Guigas, Bruno

Cellular and molecular mechanisms of metformin: an overview

Viollet, B., Guigas, B., Garcia, N. S., Leclerc, J., Foretz, M., & Andreelli, F. (2012) · Clinical Science

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 1,720

Metformin: from mechanisms of action to therapies

Foretz, M., Guigas, B., Bertrand, L., Pollak, M., & Viollet, B. (2014) · Cell Metabolism

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 1,501

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 686

Role of mitochondria in the mechanism(s) of action of metformin

Vial, G., Detaille, D., & Guigas, B. (2019) · Frontiers in Endocrinology

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 303

Metformin Activates AMP-Activated Protein Kinase in Primary Human Hepatocytes by Decreasing Cellular Energy Status

Stephenne, X., Foretz, M., Taleux, N., van der Zon, G. C., Sokal, E., Hue, L., Viollet, B., & Guigas, B. (2011) · Diabetologia

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 287

Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process

Detaille, D., Guigas, B., Chauvin, C., Batandier, C., Fontaine, E., Wiernsperger, N., & Leverve, X. (2005) · Diabetes

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 263

Role of AMP Kinase and PPARδ in the Regulation of Lipid and Glucose Metabolism in Human Skeletal Muscle

Krämer, D. K., Al-Khalili, L., Guigas, B., Leng, Y., Garcia-Roves, P. M., & Krook, A. (2007) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsMetabolism, Diabetes, and Cancer

Cited by 180

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., et al. (2012) · Biochemical Journal

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 131

Beyond AICA riboside: In search of new specific AMP‐activated protein kinase activators

Guigas, B., Sakamoto, K., Taleux, N., Reyna, S. M., Musi, N., Viollet, B., & Hue, L. (2009) · IUBMB Life

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 86

A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South Asian men but not in Caucasian men

Bakker, L. E. H., van Schinkel, L. D., Guigas, B., Streefland, T. C. M., Jonker, J. T., van Klinken, J. B., van der Zon, G. C. M., Lamb, H. J., Smit, J. W. A., Pijl, H., et al. (2014) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Cited by 77

Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice

Thomas, A., Belaidi, E., Aron-Wisnewsky, J., van der Zon, G. C., Levy, P., Clement, K., Pepin, J.-L., Godin-Ribuot, D., & Guigas, B. (2016) · Scientific Reports

Liver Disease Diagnosis and TreatmentAdipokines, Inflammation, and Metabolic Diseases

Cited by 33

Glucocorticoid treatment impairs microvascular function in healthy men in association with its adverse effects on glucose metabolism and blood pressure: A randomised controlled trial

van Raalte, D. H., Diamant, M., Ouwens, D. M., Ijzerman, R. G., Linssen, M. M. L., Guigas, B., Eringa, E. C., & Serné, E. H. (2013) · Diabetologia

Adrenal Hormones and DisordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 33