Cunningham, Colm

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 2,513

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Systemic inflammation and disease progression in Alzheimer disease

Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., & Perry, V. H. (2009) · Neurology

Dementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,139

Systemic infections and inflammation affect chronic neurodegeneration

Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 1,027

Microglia and neurodegeneration: The role of systemic inflammation

Cunningham, C. (2013) · Glia

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 769

Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsPrion Diseases and Protein Misfolding

Cited by 768

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 638

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease.

Cunningham, C., Campion, S., Lunnon, K., Murray, C. L., Woods, J. F. C., Deacon, R. M. J., Rawlins, J. N. P., & Perry, V. H. (2009) · Biological Psychiatry

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 584

The impact of systemic infection on the progression of neurodegenerative disease

Perry, V. H., Newman, T. A., & Cunningham, C. (2003) · Nature Reviews Neuroscience

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 428

The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)

Cunningham, C., Campion, S., Teeling, J., Felton, L., & Perry, V. H. (2007) · Brain Behavior and Immunity

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 318

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction

Lopez‐Rodriguez, A. B., Hennessy, E., Murray, C. L., Nazmi, A., Delaney, H. J., Healy, D., Fagan, S. G., Rooney, M., Stewart, E., Lewis, A., et al. (2021) · Alzheimer's & Dementia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 293

Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies

Davis, D. H. J., Muniz-Terrera, G., Keage, H. A. D., Stephan, B. C. M., Fleming, J., Ince, P. G., Matthews, F. E., Cunningham, C., Ely, E. W., MacLullich, A. M. J., et al. (2017) · JAMA Psychiatry

Dementia and Cognitive Impairment ResearchIntensive Care Unit Cognitive Disorders

Cited by 252

Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease

Combrinck, M. I., Perry, V. H., & Cunningham, C. (2002) · Neuroscience

Neuroinflammation and Neurodegeneration MechanismsPrion Diseases and Protein Misfolding

Cited by 231

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

Cunningham, C., & Hennessy, E. (2015) · Alzheimer's Research & Therapy

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 211

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α

Hennessy, E., Griffin, É. W., & Cunningham, C. (2015) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 178

Systemic inflammation and delirium: important co-factors in the progression of dementia

Cunningham, C. (2011) · Biochemical Society Transactions

Neuroinflammation and Neurodegeneration MechanismsIntensive Care Unit Cognitive Disorders

Cited by 153

The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1

Teeling, J. L., Cunningham, C., Newman, T. A., & Perry, V. H. (2010) · Brain, Behavior, and Immunity

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 139

Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation

Hughes, M. M., Field, R. H., Perry, V. H., Murray, C. L., & Cunningham, C. (2010) · Glia

Neuroinflammation and Neurodegeneration MechanismsPrion Diseases and Protein Misfolding

Cited by 94

Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

Skelly, D. T., Hennessy, E., Dansereau, M.-A., & Cunningham, C. (2013) · PLoS ONE

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 77

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

Wood, G. K., Sargent, B. F., Ahmad, Z.-U.-A., Tharmaratnam, K., Dunai, C., Egbe, F. N., Martin, N. H., Facer, B., Pendered, S. L., Rogers, H. C., et al. (2025) · Nature Medicine

Long-Term Effects of COVID-19Infectious Encephalopathies and Encephalitis

Cited by 67

International drive to illuminate delirium: a developing public health blueprint for action

Khachaturian, A. S., Hayden, K. M., Devlin, J. W., Fleisher, L. A., Lock, S. L., Cunningham, C., Oh, E. S., Fong, T. G., Fick, D. M., Marcantonio, E. R., et al. (2020) · Alzheimer's & Dementia

Intensive Care Unit Cognitive DisordersDementia and Cognitive Impairment Research

Cited by 60

Extremes of baseline cognitive function determine the severity of delirium: a population study

Tsui, A., Yeo, N., Searle, S. D., Bowden, H., Hoffmann, K., Hornby, J., Goslett, A., Weston-Clarke, M., Lanham, D., Hogan, P., et al. (2023) · Brain

Intensive Care Unit Cognitive DisordersDementia and Cognitive Impairment Research

Cited by 22

Characterising neuropsychiatric disorders in patients with COVID-19

Oldham, M. A., Slooter, A. J. C., Cunningham, C., Rahman, S., Davis, D., Vardy, E. R. L. C., Garcez, F. B., Neufeld, K. J., de Castro, R. E. V., Ely, E. W., et al. (2020) · The Lancet Psychiatry

Intensive Care Unit Cognitive DisordersLong-Term Effects of COVID-19

Cited by 9