Characterizing the cancer genome in lung adenocarcinoma

Weir, Barbara A.; Woo, Michele S.; Getz, Gad; Perner, Sven; Ding, Li; Beroukhim, Rameen; Lin, William M.; Province, Michael A.; Kraja, Aldi; Johnson, Laura A.; Shah, Kinjal; Sato, Mitsuo; Thomas, Roman K.; Barletta, Justine A.; Borecki, Ingrid B.; Broderick, Stephen; Chang, Andrew C.; Chiang, Derek Y.; Chirieac, Lucian R.; Cho, Jeonghee; Fujii, Yoshitaka; Gazdar, Adi F.; Giordano, Thomas; Greulich, Heidi; Hanna, Megan; Johnson, Bruce E.; Kris, Mark G.; Lash, Alex; Lin, Ling; Lindeman, Neal; Mardis, Elaine R.; McPherson, John D.; Minna, John D.; Morgan, Margaret B.; Nadel, Mark; Orringer, Mark B.; Osborne, John R.; Ozenberger, Brad; Ramos, Alex H.; Robinson, James; Roth, Jack A.; Rusch, Valerie; Sasaki, Hidefumi; Shepherd, Frances; Sougnez, Carrie; Spitz, Margaret R.; Tsao, Ming-Sound; Twomey, David; Verhaak, Roel G. W.; Weinstock, George M.

doi:10.1038/nature06358

Cited by 1,105Cancer Genomics and DiagnosticsLung Cancer Treatments and MutationsGenomic variations and chromosomal abnormalities

Characterizing the cancer genome in lung adenocarcinoma

Open access

Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, Lin, William M., Province, Michael A. +62 more·2007·Nature

DOI 10.1038/nature06358PMC PMC2538683

Open this paper in CoChat — free account Open PDF

Abstract

A wide-ranging overview of genetic alterations in lung adenocarcinomas, published in this issue, takes a new approach to genome analysis. The analysis of 371 tumours revealed 31 recurrent focal events, only six of which were known previously in lung carcinomas. A new candidate oncogene, TITF1, was found to be significant in a large number of lung cancers. This work shows that there are many more important cancer-related genes still undiscovered, and that systematic genomic study can reveal them. A large-scale study that analyses gene copy number changes in lung cancer identifies 31 recurrent focal events, which include amplification of the transcription factor NKX2.1 (also called TTF1), shown to act as an oncogene. Somatic alterations in cellular DNA underlie almost all human cancers1. The prospect of targeted therapies2 and the development of high-resolution, genome-wide approaches3,4,5,6,7,8 are now spurring systematic efforts to characterize cancer genomes. Here we report a large-scale project to characterize copy-number alterations in primary lung adenocarcinomas. By analysis of a large collection of tumours (n = 371) using dense single nucleotide polymorphism arrays, we identify a total of 57 significantly recurrent events. We find that 26 of 39 autosomal chromosome arms show consistent large-scale copy-number gain or loss, of which only a handful have been linked to a specific gene. We also identify 31 recurrent focal events, including 24 amplifications and 7 homozygous deletions. Only six of these focal events are currently associated with known mutations in lung carcinomas. The most common event, amplification of chromosome 14q13.3, is found in ∼12% of samples. On the basis of genomic and functional analyses, we identify NKX2-1 (NK2 homeobox 1, also called TITF1), which lies in the minimal 14q13.3 amplification interval and encodes a lineage-specific transcription factor, as a novel candidate proto-oncogene involved in a significant fraction of lung adenocarcinomas. More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature06358

Cites

89 of 89 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

EGFR amplification in lung adenocarcinoma is associated with PSPH overexpression.
“notably, EGFR amplification in lung adenocarcinoma which was associated with PSPH overexpression [25].”
From Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells (2022) · cites this paper as [25]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Primer3 on the WWW for General Users and for Biologist Programmers
Rozen, S., & Skaletsky, H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:365 · Cited by 14,952 · see citing works
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486 · see citing works
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368 · see citing works
Self-citation
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,185 · see citing works
Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer
Sandler, A., Gray, R., Perry, M. C., Brahmer, J., Schiller, J. H., Dowlati, A., Lilenbaum, R., & Johnson, D. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061884 · Cited by 5,761 · see citing works
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903 · see citing works
EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
Pao, W., Miller, V., Zakowski, M., Doherty, J., Politi, K., Sarkaria, I., Singh, B., Heelan, R., Rusch, V., Fulton, L., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405220101 · Cited by 4,338 · see citing works
Self-citation
A census of human cancer genes
Futreal, P. A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N., & Stratton, M. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1299 · Cited by 3,184 · see citing works
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133 · see citing works
Detection of large-scale variation in the human genome
Iafrate, A. J., Feuk, L., Rivera, M. N., Listewnik, M. L., Donahoe, P. K., Qi, Y., Scherer, S. W., & Lee, C. (2004) · Nature Genetics · doi:10.1038/ng1416 · Cited by 2,892 · see citing works
A cell cycle regulator potentially involved in genesis of many tumor types
Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751 · see citing works
Predicting Deleterious Amino Acid SubstitutionsPreprint
Ng, P. C., & Henikoff, S. (2001) · Genome Research · doi:10.1101/gr.176601 · Cited by 2,667 · see citing works
High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
Pinkel, D., Segraves, R., Sudar, D., Clark, S. M., Poole, I., Kowbel, D., Collins, C. C., Kuo, W.-L., Chen, C., Zhai, Y., et al. (1998) · Nature Genetics · doi:10.1038/2524 · Cited by 2,238 · see citing works
GenePattern 2.0
Reich, M. M., Liefeld, T., Gould, J., Lerner, J., Tamayo, P., & Mesirov, J. P. (2006) · Nature Genetics · doi:10.1038/ng0506-500 · Cited by 2,035 · see citing works
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. W., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,978 · see citing works
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
Zufferey, R., Nagy, D., Mandel, R. J., Naldini, L., & Trono, D. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-871 · Cited by 1,977 · see citing works
Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer
Johnson, D. H., Fehrenbacher, L., Novotny, W. F., Herbst, R. S., Nemunaitis, J. J., Jablons, D. M., Langer, C. J., DeVore, R. F., Gaudreault, J., Damico, L. A., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.11.022 · Cited by 1,932 · see citing works
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
Mullighan, C. G., Goorha, S., Radtke, I., Miller, C. B., Coustan‐Smith, E., Dalton, J., Girtman, K., Mathew, S., Ma, J., Pounds, S. B., et al. (2007) · Nature · doi:10.1038/nature05690 · Cited by 1,798 · see citing works
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., & Carson, D. A. (1994) · Nature · doi:10.1038/368753a0 · Cited by 1,742 · see citing works
Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways
Sordella, R., Bell, D. W., Haber, D. A., & Settleman, J. E. (2004) · Science · doi:10.1126/science.1101637 · Cited by 1,605 · see citing works
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
Garraway, L. A., Widlund, H. R., Rubin, M. A., Getz, G., Berger, A. J., Ramaswamy, S., Beroukhim, R., Milner, D. A., Granter, S. R., Du, J., et al. (2005) · Nature · doi:10.1038/nature03664 · Cited by 1,548 · see citing works
Self-citation
Genome-wide analysis of DNA copy-number changes using cDNA microarrays
Pollack, J. R., Perou, C. M., Alizadeh, A. A., Eisen, M. B., Pergamenschikov, A., Williams, C. F., Jeffrey, S. S., Botstein, D., & Brown, P. O. (1999) · Nature Genetics · doi:10.1038/12640 · Cited by 1,416 · see citing works
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.
Herman, J. G., Merlo, A. U., Mao, L., Lapidus, R. G., Issa, J. J., Davidson, N. E., Sidransky, D., & Baylin, S. B. (1995) · PubMed · Cited by 1,341 · see citing works
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
Bamford, S., Dawson, E., Forbes, S. A., Clements, J., Pettett, R., Doǧan, A., Flanagan, A. M., Teague, J. W., Futreal, P. A., Stratton, M. R., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601894 · Cited by 1,248 · see citing works
p53: A Frequent Target for Genetic Abnormalities in Lung Cancer
Takahashi, T., Nau, M. M., Chiba, I., Birrer, M. J., Rosenberg, R. K., Vinocour, M., Levitt, M. L., Pass, H. I., Gazdar, A. F., & Minna, J. D. (1989) · Science · doi:10.1126/science.2554494 · Cited by 1,196 · see citing works
Self-citation
Targeted cancer therapy
Sawyers, C. L. (2004) · Nature · doi:10.1038/nature03095 · Cited by 1,171 · see citing works
Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma
Beroukhim, R., Getz, G. A., Nghiemphu, L., Barretina, J., Hsueh, T., Linhart, D., Vivanco, I., Lee, J. C., Huang, J. H. Y., Alexander, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710052104 · Cited by 1,055 · see citing works
Self-citation
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application
Li, C., & Wong, W. H. (2001) · Genome biology · doi:10.1186/gb-2001-2-8-research0032 · Cited by 977 · see citing works
PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing
Nickerson, D. A. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.14.2745 · Cited by 931 · see citing works
Amplification and expression of the c-myc oncogene in human lung cancer cell lines
Little, C. D., Nau, M. M., Carney, D. N., Gazdar, A. F., & Minna, J. D. (1983) · Nature · doi:10.1038/306194a0 · Cited by 921 · see citing works
Self-citation
Intragenic ERBB2 kinase mutations in tumours
Stephens, P., Hunter, C., Bignell, G., Edkins, S., Davies, H., Teague, J., Stevens, C., O'Meara, S., Smith, R., Parker, A., et al. (2004) · Nature · doi:10.1038/431525b · Cited by 802 · see citing works
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.
Fakharzadeh, S. S., Trusko, S. P., & George, D. L. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07676.x · Cited by 704 · see citing works
Accounting for Human Polymorphisms Predicted to Affect Protein FunctionPreprint
Ng, P. C., & Henikoff, S. (2002) · Genome Research · doi:10.1101/gr.212802 · Cited by 695 · see citing works
Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays
Pollack, J. R., Perou, C. M., Sørlie, T., Alizadeh, A. A., Rees, C. A., Eise, M. B., Pergamenschikov, A., Williams, C. F., van de Rijn, M., Jeffrey, S. S., et al. (1999) · Nature Genetics · doi:10.1038/14385 · Cited by 632 · see citing works
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
Sánchez‐Céspedes, M., Parrella, P., Esteller, M., Nomoto, S., Trink, B., Engles, J. M., Westra, W. H., Herman, J. G., & Sidransky, D. (2002) · PubMed · Cited by 626 · see citing works
An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays
Zhao, X. J., Li, C., Paez, J. G., Chin, K., Janne, P. A., Chen, T.-H., Girard, L., Minna, J. D., Christiani, D. C., Leo, C., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3308 · Cited by 543 · see citing works
Self-citation
Mutational Activation of the K-rasOncogene
Rodenhuis, S., van de Wetering, M. L., Mooi, W. J., Evers, S. G., van Zandwijk, N., & Bos, J. L. (1987) · New England Journal of Medicine · doi:10.1056/nejm198710083171504 · Cited by 532 · see citing works
Analysis of array CGH data: from signal ratio to gain and loss of DNA regions
Hupé, P., Stransky, N., Thiery, J. P., Radvanyi, F., & Barillot, E. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth418 · Cited by 521 · see citing works
Redundant cyclin overexpression and gene amplification in breast cancer cells.
Keyomarsi, K., & Pardee, A. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.1112 · Cited by 510 · see citing works
Rates of p16 ( MTS1 ) Mutations in Primary Tumors with 9p Loss
Cairns, P., Mao, L., Merlo, A. U., Lee, D. J., Schwab, D., Eby, Y. J., Tokino, K., van der Riet, P., Blaugrund, J. E., & Sidransky, D. (1994) · Science · doi:10.1126/science.8023167 · Cited by 427 · see citing works
High-resolution genomic profiles of human lung cancer
Tonon, G., Wong, K., Maulik, G., Brennan, C. W., Feng, B., Zhang, Y., Khatry, D., Protopopov, A. I., You, M. J., Aguirre, A. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504126102 · Cited by 398 · see citing works
High-Resolution Analysis of DNA Copy Number Using Oligonucleotide MicroarraysPreprint
Bignell, G. R., Huang, J. H., Greshock, J. D., Watt, S. B., Butler, A. P., West, S., Grigorova, M., Jones, K. W., Wei, W., Stratton, M. R., et al. (2004) · Genome Research · doi:10.1101/gr.2012304 · Cited by 394 · see citing works
dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data
Lin, M. G., Wei, L., Sellers, W. R., Lieberfarb, M. E., Wong, W. H., & Li, C. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth069 · Cited by 374 · see citing works
Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis
Zhao, X., Weir, B. A., LaFramboise, T., Lin, M. G., Beroukhim, R., Garraway, L. A., Beheshti, J., Lee, J. C., Naoki, K., Richards, W. G., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4603 · Cited by 333 · see citing works
Self-citation
P16 gene in uncultured tumours
Spruck, C., Gonzalez‐Zulueta, M., Shibata, A., Simoneau, A. R., Lin, M.-F., Gonzales, F. A., Tsai, Y., & Jones, P. A. (1994) · Nature · doi:10.1038/370183a0 · Cited by 318 · see citing works
NCI-navy medical oncology branch cell line data base
Phelps, R. M., Johnson, B. E., Ihde, D. C., Gazdar, A. F., Carbone, D. P., McClintock, P. R., Linnoila, R. I., Matthews, M. J., Bunn, P. A., Carney, D. N., et al. (1996) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240630505 · Cited by 304 · see citing works
Self-citation
Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays
Lindblad‐Toh, K., Tanenbaum, D. M., Daly, M. J., Winchester, E., Lui, W., Villapakkam, A. C., Stanton, S. E., Larsson, C., Hudson, T. J., Johnson, B. E., et al. (2000) · Nature Biotechnology · doi:10.1038/79269 · Cited by 274 · see citing works
Self-citation
Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung.
Petersen, I., Bujard, M., Petersen, S., Wolf, G., Goeze, A., Schwendel, A., Langreck, H., Gellert, K., Reichel, M., Just, K., et al. (1997) · PubMed · Cited by 256 · see citing works
Parallels of craniofacial maldevelopment in down syndrome and Ts65Dn mice
Richtsmeier, J. T., Baxter, L. L., & Reeves, R. H. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200002)217:2 · Cited by 255 · see citing works
Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer
Betticher, D. C., Heighway, J., Hasleton, P. S., Altermatt, H. J., Ryder, W. D. J., Cerny, T., & Thatcher, N. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.52 · Cited by 219 · see citing works
Chromosomal imbalances in human lung cancer
Balsara, B., & Testa, J. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205836 · Cited by 210 · see citing works
ras gene Amplification and malignant transformation.
Pulciani, S., Santos, E., Long, L. K., Sorrentino, V., & Barbacid, M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.10.2836 · Cited by 202 · see citing works
Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
Mallo, G. V., Rechreche, H., Frigerio, J.-M., Rocha, D., Zweibaum, A., Lacasa, M., Jordan, B., Dusetti, N., Dagorn, J., & Iovanna, J. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970220)74:1 · Cited by 200 · see citing works
Gene Structure and Expression of Human Thyroid Transcription Factor-1 in Respiratory Epithelial Cells
Ikeda, K., Clark, J. C., Shaw-White, J. R., Stahlman, M. T., Boutell, C., & Whitsett, J. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.8108 · Cited by 197 · see citing works
Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p
Petersen, I., Langreck, H., Wolf, G., et al. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.13 · Cited by 183 · see citing works
Cytoplasmic Domain of the Ubiquitous Na+/H+ Exchanger NHE1 Can Confer Ca2+ Responsiveness to the Apical Isoform NHE3
Wakabayashi, S., Ikeda, T., Noël, J., Schmitt, B. M., Orlowski, J., Pouysségur, J., & Shigekawa, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26460 · Cited by 178 · see citing works
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers
Yokomizo, A., Tindall, D. J., Drabkin, H., Gemmill, R. M., Franklin, W. A., Yang, P., Sugio, K., Smith, D. I., & Liu, W. (1998) · Oncogene · doi:10.1038/sj.onc.1201956 · Cited by 170 · see citing works
The H-cadherin ( CDH13 ) gene is inactivated in human lung cancer
Sato, M., Mori, Y., Sakurada, A., et al. (1998) · Human Genetics · doi:10.1007/s004390050790 · Cited by 168 · see citing works
Self-citation
Overexpression, Amplification, and Androgen Regulation of TPD52 in Prostate Cancer
Rubin, M. A., Varambally, S., Beroukhim, R., Tomlins, S. A., Rhodes, D. R., Paris, P. L., Hofer, M. D., Storz-Schweizer, M., Kuefer, R., Fletcher, J. A., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3881 · Cited by 165 · see citing works
Self-citation
Somatic alterations in the human cancer genome
Weir, B. A., Zhao, X., & Meyerson, M. M. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.11.004 · Cited by 164 · see citing works
Self-citation
Frequent amplification of the telomerase reverse transcriptase gene in human tumors.
Zhang, A., Zheng, C., Lindvall, C. J., Hou, M., Ekedahl, J., Lewensohn, R., Yan, Z.-Q., Yang, X., Henriksson, M., Blennow, E., et al. (2000) · PubMed · Cited by 157 · see citing works
Comparative genomic hybridization analysis detects frequent, often high-level, overrepresentation of DNA sequences at 3q, 5p, 7p, and 8q in human non-small cell lung carcinomas.
Balsara, B., Sonoda, G., du Manoir, S., Siegfried, J. M., Gabrielson, E. W., & Testa, J. R. (1997) · PubMed · Cited by 154 · see citing works
Thyroid transcription factor-1
Bingle, C. D. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00007-1 · Cited by 149 · see citing works
Mechanism ofcyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: Analysis of allele-specific expression
Hosokawa, Y., & Arnold, A. (1998) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199805)22:1 · Cited by 147 · see citing works
Intermediate filament and cross-linked envelope expression in human lung tumor cell lines
Banks-Schlegel, S. P., Gazdar, A. F., & Harris, C. C. (1985) · Lung Cancer · doi:10.1016/s0169-5002(85)80032-5 · Cited by 145 · see citing works
Self-citation
Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancers
Kohno, T., Takahashi, M., Manda, R., & Yokota, J. (1998) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199806)22:2 · Cited by 142 · see citing works
High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH
Garnis, C., Lockwood, W. W., Vucic, E. A., Ge, Y., Girard, L., Minna, J. D., Gazdar, A. F., Lam, S. C., MacAulay, C. E., & Lam, W. L. (2005) · International Journal of Cancer · doi:10.1002/ijc.21491 · Cited by 128 · see citing works
Self-citation
Amplification of protooncogenes in surgical specimens of human lung carcinomas
Division, S. T. O. (1990) · Lung Cancer · doi:10.1016/0169-5002(90)90168-l · Cited by 121 · see citing works
High-Resolution Analysis of Chromosomal Breakpoints and Genomic Instability Identifies PTPRD as a Candidate Tumor Suppressor Gene in Neuroblastoma
Stallings, R. L., Nair, P., Maris, J. M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4154 · Cited by 120 · see citing works
Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer
Reissmann, P. T., Koga, H., Figlin, R. A., Holmes, E. C., & Slamon, D. J. (1999) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320050243 · Cited by 118 · see citing works
Somatic Mutations of the MTS (Multiple Tumor Suppressor) 1/CDK41 (Cyclin-Dependent Kinase-4 Inhibitor) Gene in Human Primary Non-small Cell Lung Carcinomas
Hayashi, N., Sugimoto, Y., Tsuchiya, E., Ogawa, M., & Nakamura, Y. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2090 · Cited by 117 · see citing works
RNA interference‐based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes
Kao, J., & Pollack, J. R. (2006) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20339 · Cited by 113 · see citing works
Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization
Luk, C. K., Tsao, M., Bayani, J., Shepherd, F. A., & Squire, J. A. (2001) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(00)00363-0 · Cited by 112 · see citing works
Self-citation
Phosphodiesterase 4D Forms a cAMP Diffusion Barrier at the Apical Membrane of the Airway Epithelium
Barnes, A. P., Livera, G., Huang, P., Sun, C., O’Neal, W. K., Conti, M., Stutts, M. J., & Milgram, S. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407521200 · Cited by 111 · see citing works
Variable mutations of the RB gene in small-cell lung carcinoma.
Mori, N., Yokota, J., Akiyama, T., et al. (1990) · PubMed · Cited by 109 · see citing works
Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer
Zhu, C.-Q., Jc, C., Liu, N., D, L., Shepherd, F. A., Squire, J. A., & Tsao, M. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603110 · Cited by 105 · see citing works
Self-citation
A survey of homozygous deletions in human cancer genomes
Cox, C., Bignell, G. R., Greenman, C., Stabenau, A., Warren, W., Stephens, P., Davies, H. R., Watt, S. B., Teague, J. W., Edkins, S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408593102 · Cited by 101 · see citing works
Comparison of DNA copy number changes in malignant mesothelioma, adenocarcinoma and large-cell anaplastic carcinoma of the lung
Björkqvist, A.-M., Tammilehto, L., Nordling, S., et al. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.42 · Cited by 99 · see citing works
Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer
Sato, M., Takahashi, K., Nagayama, K., Arai, Y., Ito, N., Okada, M., Minna, J. D., Yokota, J., & Kohno, T. (2005) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20253 · Cited by 86 · see citing works
Self-citation
CDK4 is a probable target gene in a novel amplicon at 12q13.3–q14.1 in lung cancer
Wikman, H., Nymark, P. E. H., Väyrynen, A., Jarmalaitė, S., Kallioniemi, A. H., Salmenkivi, K., Vainio-Siukola, K. J., Husgafvel‐Pursiainen, K., Knuutila, S., Wolf, M., et al. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20122 · Cited by 84 · see citing works
Cytogenetic analysis of 63 non‐small cell lung carcinomas: Recurrent chromosome alterations amid frequent and widespread genomic upheaval
Testa, J. R., Siegfried, J. M., Liu, Z., et al. (1994) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870110307 · Cited by 84 · see citing works
Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in Fallopian tube carcinoma
Snijders, A. M., Nowee, M. E., Fridlyand, J., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206621 · Cited by 72 · see citing works
mdm2 Gene Amplification and Overexpression in Non-Small Cell Lung Carcinomas with Accumulation of the p53 Protein in the Absence of p53 Gene Mutations
Marchetti, A., Buttitta, F., Pellegrini, S., Merlo, G. R., Chella, A., Angeletti, C. A., & Bevilacqua, G. (1995) · Diagnostic Molecular Pathology · doi:10.1097/00019606-199506000-00004 · Cited by 71 · see citing works
PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer
Dai, W. H., Li, Y., Ouyang, B., Pan, H., Reissmann, P. T., Li, J., Wiest, J. S., Stambrook, P. J., Gluckman, J. L., Noffsinger, A. E., et al. (2000) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(200003)27:3 · Cited by 67 · see citing works
Arrays of DNA-binding sites
Rockett, J. C. (2001) · Genome biology · doi:10.1186/gb-2001-2-10-reports0032 · Cited by 65 · see citing works
Frequent amplification of the bcl-1 locus in poorly differentiated squamous cell carcinoma of the lung. The Lung Cancer Study Group.
Berenson, J. R., Koga, H., Yang, J., Pearl, J., Ec, H., & Figlin, R. A. (1990) · PubMed · Cited by 52 · see citing works
The presence of multiple regions of homozygous deletion at the CSMD1 locus in oral squamous cell carcinoma question the role of CSMD1 in head and neck carcinogenesis
Toomes, C., Jackson, A. P., Maguire, K., et al. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10191 · Cited by 48 · see citing works
MAPK Upstream Kinase (MUK)-binding Inhibitory Protein, a Negative Regulator of MUK/Dual Leucine Zipper-bearing Kinase/Leucine Zipper Protein Kinase
Fukuyama, K., Yoshida, M., Yamashita, A., Deyama, T., Baba, M., Suzuki, A., Mohri, H., Ikezawa, Z., Nakajima, H., Hirai, S.-I., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001488200 · Cited by 47 · see citing works
Molecular implications of recurrent cytogenetic alterations in human small cell lung cancer.
Testa, & Sl, G. (1993) · PubMed · Cited by 15 · see citing works

Flagged first, then by citations

Sorted by citations

Comprehensive molecular profiling of lung adenocarcinoma
The Cancer Genome Atlas Research Network (2014) · Nature · doi:10.1038/nature13385 · Cited by 5,732 · see citing works
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017 · see citing works
Self-citation
Defining a Cancer Dependency Map
Tsherniak, A., Vazquez, F., Montgomery, P. G., Weir, B. A., Kryukov, G., Cowley, G. S., Gill, S., Harrington, W. F., Pantel, S., Krill-Burger, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.010 · Cited by 3,276 · see citing works
Self-citation
Somatic mutations affect key pathways in lung adenocarcinoma
Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature · doi:10.1038/nature07423 · Cited by 2,681 · see citing works
Self-citation
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789 · see citing works
Self-citation
Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs
Kris, M. G., Johnson, B. E., Berry, L. D., Kwiatkowski, D. J., Iafrate, A. J., Wistuba, I. I., Varella-Garcia, M., Franklin, W. A., Aronson, S. L., Su, P.-F., et al. (2014) · JAMA · doi:10.1001/jama.2014.3741 · Cited by 1,724 · see citing works
Self-citation
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
de Bruin, E. C., McGranahan, N., Mitter, R., Salm, M., Wedge, D. C., Yates, L., Jamal-Hanjani, M., Shafi, S., Murugaesu, N., Rowan, A. J., et al. (2014) · Science · doi:10.1126/science.1253462 · Cited by 1,117 · see citing works
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
Pao, W., & Chmielecki, J. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2947 · Cited by 1,083 · see citing works
Self-citation
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Mullighan, C. G., Miller, C. B., Radtke, I., Phillips, L. A., Dalton, J., Ma, J., White, D., Hughes, T. P., Le Beau, M. M., Pui, C.-H., et al. (2008) · Nature · doi:10.1038/nature06866 · Cited by 1,072 · see citing works
A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival
Singh, A., Greninger, P., Rhodes, D., Koopman, L., Violette, S., Bardeesy, N., & Settleman, J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.022 · Cited by 841 · see citing works
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Gillette, M. A., Satpathy, S., Cao, S., Dhanasekaran, S. M., Vasaikar, S. V., Krug, K., Petralia, F., Li, Y., Liang, W.-W., Reva, B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.013 · Cited by 820 · see citing works
Self-citation
Signatures of mutation and selection in the cancer genome
Bignell, G. R., Greenman, C. D., Davies, H., Butler, A. P., Edkins, S., Andrews, J. M., Buck, G., Chen, L., Beare, D., Latimer, C., et al. (2010) · Nature · doi:10.1038/nature08768 · Cited by 707 · see citing works
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
Deng, N., Goh, L. K., Wang, H., Das, K., Tao, J., Tan, I. B., Zhang, S., Lee, M., Wu, J., Lim, K. H., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301839 · Cited by 645 · see citing works
Heavy ion carcinogenesis and human space exploration
Durante, M., & Cucinotta, F. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2391 · Cited by 578 · see citing works
Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer
Yasuda, H., Park, E., Yun, C.-H., Sng, N. J., Lucena-Araujo, A. R., Yeo, W.-L., Huberman, M. S., Cohen, D. W., Nakayama, S., Ishioka, K., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007205 · Cited by 571 · see citing works
Self-citation
PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR
Sos, M. L., Koker, M., Weir, B. A., Heynck, S., Rabinovsky, R., Zander, T., Seeger, J. M., Weiss, J., Fischer, F., Frommolt, P., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4055 · Cited by 504 · see citing works
Suppression of lung adenocarcinoma progression by Nkx2-1
Winslow, M. M., Dayton, T. L., Verhaak, R. G. W., Kim-Kiselak, C., Snyder, E. L., Feldser, D. M., Hubbard, D. D., DuPage, M. J., Whittaker, C. A., Hoersch, S., et al. (2011) · Nature · doi:10.1038/nature09881 · Cited by 467 · see citing works
Self-citation
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients
Ni, X., Zhuo, M., Su, Z., Duan, J., Gao, Y., Wang, Z., Zong, C., Bai, H., Chapman, A. R., Zhao, J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320659110 · Cited by 454 · see citing works
SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism
Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.024 · Cited by 445 · see citing works
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
Chen, Z., Cheng, K., Walton, Z., Wang, Y., Ebi, H., Shimamura, T., Liu, Y., Tupper, T., Ouyang, J., Li, J., et al. (2012) · Nature · doi:10.1038/nature10937 · Cited by 446 · see citing works
Self-citation
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
Cheung, H. W., Cowley, G. S., Weir, B. A., Boehm, J. S., Rusin, S., Scott, J. A., East, A., Ali, L. D., Lizotte, P. H., Wong, T. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109363108 · Cited by 423 · see citing works
Self-citation
Copy number variations and cancer
Shlien, A., & Malkin, D. (2009) · Genome Medicine · doi:10.1186/gm62 · Cited by 386 · see citing works
Genetic alterations defining NSCLC subtypes and their therapeutic implications
Pikor, L. A., Ramnarine, V. R., Lam, S., & Lam, W. L. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2013.07.025 · Cited by 375 · see citing works
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS -Mutant Lung Adenocarcinoma
Galan-Cobo, A., Sitthideatphaiboon, P., Qu, X., Poteete, A., Pisegna, M. A., Tong, P., Chen, P.-H., Boroughs, L. K., Rodriguez, M. L. M., Zhang, W., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3527 · Cited by 292 · see citing works
Self-citation
NKX2-1/TITF1/TTF-1-Induced ROR1 Is Required to Sustain EGFR Survival Signaling in Lung Adenocarcinoma
Yamaguchi, T., Yanagisawa, K., Sugiyama, R., Hosono, Y., Shimada, Y., Arima, C., Kato, S., Tomida, S., Suzuki, M., Osada, H., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.008 · Cited by 249 · see citing works
Chromosomal Abnormalities in Cancer
Fröhling, S., & Döhner, H. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0803109 · Cited by 229 · see citing works
Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors
Hovelson, D. H., McDaniel, A. S., Cani, A. K., Johnson, B., Rhodes, K., Williams, P. D., Bandla, S., Bien, G., Choppa, P., Hyland, F., et al. (2015) · Neoplasia · doi:10.1016/j.neo.2015.03.004 · Cited by 224 · see citing works
Self-citation
Molecular pathways and therapeutic targets in lung cancer
Shtivelman, E., Hensing, T., Simon, G. R., Dennis, P. A., Otterson, G. A., Bueno, R., & Salgia, R. (2014) · Oncotarget · doi:10.18632/oncotarget.1891 · Cited by 220 · see citing works
“1 is amplified in up to 20% of lung adenocarcinoma, but not in SQCC [4, 200, 201].”
Background
The International Association for the Study of Lung Cancer Consensus Statement on Optimizing Management of EGFR Mutation–Positive Non–Small Cell Lung Cancer: Status in 2016
Tan, D. S. W., Yom, S. S., Tsao, M. S., Pass, H. I., Kelly, K., Peled, N., Yung, R. C., Wistuba, I. I., Yatabe, Y., Unger, M., et al. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.05.008 · Cited by 201 · see citing works
Self-citation
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
Nahar, R., Zhai, W., Zhang, T., Takano, A., Khng, A. J., Lee, Y. Y., Liu, X., Lim, C. H., Koh, T. P. T., Aung, Z. W., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02584-z · Cited by 173 · see citing works
An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer
Xue, Y., Martelotto, L., Baslan, T., Vides, A., Solomon, M., Mai, T. T., Chaudhary, N., Riely, G. J., Li, B. T., Scott, K., et al. (2017) · Nature Medicine · doi:10.1038/nm.4369 · Cited by 174 · see citing works
Advances in the preclinical testing of cancer therapeutic hypotheses
Caponigro, G., & Sellers, W. R. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3385 · Cited by 165 · see citing works
KrasG12D and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung
Maeda, Y., Tsuchiya, T., Hao, H., Tompkins, D. H., Xu, Y., Mucenski, M. L., Du, L., Keiser, A. R., Fukazawa, T., Naomoto, Y., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64048 · Cited by 163 · see citing works
Transcriptome sequencing of malignant pleural mesothelioma tumors
Sugarbaker, D. J., Richards, W. G., Gordon, G. J., Dong, L., De Rienzo, A., Maulik, G., Glickman, J. N., Chirieac, L. R., Hartman, M.-L., Taillon, B. E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712399105 · Cited by 155 · see citing works
Self-citation
LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma
Liu, W., Monahan, K. B., Pfefferle, A. D., Shimamura, T., Sorrentino, J., Chan, K. T., Roadcap, D. W., Ollila, D. W., Thomas, N. E., Castrillon, D. H., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.048 · Cited by 127 · see citing works
Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum
Thorwarth, A., Schnittert-Hübener, S., Schrumpf, P., Müller, I., Jyrch, S., Dame, C., Biebermann, H., Kleinau, G., Katchanov, J., Schuelke, M., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2013-102248 · Cited by 115 · see citing works
Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4
Huang, X., Di Liberto, M., Jayabalan, D., Liang, J., Ely, S., Bretz, J., Shaffer, A. L., Louie, T., Chen, I., Randolph, S., et al. (2012) · Blood · doi:10.1182/blood-2012-03-415984 · Cited by 102 · see citing works
Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification
Meeusen, B., & Janssens, V. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.10.002 · Cited by 96 · see citing works
Copy number variations and cancer susceptibility
Shlien, A., & Malkin, D. (2010) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328333dca4 · Cited by 77 · see citing works
Retracted
PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways
Liao, L., Ge, M., Zhan, Q., Huang, R., Ji, X., Liang, X., & Zhou, X. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.29203 · Cited by 48 · see citing works
Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics
Tan, D. S. W., Camilleri‐Broët, S., Tan, E. H., Alifano, M., Lim, W., Bobbio, A., Zhang, S., Ng, Q., Ang, M., Iyer, N. G., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28750 · Cited by 43 · see citing works
Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells
Huang, M.-Y., Liu, X.-Y., Shao, Q., Zhang, X., Miao, L., Wu, X.-Y., Xu, Y.-X., Wang, F., Wang, H.-Y., Zeng, L., et al. (2022) · BMC Gastroenterology · doi:10.1186/s12876-021-02073-0 · Cited by 15 · see citing works

Clinical findings in individuals with duplication of genes associated with X‐linked intellectual disability
Sahajpal, N., Ziats, C. A., Chaubey, A., DuPont, B. R., Abidi, F., Schwartz, C. E., & Stevenson, R. E. (2023) · Clinical Genetics · doi:10.1111/cge.14445 · Cited by 4 · see citing works
Duplication processes in Saccharomyces cerevisiae haploid strains
Schacherer, J. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki941 · Cited by 25 · see citing works
The genetic instability and mutagenic interaction of chromosomal duplications present together in haploid strains of Aspergillus nidulans
Lieber, M. M. (1976) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(76)90054-3 · Cited by 4 · see citing works
SELECTION FOR A LARGE GENETIC DUPLICATION IN SALMONELLA TYPHIMURIUM
Straus, D. S., & Hoffmann, G. R. (1975) · Genetics · doi:10.1093/genetics/80.2.227 · Cited by 43 · see citing works
The preliminary report on the C4 gene duplication in chinese
Xiu-zhu, Z. (1993)

Authors: Weir, B. A., Woo, M. S., Getz, G., Perner, S., Ding, L., Beroukhim, R., Lin, W. M., Province, M. A., Kraja, A., Johnson, L. A., Shah, K., Sato, M., Thomas, R. K., Barletta, J. A., Borecki, I. B., Broderick, S., Chang, A. C., Chiang, D. Y., Chirieac, L. R., Cho, J., Fujii, Y., Gazdar, A. F., Giordano, T., Greulich, H., Hanna, M., Johnson, B. E., Kris, M. G., Lash, A., Lin, L., Lindeman, N., Mardis, E. R., McPherson, J. D., Minna, J. D., Morgan, M. B., Nadel, M., Orringer, M. B., Osborne, J. R., Ozenberger, B., Ramos, A. H., Robinson, J., Roth, J. A., Rusch, V., Sasaki, H., Shepherd, F., Sougnez, C., Spitz, M. R., Tsao, M.-S., Twomey, D., Verhaak, R. G. W., Weinstock, G. M., Wheeler, D. A., Winckler, W., Yoshizawa, A., Yu, S., Zakowski, M. F., Zhang, Q., Beer, D. G., Wistuba, I. I., Watson, M. A., Garraway, L. A., Ladanyi, M., Travis, W. D., Pao, W., Rubin, M. A., Gabriel, S. B., Gibbs, R. A., Varmus, H. E., Wilson, R. K., Lander, E. S., & Meyerson, M.
Affiliations: Dana-Farber Cancer Institute (US)
Broad Institute (US)
Brigham and Women's Hospital (US)
The University of Texas Southwestern Medical Center (US)
Nagoya City University (JP)
University of Michigan (US)
Baylor College of Medicine (US)
National Institutes of Health (US)
University Health Network (CA)
The University of Texas MD Anderson Cancer Center (US)
Washington University in St. Louis (US)
Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Meyerson, Matthew
ORCID: Getz, Gad
Perner, Sven
Ding, Li
Beroukhim, Rameen
Lin, William M.
Province, Michael A.
Shah, Kinjal
Sato, Mitsuo
Thomas, Roman K.
Barletta, Justine A.
Borecki, Ingrid B.
Broderick, Stephen
Chang, Andrew C.
Chiang, Derek Y.
Chirieac, Lucian R.
Cho, Jeonghee
Fujii, Yoshitaka
Gazdar, Adi F.
Giordano, Thomas
Greulich, Heidi
Johnson, Bruce E.
Kris, Mark G.
Lash, Alex
Lin, Ling
Lindeman, Neal
Mardis, Elaine R.
McPherson, John D.
Minna, John D.
Morgan, Margaret B.
Roth, Jack A.
Rusch, Valerie
Shepherd, Frances
Tsao, Ming-Sound
Verhaak, Roel G. W.
Weinstock, George M.
Wheeler, David A.
Winckler, Wendy
Yoshizawa, Akihiko
Yu, Soyoung
Zakowski, Maureen F.
Beer, David G.
Wistuba, Ignacio I.
Watson, Mark A.
Garraway, Levi A.
Ladanyi, Marc
Travis, William D.
Pao, William
Rubin, Mark A.
Gabriel, Stacey B.
Gibbs, Richard A.
Varmus, Harold E.
Wilson, Richard K.
Lander, Eric S.
Meyerson, Matthew
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-11-04
Volume: 450
Issue: 7171
Pages: 893-898
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06358
PMC: PMC2538683
OpenAlex: W2104224322
Cited by: 1,105
References: 89
Citations by year: 2026: 11 · 2025: 9 · 2024: 16 · 2023: 46 · 2022: 29 · 2021: 43 · 2020: 32 · 2019: 28 · 2018: 44 · 2017: 41 · 2016: 43 · 2015: 56 · 2014: 84 · 2013: 100 · 2012: 108
FWCI: 35.23
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/3.0/ (tdm)
Locations: Nature (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
Deep Blue (University of Michigan) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: U.S. Department of Defense
American Cancer Society
American Lung Association
International Association for the Study of Lung Cancer
National Cancer Institute (P50CA070907, F32CA113126, K08CA122833)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords: lung adenocarcinoma, copy number alterations, TTF-1, oncogenes, homozygous deletion, transcription factors
MeSH terms: Thyroid Nuclear Factor 1, Proto-Oncogene Mas, Adenocarcinoma, Chromosome Deletion, Chromosomes, Human, Pair 14, Gene Amplification, Genotype, Humans, Lung Neoplasms, Neoplasms, Nuclear Proteins, Transcription Factors, Genome, Human, Loss of Heterozygosity, Polymorphism, Single Nucleotide, Genomics, RNA Interference, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Characterizing the cancer genome in lung adenocarcinoma

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks