Genetic and environmental control of host-gut microbiota interactions
Open accessAbstract
Genetics provides a potentially powerful approach to dissect host-gut microbiota interactions. Toward this end, we profiled gut microbiota using 16s rRNA gene sequencing in a panel of 110 diverse inbred strains of mice. This panel has previously been studied for a wide range of metabolic traits and can be used for high-resolution association mapping. Using a SNP-based approach with a linear mixed model, we estimated the heritability of microbiota composition. We conclude that, in a controlled environment, the genetic background accounts for a substantial fraction of abundance of most common microbiota. The mice were previously studied for response to a high-fat, high-sucrose diet, and we hypothesized that the dietary response was determined in part by gut microbiota composition. We tested this using a cross-fostering strategy in which a strain showing a modest response, SWR, was seeded with microbiota from a strain showing a strong response, A×B19. Consistent with a role of microbiota in dietary response, the cross-fostered SWR pups exhibited a significantly increased response in weight gain. To examine specific microbiota contributing to the response, we identified various genera whose abundance correlated with dietary response. Among these, we chose Akkermansia muciniphila, a common anaerobe previously associated with metabolic effects. When administered to strain A×B19 by gavage, the dietary response was significantly blunted for obesity, plasma lipids, and insulin resistance. In an effort to further understand host-microbiota interactions, we mapped loci controlling microbiota composition and prioritized candidate genes. Our publicly available data provide a resource for future studies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent multi-omic studies have revealed an impact of gut microbiota on host responses to dietary challenge and on epigenetic programming.
“Recent multi-omic studies [31, 33, 34] have revealed an impact of gut microbiota on host responses to dietary challenge and on epigenetic programming.”
From Multi-omics approaches to disease (2017) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Self-citationIntroduction to Quantitative Genetics.
Edwards, A. W. F., & Falconer, D. S. (1982) · Biometrics · doi:10.2307/2529912 · Cited by 21,447 · see citing works
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 20,617 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
Self-citationUltra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Huntley, J., Fierer, N., Owens, S. M., Betley, J., Fraser, L., Bauer, M., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.8 · Cited by 8,839 · see citing works
Self-citationDiversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Self-citationLinking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Self-citationThe gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Genetics and Analysis of Quantitative Traits
(2002) · Journal of Animal Breeding and Genetics · doi:10.1046/j.1439-0388.2002.00356.x · Cited by 6,172 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Self-citationMcDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,010 · see citing works
Self-citationEverard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Common SNPs explain a large proportion of the heritability for human height
Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446 · see citing works
Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing
Bokulich, N. A., Subramanian, S., Faith, J. J., Gevers, D., Gordon, J. I., Knight, R. D., Mills, D. A., & Caporaso, J. G. (2012) · Nature Methods · doi:10.1038/nmeth.2276 · Cited by 4,406 · see citing works
Self-citationGut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Self-citationBacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · see citing works
Self-citationHuman Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164 · see citing works
Self-citationVariance component model to account for sample structure in genome-wide association studies
Kang, H. M., Sul, J. H., Service, S. K., Zaitlen, N. A., Kong, S.-Y., Freimer, N. B., Sabatti, C., & Eskin, E. (2010) · Nature Genetics · doi:10.1038/ng.548 · Cited by 2,817 · see citing works
Self-citationMechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219 · see citing works
Introduction to Robust Estimation and Hypothesis Testing
Wilcox, R. R. (2012) · Elsevier eBooks · doi:10.1016/c2010-0-67044-1 · Cited by 2,102 · see citing works
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · see citing works
Self-citationInnate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Efficient Control of Population Structure in Model Organism Association Mapping
Kang, H. M., Zaitlen, N., Wade, C. M., Kirby, A. W., Heckerman, D. E., Daly, M. J., & Eskin, E. (2008) · Genetics · doi:10.1534/genetics.107.080101 · Cited by 1,848 · see citing works
Self-citationBenson, A. K., Kelly, S. A., Legge, R., Ma, F., Low, S. J., Kim, J., Zhang, M., Oh, P. L., Nehrenberg, D., Hua, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007028107 · Cited by 1,314 · see citing works
FaST linear mixed models for genome-wide association studies
Lippert, C., Listgarten, J., Liu, Y., Kadie, C. M., Davidson, R. I., & Heckerman, D. (2011) · Nature Methods · doi:10.1038/nmeth.1681 · Cited by 1,209 · see citing works
Diet dominates host genotype in shaping the murine gut microbiota
Carmody, R. N., Gerber, G. K., Luevano, J. M., Gatti, D. M., Somes, L., Svenson, K. L., & Turnbaugh, P. J. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2014.11.010 · Cited by 1,103 · see citing works
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Ryan, K. K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F., et al. (2014) · Nature · doi:10.1038/nature13135 · Cited by 931 · see citing works
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Suzuki, N., Suzuki, S., Duncan, G. S., Millar, D. G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A. C., Itié, A., Li, S., et al. (2002) · Nature · doi:10.1038/nature736 · Cited by 858 · see citing works
Mouse genetics: concepts and applications
(1995) · Choice Reviews Online · doi:10.5860/choice.33-2135 · Cited by 757 · see citing works
Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.026 · Cited by 708 · see citing works
Systems genetics approaches to understand complex traits
Civelek, M., & Lusis, A. J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3575 · Cited by 621 · see citing works
Self-citationInteractions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
Musso, G., Gambino, R., & Cassader, M. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012510-175505 · Cited by 598 · see citing works
Verdam, F. J., Fuentes, S., de Jonge, C., Zoetendal, E. G., Erbil, R., Greve, J. W., Buurman, W. A., de Vos, W. M., & Rensen, S. S. (2013) · Obesity · doi:10.1002/oby.20466 · Cited by 587 · see citing works
Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Norin, E. L., Müller, M. M., & de Vos, W. M. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00166 · Cited by 582 · see citing works
Parks, B. W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S. T., Pan, C., Civelek, M., Rau, C. D., Bennett, B. J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.007 · Cited by 544 · see citing works
Self-citationGanesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074963 · Cited by 522 · see citing works
Million, M., Angelakis, E., Paul, M., Armougom, F., Leibovici, L., & Raoult, D. (2012) · Microbial Pathogenesis · doi:10.1016/j.micpath.2012.05.007 · Cited by 431 · see citing works
Fecal microbiota in early rheumatoid arthritis.
Vaahtovuo, J., Munukka, E., Korkeamäki, M., Luukkainen, R., & Toivanen, P. (2008) · PubMed · Cited by 426 · see citing works
Microbiota conservation and BMI signatures in adult monozygotic twins
Tims, S., Derom, C., Jonkers, D. M., Vlietinck, R., Saris, W. H., Kleerebezem, M., de Vos, W. M., & Zoetendal, E. G. (2013) · The ISME Journal · doi:10.1038/ismej.2012.146 · Cited by 367 · see citing works
Liu, Z., Lee, J., Krummey, S. M., Lü, W., Cai, H., & Lenardo, M. J. (2011) · Nature Immunology · doi:10.1038/ni.2113 · Cited by 361 · see citing works
Shulzhenko, N., Morgun, A., Hsiao, W., Battle, M., Yao, M., Gavrilova, O., Orandle, M., Mayer, L., Macpherson, A. J., McCoy, K. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2505 · Cited by 349 · see citing works
The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling
Flannery, S. M., & Bowie, A. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.020 · Cited by 316 · see citing works
Relatedness in the post-genomic era: is it still useful?
Speed, D., & Balding, D. J. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3821 · Cited by 316 · see citing works
A high-resolution association mapping panel for the dissection of complex traits in micePreprint
Bennett, B. J., Farber, C. R., Orozco, L. D., Kang, H. M., Ghazalpour, A., Siemers, N. O., Neubauer, M., Neuhaus, I., Yordanova, R., Guan, B., et al. (2010) · Genome Research · doi:10.1101/gr.099234.109 · Cited by 314 · see citing works
Self-citationUbeda, C., Lipuma, L., Gobourne, A., Viale, A., Leiner, I., Equinda, M., Khanin, R., & Pamer, E. G. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120504 · Cited by 310 · see citing works
McCafferty, J., Mühlbauer, M., Gharaibeh, R. Z., Arthur, J. C., Perez-Chanona, E., Sha, W., Jobin, C., & Fodor, A. A. (2013) · The ISME Journal · doi:10.1038/ismej.2013.106 · Cited by 259 · see citing works
Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes
Ueki, K., Okada, T., Hu, J., Liew, C. W., Aßmann, A., Dahlgren, G. M., Peters, J. L., Shackman, J. G., Zhang, M., Artner, I., et al. (2006) · Nature Genetics · doi:10.1038/ng1787 · Cited by 257 · see citing works
Genetic Architecture of Insulin Resistance in the Mouse
Parks, B. W., Sallam, T., Mehrabian, M., Psychogios, N., Hui, S. T., Norheim, F., Castellani, L. W., Rau, C. D., Pan, C., Phun, J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.002 · Cited by 249 · see citing works
Self-citationMurine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits
McKnite, A. M., Pérez-Muñoz, M. E., Lu, L., Williams, E. G., Brewer, S., Andreux, P. A., Bastiaansen, J. W. M., Wang, X., Kachman, S. D., Auwerx, J. H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039191 · Cited by 222 · see citing works
Muta, T., & Takeshige, K. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02385.x · Cited by 205 · see citing works
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
Liu, Y., Liu, X.-G., Wang, L., Christian Dina, C., Yan, H., Liu, J., Levy, S., Papasian, C. J., Drees, B. M., Hamilton, J. J., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn072 · Cited by 185 · see citing works
Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice.
Hedrick, C. C., Castellani, L. W., Warden, C. H., Puppione, D. L., & Lusis, A. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80777-7 · Cited by 175 · see citing works
Self-citationLong term effect of gut microbiota transfer on diabetes development
Peng, J., Narasimhan, S., Marchesi, J. R., Benson, A. K., Wong, F. S., & Li, W. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.03.005 · Cited by 157 · see citing works
Sommer, F., Adam, N., Johansson, M., Xia, L., Hansson, G. C., & Bäckhed, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085254 · Cited by 150 · see citing works
Mouse Genetics Concepts and Applications
Silver, L. M. (1995) · doi:10.1093/oso/9780195075540.001.0001 · Cited by 149 · see citing works
Orozco, L. D., Bennett, B. J., Farber, C. R., Ghazalpour, A., Pan, C., Che, N., Wen, P.-Z., Qi, H. X., Mutukulu, A., Siemers, N. O., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.043 · Cited by 129 · see citing works
Self-citationFarber, C. R., Bennett, B. J., Orozco, L. D., Zou, W., Lira, A. K., Kostem, E., Kang, H. M., Furlotte, N. A., Berberyan, A., Ghazalpour, A., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002038 · Cited by 113 · see citing works
Self-citationGenome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering
Srinivas, G., Möller, S., Wang, J., Künzel, S., Zillikens, D., Baines, J. F., & Ibrahim, S. M. (2013) · Nature Communications · doi:10.1038/ncomms3462 · Cited by 102 · see citing works
Mapping Genetic Contributions to Cardiac Pathology Induced by Beta-Adrenergic Stimulation in Mice
Rau, C. D., Wang, J., Avetisyan, R., Romay, M. C., Martin, L., Ren, S. V., Wang, Y., & Lusis, A. J. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000732 · Cited by 84 · see citing works
Self-citationTan, L., Zhu, H., He, H., Wu, K., Li, J., Chen, X., Zhang, J., Shen, H., Tian, Q., Krousel-Wood, M. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096149 · Cited by 83 · see citing works
Apolipoprotein AII Is a Regulator of Very Low Density Lipoprotein Metabolism and Insulin Resistance
Castellani, L. W., Nguyen, C., Charugundla, S., Weinstein, M. M., Doan, C. X., Blaner, W. S., Wongsiriroj, N., & Lusis, A. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708995200 · Cited by 80 · see citing works
Self-citationLavinsky, J., Crow, A. L., Pan, C., Wang, J., Aaron, K. A., Ho, M. K., Li, Q., Salehide, P., Myint, A., Monges-Hernadez, M., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005094 · Cited by 78 · see citing works
Self-citationGarg, N., Thakur, S., McMahan, C. A., & Adamo, M. L. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.123 · Cited by 52 · see citing works
Wittmann, I., Schönefeld, M., Aichele, D., Groer, G. J., Gessner, A., & Schnare, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7546 · Cited by 33 · see citing works
Kostem, E., & Eskin, E. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.03.010 · Cited by 26 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Multi-omics approaches to disease
Hasin, Y., Seldin, M., & Lusis, A. (2017) · Genome Biology · doi:10.1186/s13059-017-1215-1 · Cited by 2,953 · see citing works
Self-citationPlovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works
Genetic determinants of the gut microbiome in UK twins
Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.017 · Cited by 1,048 · see citing works
Self-citationAkkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · see citing works
The effect of host genetics on the gut microbiome
Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3663 · Cited by 819 · see citing works
Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808 · see citing works
Sex differences and hormonal effects on gut microbiota composition in mice
Org, E., Mehrabian, M., Parks, B. W., Shipkova, P., Liu, X., Drake, T. A., & Lusis, A. J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1203502 · Cited by 796 · see citing works
Self-citationFunctional Redundancy-Induced Stability of Gut Microbiota Subjected to Disturbance
Moya, A., & Ferrer, M. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.02.002 · Cited by 690 · see citing works
Role of gut microbiota in atherosclerosis
Jonsson, A. L., & Bäckhed, F. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.183 · Cited by 647 · see citing works
Brooks, A., Kohl, K. D., Brucker, R. M., van Opstal, E. J., & Bordenstein, S. R. (2016) · PLoS Biology · doi:10.1371/journal.pbio.2000225 · Cited by 629 · see citing works
Host and Environmental Factors Affecting the Intestinal Microbiota in Chickens
Kers, J. G., Velkers, F. C., Fischer, E. A. J., Hermes, G. D. A., Stegeman, A., & Smidt, H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00235 · Cited by 522 · see citing works
Human genetic variation and the gut microbiome in disease
Hall, A. B., Tolonen, A. C., & Xavier, R. J. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.63 · Cited by 517 · see citing works
Gut microbiome and liver diseases
Tilg, H., Cani, P. D., & Mayer, E. A. (2016) · Gut · doi:10.1136/gutjnl-2016-312729 · Cited by 525 · see citing works
Differences in gut microbiota profile between women with active lifestyle and sedentary women
Bressa, C., Bailén-Andrino, M., Pérez-Santiago, J., González-Soltero, R., Pérez, M., Montalvo-Lominchar, M. G., Maté-Muñoz, J. L., Domínguez, R., Moreno, D., & Larrosa, M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171352 · Cited by 501 · see citing works
Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes
Johnson, E. L., Heaver, S. L., Walters, W. A., & Ley, R. E. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1492-2 · Cited by 389 · see citing works
Flandroy, L., Poutahidis, T., Berg, G., Clarke, G. A., Dao, M. C., Decaestecker, E., Furman, E., Haahtela, T., Massart, S., Plovier, H., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.288 · Cited by 399 · see citing works
Host genetics and the rumen microbiome jointly associate with methane emissions in dairy cows
Difford, G. F., Plichta, D. R., Løvendahl, P., Lassen, J., Noel, S. J., Højberg, O., Wright, A. G., Zhu, Z., Kristensen, L., Nielsen, H. B., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007580 · Cited by 387 · see citing works
Gut microbiota Turicibacter strains differentially modify bile acids and host lipids
Lynch, J. B., Gonzalez, E. L., Choy, K., Faull, K. F., Jewell, T., Arellano, A., Liang, J., Yu, K. B., Paramo, J., & Hsiao, E. Y. (2023) · Nature Communications · doi:10.1038/s41467-023-39403-7 · Cited by 352 · see citing works
Xie, H., Guo, R., Zhong, H., Feng, Q., Lan, Z., Qin, B., Ward, K. J., Jackson, M. A., Xia, Y., Chen, X., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.10.004 · Cited by 341 · see citing works
Probiotics, prebiotics, synbiotics and insulin sensitivity
Kim, Y. A., Keogh, J. B., & Clifton, P. M. (2017) · Nutrition Research Reviews · doi:10.1017/s095442241700018x · Cited by 341 · see citing works
Org, E., Blum, Y., Kasela, S., Mehrabian, M., Kuusisto, J., Kangas, A. J., Soininen, P., Wang, Z., Ala‐Korpela, M., Hazen, S. L., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1194-2 · Cited by 330 · see citing works
Self-citationGut Microbiota and Iron: The Crucial Actors in Health and Disease
Yilmaz, B., & Li, H. (2018) · Pharmaceuticals · doi:10.3390/ph11040098 · Cited by 317 · see citing works
Host Genetics and Gut Microbiome: Challenges and Perspectives
Kurilshikov, A., Wijmenga, C., Fu, J., & Zhernakova, A. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.06.003 · Cited by 309 · see citing works
Cross-species comparisons of host genetic associations with the microbiome
Goodrich, J. K., Davenport, E., Waters, J. L., Clark, A. G., & Ley, R. E. (2016) · Science · doi:10.1126/science.aad9379 · Cited by 290 · see citing works
Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders
Metwaly, A., Reitmeier, S., & Haller, D. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00581-2 · Cited by 263 · see citing works
Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model
Wu, W., Lv, L., Shi, D., Ye, J., Fang, D., Guo, F., Li, Y., He, X., & Li, L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01804 · Cited by 247 · see citing works
The influence of Akkermansia muciniphila on intestinal barrier function
Mo, C., Lou, X., Xue, J., Shi, Z., Zhao, Y., Wang, F., & Chen, G. (2024) · Gut Pathogens · doi:10.1186/s13099-024-00635-7 · Cited by 235 · see citing works
Gut bacterial metabolism contributes to host global purine homeostasis
Kasahara, K., Kerby, R. L., Zhang, Q., Pradhan, M., Mehrabian, M., Lusis, A. J., Bergström, G. M. L., Bäckhed, F., & Rey, F. E. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.05.011 · Cited by 233 · see citing works
Self-citationNie, Q., Chen, H., Hu, J., Fan, S., & Nie, S. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1536646 · Cited by 205 · see citing works
Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis
Xu, X., Jia, X., Mo, L., Liu, C.-C., Zheng, L.-W., Yuan, Q., & Zhou, X.-D. (2017) · Bone Research · doi:10.1038/boneres.2017.46 · Cited by 183 · see citing works
Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Microbiome · doi:10.1186/s40168-021-01040-x · Cited by 203 · see citing works
Siderophore-mediated iron acquisition and modulation of host-bacterial interactions
Ellermann, M., & Arthur, J. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.489 · Cited by 186 · see citing works
Arias, N., Arboleya, S., Allison, J., Kaliszewska, A., Higarza, S. G., Gueimonde, M., & Arias, J. L. (2020) · Nutrients · doi:10.3390/nu12082340 · Cited by 200 · see citing works
Host genetic variation and its microbiome interactions within the Human Microbiome Project
Kolde, R., Franzosa, E. A., Rahnavard, G., Hall, A. B., Vlamakis, H., Stevens, C., Daly, M. J., Xavier, R. J., & Huttenhower, C. (2018) · Genome Medicine · doi:10.1186/s13073-018-0515-8 · Cited by 182 · see citing works
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative
Wang, J., Kurilshikov, A., Radjabzadeh, D., Turpin, W., Croitoru, K., Bonder, M. J., Jackson, M. A., Medina‐Gómez, C., Frost, F., Homuth, G., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0479-3 · Cited by 177 · see citing works
The amphibian microbiome: natural range of variation, pathogenic dysbiosis, and role in conservation
Jiménez, R. R., & Sommer, S. (2016) · Biodiversity and Conservation · doi:10.1007/s10531-016-1272-x · Cited by 180 · see citing works
Expanding role of gut microbiota in lipid metabolism
Ghazalpour, A., Cespedes, I., Bennett, B. J., & Allayee, H. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000278 · Cited by 171 · see citing works
Signaling in Host-Associated Microbial Communities
Fischbach, M. A., & Segre, J. A. (2016) · Cell · doi:10.1016/j.cell.2016.02.037 · Cited by 173 · see citing works
Lusis, A. J., Seldin, M. M., Allayee, H., Bennett, B. J., Civelek, M., Davis, R. C., Eskin, E., Farber, C. R., Hui, S., Mehrabian, M., et al. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066944 · Cited by 158 · see citing works
Self-citationArnoriaga-Rodríguez, M., Mayneris-Perxachs, J., Burokas, A., Contreras-Rodríguez, O., Blasco, G., Coll, C., Biarnés, C., Miranda-Olivos, R., Latorre, J., Moreno-Navarrete, J.-M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.09.002 · Cited by 157 · see citing works
Sex and strain dependent differences in mucosal immunology and microbiota composition in mice
Elderman, M. E., Hugenholtz, F., Belzer, C., Boekschoten, M. V., van Beek, A. A., de Haan, B., Savelkoul, H. F. J., de Vos, P., & Faas, M. M. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0186-6 · Cited by 149 · see citing works
Diet, gut microbiota and cognition
Proctor, C., Thiennimitr, P., Chattipakorn, N., & Chattipakorn, S. C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9917-8 · Cited by 144 · see citing works
Diet can impact microbiota composition in children with autism spectrum disorder
Berding, K., & Donovan, S. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00515 · Cited by 144 · see citing works
Physical activity induced alterations of gut microbiota in humans: a systematic review
Dziewiecka, H., Buttar, H. S., Kasperska, A., Ostapiuk–Karolczuk, J., Domagalska, M., Cichoń-Woźniak, J., & Skarpańska-Stejnborn, A. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00513-2 · Cited by 143 · see citing works
Obesity and microbiota: an example of an intricate relationship
Duranti, S., Ferrario, C., van Sinderen, D., Ventura, M., & Turroni, F. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0566-2 · Cited by 142 · see citing works
Ijaz, M. U., Ahmed, M. I., Zou, X., Hussain, M., Zhang, M., Zhao, F., Xu, X., Zhou, G., & Li, C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02200 · Cited by 138 · see citing works
Genetic determinants of gut microbiota composition and bile acid profiles in mice
Kemis, J. H., Linke, V., Barrett, K. L., Boehm, F. J., Traeger, L. L., Keller, M. P., Rabaglia, M. E., Schueler, K. L., Stapleton, D. S., Gatti, D. M., et al. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008073 · Cited by 136 · see citing works
Akkermansia muciniphila : is it the Holy Grail for ameliorating metabolic diseases?
Yan, J., Sheng, L., & Li, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1984104 · Cited by 142 · see citing works
Schmid‐Hempel, P. (2021) · doi:10.1093/oso/9780198832140.001.0001 · Cited by 130 · see citing works
Wasimuddin, Menke, S., Melzheimer, J., Thalwitzer, S., Heinrich, S. K., Wachter, B., & Sommer, S. (2017) · Molecular Ecology · doi:10.1111/mec.14278 · Cited by 126 · see citing works
Bowen, J. L., Kearns, P. J., Byrnes, J. E. K., Wigginton, S., Allen, W. J., Greenwood, M., Tran, K., Yu, J., Cronin, J. T., & Meyerson, L. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00626-0 · Cited by 124 · see citing works
Host and microbiome multi-omics integration: applications and methodologies
Wang, Q., Wang, K., Wu, W., Giannoulatou, E., Ho, J. W. K., & Li, L. (2019) · Biophysical Reviews · doi:10.1007/s12551-018-0491-7 · Cited by 122 · see citing works
The role of adaptive immunity as an ecological filter on the gut microbiota in zebrafish
Stagaman, K., Burns, A. R., Guillemin, K. J., & Bohannan, B. J. M. (2017) · The ISME Journal · doi:10.1038/ismej.2017.28 · Cited by 121 · see citing works
Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity
Montgomery, T. L., Künstner, A., Kennedy, J. J., Fang, Q., Asarian, L., Culp‐Hill, R., D’Alessandro, A., Teuscher, C., Busch, H. S., & Krementsov, D. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002817117 · Cited by 117 · see citing works
Intestinal Sensing by Gut Microbiota: Targeting Gut Peptides
Covașă, M., Stephens, R. W., Toderean, R., & Cobuz, C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00082 · Cited by 114 · see citing works
Moreno‐Indias, I., Lahti, L., Nedyalkova, M., Elbere, I., Roshchupkin, G. V., Adilović, M., Aydemir, Ö., Bakır-Güngör, B., Pau, E. C. D. S., D’Elia, D., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.635781 · Cited by 112 · see citing works
Hussain, T., Murtaza, G., Kalhoro, D. H., Kalhoro, M. S., Metwally, E., Chughtai, M. I., Mazhar, M. U., & Khan, S. A. (2021) · Animal Nutrition · doi:10.1016/j.aninu.2020.11.005 · Cited by 110 · see citing works
Impact of Individual Traits, Saturated Fat, and Protein Source on the Gut Microbiome
Lang, J. M., Pan, C., Cantor, R. M., Tang, W. H. W., Garcı́a-Garcı́a, J. C., Kurtz, I., Hazen, S. L., Bergeron, N., Krauss, R. M., & Lusis, A. J. (2018) · mBio · doi:10.1128/mbio.01604-18 · Cited by 111 · see citing works
Self-citationHost genetic determinants of the gut microbiota of wild mice
Suzuki, T. A., Phifer‐Rixey, M., Mack, K. L., Sheehan, M. J., Lin, D., Bi, K., & Nachman, M. W. (2019) · Molecular Ecology · doi:10.1111/mec.15139 · Cited by 108 · see citing works
Mullaney, J. A., Stephens, J. E., Costello, M., Fong, C., Geeling, B. E., Gavin, P. G., Wright, C. M., Spector, T. D., Brown, M. A., & Hamilton‐Williams, E. E. (2018) · Microbiome · doi:10.1186/s40168-018-0417-4 · Cited by 109 · see citing works
Disentangling host–microbiota complexity through hologenomics
Alberdi, A., Andersen, S. B., Limborg, M. T., Dunn, R. R., & Gilbert, M. T. P. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00421-0 · Cited by 103 · see citing works
Wade, H., Pan, K., Duan, Q., Kaluzny, S., Pandey, E., Fatumoju, L., Saraswathi, V., Wu, R., Harris, E. N., & Su, Q. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00935-1 · Cited by 107 · see citing works
Beilsmith, K. R., Thoen, M. P. M., Brachi, B., Gloss, A. D., Khan, M. H., & Bergelson, J. M. (2018) · The Plant Journal · doi:10.1111/tpj.14170 · Cited by 106 · see citing works
Host genetic control of gut microbiome composition
Bubier, J. A., Chesler, E. J., & Weinstock, G. M. (2021) · Mammalian Genome · doi:10.1007/s00335-021-09884-2 · Cited by 102 · see citing works
Ding, X., Jian, T., Li, J., Lv, H., Tong, B., Li, J., Meng, X., Ren, B., & Chen, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9734560 · Cited by 103 · see citing works
Functional Genomics of Host–Microbiome Interactions in Humans
Luca, F., Kupfer, S. S., Knights, D., Khoruts, A., & Blekhman, R. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.10.001 · Cited by 99 · see citing works
Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases
Niu, H., Zhou, M., Zogona, D., Xing, Z., Wu, T., Chen, R., Cui, D., Liang, F., & Xu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1370658 · Cited by 98 · see citing works
Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties
Pellegrino, A., Coppola, G., Santopaolo, F., Gasbarrini, A., & Ponziani, F. R. (2023) · Nutrients · doi:10.3390/nu15081815 · Cited by 105 · see citing works
Revtovich, A. V., Lee, R. Y., & Kirienko, N. V. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008011 · Cited by 94 · see citing works
Chen, C., Huang, X., Fang, S., Yang, H., He, M., Zhao, Y., & Huang, L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02626 · Cited by 90 · see citing works
Busnelli, M., Manzini, S., & Chiesa, G. (2019) · Nutrients · doi:10.3390/nu12010079 · Cited by 91 · see citing works
Interactions between the microbiota and enteric nervous system during gut-brain disorders
Fried, S. G., Wemelle, E., Cani, P. D., & Knauf, C. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108721 · Cited by 90 · see citing works
Gut Microbiota and Atherosclerosis
Li, D. Y., & Tang, W. H. W. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0675-9 · Cited by 88 · see citing works
Piazzon, M. C., Naya-Català, F., Perera, E., Palenzuela, O. R., Sitjà‐Bobadilla, A., & Pérez‐Sánchez, J. (2020) · Microbiome · doi:10.1186/s40168-020-00922-w · Cited by 87 · see citing works
Elucidating the role of the host genome in shaping microbiome composition
Davenport, E. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1155022 · Cited by 87 · see citing works
The gut microbiome of laboratory mice: considerations and best practices for translational research
Ericsson, A. C., & Franklin, C. L. (2021) · Mammalian Genome · doi:10.1007/s00335-021-09863-7 · Cited by 85 · see citing works
Host genetic variation in mucosal immunity pathways influences the upper airway microbiome
Igartua, C., Davenport, E., Gilad, Y., Nicolae, D. L., Pinto, J. M., & Ober, C. (2017) · Microbiome · doi:10.1186/s40168-016-0227-5 · Cited by 83 · see citing works
Current evidence linking diet to gut microbiota and brain development and function
Ceppa, F., Mancini, A., & Tuohy, K. M. (2018) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2018.1462309 · Cited by 82 · see citing works
Pearce, D. S., Hoover, B. A., Jennings, S. L., Nevitt, G. A., & Docherty, K. M. (2017) · Microbiome · doi:10.1186/s40168-017-0365-4 · Cited by 77 · see citing works
Coral adaptation to climate change: Meta‐analysis reveals high heritability across multiple traits
Bairos‐Novak, K. R., Hoogenboom, M. O., van Oppen, M. J. H., & Connolly, S. R. (2021) · Global Change Biology · doi:10.1111/gcb.15829 · Cited by 75 · see citing works
Schugar, R. C., Gliniak, C. M., Osborn, L. J., Massey, W. J., Sangwan, N., Horak, A. J., Banerjee, R., Orabi, D., Helsley, R. N., Brown, A. L., et al. (2022) · eLife · doi:10.7554/elife.63998 · Cited by 73 · see citing works
Self-citationSharma, A. K., Jaiswal, S. K., Chaudhary, N., & Sharma, V. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-10203-6 · Cited by 77 · see citing works
Honey bee genetics shape the strain-level structure of gut microbiota in social transmission
Wu, J., Lang, H., Mu, X., Zhang, Z., Su, Q., Hu, X., & Zheng, H. (2021) · Microbiome · doi:10.1186/s40168-021-01174-y · Cited by 72 · see citing works
Singhal, M., Turturice, B. A., Manzella, C. R., Ranjan, R., Metwally, A. A., Theorell, J. A., Huang, Y. L., Alrefai, W. A., Dudeja, P. K., Finn, P. W., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38489-8 · Cited by 71 · see citing works
Mouse Systems Genetics as a Prelude to Precision Medicine
Li, H., & Auwerx, J. H. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.01.004 · Cited by 68 · see citing works
A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases
Liu, X., Tang, S., Zhong, H., Tong, X., Jie, Z., Ding, Q., Wang, D., Guo, R., Xiao, L., Xu, X., et al. (2021) · Cell Discovery · doi:10.1038/s41421-020-00239-w · Cited by 70 · see citing works
Function of Akkermansia muciniphila in type 2 diabetes and related diseases
Li, J., Yang, G., Zhang, Q., Liu, Z., Jiang, X. M., & Xin, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1172400 · Cited by 71 · see citing works
Insights into human evolution from ancient and contemporary microbiome studies
Schnorr, S. L., Sankaranarayanan, K., Lewis, C. M., & Warinner, C. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.07.003 · Cited by 68 · see citing works
Miyoshi, J., Leone, V., Nobutani, K., Musch, M. W., Martinez, K., Wang, Y., Miyoshi, S., Bobe, A. M., Eren, A. M., & Chang, E. B. (2018) · PeerJ · doi:10.7717/peerj.5166 · Cited by 65 · see citing works
Sex differences in growth performance are related to cecal microbiota in chicken
Cui, L., Zhang, X., Cheng, R., Ansari, A. R., Elokil, A., Hu, Y., Chen, Y., Nafady, A. A., & Liu, H. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104710 · Cited by 67 · see citing works
Microbiome-immune interactions in tuberculosis
Mori, G., Morrison, M., & Blumenthal, A. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009377 · Cited by 77 · see citing works
The Microbiome in Crohn's Disease
Khanna, S., & Raffals, L. E. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.05.004 · Cited by 69 · see citing works
Sex Differences in Pulmonary Responses to Ozone in Mice. Role of the Microbiome
Cho, Y., Abu-Ali, G., Tashiro, H., Brown, T. A., Osgood, R. S., Kasahara, D. I., Huttenhower, C., & Shore, S. A. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0099oc · Cited by 66 · see citing works
Greathouse, K. L., Wyatt, M., Johnson, A. J., Toy, E. P., Khan, J., Dunn, K., Clegg, D. J., & Reddy, S. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100800 · Cited by 65 · see citing works
Impact of host genetics on gut microbiome: Take‐home lessons from human and mouse studies
Cahana, I., & Iraqi, F. A. (2020) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12134 · Cited by 61 · see citing works
Duan, D., Wang, M., Han, J., Li, M., Wang, Z., Zhou, S., Xin, W., & Li, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1509117 · Cited by 69 · see citing works
Inter‐breed diversity and temporal dynamics of the faecal microbiota in healthy horses
Massacci, F. R., Clark, A. P., Ruet, A., Lansade, L., Costa, M., & Mach, N. (2019) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12441 · Cited by 62 · see citing works
Vitamin B12 produced by gut bacteria modulates cholinergic signalling
Kang, W. K., Florman, J., Araya, A., Fox, B. W., Thackeray, A., Schroeder, F. C., Walhout, A. J. M., & Alkema, M. J. (2024) · Nature Cell Biology · doi:10.1038/s41556-023-01299-2 · Cited by 60 · see citing works
Multiple testing correction in linear mixed models
Joo, J. W. J., Hormozdiari, F., Han, B., & Eskin, E. (2016) · Genome biology · doi:10.1186/s13059-016-0903-6 · Cited by 59 · see citing works
Self-citationChronic kidney disease, uremic milieu, and its effects on gut bacterial microbiota dysbiosis
Chaves, L. D., McSkimming, D. I., Bryniarski, M. A., Honan, A. M., Abyad, S., Thomas, S. A., Wells, S., Buck, M. J., Sun, Y., Genco, R. J., et al. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00092.2018 · Cited by 59 · see citing works
- Authors
- Org, E., Parks, B. W., Joo, J. W. J., Emert, B., Schwartzman, W., Kang, E. Y., Mehrabian, M., Pan, C., Knight, R., Gunsalus, R., Drake, T. A., Eskin, E., & Lusis, A. J.
- Affiliations
- University of California, Los Angeles (US)
- University of California San Diego (US)
- ORCID
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-08-10
- Volume
- 25
- Issue
- 10
- Pages
- 1558-1569
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- PMC
- PMC4579341
- OpenAlex
- W2161377204
- Cited by
- 381
- References
- 70
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 28 · 2023: 34 · 2022: 36 · 2021: 75 · 2020: 41 · 2019: 27 · 2018: 38 · 2017: 36 · 2016: 38 · 2015: 3
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (HL028481, HL30568, DK094311)
- UCLA Iris Cantor Women's Health Center
- MOBILITAS Postdoctoral Research (MJD252, 330381)
- NIH (T32-HD07228)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota composition, inbred mouse strains, association mapping, cross-fostering, high-fat high-sugar diet, Akkermansia muciniphila, obesity, insulin resistance, plasma lipids, candidate genes
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diet, Environment, Female, Male, Mice, Inbred Strains, Obesity, RNA, Ribosomal, 16S, Sucrose, Heredity, Mice, Genome-Wide Association Study, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
