Brown, Robert H.

Dystrophin: the protein product of the Duchenne muscular dystrophy locus

Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell

Muscle Physiology and DisordersCardiomyopathy and Myosin Studies

Cited by 4,693

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

Pasinelli, P., & Brown, R. H. (2006) · Nature Reviews Neuroscience

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 1,107

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Cirulli, E. T., Lasseigne, B. N., Petrovski, S., Sapp, P. C., Dion, P. A., Leblond, C. S., Couthouis, J., Lu, Y.-F., Wang, Q., Krueger, B. J., et al. (2015) · Science

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 966

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

Heneka, M. T., Golenbock, D., Latz, E., Morgan, D., & Brown, R. (2020) · Alzheimer's Research & Therapy

Long-Term Effects of COVID-19COVID-19 Clinical Research Studies

Cited by 555

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt, J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein, N., Westra, H.-J., Bakker, O. B., Deelen, P., et al. (2021) · Nature Genetics

Amyotrophic Lateral Sclerosis ResearchGenetic Associations and Epidemiology

Cited by 542

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A. M., Brown, R. H., & Glimcher, L. H. (2009) · Genes & Development

Amyotrophic Lateral Sclerosis ResearchEndoplasmic Reticulum Stress and Disease

Cited by 530

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

Chow, C. Y., Landers, J. E., Bergren, S. K., Sapp, P. C., Grant, A. E., Jones, J. M., Everett, L., Lenk, G. M., McKenna-Yasek, D. M., Weisman, L. S., et al. (2009) · The American Journal of Human Genetics

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 407

Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis

Ryan, D. P., Dias da Silva, M. R., Soong, T. W., Fontaine, B., Donaldson, M. R., Kung, A. W. C., Jongjaroenprasert, W., Liang, M. C., Khoo, D. H. C., Cheah, J. S., et al. (2010) · Cell

Ion channel regulation and functionCardiac electrophysiology and arrhythmias

Cited by 311

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72 -associated amyotrophic lateral sclerosis

Gendron, T. F., Chew, J., Stankowski, J. N., Hayes, L. R., Zhang, Y.-J., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., et al. (2017) · Science Translational Medicine

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 265

SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS

Mueller, C., Berry, J. D., McKenna-Yasek, D. M., Gernoux, G., Owegi, M. A., Pothier, L. M., Douthwright, C. L., Gelevski, D., Luppino, S. D., Blackwood, M., et al. (2020) · New England Journal of Medicine

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 264

Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10

Yang, B., Li, S., Wang, H., Guo, Y., Gessler, D. J., Cao, C., Su, Q., Kramer, J., Zhong, L., Ahmed, S. S., et al. (2014) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 213

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

Tran, H., Moazami, M. P., Yang, H., McKenna-Yasek, D., Douthwright, C. L., Pinto, C., Metterville, J., Shin, M., Sanil, N., Dooley, C., et al. (2022) · Nature Medicine

Amyotrophic Lateral Sclerosis ResearchRNA Interference and Gene Delivery

Cited by 174

AAV gene therapy for Tay-Sachs disease

Flotte, T. R., Cataltepe, O., Puri, A., Batista, A. R., Moser, R., McKenna-Yasek, D., Douthwright, C., Gernoux, G., Blackwood, M., Mueller, C., et al. (2022) · Nature Medicine

Lysosomal Storage Disorders ResearchVirus-based gene therapy research

Cited by 143

Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis

Li, Y.-J., Pericak-Vance, M. A., Haines, J. L., Siddique, N., McKenna-Yasek, D., Hung, W.-Y., Sapp, P., Allen, C. I., Chen, W., Hosler, B., et al. (2004) · Neurogenetics

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 77

Homologous Recombination Mediates Functional Recovery of Dysferlin Deficiency following AAV5 Gene Transfer

Grose, W. E., Clark, K. R., Griffin, D., Malik, V., Shontz, K. M., Montgomery, C. L., Lewis, S., Brown, R. H., Janssen, P. M. L., Mendell, J. R., et al. (2012) · PLoS ONE

Virus-based gene therapy researchNeurogenetic and Muscular Disorders Research

Cited by 76

Approaches to gene modulation therapy for ALS

Meijboom, K. E., & Brown, R. H. (2022) · Neurotherapeutics

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 38

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS

Eitan, C., Siany, A., Barkan, E., Olender, T., van Eijk, K. R., Moisse, M., Farhan, S. M. K., Danino, Y. M., Yanowski, E., Marmor-Kollet, H., et al. (2022) · Nature Neuroscience

Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research Studies

Cited by 38

Ro5‐4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats

Mills, C., Makwana, M., Wallace, A., Benn, S., Schmidt, H., Tegeder, I., Costigan, M., Brown, R. H., Raivich, G., & Woolf, C. J. (2008) · European Journal of Neuroscience

Nerve injury and regenerationHereditary Neurological Disorders

Cited by 35

ABCD1 translation–initiator mutation demonstrates genotype–phenotype correlation for AMN

O’Neill, G. N., Aoki, M., & Brown, R. H. (2001) · Neurology

Metabolism and Genetic DisordersHereditary Neurological Disorders

Cited by 28