Serrao, Erik

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

Sowd, G. A., Serrao, E., Wang, H., Wang, W., Fadel, H. J., Poeschla, E. M., & Engelman, A. N. (2016) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentVirus-based gene therapy research

Cited by 249

Structural basis for retroviral integration into nucleosomes

Maskell, D. P., Renault, L., Serrao, E., Lesbats, P., Matadeen, R., Hare, S., Lindemann, D., Engelman, A. N., Costa, A., & Cherepanov, P. (2015) · Nature

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 138

A supramolecular assembly mediates lentiviral DNA integration

Ballandras-Colas, A., Maskell, D. P., Serrao, E., Locke, J., Swuec, P., Jónsson, S. R., Kotecha, A., Cook, N. J., Pye, V. E., Taylor, I. A., et al. (2017) · Science

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 107

The cleavage and polyadenylation specificity factor 6 (CPSF6) subunit of the capsid-recruited pre-messenger RNA cleavage factor I (CFIm) complex mediates HIV-1 integration into genes

Rasheedi, S., Shun, M.-C., Serrao, E., Sowd, G. A., Qian, J., Hao, C., Dasgupta, T., Engelman, A. N., & Skowronski, J. (2016) · Journal of Biological Chemistry

HIV Research and TreatmentVirus-based gene therapy research

Cited by 65

Key determinants of target DNA recognition by retroviral intasomes

Serrao, E., Ballandras-Colas, A., Cherepanov, P., Maertens, G. N., & Engelman, A. N. (2015) · Retrovirology

Virus-based gene therapy researchHIV Research and Treatment

Cited by 62

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Serrao, E., Krishnan, L., Shun, M.-C., Li, X., Cherepanov, P., Engelman, A., & Maertens, G. N. (2014) · Nucleic Acids Research

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 59

Structural basis for spumavirus GAG tethering to chromatin

Lesbats, P., Serrao, E., Maskell, D. P., Pye, V. E., O’Reilly, N., Lindemann, D., Engelman, A. N., & Cherepanov, P. (2017) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchHIV Research and Treatment

Cited by 51

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase–LEDGF/p75 interaction

Serrao, E., Xu, Z.-L., Debnath, B., Christ, F., Debyser, Z., Long, Y.-Q., & Neamati, N. (2013) · Bioorganic & Medicinal Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 47

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

Feng, L., Dharmarajan, V., Serrao, E., Hoyte, A., Larue, R. C., Slaughter, A., Sharma, A., Plumb, M. R., Kessl, J. J., Fuchs, J. R., et al. (2016) · ACS Chemical Biology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 37

Biochemical Characterization of Novel Retroviral Integrase Proteins

Ballandras-Colas, A., Naraharisetty, H., Li, X., Serrao, E., & Engelman, A. (2013) · PLoS ONE

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 18