Feng, Gen-Sheng

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

Marengère, L. E. M., Waterhouse, P., Duncan, G. S., Mittrücker, H.-W., Feng, G.-S., & Mak, T. W. (1996) · Science

Protein Tyrosine PhosphatasesT-cell and B-cell Immunology

Cited by 551

Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway

You, M., Yu, D.-H., & Feng, G.-S. (1999) · Molecular and Cellular Biology

Protein Tyrosine PhosphatasesCytokine Signaling Pathways and Interactions

Cited by 364

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

Bard-Chapeau, E. A., Li, S., Ding, J., Zhang, S. S., Zhu, H. H., Princen, F., Fang, D. D., Han, T., Bailly-Maitre, B., Poli, V., et al. (2011) · Cancer Cell

Protein Tyrosine PhosphatasesCytokine Signaling Pathways and Interactions

Cited by 332

Shp-2 Tyrosine Phosphatase: Signaling One Cell or Many

Feng, G.-S. (1999) · Experimental Cell Research

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 285

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

Kozlowski, M., Mlinaric-Rascan, I., Feng, G. S., Shen, R., Pawson, T., & Siminovitch, K. A. (1993) · The Journal of experimental medicine

Protein Tyrosine PhosphatasesImmunodeficiency and Autoimmune Disorders

Cited by 235

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

Varanasi, S. K., Chen, D., Liu, Y., Johnson, M. A., Miller, C. M., Ganguly, S., Lande, K., LaPorta, M. A., Hoffmann, F. A., Mann, T. H., et al. (2025) · Science

Cancer Immunotherapy and BiomarkersDrug Transport and Resistance Mechanisms

Cited by 177

Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics

Liang, Y., Kaneko, K., Xin, B., Lee, J., Sun, X., Zhang, K., & Feng, G.-S. (2022) · Developmental Cell

Single-cell and spatial transcriptomicsLiver physiology and pathology

Cited by 116

Development of Diabesity in Mice with Neuronal Deletion of Shp2 Tyrosine Phosphatase

Krajewska, M., Banares, S., Zhang, E. E., Huang, X., Scadeng, M., Jhala, U. S., Feng, G.-S., & Krajewski, S. (2008) · The American Journal of Pathology

Regulation of Appetite and ObesityProtein Tyrosine Phosphatases

Cited by 72

Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment

Chen, W. S., Liang, Y., Zong, M., Liu, J. J., Kaneko, K., Hanley, K. L., Zhang, K., & Feng, G.-S. (2021) · Cell Reports

Protein Tyrosine PhosphatasesHepatocellular Carcinoma Treatment and Prognosis

Cited by 50

β‐catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β‐catenin and MET

Liang, Y., Feng, Y., Zong, M., Wei, X., Lee, J., Feng, Y., Li, H., Yang, G., Wu, Z., Fu, X., et al. (2018) · Hepatology

Wnt/β-catenin signaling in development and cancerHepatocellular Carcinoma Treatment and Prognosis

Cited by 36

Loss of Shp2-Mediated Mitogen-Activated Protein Kinase Signaling in Müller Glial Cells Results in Retinal Degeneration

Cai, Z., Simons, D. L., Fu, X.-Y., Feng, G.-S., Wu, S. M., & Zhang, X. (2011) · Molecular and Cellular Biology

Retinal Development and DisordersProtein Tyrosine Phosphatases

Cited by 34

Pharmaceutical SH2 domain–containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity

Liu, J. J., Xin, B., Du, L., Chen, L., Long, Y., & Feng, G. (2023) · Hepatology

Protein Tyrosine PhosphatasesHepatocellular Carcinoma Treatment and Prognosis

Cited by 11