Lusis, Aldons J.

Identification of 5-Lipoxygenase as a Major Gene Contributing to Atherosclerosis Susceptibility in Mice

Mehrabian, M., Allayee, H., Wong, J., Shih, W., Wang, X.-P., Shaposhnik, Z., Funk, C. D., & Lusis, A. J. (2002) · Circulation Research

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 422

Genetic and environmental control of host-gut microbiota interactions

Org, E., Parks, B. W., Joo, J. W. J., Emert, B., Schwartzman, W., Kang, E. Y., Mehrabian, M., Pan, C., Knight, R., Gunsalus, R., et al. (2015) · Genome Research

Gut microbiota and healthNutrition, Genetics, and Disease

Cited by 381

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

Shih, D. M., Wang, Z., Lee, R., Meng, Y., Che, N., Charugundla, S., Qi, H., Wu, J., Pan, C., Brown, J. M., et al. (2015) · Journal of Lipid Research

Pharmacogenetics and Drug MetabolismLipid metabolism and disorders

Cited by 335

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 291

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

Yang, X., Deignan, J. L., Qi, H., Zhu, J., Qian, S., Zhong, J., Torosyan, G., Majid, S., Falkard, B., Kleinhanz, R. R., et al. (2009) · Nature Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 288

Cis -acting expression quantitative trait loci in mice

Doss, S., Schadt, E. E., Drake, T. A., & Lusis, A. J. (2005) · Genome Research

Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and Epidemiology

Cited by 273

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., et al. (2013) · Journal of Clinical Investigation

Paraoxonase enzyme and polymorphismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 269

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Ribas, V., Drew, B. G., Zhou, Z., Phun, J., Kalajian, N. Y., Soleymani, T., Daraei, P., Widjaja, K., Wanagat, J., de Aguiar Vallim, T. Q., et al. (2016) · Science Translational Medicine

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 259

Genetic Architecture of Insulin Resistance in the Mouse

Parks, B. W., Sallam, T., Mehrabian, M., Psychogios, N., Hui, S. T., Norheim, F., Castellani, L. W., Rau, C. D., Pan, C., Phun, J., et al. (2015) · Cell Metabolism

Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and Epidemiology

Cited by 249

A multi-tissue full lifespan epigenetic clock for mice

Thompson, M. J., Chwiałkowska, K., Rubbi, L., Lusis, A. J., Davis, R. C., Srivastava, A., Korstanje, R., Churchill, G. A., Horvath, S., & Pellegrini, M. (2018) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 203

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Mäkinen, V.-P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., Levian, C., Huan, T., Segrè, A. V., Ghosh, S., Vivar, J., et al. (2014) · PLoS Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 196

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

Nakano, H., Minami, I., Braas, D., Pappoe, H., Wu, X., Sagadevan, A., Vergnes, L., Fu, K., Morselli, M., Dunham, C., et al. (2017) · eLife

Congenital heart defects researchPluripotent Stem Cells Research

Cited by 195

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential

Skye, S. M., Zhu, W., Romano, K. A., Guo, C.-J., Wang, Z., Jia, X., Kirsop, J., Haag, B., Lang, J. M., DiDonato, J. A., et al. (2018) · Circulation Research

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 189

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

Small, K. S., Todorčević, M., Civelek, M., El-Sayed Moustafa, J. S., Wang, X., Simon, M. M., Fernandez-Tajes, J., Mahajan, A., Horikoshi, M., Hugill, A., et al. (2018) · Nature Genetics

Adipokines, Inflammation, and Metabolic DiseasesGenetic Associations and Epidemiology

Cited by 168

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N‐oxide‐generating pathway, modulates platelet responsiveness and thrombosis risk

Zhu, W., Buffa, J. A., Wang, Z., Warrier, M., Schugar, R., Shih, D. M., Gupta, N., Gregory, J. C., Org, E., Fu, X., et al. (2018) · Journal of Thrombosis and Haemostasis

Blood Coagulation and Thrombosis MechanismsPlatelet Disorders and Treatments

Cited by 161

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

Lusis, A. J., Seldin, M. M., Allayee, H., Bennett, B. J., Civelek, M., Davis, R. C., Eskin, E., Farber, C. R., Hui, S., Mehrabian, M., et al. (2016) · Journal of Lipid Research

Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and Epidemiology

Cited by 158

Using genetic markers to orient the edges in quantitative trait networks: The NEO software

Aten, J. E., Fuller, T. F., Lusis, A. J., & Horvath, S. (2008) · BMC Systems Biology

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 147

Genetic factors controlling structure and expression of apolipoproteins B and E in mice.

Lusis, A. J., Taylor, B. A., Quon, D., Zollman, S., & LeBoeuf, R. C. (1987) · Journal of Biological Chemistry

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 144

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine

Hartiala, J., Bennett, B. J., Tang, W. H. W., Wang, Z., Stewart, A. F. R., Roberts, R., McPherson, R., Lusis, A. J., Hazen, S. L., & Allayee, H. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology

Genetic Associations and EpidemiologyNutrition, Genetics, and Disease

Cited by 133

The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle

Moore, T. M., Zhou, Z., Cohn, W., Norheim, F., Lin, A. J., Kalajian, N., Strumwasser, A. R., Cory, K., Whitney, K., Ho, T., et al. (2019) · Molecular Metabolism

Mitochondrial Function and PathologyCardiovascular and exercise physiology

Cited by 131

Network for Activation of Human Endothelial Cells by Oxidized Phospholipids: A Critical Role of Heme Oxygenase 1

Romanoski, C. E., Che, N., Yin, F., Mai, N., Pouldar, D., Civelek, M., Pan, C., Lee, S., Vakili, L., Yang, W.-P., et al. (2011) · Circulation Research

Atherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin Effects

Cited by 115

Systems genetics analysis of gene-by-environment interactions in human cells

Romanoski, C. E., Lee, S., Kim, M. J., Ingram-Drake, L., Plaisier, C. L., Yordanova, R., Tilford, C., Guan, B., He, A., Gargalovic, P. S., et al. (2010) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

Cited by 111

Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice

Marquart, T. J., Wu, J., Lusis, A. J., & Baldán, Á. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismMicroRNA in disease regulation

Cited by 110

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

Brænne, I., Civelek, M., Vilne, B., Di Narzo, A., Johnson, A. D., Zhao, Y., Reiz, B., Codoni, V., Webb, T. R., Foroughi Asl, H., et al. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

Cited by 109