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Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis

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Tissue-specific macrophages: how they develop and choreograph tissue biology

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Gut–liver axis: barriers and functional circuits

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Macrophage heterogeneity in the single-cell era: facts and artifacts

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Human iPSC-liver organoid transplantation reduces fibrosis through immunomodulation

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Priming and Maintenance of Adaptive Immunity in the Liver

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Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis

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Custom microfluidic chip design enables cost-effective three-dimensional spatiotemporal transcriptomics with a wide field of view

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Fetal liver development and implications for liver disease pathogenesis

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Single-cell and spatially resolved transcriptomics for liver biology

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PGLYRP2 drives hepatocyte-intrinsic innate immunity by trapping and clearing hepatitis B virus

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From multitude to singularity: An up-to-date overview of scRNA-seq data generation and analysis

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Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells

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Determination of key events in mouse hepatocyte maturation at the single-cell level

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Integrative single-cell and spatial transcriptomic analyses identify a pathogenic cholangiocyte niche and TNFRSF12A as therapeutic target for biliary atresia

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Characterisation of macrophages in healthy and diseased livers in mice: identification of necrotic lesion-associated macrophages

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Single-cell dynamics of liver development in postnatal pigs

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Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis

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Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers

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Decoding liver fibrogenesis with single-cell technologies

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Developmental programming of tissue-resident macrophages

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Immune Cell Contribution to Mammary Gland Development

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Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states

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Insights into the gut-liver axis: mechanisms and emerging therapies in hepatocellular carcinoma

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Single‐cell RNA sequencing reveals reduced intercellular adhesion molecule crosstalk between activated hepatic stellate cells and neutrophils alleviating liver fibrosis in hepatitis B virus transgenic mice post menstrual blood‐derived mesenchymal stem cell transplantation

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SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice

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The mouse multi-organ proteome from infancy to adulthood

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A sexually dimorphic hepatic cycle of periportal VLDL generation and subsequent pericentral VLDLR-mediated re-uptake

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A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis

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RISING STARS: Liver sinusoidal endothelial transcription factors in metabolic homeostasis and disease

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Deciphering the temporal transcriptional landscape of human fetal leptomeninges

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Myeloid cells in alcoholic liver diseases: Mechanism and prospect

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Endothelial Slc35a1 Deficiency Causes Loss of LSEC Identity and Exacerbates Neonatal Lipid Deposition in the Liver in Mice

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Unveiling the power of microenvironment in liver regeneration: an in-depth overview

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Single-cell analysis of diquat-induced oxidative stress and its impact on organ-specific toxicity

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MaskGraphene: an advanced framework for interpretable joint representation for multi-slice, multi-condition spatial transcriptomics

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ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells

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Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model

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Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

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Deciphering Age‐Dependent ECM Remodelling in Liver: Proteomic Profiling and Its Implications for Aging and Therapeutic Targets

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Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects

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Single‐cell multi‐omics deciphers hepatocyte dedifferentiation and illuminates maintenance strategies

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Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver

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Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit

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Transcriptomic Profile of the Mouse Postnatal Liver Development by Single-Nucleus RNA Sequencing

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A spatiotemporal single‐cell atlas of porcine development reveals regulatory dynamics and cellular targets of domestication

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Single-nucleus transcriptome reveals cell dynamic response of liver during the late chick embryonic development

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ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation

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Targeting MED23 inhibits hepatocellular carcinoma development by suppressing compensatory proliferation and facilitating ROS-mediated cell death

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A dataset of single-cell transcriptomic atlas of Bama pig and potential marker genes across seven tissues

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Single-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs

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Proenkephalin produced by neonatal T-bet+ Treg cells promotes periportal hepatocyte maturation

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Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit

Kaneko, K., Liang, Y., Liu, Q., Zhang, S., Scheiter, A., Song, D., & Feng, G. (2023) · eLife · doi:10.7554/elife.86824 · Cited by 3 · see citing works

Hepatocyte differentiation requires anisotropic expansion of bile canaliculi

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Single-cell atlas of hepatitis C virus inoculated tree shrew liver reveals immune activation, metabolic reprogramming, and persistent inflammation

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Conversion of Transplanted Mature Hepatocytes into Afp + Reprogrammed Cells for Liver Regeneration After Injury

Fang, T., Yang, C., Qiu, H., Du, Y., Wang, X., Li, Y., Xu, M., Liu, C., Li, X., Guo, N., et al. (2026) · Advanced Science · doi:10.1002/advs.202517126 · Cited by 2 · see citing works

Gestational low carbamoyl phosphate suppresses TET2-mediated DNA demethylation and induces congenital heart disease in offspring

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Synergy between oxygenation and co-culture with liver sinusoidal endothelial cells drives expansion of functional liver organoids

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A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity

Xia, M., Ma, Y., Cai, Y., Zhao, J., Zhong, Y., Guo, S., Li, M., Su, P., Shen, B., He, H., et al. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.04.005 · Cited by 2 · see citing works

Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring

Zhang, K., Tian, L., Sun, Q., Lv, J., Ding, R., Yu, Y., Yang, L., & Duan, J. (2024) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2024.104585 · Cited by 3 · see citing works

Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice

Lee, S., Ren, L., Li, W., et al. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000745 · Cited by 2 · see citing works

Investigating the hepatic developmental toxicity of synthetic phenolic antioxidant 3-BHA: A comprehensive network-based approach combined with human embryonic stem cell-derived hepatocyte models

Nijiati, N., Wang, M., Julaiti, M., et al. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119235 · Cited by 2 · see citing works

IGF2 mediates Hippo signaling to control liver sizePreprint

Zhong, Z., Jin, R., Zhong, Y., Zhang, L., Chen, D., Jiao, Z., Zhou, F., Zhu, R., Wu, J., Dong, R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.27.620455 · Cited by 2 · see citing works

Aberrant differentiation and proliferation of hepatocytes in chronic liver injury and liver tumors

Nishikawa, Y. (2024) · Pathology International · doi:10.1111/pin.13441 · Cited by 1 · see citing works

Multifaceted Role of ILCs in Metabolic Adaptations: From Adult to Neonate

Guendel, F., & Lécuyer, E. (2025) · European Journal of Immunology · doi:10.1002/eji.70088 · Cited by 1 · see citing works

Spatial- and Phospho-Proteomic Profiling Reveals Pancreatic and Hepatic Dysfunction in a Rat Model of Lethal Insulin Overdose

Zhang, J., Li, S., Kong, Q., He, A., Ke, M., Yu, Z., Wang, Y., Xiao, L., Yuan, Y., Tian, R., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211018 · Cited by 1 · see citing works

Differential effects of gestational arsenic exposure on the liver and kidney of rat offspring across postnatal development

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Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation

Vasseur, L., Gheeraert, C., Dubois‐Chevalier, J., Very, N., Guille, L., Saleh, M. B., Boulet, C., Sobolewski, C., Loyer, P., Berthier, A., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003547 · Cited by 1 · see citing works

Tissue-resident macrophage and dendritic cells drive type I IFN immunity to enteroviruses in the liver

Heckenberg, E., Davis, J. G., Hale, C., & Coyne, C. B. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1013891 · Cited by 1 · see citing works

UFMylation: biological mechanisms, functions, and clinical implications

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Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart

Rumyantseva, A., Tippetts, T. S., Wilhalm, A., Carter, W., Moedas, M. F., Rosenberger, F. A., Moore, D., Végvári, Á., Hinze, Y., Muellner-Wong, L., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeg8792 · Cited by 1 · see citing works

LDL-Bound PCSK9 Has a Slower Clearance Kinetic and Higher Use for HSPGs Than Free-PCSK9—Brief Report

Pacheco-Velázquez, S. C., Oleaga, C., Ramms, B., Hay, J., Mueller, P. A., López-Aguilar, E., Miles, J., Porell, R. N., Cheng, C., Godula, K., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.322334 · Cited by 1 · see citing works

ESRP2-microRNA-122 axis directs the postnatal onset of liver polyploidization and maturationPreprint

Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.602336 · Cited by 1 · see citing works

Spatiotemporally restricted Hippo signalings instruct the fate and maturation of hepatobiliary cellsPreprint

Wang, Y., Zhong, Z., Wang, Y., Zhu, Y., Guan, K., & Yu, F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.02.621695 · Cited by 1 · see citing works

MittoSAM-dependent lipoylation controls postnatal heart development via metabolic remodelingPreprint

Rumyantseva, A., Wilhalm, A., Carter, W., Tippetts, T. S., Moedas, M., Rosenberger, F., Moore, D., Végvári, Á., Hinze, Y., Muellner-Wong, L. S., et al. (2026) · bioRxiv · doi:10.64898/2026.04.20.719537 · Cited by 1 · see citing works

Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver FibrosisPreprint

Mašek, J., Filipovic, I., Hul, N. V., Belicová, L., Jiroušková, M., Oliveira, D. V., Frontino, A. M., Hankeová, S., He, J., Turetti, F., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.24.513578

Intercellular Communication Compensates Intracellular Proliferative Signal Deficit during Liver RegenerationPreprint

Kaneko, K., Liang, Y., Liu, Q., Zhang, S., Song, D., & Feng, G. (2023) · eLife · doi:10.7554/elife.86824.1

Reviewer #1 (Public Review): Intercellular Communication Compensates Intracellular Proliferative Signal Deficit during Liver Regeneration

Kaneko, K., Liang, Y., Qing, L., et al. (2023) · eLife · doi:10.7554/elife.86824.1.sa1

eLife Assessment: Intercellular Communication Compensates Intracellular Proliferative Signal Deficit during Liver Regeneration

Davis, R. J. (2023) · eLife · doi:10.7554/elife.86824.1.sa2

Author Response: Intercellular Communication Compensates Intracellular Proliferative Signal Deficit during Liver Regeneration

Kaneko, K., Liang, Y., Liu, Q., Zhang, S., Song, D., & Feng, G. (2023) · eLife · doi:10.7554/elife.86824.1.sa3

Reviewer #2 (Public Review): Intercellular Communication Compensates Intracellular Proliferative Signal Deficit during Liver Regeneration

Kaneko, K., Liang, Y., Qing, L., et al. (2023) · eLife · doi:10.7554/elife.86824.1.sa0

Identification of CD133+ Intercellsomes in Intercellular Communication to Offset Intracellular Signal DeficitPreprint

Kaneko, K., Liang, Y., Liu, Q., Zhang, S., Scheiter, A., Song, D., & Feng, G. (2023) · eLife · doi:10.7554/elife.86824.2

Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver

Yoshihara, M., Nakayama, T., & Takahashi, S. (2023) · BMC Research Notes · doi:10.1186/s13104-023-06674-8

Hepatocyte differentiation requires anisotropic expansion of bile canaliculiPreprint

Belicová, L., Bebelman, M. P., Gralinska, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.19.581065

Nutritional programming of white adipose tissue and mitochondrial function : Fat quality matters

Kodde, F. D. (2024) · doi:10.18174/644648

Single-Cell Sequencing Analysis of the Differentiation of Mouse Hepatic Oval Cells

张, 峻. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1451496

Peroxisomes and their role in pediatric diseases

Васильевна, В. Г., Хавкин, А. И., Андреевна, С. Т., & Nikitin, A. V. (2025) · Russian Journal of Evidence-Based Gastroenterology · doi:10.17116/dokgastro20251401191

APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells

Wang, M., Rahmawati, F. N., Li, W., Bal, Z., Sitompul, F. N., Muramatsu, F., Jia, W., & Takakura, N. (2025) · Inflammation and Regeneration · doi:10.1186/s41232-025-00389-y

The gut microbiome promotes detoxification responses to an environmental toxicantPreprint

Krout, I. N., Matsuzaki, R., White, A. C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.14.670327

Deciphering context-specific gene programs from single-cell and spatial transcriptomics data with DeCEPPreprint

Li, L., Su, X., & Han, Z. (2025) · Genome Research · doi:10.1101/gr.279689.124

Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood

Wang, Y., Chu, L., Zhou, Y., Jin, Z., Kim, K., Heiden, K. D., Monreal, M. A. G., Ren, J., Li, Y., Cheng, Z., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-10769-w

Embryonic Circadian Rhythm Establishment, Homeostasis, and Dysfunction During Organogenesis

Chen, S.-L., Zhou, H., Li, Y.-M., & Zheng, Y.-W. (2025) · Stem Cells International · doi:10.1155/sci/9621027

Postnatal hepatocyte proliferation – challenge and opportunity for gene therapy

Chen, F., & Tchorz, J. S. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.09.025

Single-cell activation screen identifies hepatic maturation regulators with zonal resolution

Taguchi, A., Magalhães, A. P., Bolondi, A., Lee, M.-K., Kretzmer, H., Wittler, L., Hnisz, D., & Meissner, A. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.10.014

Additional file 8 of Single-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs

Zhu, J., Guan, X., Yi, L.-L., Xu, H., Li, Q.-Y., Cheng, W.-J., Xie, Y., Li, W.-Z., Zhao, H., Wei, H.-J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26652858

Additional file 1 of Single-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs

Zhu, J., Guan, X., Lanlan, Y., Xu, H., Li, Q.-Y., Cheng, W.-J., Xie, Y., Li, W.-Z., Zhao, H., Wei, H.-J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26652837

Additional file 5 of Single-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs

Zhu, J., Guan, X., Yi, L.-L., Xu, H., Li, Q., Cheng, W.-J., Xie, Y., Li, W.-Z., Zhao, H.-Y., Wei, H.-J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26652849

Regulation of cultured rat hepatocyte proliferation by stellate cells

Uyama, N., Shimahara, Y., Kawada, N., Seki, S., Okuyama, H., Iimuro, Y., & Yamaoka, Y. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00023-5 · Cited by 54 · see citing works

The Experimental Studies on the So-called Kupffer's Stellate Cell: Part I. The Influence of the Indian Ink-injection upon the Stellate Cell and its Relation with the Liver-glycogen

Tamura, O. (2009)

Hepatic stellate and endothelial cells maintain hematopoietic stem cells in the developing liver

Lee, Y., Leslie, J. S., Yang, Y., & Ding, L. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200882 · Cited by 54 · see citing works

Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat

MABUCHI, A. (2004) · Journal of Hepatology · doi:10.1016/s0168-8278(04)00055-8 · Cited by 11 · see citing works

Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat

MABUCHI, A. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.02.005 · Cited by 103 · see citing works