Genomics and DiagnosticsLung Cancer Treatments and Mutations

Cited by 194

Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma

Maity, T. K., Venugopalan, A., Linnoila, I., Cultraro, C. M., Giannakou, A., Nemati, R., Zhang, X., Webster, J. D., Ritt, D., Ghosal, S., et al. (2015) · Cancer Discovery

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 73

Synthesis of plus strands of retroviral DNA in cells infected with avian sarcoma virus and mouse mammary tumor virus

Kung, H. J., Fung, Y. K., Majors, J. E., Bishop, J. M., & Varmus, H. E. (1981) · Journal of Virology

T-cell and Retrovirus StudiesHIV Research and Treatment

Cited by 48