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Mechanism and application of metformin in kidney diseases: An update

Song, A., Zhang, C., & Meng, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111454 · Cited by 116 · see citing works

Towards natural mimetics of metformin and rapamycin

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Sodium Butyrate Supplementation Inhibits Hepatic Steatosis by Stimulating Liver Kinase B1 and Insulin-Induced Gene

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Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver

Zhang, X., Song, Y., Feng, M., Zhou, X., Lu, Y., Gao, L., Yu, C., Jiang, X., & Zhao, J. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m047654 · Cited by 108 · see citing works

Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation

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Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights

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Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells

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Profiles of Circulating miRNAs Following Metformin Treatment in Patients with Type 2 Diabetes

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Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes

Ye, R., Onodera, T., & Scherer, P. E. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00372 · Cited by 94 · see citing works

Metformin prevents against oxidative stress-induced senescence in human periodontal ligament cells

Kuang, Y., Hu, B., Ge, F., Xiang, M., Deng, Y., Tan, M., Li, J., & Song, J. (2019) · Biogerontology · doi:10.1007/s10522-019-09838-x · Cited by 94 · see citing works

Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

Zhou, Z.-Y., Ren, L.-W., Zhan, P., Yang, H.-Y., Chai, D.-D., & Yu, Z.-W. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.21 · Cited by 92 · see citing works

Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways

Ma, L., Wei, J., Wan, J., Wang, W., Wang, L., Yuan, Y., Yang, Z., Liu, X., & Ming, L. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1090-6 · Cited by 91 · see citing works

New drugs are not enough‑drug repositioning in oncology: An update

Armando, R., Mengual G�mez, D., & Gomez, D. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.4966 · Cited by 90 · see citing works

Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism

Janzen, N. R., Whitfield, J., & Hoffman, N. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113344 · Cited by 85 · see citing works

A reappraisal on metformin

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A Comprehensive Review of Drug–Drug Interactions with Metformin

Stage, T. B., Brøsen, K., & Christensen, M. M. H. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0270-6 · Cited by 89 · see citing works

Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

Allard, J. S., Perez, E., Fukui, K., Carpenter, P., Ingram, D. K., & de Cabo, R. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.012 · Cited by 87 · see citing works

Promise and challenges for direct small molecule AMPK activators

Olivier, S., Foretz, M., & Viollet, B. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.049 · Cited by 86 · see citing works

The Impacts ofSLC22A1rs594709 andSLC47A1rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients

Xiao, D., Yu, G., Li, X., Yin, J., Zheng, W., Qiu, X., Xiao, L., Liu, R., Wang, S., Gong, W., et al. (2016) · International Journal of Endocrinology · doi:10.1155/2016/4350712 · Cited by 83 · see citing works

Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system

Ismaiel, A. A., Espinosa‐Oliva, A. M., Santiago, M., García-Quintanilla, A., Oliva-Martín, M. J., Herrera, A. J., Venero, J. L., & de Pablos, R. M. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.03.004 · Cited by 81 · see citing works

FAM3 gene family: A promising therapeutical target for NAFLD and type 2 diabetes

Zhang, X., Yang, W., Wang, J., Meng, Y., Guan, Y., & Yang, J. (2017) · Metabolism · doi:10.1016/j.metabol.2017.12.001 · Cited by 80 · see citing works

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

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Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

García-Calzón, S., Perfilyev, A., Männistö, V., de Mello, V. D., Nilsson, E., Pihlajamäki, J., & Ling, C. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0400-0 · Cited by 79 · see citing works

Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2

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Metformin Protects Against Systolic Overload–Induced Heart Failure Independent of AMP-Activated Protein Kinase α2

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Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities

Pulito, C., Mori, F., Sacconi, A., Goeman, F., Ferraiuolo, M. A., Pasanisi, P., Campagnoli, C., Berrino, F., Fanciulli, M., Ford, R. J., et al. (2017) · Cell Discovery · doi:10.1038/celldisc.2017.22 · Cited by 76 · see citing works

Protective effect of metformin against palmitate-induced hepatic cell death

Geng, Y., Villanueva, A. H., Oun, A., Buist‐Homan, M., Blokzijl, H., Faber, K. N., Dolga, A. M., & Moshage, H. J. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165621 · Cited by 76 · see citing works

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

Bultot, L., Jensen, T. E., Lai, Y., Madsen, A. B., Collodet, C., Kviklyte, S., Deák, M., Yavari, A., Foretz, M., Ghaffari, S., et al. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00237.2016 · Cited by 75 · see citing works

Metformin and Breast Cancer: Molecular Targets

Faria, J., Negalha, G. D. C., Azevedo, A., & Martel, F. (2019) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-019-09429-z · Cited by 75 · see citing works

Metformin as a Therapeutic Target in Endometrial Cancers

Lee, T. Y., Martinez‐Outschoorn, U., Schilder, R. J., Kim, C. H., Richard, S. D., Rosenblum, N. G., & Johnson, J. M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00341 · Cited by 76 · see citing works

Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism

Postler, T. S., Peng, V., Bhatt, D. M., & Ghosh, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-97441-x · Cited by 72 · see citing works

Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes

Kato, H., Nagai, Y., Ohta, A., Tenjin, A., Nakamura, Y., Tsukiyama, H., Sasaki, Y., Fukuda, H., Ohshige, T., Terashima, Y., et al. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.04.008 · Cited by 71 · see citing works

The Mechanism of Action of Biguanides: New Answers to a Complex Question

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An Update on the Pharmacogenomics of Metformin: Progress, Problems and Potential

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Metformin overdose causes platelet mitochondrial dysfunction in humans

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Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes

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Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis

Xu, J., Liu, L., Xu, L., Xing, Y., & Ye, S. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13226 · Cited by 69 · see citing works

Revisiting the mechanisms of metformin action in the liver

Viollet, B., & Foretz, M. (2013) · Annales d Endocrinologie · doi:10.1016/j.ando.2013.03.006 · Cited by 68 · see citing works

Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

Liu, X., Zheng, H., Yu, W., Cooper, T. M., Bunting, K. D., & Qu, C. (2015) · Blood · doi:10.1182/blood-2014-04-568949 · Cited by 66 · see citing works

mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?

Kezić, A., Popović, L., & Lalic, K. S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2640342 · Cited by 67 · see citing works

The metabolic sensor AMPK: Twelve enzymes in one

Smiles, W. J., Ovens, A. J., Oakhill, J. S., & Kofler, B. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102042 · Cited by 65 · see citing works

Chemoproteomic Analysis of Intertissue and Interspecies Isoform Diversity of AMP-activated Protein Kinase (AMPK)

Wu, J., Puppala, D., Feng, X., Monetti, M., Lapworth, A. L., & Geoghegan, K. F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.508747 · Cited by 66 · see citing works

Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals

Wijngaarden, M. A., van der Zon, G. C., van Dijk, K. W., Pijl, H., & Guigas, B. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00008.2013 · Cited by 63 · see citing works

Steady-State Pharmacokinetics of Metformin Is Independent of the OCT1 Genotype in Healthy Volunteers

Christensen, M. M. H., Højlund, K., Hother-Nielsen, O., Stage, T. B., Damkier, P., Beck-Nielsen, H., & Brøsen, K. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1853-8 · Cited by 62 · see citing works

Significance of Metformin Use in Diabetic Kidney Disease

Kawanami, D., Takashi, Y., & Tanabe, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124239 · Cited by 62 · see citing works

Hepatic Overexpression of ATP Synthase β Subunit Activates PI3K/Akt Pathway to Ameliorate Hyperglycemia of Diabetic Mice

Wang, C., Chen, Z., Li, S., Zhang, Y., Shi, J., Li, J., Chi, Y., Miao, Y., Guan, Y., & Yang, J. (2013) · Diabetes · doi:10.2337/db13-1096 · Cited by 62 · see citing works

Therapeutic application of GPR119 ligands in metabolic disorders

Yang, J. W., Kim, H. S., Choi, Y., Kim, Y., & Kang, K. W. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13062 · Cited by 62 · see citing works

Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells

Babcook, M. A., Sramkoski, R. M., Fujioka, H., Daneshgari, F., Almasan, A., Shukla, S., Nanavaty, R. R., & Gupta, S. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.500 · Cited by 61 · see citing works

Mitochondrial dysfunction plays a key role in the development of neurodegenerative diseases in diabetes

Cheng, H., Gang, X., Liu, Y., Wang, G., Zhao, X., & Wang, G. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2019 · Cited by 62 · see citing works

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4

Ngoei, K. R. W., Langendorf, C. G., Ling, N. X. Y., Hoque, A., Varghese, S., Camerino, M. A., Walker, S. R., Bozikis, Y. E., Dite, T. A., Ovens, A. J., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.03.008 · Cited by 60 · see citing works

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

García-Calzón, S., Perfilyev, A., Martinell, M., Ustinova, M., Kalamajski, S., Franks, P. W., Bacos, K., Elbere, I., Pihlajamäki, J., Volkov, P., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz1803 · Cited by 59 · see citing works

Pharmacology of metformin – An update

Glossmann, H. H., & Lutz, O. M. D. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172782 · Cited by 61 · see citing works

Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high-fat diet-fed mice

Zamani‐Garmsiri, F., Hashemnia, S. M. R., Shabani, M., Bagherieh, M., Emamgholipour, S., & Meshkani, R. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108505 · Cited by 59 · see citing works

Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes

Hozumi, K., Sugawara, K., Ishihara, T., Ishihara, N., & Ogawa, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-27689-y · Cited by 62 · see citing works

Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats

Boyda, H. N., Procyshyn, R. M., Tse, L., Hawkes, E., Chen, J., Pang, C. C. Y., Honer, W. G., & Barr, A. M. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110140 · Cited by 55 · see citing works

Preparation and characterization of metformin surface modified cellulose nanofiber gel and evaluation of its anti-metastatic potentials

Nurani, M., Akbari, V., & Taheri, A. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.02.067 · Cited by 54 · see citing works

Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease

Kim, J., Choe, J., & Park, S. (2021) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2021.363 · Cited by 56 · see citing works

Metformin Reduces Hepatic Expression of SIRT3, the Mitochondrial Deacetylase Controlling Energy Metabolism

Buler, M., Aatsinki, S., Izzi, V., & Hakkola, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049863 · Cited by 53 · see citing works

Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis

Li, J., Zhang, S., Li, C., Zhang, X., Shan, Y., Zhang, Z., Hai, B., & Zhang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-72088-6 · Cited by 57 · see citing works

Metformin Increases Mitochondrial Energy Formation in L6 Muscle Cell Cultures

Vytla, V. S., & Ochs, R. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482646 · Cited by 51 · see citing works

Genomic Characterization of Metformin Hepatic Response

Luizon, M. R., Eckalbar, W. L., Wang, Y., Jones, S. L., Smith, R. P., Megan, L., Lin, L., Gallins, P. J., Etheridge, A. S., Wright, F. A., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006449 · Cited by 49 · see citing works

Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice

Kristensen, J. M., Larsen, S., Helge, J. W., Dela, F., & Wojtaszewski, J. F. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053533 · Cited by 48 · see citing works

Metformin: the updated protective property in kidney disease

Pan, Q., Lü, X., Zhao, C., Liao, S., Chen, X., Guo, F., Yang, C., & Liu, H.-F. (2020) · Aging · doi:10.18632/aging.103095 · Cited by 48 · see citing works

Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase

Ovens, A. J., Scott, J. W., Langendorf, C. G., Kemp, B. E., Oakhill, J. S., & Smiles, W. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031229 · Cited by 48 · see citing works

The multifaceted activities of AMPK in tumor progression-why the “one size fits all” definition does not fit at all?

Bonini, M. G., & Gantner, B. N. (2013) · IUBMB Life · doi:10.1002/iub.1213 · Cited by 47 · see citing works

microRNAs and cancer metabolism reprogramming: the paradigm of metformin.

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ARTICLE

(2011)

Metformin action in hepatocytes is not mimicked by selective activation of AMPactivated protein kinase

Moonira, T., Al‐Oanzi, Z. H., Arden, C., & Agius, L. (2016) · Newcastle University ePrints (Newcastle Univesity) · doi:10.25405/ncl.34275858

Hepatic AMPK activation mechanism by metformin is linked to a change in the cellular energetic state

Guigas, B., Stéphenne, X., Sokal, E. M., Foretz, M., Taleux, N., Viollet, B., & Hue, L. (2008) · Digital Access to Libraries

O32 Le mécanisme d’activation de l’AMPK hépatique par la metformine est lié à une modification de l’état énergétique cellulaire

Guigas, B., Foretz, M., Stéphenne, X., Taleux, N., Sokal, E. M., Viollet, B., & Hue, L. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)72842-8

Revisiting the mechanisms of metformin action in the liver

Viollet, B., & Foretz, M. (2013) · Annales d Endocrinologie · doi:10.1016/j.ando.2013.03.006 · Cited by 68 · see citing works