Behlke, Mark A.

Identification of preexisting adaptive immunity to Cas9 proteins in humans

Charlesworth, C. T., Deshpande, P. S., Dever, D. P., Camarena, J., Lemgart, V. T., Cromer, M. K., Vakulskas, C. A., Collingwood, M. A., Zhang, L., Bode, N. M., et al. (2019) · Nature Medicine

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,093

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells

Vakulskas, C. A., Dever, D. P., Rettig, G. R., Turk, R., Jacobi, A. M., Collingwood, M. A., Bode, N. M., McNeill, M. S., Yan, S., Camarena, J., et al. (2018) · Nature Medicine

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 782

Progress towards in Vivo Use of siRNAs

Behlke, M. A. (2006) · Molecular Therapy

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 677

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

Rosenblum, D., Gutkin, A., Kedmi, R., Ramishetti, S., Veiga, N., Jacobi, A. M., Schubert, M. S., Friedmann-Morvinski, D., Cohen, Z. R., Behlke, M. A., et al. (2020) · Science Advances

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 614

A modular platform for targeted RNAi therapeutics

Kedmi, R., Veiga, N., Ramishetti, S., Goldsmith, M., Rosenblum, D., Dammes, N., Hazan-Halevy, I., Nahary, L., Leviatan-Ben-Arye, S., Harlev, M., et al. (2018) · Nature Nanotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 320

miRNAs control insulin content in pancreatic β‐cells via downregulation of transcriptional repressors

Melkman‐Zehavi, T., Oren, R., Kredo‐Russo, S., Shapira, T., Mandelbaum, A. D., Rivkin, N., Nir, T., Lennox, K. A., Behlke, M. A., Dor, Y., et al. (2011) · The EMBO Journal

Pancreatic function and diabetesMicroRNA in disease regulation

Cited by 280

RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers

Dobosy, J. R., Rose, S. D., Beltz, K. R., Rupp, S. M., Powers, K. M., Behlke, M. A., & Walder, J. A. (2011) · BMC Biotechnology

Molecular Biology Techniques and ApplicationsDNA and Nucleic Acid Chemistry

Cited by 184

Comparative analysis of CRISPR off-target discovery tools following ex vivo editing of CD34(+) hematopoietic stem and progenitor cells

Cromer, M. K., Majeti, K. R., Rettig, G. R., Murugan, K., Kurgan, G. L., Bode, N. M., Hampton, J. P., Vakulskas, C. A., Behlke, M. A., & Porteus, M. H. (2023) · Molecular Therapy

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 42