Blyth, Karen

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 1,007

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 820

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Maddocks, O. D. K., Athineos, D., Cheung, E. C., Lee, P., Zhang, T., van den Broek, N. J. F., Mackay, G. M., Labuschagne, C. F., Gay, D., Kruiswijk, F., et al. (2017) · Nature

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 603

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

Ichim, G., Lopez, J., Ahmed, S. U., Muthalagu, N., Giampazolias, E., Delgado, M. E., Haller, M., Riley, J. S., Mason, S. M., Athineos, D., et al. (2015) · Molecular Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 479

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Cardaci, S., Zheng, L., MacKay, G., van den Broek, N. J. F., MacKenzie, E. D., Nixon, C., Stevenson, D., Tumanov, S., Bulusu, V., Kamphorst, J. J., et al. (2015) · Nature Cell Biology

Cancer, Hypoxia, and MetabolismCancer and biochemical research

Cited by 286

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

Zheng, L., Cardaci, S., Jerby, L., MacKenzie, E. D., Sciacovelli, M., Johnson, T. I., Gaude, E., King, A., Leach, J. D. G., Edrada-Ebel, R., et al. (2015) · Nature Communications

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 281

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

Giampazolias, E., Zunino, B., Dhayade, S., Bock, F., Cloix, C., Cao, K., Roca, A., Lopez, J., Ichim, G., Proïcs, E., et al. (2017) · Nature Cell Biology

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 258

Serine one-carbon catabolism with formate overflow

Meiser, J., Tumanov, S., Maddocks, O., Labuschagne, C. F., Athineos, D., Van Den Broek, N., Mackay, G. M., Gottlieb, E., Blyth, K., Vousden, K., et al. (2016) · Science Advances

Cancer, Hypoxia, and MetabolismFolate and B Vitamins Research

Cited by 174

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

Rai, T. S., Cole, J. J., Nelson, D. M., Dikovskaya, D., Faller, W. J., Vizioli, M. G., Hewitt, R. N., Anannya, O., McBryan, T., Manoharan, I., et al. (2014) · Genes & Development

Genomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

Cited by 162

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

Zheng, L., MacKenzie, E. D., Karim, S. A., Hedley, A., Blyth, K., Kalna, G., Watson, D. G., Szlosarek, P., Frezza, C., & Gottlieb, E. (2013) · Cancer & Metabolism

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 103

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

Dikovskaya, D., Cole, J. J., Mason, S. M., Nixon, C., Karim, S. A., McGarry, L., Clark, W., Hewitt, R. N., Sammons, M. A., Zhu, J., et al. (2015) · Cell Reports

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 89

THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer

Blomme, A., Peter, C., Mui, E., Rodriguez Blanco, G., An, N., Mason, L. M., Jamieson, L. E., McGregor, G. H., Lilla, S., Ntala, C., et al. (2022) · EMBO Molecular Medicine

Prostate Cancer Treatment and ResearchCancer, Lipids, and Metabolism

Cited by 36